| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Sapanisertib perturbation in SNU-423 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Sapanisertib_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | 0.184316 |
| CD44 | CD44 molecule (Indian blood group) | 0.178369 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.174947 |
| COL6A3 | collagen, type VI, alpha 3 | 0.167308 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.148389 |
| HDAC9 | histone deacetylase 9 | 0.135408 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.129215 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.123406 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.114278 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | 0.10748 |
| PDE10A | phosphodiesterase 10A | 0.101927 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.100469 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0987323 |
| NDRG1 | N-myc downstream regulated 1 | 0.0982236 |
| LDHA | lactate dehydrogenase A | 0.0979748 |
| GPC6 | glypican 6 | 0.0935015 |
| GLIS3 | GLIS family zinc finger 3 | 0.0878564 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0866159 |
| VCAN | versican | 0.0855298 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0845004 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0807433 |
| HMGA2 | high mobility group AT-hook 2 | 0.0802452 |
| ASPH | aspartate beta-hydroxylase | 0.080073 |
| VEGFA | vascular endothelial growth factor A | 0.0778869 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0751491 |
| ATXN1 | ataxin 1 | 0.0750358 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0741096 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0709623 |
| FRMD4A | FERM domain containing 4A | 0.0667977 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0644999 |
| TNS3 | tensin 3 | 0.0623045 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.061282 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0595881 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0578356 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0569538 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0566961 |
| EGFR | epidermal growth factor receptor | 0.0563156 |
| NAV1 | neuron navigator 1 | 0.0561976 |
| GRIN2A | glutamate receptor, ionotropic, N-methyl D-aspartate 2A | 0.0561281 |
| HLA-A | major histocompatibility complex, class I, A | 0.0555554 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0551927 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0547657 |
| SQSTM1 | sequestosome 1 | 0.0544855 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0541076 |
| TMEM132D | transmembrane protein 132D | 0.0540584 |
| SMAD3 | SMAD family member 3 | 0.0538963 |
| SFTPA2 | surfactant protein A2 | 0.053875 |
| CDH13 | cadherin 13 | 0.051295 |
| AFF3 | AF4/FMR2 family, member 3 | 0.0510134 |
| EFNA5 | ephrin-A5 | 0.0496824 |
| NAV2 | neuron navigator 2 | 0.0491459 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0490573 |
| DST | dystonin | 0.0476253 |
| DIAPH2 | diaphanous-related formin 2 | 0.0474249 |
| RAD51B | RAD51 paralog B | 0.0472275 |
| SMYD3 | SET and MYND domain containing 3 | 0.0464352 |
| RND3 | Rho family GTPase 3 | 0.0455997 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.0454735 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0444415 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0441174 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0440422 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0434698 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0426388 |
| RAI14 | retinoic acid induced 14 | 0.0410347 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0409074 |
| SVIL | supervillin | 0.0401357 |
| JMJD1C | jumonji domain containing 1C | 0.0397033 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | 0.0392301 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0390064 |
| GOLGB1 | golgin B1 | 0.0386396 |
| SEPTIN9 | septin 9 | 0.0384687 |
| FMNL2 | formin-like 2 | 0.0381856 |
| ARFGEF3 | ARFGEF family member 3 | 0.0379301 |
| CTSB | cathepsin B | 0.0378322 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0376626 |
| C3 | complement component 3 | 0.0375828 |
| MYOF | myoferlin | 0.0370161 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0369882 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0369542 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | 0.036874 |
| COL5A1 | collagen, type V, alpha 1 | 0.0366979 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0364936 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0361855 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0360356 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | 0.0352232 |
| RUNX1 | runt-related transcription factor 1 | 0.0351431 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0348242 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0345145 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0342858 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0338475 |
| LOXL2 | lysyl oxidase-like 2 | 0.0336109 |
| FNIP1 | folliculin interacting protein 1 | 0.0335305 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0333784 |
| VMP1 | vacuole membrane protein 1 | 0.0333372 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0332501 |
| STC1 | stanniocalcin 1 | 0.0332496 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0330769 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0329825 |
| PTK2 | protein tyrosine kinase 2 | 0.0328743 |
| RAB7A | RAB7A, member RAS oncogene family | 0.032846 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0931469 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0868011 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0841502 |
| PTMA | prothymosin, alpha | -0.0573608 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0514053 |
| IER3 | immediate early response 3 | -0.0489592 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0469855 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0444174 |
| WTAP | Wilms tumor 1 associated protein | -0.0443286 |
| ANLN | anillin, actin binding protein | -0.043159 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0420957 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0372162 |
| SRGN | serglycin | -0.0353432 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0337171 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0329253 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0326742 |
| OGA | O-GlcNAcase | -0.0326333 |
| GNAS | GNAS complex locus | -0.0318546 |
| RBM39 | RNA binding motif protein 39 | -0.0315252 |
| RPS24 | ribosomal protein S24 | -0.0311025 |
| TMSB10 | thymosin beta 10 | -0.030081 |
| KIF4A | kinesin family member 4A | -0.0298994 |
| MKI67 | marker of proliferation Ki-67 | -0.0297764 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0292855 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0288943 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0280226 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0279404 |
| DEK | DEK proto-oncogene | -0.0278658 |
| SLC25A5 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | -0.0276538 |
| CENPF | centromere protein F, 350/400kDa | -0.0268976 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0268755 |
| TMEM123 | transmembrane protein 123 | -0.0268078 |
| RPS6 | ribosomal protein S6 | -0.0260276 |
| TPX2 | TPX2, microtubule-associated | -0.0259923 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0256654 |
| TUBB | tubulin, beta class I | -0.0251123 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0250736 |
| TFG | TRK-fused gene | -0.0246183 |
| CCNL1 | cyclin L1 | -0.0243948 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0242793 |
| SDC4 | syndecan 4 | -0.0238772 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0237206 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0233094 |
| HELZ | helicase with zinc finger | -0.0217991 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0213159 |
| ATP13A3 | ATPase type 13A3 | -0.0208564 |
| DIAPH3 | diaphanous-related formin 3 | -0.019909 |
| COL1A1 | collagen, type I, alpha 1 | -0.0198945 |
| ICAM1 | intercellular adhesion molecule 1 | -0.0196919 |
| FUS | FUS RNA binding protein | -0.0196108 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0195808 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0194592 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0194431 |
| TTK | TTK protein kinase | -0.0192275 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0191445 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0191085 |
| CADM1 | cell adhesion molecule 1 | -0.0185545 |
| PRR11 | proline rich 11 | -0.0184849 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0184552 |
| FBXO32 | F-box protein 32 | -0.0184139 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.018224 |
| RTN4 | reticulon 4 | -0.0181897 |
| RPL32 | ribosomal protein L32 | -0.0179516 |
| WDR45B | WD repeat domain 45B | -0.0178729 |
| HMGB2 | high mobility group box 2 | -0.0177524 |
| POTEF | POTE ankyrin domain family, member F | -0.0173068 |
| GAS2L3 | growth arrest-specific 2 like 3 | -0.017289 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0171733 |
| ACTG1 | actin gamma 1 | -0.0169691 |
| SEC11A | SEC11 homolog A (S. cerevisiae) | -0.01689 |
| FN1 | fibronectin 1 | -0.0168453 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0166834 |
| RPLP0 | ribosomal protein, large, P0 | -0.0166637 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | -0.0165913 |
| NABP1 | nucleic acid binding protein 1 | -0.0163895 |
| HLA-B | major histocompatibility complex, class I, B | -0.0163517 |
| THBS1 | thrombospondin 1 | -0.0162554 |
| PHIP | pleckstrin homology domain interacting protein | -0.0159707 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0158476 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0157641 |
| RLF | rearranged L-myc fusion | -0.0157244 |
| ZNF292 | zinc finger protein 292 | -0.0155202 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0155165 |
| TMEM41B | transmembrane protein 41B | -0.0154977 |
| RPL19 | ribosomal protein L19 | -0.0154806 |
| RPS23 | ribosomal protein S23 | -0.0151921 |
| CENPE | centromere protein E, 312kDa | -0.0149147 |
| USP3 | ubiquitin specific peptidase 3 | -0.0149065 |
| SEPTIN7 | septin 7 | -0.0147518 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.014738 |
| NOP58 | NOP58 ribonucleoprotein | -0.0144655 |
| PDPK1 | 3-phosphoinositide dependent protein kinase 1 | -0.0144427 |
| TEX10 | testis expressed 10 | -0.0143891 |
| GNA13 | guanine nucleotide binding protein (G protein), alpha 13 | -0.0141729 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0141351 |
| OLA1 | Obg-like ATPase 1 | -0.0137939 |
| FLOT1 | flotillin 1 | -0.0137802 |
| RNF145 | ring finger protein 145 | -0.0137563 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0136989 |
| FOXO3 | forkhead box O3 | -0.0135023 |
