| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Sapanisertib perturbation in NCI-H1792 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Sapanisertib_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CD44 | CD44 molecule (Indian blood group) | 0.149816 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0942574 |
| SMAD3 | SMAD family member 3 | 0.0681488 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0635589 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0634294 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0634136 |
| VIM | vimentin | 0.0630921 |
| NAV2 | neuron navigator 2 | 0.0596354 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0525715 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.052159 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0479426 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0457818 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0446354 |
| PCBP2 | poly(rC) binding protein 2 | 0.0430154 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0427903 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.041972 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0412133 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.040376 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.0398004 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0389866 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0385019 |
| KYNU | kynureninase | 0.0364915 |
| ECE1 | endothelin converting enzyme 1 | 0.0359638 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0357042 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0351914 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0340429 |
| ANKRD28 | ankyrin repeat domain 28 | 0.034033 |
| OSMR | oncostatin M receptor | 0.0334337 |
| TGM2 | transglutaminase 2 | 0.0333631 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0327093 |
| MYO10 | myosin X | 0.0321909 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0321248 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.031189 |
| SIK3 | SIK family kinase 3 | 0.0287123 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0283365 |
| CDCP1 | CUB domain containing protein 1 | 0.0279544 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0278978 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0277927 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0275314 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0271608 |
| LOX | lysyl oxidase | 0.0263123 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0259522 |
| RFFL | ring finger and FYVE-like domain containing E3 ubiquitin protein ligase | 0.0259027 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0258703 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0238857 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0238807 |
| LDHA | lactate dehydrogenase A | 0.0229959 |
| ATP13A3 | ATPase type 13A3 | 0.0226367 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0225726 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0225624 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | 0.0225525 |
| IRAK2 | interleukin-1 receptor-associated kinase 2 | 0.0224862 |
| C15ORF48 | chromosome 15 open reading frame 48 | 0.0224573 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0224413 |
| RAB27B | RAB27B, member RAS oncogene family | 0.0222631 |
| NPC1 | Niemann-Pick disease, type C1 | 0.0220677 |
| MT2A | metallothionein 2A | 0.0217273 |
| HAS2 | hyaluronan synthase 2 | 0.0215805 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0210982 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0209758 |
| SYAP1 | synapse associated protein 1 | 0.0207195 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.0206317 |
| YBX3 | Y box binding protein 3 | 0.020553 |
| LOXL2 | lysyl oxidase-like 2 | 0.0205444 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0205291 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0202724 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0200115 |
| NTN4 | netrin 4 | 0.0198707 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0197688 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0194115 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0193075 |
| TBC1D5 | TBC1 domain family, member 5 | 0.01919 |
| IL1R1 | interleukin 1 receptor, type I | 0.0191849 |
| SFTPA2 | surfactant protein A2 | 0.0191769 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | 0.018781 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.0187683 |
| OS9 | osteosarcoma amplified 9, endoplasmic reticulum lectin | 0.0184322 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0182824 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0182012 |
| RNF24 | ring finger protein 24 | 0.0178002 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0177928 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | 0.0177297 |
| DAAM1 | dishevelled associated activator of morphogenesis 1 | 0.0177292 |
| LAMA4 | laminin, alpha 4 | 0.0177221 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0176018 |
| TXNRD1 | thioredoxin reductase 1 | 0.017039 |
| USP47 | ubiquitin specific peptidase 47 | 0.0170361 |
| OPTN | optineurin | 0.0169583 |
| LRP1B | low density lipoprotein receptor-related protein 1B | 0.0169021 |
| SBF2 | SET binding factor 2 | 0.0168015 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0167677 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0167516 |
| VMP1 | vacuole membrane protein 1 | 0.0166515 |
| PRKCSH | protein kinase C substrate 80K-H | 0.0164741 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.0162419 |
| B2M | beta-2-microglobulin | 0.0161997 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0161745 |
| DPYSL3 | dihydropyrimidinase-like 3 | 0.0160573 |
| DUSP5 | dual specificity phosphatase 5 | 0.0160567 |
| RAB8B | RAB8B, member RAS oncogene family | 0.0159486 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.112078 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.110618 |
| CDH13 | cadherin 13 | -0.0881775 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0691632 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0565856 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0524046 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0466914 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0457736 |
| TMSB10 | thymosin beta 10 | -0.0430472 |
| MTSS1 | metastasis suppressor 1 | -0.0407564 |
| MEF2A | myocyte enhancer factor 2A | -0.0391494 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0384129 |
| PRELID2 | PRELI domain containing 2 | -0.0380873 |
| NRG1 | neuregulin 1 | -0.0377647 |
| FAM20C | family with sequence similarity 20, member C | -0.0371296 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | -0.0335265 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0320531 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0318677 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.031403 |
| FBN1 | fibrillin 1 | -0.0313687 |
| TMTC1 | transmembrane and tetratricopeptide repeat containing 1 | -0.0308411 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0307847 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0293747 |
| ZNF804A | zinc finger protein 804A | -0.0290107 |
| HDAC4 | histone deacetylase 4 | -0.0285529 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0274561 |
| GALNT18 | polypeptide N-acetylgalactosaminyltransferase 18 | -0.0268602 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0266874 |
| CUX1 | cut-like homeobox 1 | -0.0266003 |
| CDK14 | cyclin-dependent kinase 14 | -0.0254719 |
| OXR1 | oxidation resistance 1 | -0.0253867 |
| HMGA2 | high mobility group AT-hook 2 | -0.0252719 |
| DDIT3 | DNA-damage-inducible transcript 3 | -0.0247868 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0241018 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0240888 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0236519 |
| COL7A1 | collagen, type VII, alpha 1 | -0.0234402 |
| DST | dystonin | -0.0231643 |
| MECOM | MDS1 and EVI1 complex locus | -0.023091 |
| INTS6 | integrator complex subunit 6 | -0.0229984 |
| GLCCI1 | glucocorticoid induced 1 | -0.0228313 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | -0.0218371 |
| SYT1 | synaptotagmin I | -0.0215022 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0211487 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.02063 |
| PTMA | prothymosin, alpha | -0.0201178 |
| PRR16 | proline rich 16 | -0.019998 |
| EFCAB13 | EF-hand calcium binding domain 13 | -0.0199463 |
| CFAP20DC | CFAP20 domain containing | -0.0199311 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0197541 |
| PYGL | phosphorylase, glycogen, liver | -0.0196801 |
| DTNA | dystrobrevin, alpha | -0.0196512 |
| NLK | nemo-like kinase | -0.0196368 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0193376 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0189949 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0186737 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0184203 |
| ABCA6 | ATP-binding cassette, sub-family A (ABC1), member 6 | -0.0183164 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0180611 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0180146 |
| RAI14 | retinoic acid induced 14 | -0.0177754 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0174884 |
| PRRX1 | paired related homeobox 1 | -0.0173802 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0171861 |
| CLMP | CXADR-like membrane protein | -0.0171834 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0170938 |
| DIAPH2 | diaphanous-related formin 2 | -0.0169304 |
| NAV3 | neuron navigator 3 | -0.0168973 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.016881 |
| TBC1D22A | TBC1 domain family, member 22A | -0.016703 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0166023 |
| PTPRB | protein tyrosine phosphatase, receptor type, B | -0.0163217 |
| CP | ceruloplasmin (ferroxidase) | -0.0162722 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0161653 |
| PTPN13 | protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) | -0.0158905 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0158871 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0157039 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0154135 |
| ABCA9 | ATP-binding cassette, sub-family A (ABC1), member 9 | -0.0152523 |
| BMERB1 | bMERB domain containing 1 | -0.0150582 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | -0.0149099 |
| SUMF1 | sulfatase modifying factor 1 | -0.0148724 |
| SH3RF3 | SH3 domain containing ring finger 3 | -0.0147536 |
| GNAS | GNAS complex locus | -0.014724 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0145918 |
| AHNAK | AHNAK nucleoprotein | -0.014537 |
| NAV1 | neuron navigator 1 | -0.0145106 |
| CACNB4 | calcium channel, voltage-dependent, beta 4 subunit | -0.0145066 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0144234 |
| TMEM165 | transmembrane protein 165 | -0.0144179 |
| ARHGEF10 | Rho guanine nucleotide exchange factor (GEF) 10 | -0.014318 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0143051 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0142744 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0142215 |
| STXBP5 | syntaxin binding protein 5 (tomosyn) | -0.0137218 |
| ITGB3 | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | -0.0136887 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | -0.0136744 |
| RPL35A | ribosomal protein L35a | -0.01349 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | -0.0132605 |
| ENOSF1 | enolase superfamily member 1 | -0.0131688 |
