| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Sapanisertib perturbation in SW 1088 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Sapanisertib_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | 0.0877181 |
| NDRG1 | N-myc downstream regulated 1 | 0.0732996 |
| NRXN3 | neurexin 3 | 0.0712306 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0596643 |
| ARRDC3 | arrestin domain containing 3 | 0.0526654 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0481339 |
| FAM13A | family with sequence similarity 13, member A | 0.0444063 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0432878 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | 0.0431242 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0428979 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0396491 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0357147 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0347166 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0344166 |
| ZNF292 | zinc finger protein 292 | 0.0322721 |
| ARB2A | ARB2 cotranscriptional regulator A | 0.0312581 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0310656 |
| RLF | rearranged L-myc fusion | 0.0306584 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0295747 |
| SMAD3 | SMAD family member 3 | 0.0293507 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0282202 |
| MEF2A | myocyte enhancer factor 2A | 0.0274052 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0266384 |
| PCBP2 | poly(rC) binding protein 2 | 0.0263221 |
| SNX13 | sorting nexin 13 | 0.0261116 |
| ZNF638 | zinc finger protein 638 | 0.026005 |
| WASF2 | WAS protein family, member 2 | 0.0255776 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0252738 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0250613 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0246662 |
| THBS1 | thrombospondin 1 | 0.0244327 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0241815 |
| GOLGA4 | golgin A4 | 0.0241458 |
| ZNF148 | zinc finger protein 148 | 0.0239856 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0233518 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | 0.0232855 |
| RIOK3 | RIO kinase 3 | 0.0229934 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0228918 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.022539 |
| RACK1 | receptor for activated C kinase 1 | 0.0222749 |
| RUNX1 | runt-related transcription factor 1 | 0.0221996 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0221714 |
| RNF24 | ring finger protein 24 | 0.0219865 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | 0.0214908 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0214483 |
| ZNF654 | zinc finger protein 654 | 0.0211303 |
| COPA | coatomer protein complex, subunit alpha | 0.0207247 |
| FAM107B | family with sequence similarity 107, member B | 0.0206848 |
| RYBP | RING1 and YY1 binding protein | 0.0205483 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0204678 |
| PDXDC1 | pyridoxal-dependent decarboxylase domain containing 1 | 0.0204489 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.020441 |
| RNF145 | ring finger protein 145 | 0.0203303 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0202243 |
| CD109 | CD109 molecule | 0.0200076 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0199625 |
| ARHGAP35 | Rho GTPase activating protein 35 | 0.0196429 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.0195923 |
| DKK3 | dickkopf WNT signaling pathway inhibitor 3 | 0.0194566 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0193695 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0190364 |
| SFXN1 | sideroflexin 1 | 0.0189297 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0189064 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0186579 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0185212 |
| CADM1 | cell adhesion molecule 1 | 0.0184939 |
| NF1 | neurofibromin 1 | 0.0184766 |
| RPL28 | ribosomal protein L28 | 0.0183777 |
| SEPTIN9 | septin 9 | 0.0183232 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0182885 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | 0.0181894 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | 0.0180472 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0178687 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0177444 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.0177001 |
| NUBPL | nucleotide binding protein-like | 0.0176264 |
| YBX1 | Y box binding protein 1 | 0.0174979 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | 0.0174055 |
| RAB8B | RAB8B, member RAS oncogene family | 0.0172738 |
| NME7 | NME/NM23 family member 7 | 0.0170842 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0170833 |
| CYLD | cylindromatosis (turban tumor syndrome) | 0.0169961 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0169175 |
| TXNIP | thioredoxin interacting protein | 0.0168053 |
| FRMD6 | FERM domain containing 6 | 0.0166097 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0165861 |
| EP300 | E1A binding protein p300 | 0.0165626 |
| UBN2 | ubinuclein 2 | 0.0165493 |
| L1CAM | L1 cell adhesion molecule | 0.0164502 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0164382 |
| RAB22A | RAB22A, member RAS oncogene family | 0.0164351 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.016288 |
| MYADM | myeloid-associated differentiation marker | 0.0162022 |
| KIF1B | kinesin family member 1B | 0.0162017 |
| DENND5A | DENN/MADD domain containing 5A | 0.0161996 |
| RPL37A | ribosomal protein L37a | 0.016144 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.016105 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0160928 |
| AHR | aryl hydrocarbon receptor | 0.0158889 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.0158579 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.281392 |
| FN1 | fibronectin 1 | -0.171441 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.143476 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.142553 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.122676 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.11578 |
| CDH13 | cadherin 13 | -0.0953956 |
| COL1A1 | collagen, type I, alpha 1 | -0.0943888 |
| TPM4 | tropomyosin 4 | -0.0938807 |
| VCL | vinculin | -0.0937082 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0880063 |
| TMSB10 | thymosin beta 10 | -0.0861638 |
| COL1A2 | collagen, type I, alpha 2 | -0.0818145 |
| HLA-B | major histocompatibility complex, class I, B | -0.0779588 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0770626 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.074976 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0706633 |
| AHNAK | AHNAK nucleoprotein | -0.0599331 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0571191 |
| ENO1 | enolase 1, (alpha) | -0.0556742 |
| KAZN | kazrin, periplakin interacting protein | -0.0554335 |
| CALU | calumenin | -0.0552265 |
| LOXL2 | lysyl oxidase-like 2 | -0.0539541 |
| HLA-C | major histocompatibility complex, class I, C | -0.0473246 |
| POTEF | POTE ankyrin domain family, member F | -0.0464095 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0463546 |
| ACTG1 | actin gamma 1 | -0.0447839 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0439914 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0420026 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0419931 |
| PRSS23 | protease, serine, 23 | -0.0387916 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.037138 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.0362614 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0356629 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0350187 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0348599 |
| CALD1 | caldesmon 1 | -0.0347029 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0346588 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.033949 |
| STC1 | stanniocalcin 1 | -0.0330293 |
| TMSB4X | thymosin beta 4, X-linked | -0.0330173 |
| RAD51B | RAD51 paralog B | -0.0328252 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0323634 |
| ASPH | aspartate beta-hydroxylase | -0.031359 |
| PTMA | prothymosin, alpha | -0.0305917 |
| OXR1 | oxidation resistance 1 | -0.0302328 |
| SDC4 | syndecan 4 | -0.0302272 |
| TNNC1 | troponin C type 1 (slow) | -0.0302107 |
| COL3A1 | collagen, type III, alpha 1 | -0.0298059 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0297642 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0293938 |
| EGFR | epidermal growth factor receptor | -0.0291059 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0290501 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0288266 |
| MAP4 | microtubule-associated protein 4 | -0.0280686 |
| LAMB1 | laminin, beta 1 | -0.0280154 |
| CLIC4 | chloride intracellular channel 4 | -0.0276994 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0273532 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0273203 |
| PALLD | palladin, cytoskeletal associated protein | -0.0271318 |
| COL5A1 | collagen, type V, alpha 1 | -0.0271041 |
| MAP1B | microtubule-associated protein 1B | -0.0267757 |
| PGK1 | phosphoglycerate kinase 1 | -0.0264265 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0264141 |
| AKR1B1 | aldo-keto reductase family 1, member B1 (aldose reductase) | -0.0262374 |
| TPM1 | tropomyosin 1 (alpha) | -0.0261064 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0256985 |
| VIM | vimentin | -0.0253785 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.024984 |
| ARHGAP24 | Rho GTPase activating protein 24 | -0.0245877 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0243932 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.023946 |
| IGFBP7 | insulin-like growth factor binding protein 7 | -0.0233422 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0233084 |
| NABP1 | nucleic acid binding protein 1 | -0.0231357 |
| NAV1 | neuron navigator 1 | -0.0229031 |
| TUBA1B | tubulin, alpha 1b | -0.0226552 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0220354 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.02194 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.021757 |
| LOX | lysyl oxidase | -0.0216145 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0215441 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0213269 |
| CALR | calreticulin | -0.0212255 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0209735 |
| NRP1 | neuropilin 1 | -0.0207215 |
| TUBB | tubulin, beta class I | -0.0207065 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0206364 |
| B2M | beta-2-microglobulin | -0.0204257 |
| KCNE4 | potassium channel, voltage gated subfamily E regulatory beta subunit 4 | -0.0202455 |
| CKAP4 | cytoskeleton-associated protein 4 | -0.0201119 |
| HMGA2 | high mobility group AT-hook 2 | -0.0200684 |
| RTN4 | reticulon 4 | -0.0199912 |
| CANX | calnexin | -0.0199527 |
| FBN1 | fibrillin 1 | -0.0199435 |
| CAVIN1 | caveolae associated protein 1 | -0.0198753 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0198566 |
| FBXO11 | F-box protein 11 | -0.0198061 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | -0.0197421 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | -0.0194971 |
