| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Sapanisertib perturbation in NCI-H596 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Sapanisertib_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.133304 |
| MCL1 | myeloid cell leukemia 1 | 0.126336 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.107788 |
| NRG1 | neuregulin 1 | 0.0986251 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0985779 |
| SQSTM1 | sequestosome 1 | 0.0959605 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0912148 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0907197 |
| PDE10A | phosphodiesterase 10A | 0.0886081 |
| STK24 | serine/threonine kinase 24 | 0.088353 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | 0.0842367 |
| STC1 | stanniocalcin 1 | 0.0778197 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0777277 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | 0.0773419 |
| SVIL | supervillin | 0.0766514 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | 0.0760457 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0759706 |
| MEF2A | myocyte enhancer factor 2A | 0.0754596 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0752569 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0748633 |
| PRELID2 | PRELI domain containing 2 | 0.0743531 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0711889 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0710889 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 0.0699622 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0693832 |
| SLC44A1 | solute carrier family 44 (choline transporter), member 1 | 0.0686958 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.067694 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | 0.0671083 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0667314 |
| RAD51B | RAD51 paralog B | 0.0667234 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0658429 |
| OXSR1 | oxidative stress responsive 1 | 0.0649028 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0634654 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0632711 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.0627411 |
| VCL | vinculin | 0.0612687 |
| PCBP2 | poly(rC) binding protein 2 | 0.0612607 |
| CDH13 | cadherin 13 | 0.0604133 |
| AUTS2 | autism susceptibility candidate 2 | 0.0595248 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0581498 |
| NCKAP1 | NCK-associated protein 1 | 0.0580758 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0571347 |
| TXNRD1 | thioredoxin reductase 1 | 0.0570373 |
| RACK1 | receptor for activated C kinase 1 | 0.0554717 |
| MMP1 | matrix metallopeptidase 1 | 0.055095 |
| RTN4 | reticulon 4 | 0.0539764 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0520011 |
| RPL26 | ribosomal protein L26 | 0.049024 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0489044 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0482463 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0477801 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0473162 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0450211 |
| NAP1L4 | nucleosome assembly protein 1-like 4 | 0.0448834 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0442563 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0431553 |
| PATJ | PATJ crumbs cell polarity complex component | 0.0431175 |
| VMP1 | vacuole membrane protein 1 | 0.0430775 |
| SMAD3 | SMAD family member 3 | 0.0416817 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0414492 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0413596 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.040845 |
| RPS12 | ribosomal protein S12 | 0.0407336 |
| LDHA | lactate dehydrogenase A | 0.0406458 |
| RPL12 | ribosomal protein L12 | 0.0394871 |
| INHBA | inhibin, beta A | 0.0387659 |
| SENP6 | SUMO1/sentrin specific peptidase 6 | 0.0387462 |
| AK1 | adenylate kinase 1 | 0.0385763 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0384644 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0377726 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0367885 |
| ATXN1 | ataxin 1 | 0.0340658 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0327229 |
| FMNL2 | formin-like 2 | 0.0323589 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0323121 |
| TCF12 | transcription factor 12 | 0.0312065 |
| HMGA2 | high mobility group AT-hook 2 | 0.0305287 |
| CLTC | clathrin, heavy chain (Hc) | 0.0304287 |
| USP3 | ubiquitin specific peptidase 3 | 0.0294942 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.028745 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0279999 |
| RORA | RAR-related orphan receptor A | 0.0276358 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0260995 |
| RPS3 | ribosomal protein S3 | 0.0258809 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0257391 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0251526 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0244288 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0242108 |
| RUNX1 | runt-related transcription factor 1 | 0.0236744 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.0235188 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0233599 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0228427 |
| APP | amyloid beta (A4) precursor protein | 0.0227011 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | 0.0224067 |
| DOP1B | DOP1 leucine zipper like protein B | 0.0217965 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0216107 |
| ZNF292 | zinc finger protein 292 | 0.0210747 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.0207906 |
| NF1 | neurofibromin 1 | 0.0191796 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.01686 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.249621 |
| IGF2 | insulin-like growth factor 2 | -0.154974 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | -0.151155 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.1241 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.113326 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.108233 |
| EFNA5 | ephrin-A5 | -0.102987 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0965002 |
| FTL | ferritin, light polypeptide | -0.0945147 |
| HELZ | helicase with zinc finger | -0.0944705 |
| TMSB10 | thymosin beta 10 | -0.0942536 |
| FAM13A | family with sequence similarity 13, member A | -0.0942278 |
| VIM | vimentin | -0.0896386 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0888859 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0887868 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0887427 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0883823 |
| NFIA | nuclear factor I/A | -0.0825435 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0766812 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0762247 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0760331 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0752806 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0748837 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0746141 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0740366 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0723069 |
| TFG | TRK-fused gene | -0.0714482 |
| TENM3 | teneurin transmembrane protein 3 | -0.0685236 |
| KDM4C | lysine (K)-specific demethylase 4C | -0.0663153 |
| TPR | translocated promoter region, nuclear basket protein | -0.0641229 |
| BAZ2B | bromodomain adjacent to zinc finger domain, 2B | -0.0568169 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0564588 |
| RYBP | RING1 and YY1 binding protein | -0.0547918 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0544613 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0541086 |
| RPLP1 | ribosomal protein, large, P1 | -0.053903 |
| PRKCA | protein kinase C, alpha | -0.0538173 |
| CCNI | cyclin I | -0.0533292 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.0527709 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0516546 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0512665 |
| FGFR2 | fibroblast growth factor receptor 2 | -0.0509347 |
| OGA | O-GlcNAcase | -0.0505181 |
| ETNK1 | ethanolamine kinase 1 | -0.0502244 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0499184 |
| CDKAL1 | CDK5 regulatory subunit associated protein 1-like 1 | -0.0496004 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0490477 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | -0.0489599 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0481314 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0468976 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0466974 |
| PGK1 | phosphoglycerate kinase 1 | -0.0466283 |
| RAB10 | RAB10, member RAS oncogene family | -0.046129 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0458346 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0439903 |
| MATR3 | matrin 3 | -0.0435482 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0425309 |
| RPL8 | ribosomal protein L8 | -0.0422384 |
| ASPH | aspartate beta-hydroxylase | -0.0422235 |
| COL5A2 | collagen, type V, alpha 2 | -0.041136 |
| ERBIN | erbb2 interacting protein | -0.0403458 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0397712 |
| RPL32 | ribosomal protein L32 | -0.0395871 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0392831 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0387999 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0380271 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0377545 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0377535 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0365835 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0364295 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.036122 |
| HOOK2 | hook microtubule-tethering protein 2 | -0.033207 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0330086 |
| LMO7 | LIM domain 7 | -0.0329444 |
| CHD9 | chromodomain helicase DNA binding protein 9 | -0.0319825 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0317095 |
| GNAS | GNAS complex locus | -0.0315619 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0307405 |
| RPL37A | ribosomal protein L37a | -0.0304808 |
| EGFR | epidermal growth factor receptor | -0.0301519 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0284079 |
| CANX | calnexin | -0.0279923 |
| ZFHX3 | zinc finger homeobox 3 | -0.026939 |
| RPL34 | ribosomal protein L34 | -0.0265396 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0263177 |
| B2M | beta-2-microglobulin | -0.0261882 |
| RBM39 | RNA binding motif protein 39 | -0.0254407 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0247388 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0238839 |
| FN1 | fibronectin 1 | -0.0217887 |
| SRRM2 | serine/arginine repetitive matrix 2 | -0.0217623 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.021519 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0214139 |
| PKM | pyruvate kinase, muscle | -0.0210681 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0209195 |
| CD46 | CD46 molecule, complement regulatory protein | -0.0200333 |
| RBM25 | RNA binding motif protein 25 | -0.0199925 |
| PTK2 | protein tyrosine kinase 2 | -0.0197989 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0197353 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0196984 |
