Sapanisertib_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sapanisertib perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sapanisertib_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.393521
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.157269
EEF2 eukaryotic translation elongation factor 2 0.105247
ERRFI1 ERBB receptor feedback inhibitor 1 0.0811064
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0760868
VIM vimentin 0.0724024
YBX3 Y box binding protein 3 0.0609027
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.058783
THSD4 thrombospondin, type I, domain containing 4 0.0533598
MCL1 myeloid cell leukemia 1 0.0531616
EGR1 early growth response 1 0.0486397
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0450536
ACTG1 actin gamma 1 0.0445637
OSMR oncostatin M receptor 0.0438488
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0409747
EXT1 exostosin glycosyltransferase 1 0.0409227
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0404002
POTEF POTE ankyrin domain family, member F 0.0394639
ELL2 elongation factor, RNA polymerase II, 2 0.0387448
KTN1 kinectin 1 (kinesin receptor) 0.0386201
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0384463
KRT18 keratin 18, type I 0.0371932
GRAMD1B GRAM domain containing 1B 0.0369156
HMGA2 high mobility group AT-hook 2 0.0359427
TM4SF1 transmembrane 4 L six family member 1 0.0354487
SVIL supervillin 0.0321607
STC1 stanniocalcin 1 0.0317642
TXNRD1 thioredoxin reductase 1 0.0312868
AFF3 AF4/FMR2 family, member 3 0.0311895
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0306129
RPS27 ribosomal protein S27 0.0305853
IGF2 insulin-like growth factor 2 0.0303886
HOMER1 homer scaffolding protein 1 0.0297405
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0294521
FMNL2 formin-like 2 0.0284121
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0275462
RPLP0 ribosomal protein, large, P0 0.0274434
SNX9 sorting nexin 9 0.0272554
MMP12 matrix metallopeptidase 12 0.0267282
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0261665
VMP1 vacuole membrane protein 1 0.0261604
RPS8 ribosomal protein S8 0.0260804
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0258771
MACF1 microtubule-actin crosslinking factor 1 0.0255633
MYO10 myosin X 0.0255591
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0254551
ZFAND3 zinc finger, AN1-type domain 3 0.0250584
RACK1 receptor for activated C kinase 1 0.0249712
FTH1 ferritin, heavy polypeptide 1 0.0246324
RAB7A RAB7A, member RAS oncogene family 0.0244955
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0243841
ACTN1 actinin, alpha 1 0.0242218
RPS6 ribosomal protein S6 0.0241941
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0236209
JMJD1C jumonji domain containing 1C 0.0234884
RICTOR RPTOR independent companion of MTOR, complex 2 0.0222328
RPS4X ribosomal protein S4, X-linked 0.0222156
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0221526
TPM3 tropomyosin 3 0.0213801
CDCP1 CUB domain containing protein 1 0.0212302
RPL37 ribosomal protein L37 0.0211398
IGF1R insulin-like growth factor 1 receptor 0.0210033
PYGL phosphorylase, glycogen, liver 0.020594
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa 0.0205338
EGFR epidermal growth factor receptor 0.0204865
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0200801
DSPP dentin sialophosphoprotein 0.0199311
TPM4 tropomyosin 4 0.0198428
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0195739
MSN moesin 0.0195118
DOCK5 dedicator of cytokinesis 5 0.0186064
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0185817
HLA-B major histocompatibility complex, class I, B 0.0184612
ATP11A ATPase, class VI, type 11A 0.0184359
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0181735
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0181073
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0180333
CDK17 cyclin-dependent kinase 17 0.0180235
ANXA5 annexin A5 0.0178678
NRG1 neuregulin 1 0.0177868
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0177853
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0175691
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0175131
DCLK1 doublecortin-like kinase 1 0.0173255
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0170331
NT5E 5'-nucleotidase, ecto (CD73) 0.0169792
RPL35A ribosomal protein L35a 0.0169598
ATP13A3 ATPase type 13A3 0.0167143
CHIC2 cysteine-rich hydrophobic domain 2 0.0167014
RPS3 ribosomal protein S3 0.0166829
RPL11 ribosomal protein L11 0.0165487
ANO6 anoctamin 6 0.0164841
HSPA8 heat shock 70kDa protein 8 0.0163267
RPL8 ribosomal protein L8 0.0163207
IPO7 importin 7 0.0162801
CD44 CD44 molecule (Indian blood group) 0.0161906
RPS19 ribosomal protein S19 0.0160408
RPS14 ribosomal protein S14 0.0159548
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0158897
RPL5 ribosomal protein L5 0.0158377

decreased expression

Symbol Name Standardized Value
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0429415
PTMA prothymosin, alpha -0.0409925
RAD51B RAD51 paralog B -0.0386851
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0384171
TFPI2 tissue factor pathway inhibitor 2 -0.0326613
RRM2 ribonucleotide reductase M2 -0.0260966
SMC4 structural maintenance of chromosomes 4 -0.0254802
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0253495
PRELID2 PRELI domain containing 2 -0.0212199
UBC ubiquitin C -0.0211679
EML4 echinoderm microtubule associated protein like 4 -0.0211212
WWOX WW domain containing oxidoreductase -0.0189527
CAMKMT calmodulin-lysine N-methyltransferase -0.0184898
H1-0 H1.0 linker histone -0.0182813
GPHN gephyrin -0.0180847
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0177686
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0176395
RBM25 RNA binding motif protein 25 -0.0173825
RBM39 RNA binding motif protein 39 -0.0171847
PDE4D phosphodiesterase 4D, cAMP-specific -0.0171163
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0168367
ANKRD36C ankyrin repeat domain 36C -0.0163173
RPS27A ribosomal protein S27a -0.016178
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0158695
OGA O-GlcNAcase -0.0158542
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0158185
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0157665
PNISR PNN-interacting serine/arginine-rich protein -0.0157273
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.0156988
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0154058
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E -0.0152183
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0152024
PHIP pleckstrin homology domain interacting protein -0.0147535
TAS2R14 taste receptor, type 2, member 14 -0.0143089
CEP192 centrosomal protein 192kDa -0.0142784
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0142501
ANKRD36 ankyrin repeat domain 36 -0.0142491
ZNF638 zinc finger protein 638 -0.0141414
THOC2 THO complex 2 -0.0140887
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0139526
XPOT exportin, tRNA -0.0138985
PRRC2C proline-rich coiled-coil 2C -0.0138465
CSE1L CSE1 chromosome segregation 1-like (yeast) -0.0138438
PDIA4 protein disulfide isomerase family A, member 4 -0.0135757
NASP nuclear autoantigenic sperm protein (histone-binding) -0.0134964
ANKRD12 ankyrin repeat domain 12 -0.0130586
NCOR1 nuclear receptor corepressor 1 -0.0129556
PDE10A phosphodiesterase 10A -0.0128977
EIF5B eukaryotic translation initiation factor 5B -0.0128809
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -0.0125538
AEBP2 AE binding protein 2 -0.0125406
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0124915
NCOA7 nuclear receptor coactivator 7 -0.0123944
RFC3 replication factor C (activator 1) 3, 38kDa -0.0123194
DIAPH3 diaphanous-related formin 3 -0.0123135
WDPCP WD repeat containing planar cell polarity effector -0.0123074
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0122685
R3HDM1 R3H domain containing 1 -0.0122614
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.0121955
NCAPD2 non-SMC condensin I complex, subunit D2 -0.0121299
KHDC4 KH domain containing 4, pre-mRNA splicing factor -0.012086
SRSF7 serine/arginine-rich splicing factor 7 -0.0120269
ADGRG6 adhesion G protein-coupled receptor G6 -0.0116372
FAF1 Fas (TNFRSF6) associated factor 1 -0.0115715
NSD2 nuclear receptor binding SET domain protein 2 -0.0114324
XPO1 exportin 1 -0.0113688
CCND2 cyclin D2 -0.0112496
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0111721
NR6A1 nuclear receptor subfamily 6, group A, member 1 -0.0111611
SRRM1 serine/arginine repetitive matrix 1 -0.0109423
ANLN anillin, actin binding protein -0.0109167
FOXJ3 forkhead box J3 -0.0108605
PNN pinin, desmosome associated protein -0.0107258
DENND1A DENN/MADD domain containing 1A -0.0106841
ANKRD36B ankyrin repeat domain 36B -0.0106486
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0106026
PA2G4 proliferation-associated 2G4, 38kDa -0.0105658
HELLS helicase, lymphoid-specific -0.0105295
KIAA1328 KIAA1328 -0.0104356
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 -0.0103901
BIRC6 baculoviral IAP repeat containing 6 -0.0102343
SDK1 sidekick cell adhesion molecule 1 -0.0102199
USP34 ubiquitin specific peptidase 34 -0.010189
TLK1 tousled-like kinase 1 -0.0101715
CDC27 cell division cycle 27 -0.0101069
SRSF11 serine/arginine-rich splicing factor 11 -0.0100378
KDM4B lysine (K)-specific demethylase 4B -0.0100265
EFNA5 ephrin-A5 -0.00994901
PTEN phosphatase and tensin homolog -0.00986837
TMEM165 transmembrane protein 165 -0.00982054
CCDC88A coiled-coil domain containing 88A -0.00980006
MTF2 metal response element binding transcription factor 2 -0.00974368
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 -0.00973431
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.00970166
BLTP2 bridge-like lipid transfer protein family member 2 -0.00966459
MNAT1 MNAT CDK-activating kinase assembly factor 1 -0.00965801
NFIA nuclear factor I/A -0.00964954
MARS1 methionyl-tRNA synthetase 1 -0.00962872
SAMD4A sterile alpha motif domain containing 4A -0.00962699
NCAPG2 non-SMC condensin II complex, subunit G2 -0.00959838