| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Sapanisertib perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Sapanisertib_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| LMO7 | LIM domain 7 | 0.107127 |
| NUP93 | nucleoporin 93kDa | 0.0966557 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0790582 |
| MUC16 | mucin 16, cell surface associated | 0.0745218 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.073125 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0705477 |
| KYNU | kynureninase | 0.0689461 |
| IGF2 | insulin-like growth factor 2 | 0.0679976 |
| LAMB3 | laminin, beta 3 | 0.0645559 |
| RAD51B | RAD51 paralog B | 0.0638114 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0615459 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0608273 |
| EZR | ezrin | 0.0590733 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0590019 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0588624 |
| EFNA5 | ephrin-A5 | 0.0572316 |
| FOXO1 | forkhead box O1 | 0.056068 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0557698 |
| MT2A | metallothionein 2A | 0.052993 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | 0.0524417 |
| MYO5B | myosin VB | 0.0508044 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0476338 |
| ANXA2 | annexin A2 | 0.0468297 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | 0.0458819 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0453946 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0439007 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.042517 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0424228 |
| SVIL | supervillin | 0.0418884 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0416653 |
| MTUS1 | microtubule associated tumor suppressor 1 | 0.0412254 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0397095 |
| EGFR | epidermal growth factor receptor | 0.0384091 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0379717 |
| RBM47 | RNA binding motif protein 47 | 0.0377881 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.0375927 |
| MYOF | myoferlin | 0.0370957 |
| NAV3 | neuron navigator 3 | 0.0369968 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.036818 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0367425 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0364549 |
| STEAP4 | STEAP family member 4 | 0.0357826 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | 0.0352619 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0346179 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0343136 |
| PARD3 | par-3 family cell polarity regulator | 0.0342458 |
| RORA | RAR-related orphan receptor A | 0.0337569 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | 0.0332275 |
| OSBPL10 | oxysterol binding protein-like 10 | 0.0326544 |
| PDE10A | phosphodiesterase 10A | 0.032376 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0318306 |
| ATP11A | ATPase, class VI, type 11A | 0.0317968 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0314885 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0312769 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 0.0306925 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0304072 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0301397 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0301236 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | 0.0301231 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | 0.0290973 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.0289124 |
| EPB41L5 | erythrocyte membrane protein band 4.1 like 5 | 0.0285174 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0278159 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | 0.0276992 |
| PATJ | PATJ crumbs cell polarity complex component | 0.027549 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0275233 |
| SMAD2 | SMAD family member 2 | 0.0272079 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0272033 |
| UBAP2 | ubiquitin associated protein 2 | 0.0268902 |
| RAB3GAP1 | RAB3 GTPase activating protein subunit 1 (catalytic) | 0.0266607 |
| GLG1 | golgi glycoprotein 1 | 0.0266082 |
| CMIP | c-Maf inducing protein | 0.0261491 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0260935 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0260289 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | 0.0259527 |
| ANXA11 | annexin A11 | 0.0259043 |
| SIK3 | SIK family kinase 3 | 0.0257795 |
| C3 | complement component 3 | 0.0257604 |
| GCC2 | GRIP and coiled-coil domain containing 2 | 0.0254579 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0254208 |
| BCAS3 | breast carcinoma amplified sequence 3 | 0.025244 |
| GRAMD1B | GRAM domain containing 1B | 0.025165 |
| RAPGEF6 | Rap guanine nucleotide exchange factor (GEF) 6 | 0.0251314 |
| SPIDR | scaffolding protein involved in DNA repair | 0.0251216 |
| ARHGAP32 | Rho GTPase activating protein 32 | 0.0250484 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | 0.0247954 |
| CCND1 | cyclin D1 | 0.0247921 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0246643 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.0246341 |
| SLC39A11 | solute carrier family 39, member 11 | 0.0245099 |
| STK4 | serine/threonine kinase 4 | 0.0241898 |
| STC1 | stanniocalcin 1 | 0.0241248 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0241022 |
| MYO6 | myosin VI | 0.0240387 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0239523 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0238855 |
| FRMD6 | FERM domain containing 6 | 0.023813 |
| USP47 | ubiquitin specific peptidase 47 | 0.0237178 |
| SASH1 | SAM and SH3 domain containing 1 | 0.0236664 |
| PLEC | plectin | 0.0235949 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.178907 |
| FN1 | fibronectin 1 | -0.146092 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.108774 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0922183 |
| NDRG1 | N-myc downstream regulated 1 | -0.0783615 |
| VIM | vimentin | -0.0697815 |
| INHBA | inhibin, beta A | -0.0660375 |
| TMSB10 | thymosin beta 10 | -0.0628442 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.061819 |
| RPL35A | ribosomal protein L35a | -0.0597994 |
| IER3 | immediate early response 3 | -0.0557041 |
| RPS8 | ribosomal protein S8 | -0.0548218 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0501169 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0493648 |
| CANX | calnexin | -0.0491891 |
| MXD1 | MAX dimerization protein 1 | -0.0491386 |
| RPL26 | ribosomal protein L26 | -0.0464433 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0453111 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0451153 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0435195 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0433302 |
| ABHD17C | abhydrolase domain containing 17C | -0.0427714 |
| HLA-B | major histocompatibility complex, class I, B | -0.0424901 |
| RPS12 | ribosomal protein S12 | -0.0420168 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0416927 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0416345 |
| RPLP1 | ribosomal protein, large, P1 | -0.0413304 |
| RPL12 | ribosomal protein L12 | -0.0409122 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.040297 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0399511 |
| ADM | adrenomedullin | -0.0398165 |
| FMNL2 | formin-like 2 | -0.0388644 |
| RRBP1 | ribosome binding protein 1 | -0.0387973 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0386613 |
| MORF4L2 | mortality factor 4 like 2 | -0.0375019 |
| S100A9 | S100 calcium binding protein A9 | -0.0368466 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0358167 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0355845 |
| VGF | VGF nerve growth factor inducible | -0.0350611 |
| CD44 | CD44 molecule (Indian blood group) | -0.0344082 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0343004 |
| RAI14 | retinoic acid induced 14 | -0.0341615 |
| RPL23 | ribosomal protein L23 | -0.0338512 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0334822 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0332043 |
| RPS19 | ribosomal protein S19 | -0.0331829 |
| ANKRD11 | ankyrin repeat domain 11 | -0.03316 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0330543 |
| ACTG1 | actin gamma 1 | -0.0329292 |
| LDHA | lactate dehydrogenase A | -0.0329168 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0327479 |
| ASPH | aspartate beta-hydroxylase | -0.032418 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0322034 |
| GOLGA4 | golgin A4 | -0.0321033 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0316866 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.0310892 |
| RPL9 | ribosomal protein L9 | -0.0306644 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | -0.0306546 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0304345 |
| USP53 | ubiquitin specific peptidase 53 | -0.0303248 |
| HDLBP | high density lipoprotein binding protein | -0.0301469 |
| FTL | ferritin, light polypeptide | -0.0298992 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.029793 |
| RTN4 | reticulon 4 | -0.0297778 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0296969 |
| LAMC2 | laminin, gamma 2 | -0.0294146 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0290284 |
| RND3 | Rho family GTPase 3 | -0.0288999 |
| MMP1 | matrix metallopeptidase 1 | -0.0287056 |
| RPS24 | ribosomal protein S24 | -0.0285085 |
| CLTC | clathrin, heavy chain (Hc) | -0.0283146 |
| RTN3 | reticulon 3 | -0.0282829 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0282031 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0279398 |
| COPA | coatomer protein complex, subunit alpha | -0.0278309 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0274051 |
| MXI1 | MAX interactor 1, dimerization protein | -0.0273844 |
| OXR1 | oxidation resistance 1 | -0.0271995 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0269333 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0268111 |
| PDE8A | phosphodiesterase 8A | -0.0266667 |
| THOC2 | THO complex 2 | -0.0262491 |
| RNF145 | ring finger protein 145 | -0.026092 |
| TMEM165 | transmembrane protein 165 | -0.0258652 |
| ZNF644 | zinc finger protein 644 | -0.0258422 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0256571 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | -0.0254639 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0251815 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0250438 |
| ENO1 | enolase 1, (alpha) | -0.024962 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0249164 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0248321 |
| RPS3 | ribosomal protein S3 | -0.0247615 |
| USP24 | ubiquitin specific peptidase 24 | -0.0246981 |
| HOOK2 | hook microtubule-tethering protein 2 | -0.0245835 |
| RPS25 | ribosomal protein S25 | -0.0244088 |
| SCFD1 | sec1 family domain containing 1 | -0.024338 |
| MIB1 | mindbomb E3 ubiquitin protein ligase 1 | -0.024323 |
| RPS27 | ribosomal protein S27 | -0.0241176 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0240582 |
