Sapanisertib_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sapanisertib perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sapanisertib_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PABPC1 poly(A) binding protein, cytoplasmic 1 0.153913
POTEF POTE ankyrin domain family, member F 0.118809
NDRG1 N-myc downstream regulated 1 0.116688
EEF2 eukaryotic translation elongation factor 2 0.085094
FTH1 ferritin, heavy polypeptide 1 0.0808168
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0760549
PCBP2 poly(rC) binding protein 2 0.0663406
MSN moesin 0.0648467
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0641842
ZFP36L1 ZFP36 ring finger protein-like 1 0.0639869
AKAP13 A kinase (PRKA) anchor protein 13 0.057101
MYO5B myosin VB 0.05545
DSPP dentin sialophosphoprotein 0.0541453
HMGA1 high mobility group AT-hook 1 0.0526704
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0515658
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0511064
APLP2 amyloid beta (A4) precursor-like protein 2 0.0492395
CCNL1 cyclin L1 0.0480836
TSC22D2 TSC22 domain family, member 2 0.0474447
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0443032
RNF145 ring finger protein 145 0.0426268
IGFBP3 insulin-like growth factor binding protein 3 0.0407227
EGR1 early growth response 1 0.0406541
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0403728
ADAM9 ADAM metallopeptidase domain 9 0.0386621
FAM13A family with sequence similarity 13, member A 0.0381472
VEGFA vascular endothelial growth factor A 0.0372845
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0365249
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0362596
FOSL1 FOS-like antigen 1 0.0358255
ZNF292 zinc finger protein 292 0.0356888
FXR1 fragile X mental retardation, autosomal homolog 1 0.0340979
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0340171
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0339174
DUSP5 dual specificity phosphatase 5 0.0332117
UBA6 ubiquitin-like modifier activating enzyme 6 0.0329305
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0327945
FTL ferritin, light polypeptide 0.0326657
MACC1 metastasis associated in colon cancer 1 0.0326492
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0317471
SGMS2 sphingomyelin synthase 2 0.0317191
PGBD5 piggyBac transposable element derived 5 0.0312072
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0310917
TPM3 tropomyosin 3 0.0305194
EEF1G eukaryotic translation elongation factor 1 gamma 0.0303415
NR3C2 nuclear receptor subfamily 3, group C, member 2 0.0302939
RICTOR RPTOR independent companion of MTOR, complex 2 0.030256
KMT2E lysine (K)-specific methyltransferase 2E 0.0296434
UPP1 uridine phosphorylase 1 0.0289319
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0288149
NAV2 neuron navigator 2 0.0286813
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0286151
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0285497
DTNA dystrobrevin, alpha 0.0284584
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0281122
EIF5 eukaryotic translation initiation factor 5 0.026914
RPL3 ribosomal protein L3 0.026662
DUSP10 dual specificity phosphatase 10 0.0266396
ANXA5 annexin A5 0.0264377
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0263192
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.0259828
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0257777
GRB10 growth factor receptor-bound protein 10 0.0254266
DSTN destrin (actin depolymerizing factor) 0.0252254
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0243531
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0243415
SNX9 sorting nexin 9 0.0241784
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0241561
PCM1 pericentriolar material 1 0.0241294
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.024012
YBX1 Y box binding protein 1 0.0239814
PPARD peroxisome proliferator-activated receptor delta 0.023926
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0233947
PUM1 pumilio RNA-binding family member 1 0.023372
SFPQ splicing factor proline/glutamine-rich 0.0232978
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0228576
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0227626
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0227267
KTN1 kinectin 1 (kinesin receptor) 0.022724
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.0226658
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.0226429
RYBP RING1 and YY1 binding protein 0.0224305
SRSF3 serine/arginine-rich splicing factor 3 0.0223202
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0219542
MATR3 matrin 3 0.0219054
RAB11FIP1 RAB11 family interacting protein 1 (class I) 0.0218381
RBM39 RNA binding motif protein 39 0.0218078
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0214998
HDGF hepatoma-derived growth factor 0.0212276
CLDN4 claudin 4 0.0209853
DIAPH1 diaphanous-related formin 1 0.0209774
MYO6 myosin VI 0.0209088
SSBP2 single-stranded DNA binding protein 2 0.0205126
VGLL3 vestigial-like family member 3 0.0204453
RIOK3 RIO kinase 3 0.0203963
CENPF centromere protein F, 350/400kDa 0.0202166
SVIL supervillin 0.0202006
MYO10 myosin X 0.0201501
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0200677
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0199916

decreased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 -0.128747
TMSB10 thymosin beta 10 -0.126003
PTMA prothymosin, alpha -0.114032
TMSB4X thymosin beta 4, X-linked -0.109538
LIMCH1 LIM and calponin homology domains 1 -0.108867
LAMB3 laminin, beta 3 -0.101584
LPP LIM domain containing preferred translocation partner in lipoma -0.0942774
EXT1 exostosin glycosyltransferase 1 -0.0846302
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0749728
EFNA5 ephrin-A5 -0.0684895
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0661493
VCL vinculin -0.0659298
IFI16 interferon, gamma-inducible protein 16 -0.0659163
IFI6 interferon, alpha-inducible protein 6 -0.064647
RPL34 ribosomal protein L34 -0.0635467
ASPH aspartate beta-hydroxylase -0.061305
GNAS GNAS complex locus -0.0595346
ARHGAP5 Rho GTPase activating protein 5 -0.0588862
CD2AP CD2-associated protein -0.0577272
BZW1 basic leucine zipper and W2 domains 1 -0.0571244
BASP1 brain abundant, membrane attached signal protein 1 -0.0554236
FBXO34 F-box protein 34 -0.0544872
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.05442
RRBP1 ribosome binding protein 1 -0.0526417
WSB1 WD repeat and SOCS box containing 1 -0.0511539
AHNAK AHNAK nucleoprotein -0.0508983
ACTG1 actin gamma 1 -0.0500004
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0485002
RPL35A ribosomal protein L35a -0.0478803
CAVIN1 caveolae associated protein 1 -0.0473735
TMEM263 transmembrane protein 263 -0.0472451
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0467902
CEP350 centrosomal protein 350kDa -0.0447243
MYO1E myosin IE -0.0441811
KDM3A lysine (K)-specific demethylase 3A -0.0438537
SEC31A SEC31 homolog A (S. cerevisiae) -0.043399
RPS24 ribosomal protein S24 -0.0432679
ANXA2 annexin A2 -0.0423969
RNF213 ring finger protein 213 -0.0423286
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0416234
ISG15 ISG15 ubiquitin-like modifier -0.0414938
EPCAM epithelial cell adhesion molecule -0.040883
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0406536
HLA-B major histocompatibility complex, class I, B -0.0401197
PALLD palladin, cytoskeletal associated protein -0.0400761
FN1 fibronectin 1 -0.0399577
HLA-E major histocompatibility complex, class I, E -0.0393208
IFIH1 interferon induced with helicase C domain 1 -0.0384255
TM4SF1 transmembrane 4 L six family member 1 -0.0383876
MAP4 microtubule-associated protein 4 -0.0383077
GOLGA4 golgin A4 -0.0377956
OSBPL3 oxysterol binding protein-like 3 -0.0375077
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0369176
H1-0 H1.0 linker histone -0.0359763
LMO7 LIM domain 7 -0.0355881
HDLBP high density lipoprotein binding protein -0.0353539
PLSCR1 phospholipid scramblase 1 -0.0351508
CAB39 calcium binding protein 39 -0.0351462
OGA O-GlcNAcase -0.0350583
CCND1 cyclin D1 -0.0350063
S100A6 S100 calcium binding protein A6 -0.0349119
ARF1 ADP-ribosylation factor 1 -0.0345716
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0345166
TMEM165 transmembrane protein 165 -0.0344355
CAPN2 calpain 2, (m/II) large subunit -0.0338476
NF1 neurofibromin 1 -0.0338309
S100A10 S100 calcium binding protein A10 -0.0332927
CANX calnexin -0.0328001
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0321366
ADAR adenosine deaminase, RNA-specific -0.0320807
COPB1 coatomer protein complex, subunit beta 1 -0.0320539
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0316768
STRN3 striatin, calmodulin binding protein 3 -0.0315323
RIGI RNA sensor RIG-I -0.0315255
EIF1 eukaryotic translation initiation factor 1 -0.0314652
RAD21 RAD21 homolog (S. pombe) -0.0312772
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0312573
RPL23 ribosomal protein L23 -0.0309633
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0307953
SACK1A scaffolding CK1 anchoring protein A -0.0307265
HMGB2 high mobility group box 2 -0.0303749
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.030197
ZFAND6 zinc finger, AN1-type domain 6 -0.0301322
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0300187
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB -0.0295869
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0295396
SQSTM1 sequestosome 1 -0.0290374
MAP3K13 mitogen-activated protein kinase kinase kinase 13 -0.0288306
NPEPPS aminopeptidase puromycin sensitive -0.0284743
MON2 MON2 homolog (S. cerevisiae) -0.0284668
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0284338
BIRC6 baculoviral IAP repeat containing 6 -0.0283347
TTC3 tetratricopeptide repeat domain 3 -0.0281211
FRMD5 FERM domain containing 5 -0.0277344
RPS29 ribosomal protein S29 -0.0276753
SP100 SP100 nuclear antigen -0.0275971
WARS1 tryptophanyl-tRNA synthetase 1 -0.0275771
AFF1 AF4/FMR2 family, member 1 -0.0275603
CALU calumenin -0.0275084
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0274993