| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Sapanisertib perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Sapanisertib_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| COL11A1 | collagen, type XI, alpha 1 | 0.0707381 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0559211 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0548413 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0483955 |
| CENPF | centromere protein F, 350/400kDa | 0.0453686 |
| DST | dystonin | 0.0373766 |
| ITGAV | integrin, alpha V | 0.0371822 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0359966 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0351897 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0328446 |
| POTEF | POTE ankyrin domain family, member F | 0.031783 |
| TENM3 | teneurin transmembrane protein 3 | 0.0304686 |
| PFN1 | profilin 1 | 0.0299288 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0295845 |
| MKI67 | marker of proliferation Ki-67 | 0.0291293 |
| TRPS1 | trichorhinophalangeal syndrome I | 0.0288895 |
| HDAC9 | histone deacetylase 9 | 0.0288296 |
| HMGA2 | high mobility group AT-hook 2 | 0.0284657 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0275525 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0271576 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0270684 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0268471 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0261845 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0260961 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0260262 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0255597 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0254728 |
| MATR3 | matrin 3 | 0.0253232 |
| STAG2 | stromal antigen 2 | 0.0252766 |
| PCBP2 | poly(rC) binding protein 2 | 0.0249752 |
| FER | fer (fps/fes related) tyrosine kinase | 0.0247264 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0243427 |
| TMSB4X | thymosin beta 4, X-linked | 0.0241851 |
| NTM | neurotrimin | 0.0229956 |
| ANK2 | ankyrin 2, neuronal | 0.0227755 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0224756 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0223812 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | 0.0222832 |
| PDGFC | platelet derived growth factor C | 0.0221348 |
| ZFR | zinc finger RNA binding protein | 0.0216623 |
| HS3ST5 | heparan sulfate (glucosamine) 3-O-sulfotransferase 5 | 0.021532 |
| DDX56 | DEAD (Asp-Glu-Ala-Asp) box helicase 56 | 0.0214024 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0213767 |
| TPX2 | TPX2, microtubule-associated | 0.0211355 |
| PEG10 | paternally expressed 10 | 0.0209475 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.0207646 |
| NUSAP1 | nucleolar and spindle associated protein 1 | 0.0206179 |
| KIF4A | kinesin family member 4A | 0.0203888 |
| CANX | calnexin | 0.0203168 |
| YBX1 | Y box binding protein 1 | 0.0200891 |
| DPYD | dihydropyrimidine dehydrogenase | 0.0199987 |
| RASAL2 | RAS protein activator like 2 | 0.0199046 |
| TCF12 | transcription factor 12 | 0.0198462 |
| RPS4X | ribosomal protein S4, X-linked | 0.0198317 |
| TPM3 | tropomyosin 3 | 0.0191679 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0189575 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0186812 |
| OSBPL6 | oxysterol binding protein-like 6 | 0.0184126 |
| ANLN | anillin, actin binding protein | 0.0183702 |
| CELF2 | CUGBP, Elav-like family member 2 | 0.0182815 |
| SERINC1 | serine incorporator 1 | 0.018107 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | 0.0180481 |
| H3-3B | H3.3 histone B | 0.018047 |
| TAOK1 | TAO kinase 1 | 0.0180237 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0178917 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0177326 |
| CBX3 | chromobox homolog 3 | 0.0176119 |
| KIF5B | kinesin family member 5B | 0.017601 |
| VPS26A | vacuolar protein sorting 26 homolog A (S. pombe) | 0.0175655 |
| NDC80 | NDC80 kinetochore complex component | 0.017418 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0173108 |
| EIF3E | eukaryotic translation initiation factor 3, subunit E | 0.017246 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0172433 |
| SGO2 | shugoshin 2 | 0.0171639 |
| GPC4 | glypican 4 | 0.0171422 |
| COL5A2 | collagen, type V, alpha 2 | 0.0167447 |
| ZNF292 | zinc finger protein 292 | 0.0167035 |
| ANXA5 | annexin A5 | 0.0165927 |
| U2SURP | U2 snRNP-associated SURP domain containing | 0.0164889 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0163568 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | 0.0163339 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | 0.0161181 |
| MRPS30 | mitochondrial ribosomal protein S30 | 0.0157831 |
| AMBRA1 | autophagy/beclin-1 regulator 1 | 0.0157757 |
| MTDH | metadherin | 0.0157072 |
| CDK6 | cyclin-dependent kinase 6 | 0.0156386 |
| MARCHF7 | membrane associated ring-CH-type finger 7 | 0.0155776 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.015488 |
| ICE1 | interactor of little elongation complex ELL subunit 1 | 0.0154247 |
| ZNF608 | zinc finger protein 608 | 0.0153336 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 0.0152822 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | 0.0152753 |
| ARB2A | ARB2 cotranscriptional regulator A | 0.0150832 |
| DEK | DEK proto-oncogene | 0.0149914 |
| ZMYM4 | zinc finger, MYM-type 4 | 0.0149234 |
| DYNC1I2 | dynein, cytoplasmic 1, intermediate chain 2 | 0.0149049 |
| KLHL5 | kelch-like family member 5 | 0.0148967 |
| CDC42BPB | CDC42 binding protein kinase beta (DMPK-like) | 0.0148789 |
| NFIB | nuclear factor I/B | 0.0148709 |
| CLTC | clathrin, heavy chain (Hc) | 0.0148433 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PTMA | prothymosin, alpha | -0.136408 |
| RPS16 | ribosomal protein S16 | -0.0789816 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | -0.071325 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0684357 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0662797 |
| RPL35A | ribosomal protein L35a | -0.0593783 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0592315 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0582932 |
| RPS8 | ribosomal protein S8 | -0.058236 |
| GALNTL6 | polypeptide N-acetylgalactosaminyltransferase-like 6 | -0.0571414 |
| COL1A2 | collagen, type I, alpha 2 | -0.0569697 |
| B2M | beta-2-microglobulin | -0.0538581 |
| GPC3 | glypican 3 | -0.0500794 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0497261 |
| RPL37 | ribosomal protein L37 | -0.0493044 |
| MDK | midkine (neurite growth-promoting factor 2) | -0.0457417 |
| RIGI | RNA sensor RIG-I | -0.045311 |
| PCDH9 | protocadherin 9 | -0.0443648 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0433306 |
| RPL9 | ribosomal protein L9 | -0.0403608 |
| SPAG9 | sperm associated antigen 9 | -0.0396411 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.0391636 |
| RPL37A | ribosomal protein L37a | -0.0375579 |
| RPS24 | ribosomal protein S24 | -0.0374625 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0363014 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0360145 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0351814 |
| GNAS | GNAS complex locus | -0.0351272 |
| CDH6 | cadherin 6, type 2, K-cadherin (fetal kidney) | -0.0351016 |
| RPL31 | ribosomal protein L31 | -0.034736 |
| RPL11 | ribosomal protein L11 | -0.0340839 |
| ANKRD33B | ankyrin repeat domain 33B | -0.0339739 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | -0.0325695 |
| RPS6 | ribosomal protein S6 | -0.0323329 |
| CAVIN1 | caveolae associated protein 1 | -0.0320157 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | -0.0319374 |
| JMJD1C | jumonji domain containing 1C | -0.0318252 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0315634 |
| RPS13 | ribosomal protein S13 | -0.0308629 |
| LRRC4C | leucine rich repeat containing 4C | -0.0306636 |
| PGK1 | phosphoglycerate kinase 1 | -0.0306417 |
| FGF13 | fibroblast growth factor 13 | -0.0305078 |
| MPG | N-methylpurine-DNA glycosylase | -0.0304778 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0294693 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0287095 |
| GSE1 | Gse1 coiled-coil protein | -0.0285663 |
| RPL7A | ribosomal protein L7a | -0.0283963 |
| TMSB10 | thymosin beta 10 | -0.0283682 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0281652 |
| H1-0 | H1.0 linker histone | -0.0278983 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0277953 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0277676 |
| TBCA | tubulin folding cofactor A | -0.0277615 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0273423 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0273093 |
| IGF2 | insulin-like growth factor 2 | -0.0270956 |
| RPL34 | ribosomal protein L34 | -0.0270464 |
| RPL19 | ribosomal protein L19 | -0.0267961 |
| RPS17 | ribosomal protein S17 | -0.0267819 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0267112 |
| RPS10 | ribosomal protein S10 | -0.0267078 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0264863 |
| PHIP | pleckstrin homology domain interacting protein | -0.026432 |
| PGAP1 | post-GPI attachment to proteins 1 | -0.0261843 |
| SIK2 | salt-inducible kinase 2 | -0.025917 |
| RPS12 | ribosomal protein S12 | -0.025772 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0255539 |
| ADNP | activity-dependent neuroprotector homeobox | -0.0253333 |
| ZNF217 | zinc finger protein 217 | -0.0252177 |
| APOE | apolipoprotein E | -0.0247931 |
| S100A10 | S100 calcium binding protein A10 | -0.0247737 |
| BMPR1A | bone morphogenetic protein receptor, type IA | -0.024713 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.024675 |
| TUT4 | terminal uridylyl transferase 4 | -0.0244162 |
| MAP4 | microtubule-associated protein 4 | -0.0244113 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0241099 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0241015 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0238042 |
| PLEKHG1 | pleckstrin homology domain containing, family G (with RhoGef domain) member 1 | -0.0237656 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.023648 |
| NEBL | nebulette | -0.0230471 |
| PALLD | palladin, cytoskeletal associated protein | -0.0224329 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | -0.0221661 |
| ATF4 | activating transcription factor 4 | -0.0219629 |
| CCNY | cyclin Y | -0.0219629 |
| FOXK1 | forkhead box K1 | -0.0218134 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0215288 |
| RPS27A | ribosomal protein S27a | -0.0213657 |
| TMEM87A | transmembrane protein 87A | -0.021363 |
| NXN | nucleoredoxin | -0.0212735 |
| UBN2 | ubinuclein 2 | -0.021232 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0211041 |
| AHNAK | AHNAK nucleoprotein | -0.0207799 |
| FST | follistatin | -0.0207617 |
| UBE2K | ubiquitin-conjugating enzyme E2K | -0.0200779 |
| SMIM44 | small integral membrane protein 44 | -0.0200698 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | -0.0198618 |
| RPS29 | ribosomal protein S29 | -0.0198095 |
| INTS6 | integrator complex subunit 6 | -0.0198086 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0197539 |
