Sapanisertib_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sapanisertib perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sapanisertib_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EEF2 eukaryotic translation elongation factor 2 0.0535638
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0435332
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0430765
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0366787
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.029934
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0264767
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0255319
GLI3 GLI family zinc finger 3 0.0248385
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0244715
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.0241991
ZBTB20 zinc finger and BTB domain containing 20 0.0239534
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0208537
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0204442
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0202125
ATOSA atos homolog A 0.0195831
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.019519
EFNA5 ephrin-A5 0.0191231
BMP10 bone morphogenetic protein 10 0.0190165
EPS8 epidermal growth factor receptor pathway substrate 8 0.0189897
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0187088
RPLP0 ribosomal protein, large, P0 0.0183642
GNAS GNAS complex locus 0.0181432
BZW2 basic leucine zipper and W2 domains 2 0.0180901
CALR calreticulin 0.0179678
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0179599
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0173944
FTL ferritin, light polypeptide 0.0171806
TSC22D1 TSC22 domain family, member 1 0.017114
HMGA1 high mobility group AT-hook 1 0.0169972
FTH1 ferritin, heavy polypeptide 1 0.0164868
SMC3 structural maintenance of chromosomes 3 0.0163151
MTF2 metal response element binding transcription factor 2 0.0156897
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2 0.0152549
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.0148015
PFN1 profilin 1 0.0147813
AGO2 argonaute RISC catalytic component 2 0.014392
PPP1R9A protein phosphatase 1, regulatory subunit 9A 0.0143787
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0143678
SLC38A2 solute carrier family 38, member 2 0.0142977
HEG1 heart development protein with EGF-like domains 1 0.0142254
AKAP12 A kinase (PRKA) anchor protein 12 0.0140722
TRERF1 transcriptional regulating factor 1 0.0140687
PPM1L protein phosphatase, Mg2+/Mn2+ dependent, 1L 0.0140476
PDIA6 protein disulfide isomerase family A, member 6 0.0140204
PCBP2 poly(rC) binding protein 2 0.0140145
TXNIP thioredoxin interacting protein 0.013804
DPH6 diphthamine biosynthesis 6 0.0137893
HSPB1 heat shock 27kDa protein 1 0.0137658
FHIT fragile histidine triad 0.0134938
NCOA3 nuclear receptor coactivator 3 0.0134021
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 0.013307
VIM vimentin 0.0130304
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 0.0129411
CPED1 cadherin-like and PC-esterase domain containing 1 0.0126128
PDIA3 protein disulfide isomerase family A, member 3 0.0122889
MORF4L1 mortality factor 4 like 1 0.0121926
CNOT6L CCR4-NOT transcription complex, subunit 6-like 0.0121072
DNAJB11 DnaJ (Hsp40) homolog, subfamily B, member 11 0.012079
S100A4 S100 calcium binding protein A4 0.0120113
DENND4C DENN/MADD domain containing 4C 0.0116726
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0116635
TAPBP TAP binding protein (tapasin) 0.0114405
LOXL3 lysyl oxidase-like 3 0.0113905
MYADM myeloid-associated differentiation marker 0.0113497
SLX4IP SLX4 interacting protein 0.0113414
SRSF10 serine/arginine-rich splicing factor 10 0.0112642
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) 0.0112425
KIF5C kinesin family member 5C 0.0111511
SCAF11 SR-related CTD-associated factor 11 0.0110545
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.0107928
NBEA neurobeachin 0.0107882
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 0.0107491
EMP1 epithelial membrane protein 1 0.0107464
TMEM158 transmembrane protein 158 (gene/pseudogene) 0.0107165
NFIL3 nuclear factor, interleukin 3 regulated 0.0106933
GSPT1 G1 to S phase transition 1 0.0106366
EXOC4 exocyst complex component 4 0.0105986
TNRC6A trinucleotide repeat containing 6A 0.0105759
MBNL2 muscleblind-like splicing regulator 2 0.0104974
WARS1 tryptophanyl-tRNA synthetase 1 0.0104835
PER1 period circadian clock 1 0.0104481
RAD51B RAD51 paralog B 0.0104036
MED17 mediator complex subunit 17 0.0103484
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0102987
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0102972
H1-0 H1.0 linker histone 0.0102855
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0102726
CANX calnexin 0.0101344
BTBD3 BTB (POZ) domain containing 3 0.0100525
RHOA ras homolog family member A 0.0100465
SYF2 SYF2 pre-mRNA-splicing factor 0.00989719
LMCD1 LIM and cysteine-rich domains 1 0.00974711
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.00971255
FAM162A family with sequence similarity 162, member A 0.00970113
QKI QKI, KH domain containing, RNA binding 0.00965729
DCUN1D1 DCN1, defective in cullin neddylation 1, domain containing 1 0.00960799
FN1 fibronectin 1 0.00951951
DNAAF3 dynein, axonemal, assembly factor 3 0.00938937
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 0.00931323
SNX9 sorting nexin 9 0.00928211

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.167201
TMSB4X thymosin beta 4, X-linked -0.0877996
PDE4D phosphodiesterase 4D, cAMP-specific -0.0726254
AHNAK AHNAK nucleoprotein -0.0725429
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.070776
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0642993
MKI67 marker of proliferation Ki-67 -0.0597134
CCND1 cyclin D1 -0.055792
GOLGA4 golgin A4 -0.0554613
ADAM10 ADAM metallopeptidase domain 10 -0.0548843
EZR ezrin -0.0522745
RPS6 ribosomal protein S6 -0.0517556
FLNB filamin B, beta -0.0515001
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0508063
RPS2 ribosomal protein S2 -0.0500744
SQSTM1 sequestosome 1 -0.044652
DSCAM Down syndrome cell adhesion molecule -0.0446255
GPHN gephyrin -0.0438416
EXT1 exostosin glycosyltransferase 1 -0.0433976
PKM pyruvate kinase, muscle -0.0420896
TXNRD1 thioredoxin reductase 1 -0.0406327
USP34 ubiquitin specific peptidase 34 -0.0405495
CAMTA1 calmodulin binding transcription activator 1 -0.0397413
RPS8 ribosomal protein S8 -0.0385839
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.03745
ZFAND3 zinc finger, AN1-type domain 3 -0.0373145
ANK2 ankyrin 2, neuronal -0.037207
TPT1 tumor protein, translationally-controlled 1 -0.0359215
RPL37A ribosomal protein L37a -0.0352628
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0340139
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0338247
RPL26 ribosomal protein L26 -0.0328612
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 -0.032511
RPL19 ribosomal protein L19 -0.0323491
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0322938
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0318906
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) -0.0316036
CENPF centromere protein F, 350/400kDa -0.0314415
SMNDC1 survival motor neuron domain containing 1 -0.0305658
BRD2 bromodomain containing 2 -0.0297207
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0292006
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0289833
RTN4 reticulon 4 -0.0277867
TTC3 tetratricopeptide repeat domain 3 -0.0276171
CACNB4 calcium channel, voltage-dependent, beta 4 subunit -0.0275049
ANLN anillin, actin binding protein -0.0274889
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0274794
RPS12 ribosomal protein S12 -0.0270724
EIF1 eukaryotic translation initiation factor 1 -0.0261135
TUBB4B tubulin, beta 4B class IVb -0.0260971
TASOR2 transcription activation suppressor family member 2 -0.026073
LOC112694756 uncharaterized LOC112694756 -0.0259306
RPL11 ribosomal protein L11 -0.0257414
PRRC2C proline-rich coiled-coil 2C -0.025667
TRIM44 tripartite motif containing 44 -0.0255537
PRELID2 PRELI domain containing 2 -0.0251458
SRRM2 serine/arginine repetitive matrix 2 -0.0249244
CARS1 cysteinyl-tRNA synthetase 1 -0.0249084
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -0.024718
SPTAN1 spectrin, alpha, non-erythrocytic 1 -0.0246795
ANKRD36 ankyrin repeat domain 36 -0.0246341
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0242461
RUNX1 runt-related transcription factor 1 -0.0241647
RPL9 ribosomal protein L9 -0.0240108
PDE4B phosphodiesterase 4B, cAMP-specific -0.0240048
TTC28 tetratricopeptide repeat domain 28 -0.02396
CLTC clathrin, heavy chain (Hc) -0.0239062
NPAS2 neuronal PAS domain protein 2 -0.0238522
HJURP Holliday junction recognition protein -0.0236603
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0235408
TAS2R14 taste receptor, type 2, member 14 -0.0234805
RRBP1 ribosome binding protein 1 -0.0233842
COG5 component of oligomeric golgi complex 5 -0.0232129
TMF1 TATA element modulatory factor 1 -0.0231696
UBC ubiquitin C -0.0230537
MAP4 microtubule-associated protein 4 -0.0230392
FBXO11 F-box protein 11 -0.0230217
JMJD1C jumonji domain containing 1C -0.022959
YEATS2 YEATS domain containing 2 -0.0227793
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.0227445
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa -0.0227073
DIAPH3 diaphanous-related formin 3 -0.0226962
IARS1 isoleucyl-tRNA synthetase 1 -0.0226843
MAPK8 mitogen-activated protein kinase 8 -0.022461
EIF4A2 eukaryotic translation initiation factor 4A2 -0.0224295
RPS13 ribosomal protein S13 -0.022304
NIPBL Nipped-B homolog (Drosophila) -0.0222494
B2M beta-2-microglobulin -0.0219946
RPL7 ribosomal protein L7 -0.0219352
RFC3 replication factor C (activator 1) 3, 38kDa -0.0218007
RPS3 ribosomal protein S3 -0.0215909
ANXA3 annexin A3 -0.0214781
RBM6 RNA binding motif protein 6 -0.0213576
GOLGB1 golgin B1 -0.0213477
H1-4 H1.4 linker histone, cluster member -0.0213401
MYO5C myosin VC -0.0213125
ZC3H11A zinc finger CCCH-type containing 11A -0.02129
PHF3 PHD finger protein 3 -0.0212568
ZNF217 zinc finger protein 217 -0.0211547
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.0211456