| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Sapanisertib perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Sapanisertib_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GDA | guanine deaminase | 0.10887 |
| TXNRD1 | thioredoxin reductase 1 | 0.0879693 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0704452 |
| FMNL2 | formin-like 2 | 0.0647128 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0641128 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0576089 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.0527268 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0468932 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0447717 |
| KYNU | kynureninase | 0.0424573 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0421599 |
| CD109 | CD109 molecule | 0.0415151 |
| GRAMD1B | GRAM domain containing 1B | 0.0394463 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0353111 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0332337 |
| PCBP2 | poly(rC) binding protein 2 | 0.032554 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0321409 |
| SPAG9 | sperm associated antigen 9 | 0.0319311 |
| EZR | ezrin | 0.0314976 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0312246 |
| TGFBR1 | transforming growth factor, beta receptor 1 | 0.0310861 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0306017 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0298348 |
| MCL1 | myeloid cell leukemia 1 | 0.0295521 |
| MYOF | myoferlin | 0.0294887 |
| FNIP1 | folliculin interacting protein 1 | 0.0294185 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0292136 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0291499 |
| SLC16A6 | solute carrier family 16, member 6 | 0.0284903 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0275188 |
| JMJD1C | jumonji domain containing 1C | 0.027402 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.027011 |
| TNPO1 | transportin 1 | 0.0267466 |
| CENPF | centromere protein F, 350/400kDa | 0.0262929 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0259868 |
| RTN4 | reticulon 4 | 0.0258008 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0255685 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0251882 |
| AVL9 | AVL9 homolog (S. cerevisiase) | 0.0244268 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0233455 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0232867 |
| EPB41L3 | erythrocyte membrane protein band 4.1-like 3 | 0.0224535 |
| SQSTM1 | sequestosome 1 | 0.0223767 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0221416 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0221335 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0220024 |
| LAMA1 | laminin, alpha 1 | 0.0214316 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0212739 |
| CUL4A | cullin 4A | 0.0212345 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0209437 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0208861 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0207871 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0206182 |
| NEK7 | NIMA-related kinase 7 | 0.020588 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0199782 |
| NCKAP1 | NCK-associated protein 1 | 0.0197406 |
| RPL3 | ribosomal protein L3 | 0.0197387 |
| CTSL | cathepsin L | 0.0196409 |
| TUSC3 | tumor suppressor candidate 3 | 0.0194397 |
| SLK | STE20-like kinase | 0.0188779 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0188484 |
| PHIP | pleckstrin homology domain interacting protein | 0.0188384 |
| PTEN | phosphatase and tensin homolog | 0.0186101 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0184749 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0181374 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | 0.0181287 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0180086 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0178995 |
| VPS13C | vacuolar protein sorting 13 homolog C (S. cerevisiae) | 0.0174375 |
| MATR3 | matrin 3 | 0.0174084 |
| ANXA5 | annexin A5 | 0.017316 |
| EXOC4 | exocyst complex component 4 | 0.017222 |
| NPC1 | Niemann-Pick disease, type C1 | 0.017093 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | 0.0170475 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0170004 |
| SNX9 | sorting nexin 9 | 0.0169899 |
| SDCBP | syndecan binding protein (syntenin) | 0.016977 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0168194 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0167451 |
| UTY | ubiquitously transcribed tetratricopeptide repeat containing, Y-linked | 0.0166557 |
| FAM13A | family with sequence similarity 13, member A | 0.0166533 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | 0.0165246 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0161195 |
| MSN | moesin | 0.016049 |
| CLTC | clathrin, heavy chain (Hc) | 0.0160392 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0159761 |
| GOLGA4 | golgin A4 | 0.0157771 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0157414 |
| ZNF292 | zinc finger protein 292 | 0.0156918 |
| ANXA1 | annexin A1 | 0.0156668 |
| CARD16 | caspase recruitment domain family, member 16 | 0.0156196 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0153998 |
| FAT1 | FAT atypical cadherin 1 | 0.0152783 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0152069 |
| NHSL1 | NHS-like 1 | 0.0150956 |
| EXOC6B | exocyst complex component 6B | 0.0150556 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.0148416 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0146864 |
| AFF4 | AF4/FMR2 family, member 4 | 0.0146155 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.01429 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.288643 |
| FN1 | fibronectin 1 | -0.173938 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.156079 |
| DST | dystonin | -0.106229 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0936733 |
| VCL | vinculin | -0.0844182 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0804248 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0803075 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0777115 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0745384 |
| DPP10 | dipeptidyl-peptidase 10 (non-functional) | -0.0721457 |
| COL5A2 | collagen, type V, alpha 2 | -0.0718489 |
| TMSB10 | thymosin beta 10 | -0.0685987 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0685776 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.063058 |
| PTMA | prothymosin, alpha | -0.0592115 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0590349 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0567001 |
| PRELID2 | PRELI domain containing 2 | -0.0561645 |
| P3H2 | prolyl 3-hydroxylase 2 | -0.0560718 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0552057 |
| RPS24 | ribosomal protein S24 | -0.0542455 |
| PCBP3 | poly(rC) binding protein 3 | -0.0538494 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0525834 |
| PDE10A | phosphodiesterase 10A | -0.048541 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.047201 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0440658 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0437633 |
| NCKAP5 | NCK-associated protein 5 | -0.0437464 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | -0.0436971 |
| COL4A5 | collagen, type IV, alpha 5 | -0.0434919 |
| RPL35A | ribosomal protein L35a | -0.043169 |
| PM20D1 | peptidase M20 domain containing 1 | -0.0431304 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.042935 |
| INTS6 | integrator complex subunit 6 | -0.0415391 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | -0.0411819 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0403862 |
| NRCAM | neuronal cell adhesion molecule | -0.0388962 |
| LSAMP | limbic system-associated membrane protein | -0.037739 |
| RPL31 | ribosomal protein L31 | -0.0376393 |
| RPL26 | ribosomal protein L26 | -0.0376293 |
| RPL37A | ribosomal protein L37a | -0.0374542 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0367862 |
| ADGRD1 | adhesion G protein-coupled receptor D1 | -0.0352472 |
| TENM3 | teneurin transmembrane protein 3 | -0.035227 |
| PDE1C | phosphodiesterase 1C, calmodulin-dependent 70kDa | -0.0341424 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0336097 |
| CTNND2 | catenin (cadherin-associated protein), delta 2 | -0.0332719 |
| KIAA0825 | KIAA0825 | -0.0324814 |
| PCDH15 | protocadherin-related 15 | -0.0323499 |
| HLA-B | major histocompatibility complex, class I, B | -0.0323126 |
| EPHA4 | EPH receptor A4 | -0.0313621 |
| AUTS2 | autism susceptibility candidate 2 | -0.0311133 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.030818 |
| RPS19 | ribosomal protein S19 | -0.0307075 |
| RPLP1 | ribosomal protein, large, P1 | -0.0305243 |
| EFNA5 | ephrin-A5 | -0.0304158 |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 | -0.0303553 |
| RTN1 | reticulon 1 | -0.0303072 |
| GNAS | GNAS complex locus | -0.0299797 |
| RPL9 | ribosomal protein L9 | -0.0298155 |
| RPS12 | ribosomal protein S12 | -0.0291674 |
| RPL12 | ribosomal protein L12 | -0.0287169 |
| DENND1A | DENN/MADD domain containing 1A | -0.0282692 |
| TENM2 | teneurin transmembrane protein 2 | -0.0281987 |
| COL4A6 | collagen, type IV, alpha 6 | -0.0275052 |
| GPC6 | glypican 6 | -0.0271535 |
| RPS8 | ribosomal protein S8 | -0.0269403 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0267857 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0267162 |
| RPL34 | ribosomal protein L34 | -0.0265876 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0261715 |
| RPS27A | ribosomal protein S27a | -0.0254199 |
| AEBP2 | AE binding protein 2 | -0.0247942 |
| RPS3 | ribosomal protein S3 | -0.0245796 |
| RPS25 | ribosomal protein S25 | -0.0240657 |
| RPL36A | ribosomal protein L36a | -0.023973 |
| RPL38 | ribosomal protein L38 | -0.0238577 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0233428 |
| RPLP2 | ribosomal protein, large, P2 | -0.023115 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0230676 |
| RPL19 | ribosomal protein L19 | -0.0230599 |
| RPS21 | ribosomal protein S21 | -0.0227589 |
| RPS17 | ribosomal protein S17 | -0.0224908 |
| GLCCI1 | glucocorticoid induced 1 | -0.0224531 |
| RGS2 | regulator of G-protein signaling 2 | -0.0223734 |
| OASL | 2'-5'-oligoadenylate synthetase-like | -0.0223726 |
| RPL36 | ribosomal protein L36 | -0.0223073 |
| PDE7B | phosphodiesterase 7B | -0.0221897 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0219496 |
| RIGI | RNA sensor RIG-I | -0.021165 |
| RPL7A | ribosomal protein L7a | -0.0209295 |
| ADGRB3 | adhesion G protein-coupled receptor B3 | -0.020908 |
| HLA-A | major histocompatibility complex, class I, A | -0.0208292 |
| RPH3AL | rabphilin 3A-like (without C2 domains) | -0.0205626 |
| RPS29 | ribosomal protein S29 | -0.0204465 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0204101 |
| UNC5D | unc-5 homolog D (C. elegans) | -0.0203091 |
| FSTL4 | follistatin-like 4 | -0.0201368 |
| ARHGEF7 | Rho guanine nucleotide exchange factor (GEF) 7 | -0.0198115 |
