| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Sapanisertib perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Sapanisertib_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FTH1 | ferritin, heavy polypeptide 1 | 0.0589959 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0580759 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0475445 |
| MCL1 | myeloid cell leukemia 1 | 0.0466705 |
| PCBP2 | poly(rC) binding protein 2 | 0.0464684 |
| FMNL2 | formin-like 2 | 0.0438361 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.039309 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0392823 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0356966 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0349538 |
| TPM3 | tropomyosin 3 | 0.0324935 |
| BRD2 | bromodomain containing 2 | 0.0318119 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0317761 |
| PFN1 | profilin 1 | 0.0313379 |
| CCNL1 | cyclin L1 | 0.0303012 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 0.030032 |
| RPS12 | ribosomal protein S12 | 0.0299751 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0299719 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.029491 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0292112 |
| RNF145 | ring finger protein 145 | 0.0290139 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0285873 |
| NDRG1 | N-myc downstream regulated 1 | 0.0283093 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0282338 |
| RPL3 | ribosomal protein L3 | 0.027828 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0268789 |
| MSN | moesin | 0.0265784 |
| CDK2AP2 | cyclin-dependent kinase 2 associated protein 2 | 0.0258456 |
| EIF5 | eukaryotic translation initiation factor 5 | 0.025429 |
| POTEF | POTE ankyrin domain family, member F | 0.0252591 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0249581 |
| HLA-A | major histocompatibility complex, class I, A | 0.0247019 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0245013 |
| FLNB | filamin B, beta | 0.0244077 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0243147 |
| IL6 | interleukin 6 | 0.0242669 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0241407 |
| COPA | coatomer protein complex, subunit alpha | 0.0232464 |
| ATF4 | activating transcription factor 4 | 0.0228923 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0223943 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0204972 |
| RNPS1 | RNA binding protein S1, serine-rich domain | 0.0191248 |
| GOLGA4 | golgin A4 | 0.0190475 |
| STC2 | stanniocalcin 2 | 0.0189768 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0187843 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0186127 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0185379 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0181983 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0180802 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0178658 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0178604 |
| CD44 | CD44 molecule (Indian blood group) | 0.0175686 |
| NUP58 | nucleoporin 58 | 0.0175351 |
| RPS6 | ribosomal protein S6 | 0.0175165 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | 0.017333 |
| EGR1 | early growth response 1 | 0.0173017 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0170743 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0168938 |
| RPL21 | ribosomal protein L21 | 0.0168552 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | 0.0167441 |
| RPS8 | ribosomal protein S8 | 0.0166849 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0165896 |
| SNX3 | sorting nexin 3 | 0.0163933 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0156733 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0155754 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0154435 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0149264 |
| BAG6 | BCL2-associated athanogene 6 | 0.0148558 |
| RPS19 | ribosomal protein S19 | 0.014772 |
| SRP54 | signal recognition particle 54kDa | 0.0147674 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0147514 |
| MEF2D | myocyte enhancer factor 2D | 0.0145228 |
| ANXA5 | annexin A5 | 0.0144382 |
| PNN | pinin, desmosome associated protein | 0.014325 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.014309 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0142241 |
| CCNY | cyclin Y | 0.0141892 |
| CYB5R3 | cytochrome b5 reductase 3 | 0.0139382 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0136822 |
| HDGF | hepatoma-derived growth factor | 0.0136579 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.0135433 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0135039 |
| DUSP5 | dual specificity phosphatase 5 | 0.0134895 |
| DHRS7 | dehydrogenase/reductase (SDR family) member 7 | 0.0134261 |
| SRSF3 | serine/arginine-rich splicing factor 3 | 0.0132769 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0132572 |
| MYO10 | myosin X | 0.0130004 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0128504 |
| KCMF1 | potassium channel modulatory factor 1 | 0.0126418 |
| ZFP36 | ZFP36 ring finger protein | 0.0125478 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | 0.0125154 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0124362 |
| NCKAP1 | NCK-associated protein 1 | 0.0124196 |
| BMP6 | bone morphogenetic protein 6 | 0.012372 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0123097 |
| MYADM | myeloid-associated differentiation marker | 0.0123023 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0122843 |
| RNASE3 | ribonuclease, RNase A family, 3 | 0.0121546 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0121317 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0121186 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.16209 |
| GRAMD1B | GRAM domain containing 1B | -0.142147 |
| PM20D1 | peptidase M20 domain containing 1 | -0.127228 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.125228 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.11679 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.113391 |
| TXNRD1 | thioredoxin reductase 1 | -0.106345 |
| TMSB10 | thymosin beta 10 | -0.102475 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0992016 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0957428 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0843828 |
| IER3 | immediate early response 3 | -0.0838297 |
| MT2A | metallothionein 2A | -0.0793475 |
| CAVIN1 | caveolae associated protein 1 | -0.0766877 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0688474 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0673374 |
| ACTG1 | actin gamma 1 | -0.0667043 |
| PTMA | prothymosin, alpha | -0.0651832 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.063965 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0612436 |
| ASPH | aspartate beta-hydroxylase | -0.0594037 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0584002 |
| FTL | ferritin, light polypeptide | -0.0573538 |
| BICC1 | BicC family RNA binding protein 1 | -0.054977 |
| RPL19 | ribosomal protein L19 | -0.0530061 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0523734 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0516564 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | -0.0516428 |
| EFNA5 | ephrin-A5 | -0.0513892 |
| KYNU | kynureninase | -0.0498008 |
| ANXA2 | annexin A2 | -0.0491351 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0479884 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0471208 |
| DENND4A | DENN/MADD domain containing 4A | -0.0450987 |
| AHNAK | AHNAK nucleoprotein | -0.0437709 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0436407 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0436401 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0424098 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0421984 |
| NEGR1 | neuronal growth regulator 1 | -0.0421499 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.041681 |
| S100A10 | S100 calcium binding protein A10 | -0.04162 |
| UTRN | utrophin | -0.0409743 |
| RPS21 | ribosomal protein S21 | -0.0405929 |
| NNMT | nicotinamide N-methyltransferase | -0.0405244 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0399078 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0398855 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0398651 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0393094 |
| HDAC9 | histone deacetylase 9 | -0.0390246 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0383143 |
| KLF6 | Kruppel-like factor 6 | -0.0382893 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.038167 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0370096 |
| GLIS3 | GLIS family zinc finger 3 | -0.0360212 |
| TPM4 | tropomyosin 4 | -0.0354215 |
| DST | dystonin | -0.0353416 |
| FAM168A | family with sequence similarity 168, member A | -0.0353276 |
| SRGN | serglycin | -0.0352549 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0350847 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | -0.0342489 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | -0.0341984 |
| RAD51B | RAD51 paralog B | -0.032834 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0326031 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.0319961 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0319555 |
| NTN4 | netrin 4 | -0.031805 |
| WWOX | WW domain containing oxidoreductase | -0.030949 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0307199 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0306067 |
| DEK | DEK proto-oncogene | -0.0303056 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0301393 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -0.0299146 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0293876 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.0293722 |
| VCL | vinculin | -0.0288954 |
| S100A6 | S100 calcium binding protein A6 | -0.0286281 |
| RPL23 | ribosomal protein L23 | -0.0283327 |
| RPS24 | ribosomal protein S24 | -0.0280235 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0278196 |
| USP34 | ubiquitin specific peptidase 34 | -0.0277901 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0272716 |
| CDK12 | cyclin-dependent kinase 12 | -0.0268841 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0267038 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0266021 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -0.0261827 |
| PDE8A | phosphodiesterase 8A | -0.0261202 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0258684 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0258618 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0255643 |
| TBC1D5 | TBC1 domain family, member 5 | -0.02548 |
| FUS | FUS RNA binding protein | -0.025419 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | -0.0251547 |
| MKI67 | marker of proliferation Ki-67 | -0.0250361 |
| GNAS | GNAS complex locus | -0.0249571 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0248605 |
| LANCL1 | LanC lantibiotic synthetase component C-like 1 (bacterial) | -0.0248578 |
| TUBB | tubulin, beta class I | -0.0248433 |
| SERF2 | small EDRK-rich factor 2 | -0.0248346 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.024744 |
