| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Sapanisertib perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Sapanisertib_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.038149 |
| SLTM | SAFB-like, transcription modulator | 0.0254743 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0183311 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0156084 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0154497 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0148914 |
| PCBP2 | poly(rC) binding protein 2 | 0.0141309 |
| DTNA | dystrobrevin, alpha | 0.0140419 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0122945 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0112152 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0109854 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0105745 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0104151 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0100584 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0091983 |
| RPL3 | ribosomal protein L3 | 0.00911591 |
| HMGA2 | high mobility group AT-hook 2 | 0.00892502 |
| ARRDC3 | arrestin domain containing 3 | 0.00875573 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.00786837 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.00784064 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.00769039 |
| ANXA5 | annexin A5 | 0.00753562 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.00732052 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.00723803 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.00705105 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.00689967 |
| PAPOLA | poly(A) polymerase alpha | 0.00686879 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.00663636 |
| RPS2 | ribosomal protein S2 | 0.00639817 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | 0.00638413 |
| RPL7 | ribosomal protein L7 | 0.00636671 |
| DOCK4 | dedicator of cytokinesis 4 | 0.00636593 |
| BMP6 | bone morphogenetic protein 6 | 0.00632767 |
| SPAG9 | sperm associated antigen 9 | 0.00612659 |
| FNIP1 | folliculin interacting protein 1 | 0.00610784 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.00610153 |
| PER3 | period circadian clock 3 | 0.00607144 |
| SFPQ | splicing factor proline/glutamine-rich | 0.00605688 |
| ELOVL7 | ELOVL fatty acid elongase 7 | 0.00589969 |
| FLT1 | fms-related tyrosine kinase 1 | 0.00581591 |
| MSN | moesin | 0.00576145 |
| RPS7 | ribosomal protein S7 | 0.0057093 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.00565583 |
| SCFD1 | sec1 family domain containing 1 | 0.00560165 |
| RPS8 | ribosomal protein S8 | 0.00556085 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | 0.00539492 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.00535739 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.00533972 |
| SLC35F5 | solute carrier family 35, member F5 | 0.00522951 |
| RPS12 | ribosomal protein S12 | 0.00521449 |
| ELK4 | ELK4, ETS-domain protein (SRF accessory protein 1) | 0.00521183 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.00513696 |
| NGLY1 | N-glycanase 1 | 0.00508977 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.00506161 |
| SIK3 | SIK family kinase 3 | 0.0050023 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.00489124 |
| MAP3K13 | mitogen-activated protein kinase kinase kinase 13 | 0.00488691 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.00487637 |
| RUNX1 | runt-related transcription factor 1 | 0.00483236 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.00477964 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.00476826 |
| NPTN | neuroplastin | 0.00473065 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.004719 |
| MANBA | mannosidase, beta A, lysosomal | 0.00463977 |
| SPCS2 | signal peptidase complex subunit 2 homolog (S. cerevisiae) | 0.00462767 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.00461144 |
| PGM3 | phosphoglucomutase 3 | 0.00460979 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.00459344 |
| DNAJB11 | DnaJ (Hsp40) homolog, subfamily B, member 11 | 0.00458751 |
| ARHGAP31 | Rho GTPase activating protein 31 | 0.00457693 |
| FBRS | fibrosin | 0.00457099 |
| C1D | C1D nuclear receptor corepressor | 0.00456908 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.00454307 |
| C3ORF52 | chromosome 3 open reading frame 52 | 0.00452879 |
| HYOU1 | hypoxia up-regulated 1 | 0.00450555 |
| NT5E | 5'-nucleotidase, ecto (CD73) | 0.00441384 |
| EIF2A | eukaryotic translation initiation factor 2A, 65kDa | 0.00439132 |
| IGSF9B | immunoglobulin superfamily, member 9B | 0.00435125 |
| MYO5B | myosin VB | 0.00431116 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.00426326 |
| SRP54 | signal recognition particle 54kDa | 0.00424962 |
| COPA | coatomer protein complex, subunit alpha | 0.00424769 |
| PMM2 | phosphomannomutase 2 | 0.00424319 |
| SLC9A1 | solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 | 0.00419084 |
| ARFGEF3 | ARFGEF family member 3 | 0.00415829 |
| SEC24A | SEC24 family member A | 0.00413021 |
| GPATCH2L | G patch domain containing 2-like | 0.00411849 |
| TRAM1 | translocation associated membrane protein 1 | 0.00411429 |
| B3GNT5 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 | 0.00411204 |
| COG6 | component of oligomeric golgi complex 6 | 0.00410859 |
| AJAP1 | adherens junctions associated protein 1 | 0.00409875 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.00408506 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0040821 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0040602 |
| SEC24D | SEC24 family member D | 0.0040364 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | 0.00401786 |
| LRRC8C | leucine rich repeat containing 8 family, member C | 0.00390606 |
| ACTN1 | actinin, alpha 1 | 0.00389446 |
| MCL1 | myeloid cell leukemia 1 | 0.00389374 |
| DOCK1 | dedicator of cytokinesis 1 | 0.00379978 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.202647 |
| TXNRD1 | thioredoxin reductase 1 | -0.104834 |
| EGFR | epidermal growth factor receptor | -0.102795 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0810494 |
| TMSB10 | thymosin beta 10 | -0.0803672 |
| ASPH | aspartate beta-hydroxylase | -0.0734929 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0666912 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0650319 |
| LMO7 | LIM domain 7 | -0.0622741 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0621781 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.059846 |
| MT2A | metallothionein 2A | -0.0589033 |
| OSMR | oncostatin M receptor | -0.0471811 |
| LRP1B | low density lipoprotein receptor-related protein 1B | -0.0470188 |
| EFNA5 | ephrin-A5 | -0.0445466 |
| ANXA2 | annexin A2 | -0.0419431 |
| PKM | pyruvate kinase, muscle | -0.0397423 |
| LAMC2 | laminin, gamma 2 | -0.0394794 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0394794 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | -0.0385539 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0379619 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0353352 |
| S100A10 | S100 calcium binding protein A10 | -0.0348551 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0335107 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0329782 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0323908 |
| LAMA4 | laminin, alpha 4 | -0.0315851 |
| RAB27B | RAB27B, member RAS oncogene family | -0.0310652 |
| H1-0 | H1.0 linker histone | -0.0301005 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0297474 |
| MYOF | myoferlin | -0.0285446 |
| RNF213 | ring finger protein 213 | -0.0284896 |
| AHNAK | AHNAK nucleoprotein | -0.0284409 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0277603 |
| ARHGAP32 | Rho GTPase activating protein 32 | -0.0276189 |
| PM20D1 | peptidase M20 domain containing 1 | -0.0272428 |
| CPE | carboxypeptidase E | -0.0271613 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0269023 |
| GRAMD1B | GRAM domain containing 1B | -0.0268539 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0256946 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0256522 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0255869 |
| GPC6 | glypican 6 | -0.0252193 |
| CST3 | cystatin C | -0.0248213 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.024474 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0242988 |
| RAB10 | RAB10, member RAS oncogene family | -0.0238865 |
| ACTG1 | actin gamma 1 | -0.0237885 |
| LDHA | lactate dehydrogenase A | -0.023753 |
| VCL | vinculin | -0.0231869 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0225994 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0223336 |
| SCEL | sciellin | -0.021851 |
| CCND1 | cyclin D1 | -0.021335 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0210584 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0210295 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.0207586 |
| VOPP1 | vesicular, overexpressed in cancer, prosurvival protein 1 | -0.0206753 |
| DSPP | dentin sialophosphoprotein | -0.0204091 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0200328 |
| PTMA | prothymosin, alpha | -0.0199734 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0198557 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0194377 |
| EGR1 | early growth response 1 | -0.0193679 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0193317 |
| KRT7 | keratin 7, type II | -0.0193281 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0192915 |
| NCOA3 | nuclear receptor coactivator 3 | -0.0191977 |
| FTL | ferritin, light polypeptide | -0.0190052 |
| SEC61G | Sec61 gamma subunit | -0.018485 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0184309 |
| PGK1 | phosphoglycerate kinase 1 | -0.018384 |
| FOXP1 | forkhead box P1 | -0.0182775 |
| KRT8 | keratin 8, type II | -0.0182458 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0181737 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0177968 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0177502 |
| HLA-B | major histocompatibility complex, class I, B | -0.0177128 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0177069 |
| MT1X | metallothionein 1X | -0.0175618 |
| TES | testin LIM domain protein | -0.0175087 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0173588 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0173316 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0172797 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0170791 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0164973 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0160592 |
| ENO1 | enolase 1, (alpha) | -0.0160076 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0159629 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.0158571 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0158322 |
| B2M | beta-2-microglobulin | -0.0158072 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0157884 |
| CCSER1 | coiled-coil serine-rich protein 1 | -0.0157166 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0155479 |
| NTN4 | netrin 4 | -0.0155469 |
| IER3 | immediate early response 3 | -0.0155243 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0154675 |
| PDLIM5 | PDZ and LIM domain 5 | -0.015453 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0154199 |
