Sapanisertib_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sapanisertib perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sapanisertib_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0669711
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0581132
RPS12 ribosomal protein S12 0.0349579
EEF2 eukaryotic translation elongation factor 2 0.0344048
GOLGA4 golgin A4 0.0322792
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 0.0226319
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0225446
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0194203
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0167766
RPS2 ribosomal protein S2 0.0154262
PDIA4 protein disulfide isomerase family A, member 4 0.0153778
RNF43 ring finger protein 43 0.0150044
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0148702
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0147573
RNF145 ring finger protein 145 0.0138883
CALR calreticulin 0.0135964
HSPA8 heat shock 70kDa protein 8 0.0131092
RPL3 ribosomal protein L3 0.0128527
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.012334
RPL12 ribosomal protein L12 0.0118847
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0118545
GDF15 growth differentiation factor 15 0.0112974
ZFAND3 zinc finger, AN1-type domain 3 0.0112366
RPL18 ribosomal protein L18 0.0112365
EREG epiregulin 0.0111895
FTH1 ferritin, heavy polypeptide 1 0.0111419
NUP58 nucleoporin 58 0.0109078
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0108645
NBAS neuroblastoma amplified sequence 0.0107878
MON2 MON2 homolog (S. cerevisiae) 0.0105074
RPS27 ribosomal protein S27 0.010499
COG5 component of oligomeric golgi complex 5 0.010486
EXT1 exostosin glycosyltransferase 1 0.0102896
KITLG KIT ligand 0.0102123
RPL36 ribosomal protein L36 0.00995662
PDZD8 PDZ domain containing 8 0.00993537
SRP54 signal recognition particle 54kDa 0.0098275
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.00954871
MACF1 microtubule-actin crosslinking factor 1 0.00953888
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.00931245
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 0.00914131
RPS19 ribosomal protein S19 0.00912799
CDH17 cadherin 17, LI cadherin (liver-intestine) 0.00900722
NCEH1 neutral cholesterol ester hydrolase 1 0.00900108
MED13 mediator complex subunit 13 0.00894431
ANKRD17 ankyrin repeat domain 17 0.00892532
GSK3B glycogen synthase kinase 3 beta 0.00890418
TSC22D2 TSC22 domain family, member 2 0.00888434
BRD2 bromodomain containing 2 0.00885099
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 0.00866759
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) 0.00859255
NFXL1 nuclear transcription factor, X-box binding-like 1 0.008587
GARS1 glycyl-tRNA synthetase 1 0.00851923
DERA deoxyribose-phosphate aldolase (putative) 0.00847589
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 0.00846226
SEC24A SEC24 family member A 0.00845088
SEC24D SEC24 family member D 0.00842423
SIPA1L2 signal-induced proliferation-associated 1 like 2 0.00841533
CEMIP2 cell migration inducing hyaluronidase 2 0.00840893
TRPS1 trichorhinophalangeal syndrome I 0.00821888
POF1B premature ovarian failure, 1B 0.00813803
NPTN neuroplastin 0.00795058
RPS3 ribosomal protein S3 0.007937
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.00785464
COG6 component of oligomeric golgi complex 6 0.00784264
EIF2A eukaryotic translation initiation factor 2A, 65kDa 0.00781729
MKNK2 MAP kinase interacting serine/threonine kinase 2 0.00777951
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.00773351
DPY19L1 dpy-19-like 1 (C. elegans) 0.00768161
RPS7 ribosomal protein S7 0.00762614
HYOU1 hypoxia up-regulated 1 0.00761856
HDLBP high density lipoprotein binding protein 0.00755408
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.00751936
NDRG1 N-myc downstream regulated 1 0.00742287
KMT2E lysine (K)-specific methyltransferase 2E 0.00722444
PNN pinin, desmosome associated protein 0.00714884
SERP1 stress-associated endoplasmic reticulum protein 1 0.0071373
GCLC glutamate-cysteine ligase, catalytic subunit 0.00707342
PGM3 phosphoglucomutase 3 0.00706075
TMED2 transmembrane emp24 domain trafficking protein 2 0.00701674
WAC WW domain containing adaptor with coiled-coil 0.00701536
RELCH RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing 0.00699182
CSNK1A1 casein kinase 1, alpha 1 0.00694426
PMM2 phosphomannomutase 2 0.00692585
USP47 ubiquitin specific peptidase 47 0.00683335
SHROOM3 shroom family member 3 0.00682143
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.00681038
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 0.00680865
LURAP1L leucine rich adaptor protein 1-like 0.00680543
TFG TRK-fused gene 0.00678304
ASNS asparagine synthetase (glutamine-hydrolyzing) 0.00666307
ASCC3 activating signal cointegrator 1 complex subunit 3 0.00665146
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.00657316
CLCN3 chloride channel, voltage-sensitive 3 0.00655241
WDR43 WD repeat domain 43 0.00651105
RPL37A ribosomal protein L37a 0.00650384
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.00648706
DUSP16 dual specificity phosphatase 16 0.00648524
SLC31A1 solute carrier family 31 (copper transporter), member 1 0.00643845
RPL26 ribosomal protein L26 0.00640798

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.225788
NPSR1 neuropeptide S receptor 1 -0.167987
TMSB10 thymosin beta 10 -0.117029
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.116047
NALF1 NALCN channel auxiliary factor 1 -0.079463
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0728643
ITGA6 integrin, alpha 6 -0.06528
ACTG1 actin gamma 1 -0.0615674
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0605923
KRT18 keratin 18, type I -0.0584821
EZR ezrin -0.0563511
ANXA2 annexin A2 -0.0527312
MUC6 mucin 6, oligomeric mucus/gel-forming -0.05248
ALCAM activated leukocyte cell adhesion molecule -0.0508461
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0497645
TPT1 tumor protein, translationally-controlled 1 -0.0487142
CEMIP cell migration inducing protein, hyaluronan binding -0.0483996
S100A6 S100 calcium binding protein A6 -0.0475402
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0446743
VCL vinculin -0.0441059
AHNAK AHNAK nucleoprotein -0.0408706
GREB1L growth regulation by estrogen in breast cancer-like -0.0406163
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0391598
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0383727
PTPRR protein tyrosine phosphatase, receptor type, R -0.0379273
PDE4D phosphodiesterase 4D, cAMP-specific -0.0368594
ACTN4 actinin, alpha 4 -0.0366519
GCC2 GRIP and coiled-coil domain containing 2 -0.0353648
CCSER1 coiled-coil serine-rich protein 1 -0.0348974
DEK DEK proto-oncogene -0.0343135
RNF217 ring finger protein 217 -0.0340495
FLNB filamin B, beta -0.0321267
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0321152
KRT19 keratin 19, type I -0.031999
MYO1E myosin IE -0.0318732
DIAPH2 diaphanous-related formin 2 -0.0314068
TPM4 tropomyosin 4 -0.0313475
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0306743
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -0.0304794
PPARG peroxisome proliferator-activated receptor gamma -0.0302607
KLK10 kallikrein-related peptidase 10 -0.029488
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0291602
TFF3 trefoil factor 3 (intestinal) -0.0291194
SH3D19 SH3 domain containing 19 -0.028791
FOXO1 forkhead box O1 -0.028305
PDLIM5 PDZ and LIM domain 5 -0.028172
S100A10 S100 calcium binding protein A10 -0.027748
MAML3 mastermind-like 3 (Drosophila) -0.0276269
HMGB1 high mobility group box 1 -0.0272105
CCND1 cyclin D1 -0.0271062
LGALS3 lectin, galactoside-binding, soluble, 3 -0.0270635
DSPP dentin sialophosphoprotein -0.0268561
LMNA lamin A/C -0.026754
GMDS GDP-mannose 4,6-dehydratase -0.0267444
SNX9 sorting nexin 9 -0.0266855
SAMD5 sterile alpha motif domain containing 5 -0.0260514
KRT8 keratin 8, type II -0.0254707
ANTXR2 anthrax toxin receptor 2 -0.0253791
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0252115
POTEF POTE ankyrin domain family, member F -0.0251976
FERMT1 fermitin family member 1 -0.0251704
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0250087
PTPRB protein tyrosine phosphatase, receptor type, B -0.0248598
PERP PERP, TP53 apoptosis effector -0.0248284
RAD51B RAD51 paralog B -0.0246134
LPP LIM domain containing preferred translocation partner in lipoma -0.0244222
IER3 immediate early response 3 -0.0243989
TUBB4B tubulin, beta 4B class IVb -0.0242951
LAMA4 laminin, alpha 4 -0.0240898
SLC35F3 solute carrier family 35, member F3 -0.0240291
ONECUT3 one cut homeobox 3 -0.0239312
SPON1 spondin 1, extracellular matrix protein -0.0237137
HMGA1 high mobility group AT-hook 1 -0.0235019
MYO1D myosin ID -0.0231154
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0228968
RPS6 ribosomal protein S6 -0.0228873
BACE2 beta-site APP-cleaving enzyme 2 -0.0225513
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0222231
TFF1 trefoil factor 1 -0.022149
CNKSR3 CNKSR family member 3 -0.0220389
ABHD2 abhydrolase domain containing 2 -0.021753
CALB1 calbindin 1, 28kDa -0.0216206
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0215305
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0214368
RPL8 ribosomal protein L8 -0.02127
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0210608
SOX4 SRY (sex determining region Y)-box 4 -0.0210179
B4GALNT3 beta-1,4-N-acetyl-galactosaminyl transferase 3 -0.0209946
HDAC2 histone deacetylase 2 -0.0209324
MUC17 mucin 17, cell surface associated -0.0207433
ZBTB20 zinc finger and BTB domain containing 20 -0.0204699
ARHGAP6 Rho GTPase activating protein 6 -0.0203018
TNS4 tensin 4 -0.0202756
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0201276
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0199209
FOXP1 forkhead box P1 -0.0198945
TCF12 transcription factor 12 -0.0197998
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0197971
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.019785
LOC102724023 ES1 protein homolog, mitochondrial -0.0197141