| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Sapanisertib perturbation in SW 1271 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Sapanisertib_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FNDC3B | fibronectin type III domain containing 3B | 0.106919 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.088184 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0868376 |
| CD44 | CD44 molecule (Indian blood group) | 0.0757476 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0736029 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0707096 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0675622 |
| LDHA | lactate dehydrogenase A | 0.064369 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0596534 |
| ANGPTL4 | angiopoietin-like 4 | 0.0534669 |
| FMNL2 | formin-like 2 | 0.0502107 |
| HMGA2 | high mobility group AT-hook 2 | 0.0477054 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0475154 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0455211 |
| DST | dystonin | 0.0453594 |
| NT5E | 5'-nucleotidase, ecto (CD73) | 0.0452943 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0448203 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0447332 |
| VIM | vimentin | 0.0435993 |
| SMAD3 | SMAD family member 3 | 0.0409158 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0399629 |
| FLNB | filamin B, beta | 0.039936 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0397838 |
| ATXN1 | ataxin 1 | 0.0396409 |
| RAI14 | retinoic acid induced 14 | 0.0393048 |
| NAV2 | neuron navigator 2 | 0.0386929 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.0379013 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0374885 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0371721 |
| PRKCA | protein kinase C, alpha | 0.0365688 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0361134 |
| OSMR | oncostatin M receptor | 0.0356113 |
| ASPH | aspartate beta-hydroxylase | 0.0349951 |
| IRAK2 | interleukin-1 receptor-associated kinase 2 | 0.0336288 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0332327 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0330385 |
| ANO6 | anoctamin 6 | 0.0326126 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0324756 |
| PRSS23 | protease, serine, 23 | 0.0308795 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.030844 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0306632 |
| PBX3 | pre-B-cell leukemia homeobox 3 | 0.0305966 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | 0.0304573 |
| CDCP1 | CUB domain containing protein 1 | 0.0304274 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.0300894 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | 0.0299533 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0294351 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0291351 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0286961 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.027907 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0278176 |
| DNER | delta/notch-like EGF repeat containing | 0.027381 |
| SKIL | SKI-like proto-oncogene | 0.0273017 |
| VMP1 | vacuole membrane protein 1 | 0.0271197 |
| SQSTM1 | sequestosome 1 | 0.0268303 |
| NDRG1 | N-myc downstream regulated 1 | 0.0266267 |
| PTK2 | protein tyrosine kinase 2 | 0.0264543 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0261452 |
| EGFR | epidermal growth factor receptor | 0.0260962 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0260672 |
| SVIL | supervillin | 0.0252879 |
| HDAC9 | histone deacetylase 9 | 0.02492 |
| NEDD4 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | 0.0246748 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0245829 |
| PKM | pyruvate kinase, muscle | 0.0244521 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0244141 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.024355 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0238745 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0238734 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.0237788 |
| MCL1 | myeloid cell leukemia 1 | 0.0237587 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0236444 |
| GOLGB1 | golgin B1 | 0.0235759 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0234299 |
| EXOC4 | exocyst complex component 4 | 0.0233428 |
| IL1RAP | interleukin 1 receptor accessory protein | 0.0232172 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0230913 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | 0.0229878 |
| PODXL | podocalyxin-like | 0.0229756 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | 0.0229263 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | 0.0227514 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | 0.0225921 |
| RAD51B | RAD51 paralog B | 0.0223969 |
| MYO9B | myosin IXB | 0.0223867 |
| ATG7 | autophagy related 7 | 0.0223394 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0222419 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | 0.022033 |
| PCED1B | PC-esterase domain containing 1B | 0.0219755 |
| ITGAV | integrin, alpha V | 0.0213519 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0212879 |
| DPYD | dihydropyrimidine dehydrogenase | 0.0211155 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0210296 |
| SYNJ2 | synaptojanin 2 | 0.0207301 |
| PRR16 | proline rich 16 | 0.0207161 |
| DLGAP4 | discs, large (Drosophila) homolog-associated protein 4 | 0.0206602 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0206379 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0202121 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0199402 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.019911 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0196462 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0631624 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.048029 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0397954 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0364402 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0359445 |
| NUP58 | nucleoporin 58 | -0.0316999 |
| DEK | DEK proto-oncogene | -0.0306206 |
| TPX2 | TPX2, microtubule-associated | -0.0290939 |
| PHIP | pleckstrin homology domain interacting protein | -0.0287816 |
| ANLN | anillin, actin binding protein | -0.028465 |
| SNX14 | sorting nexin 14 | -0.0281993 |
| MKI67 | marker of proliferation Ki-67 | -0.026901 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0266882 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0261976 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0257705 |
| SGO2 | shugoshin 2 | -0.0244949 |
| CKAP2 | cytoskeleton associated protein 2 | -0.0228616 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0226376 |
| DIAPH3 | diaphanous-related formin 3 | -0.0222173 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | -0.0216668 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0216299 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0200901 |
| APOLD1 | apolipoprotein L domain containing 1 | -0.0200487 |
| BUB1 | BUB1 mitotic checkpoint serine/threonine kinase | -0.0192761 |
| HELZ | helicase with zinc finger | -0.0192624 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.019065 |
| RBM39 | RNA binding motif protein 39 | -0.0190339 |
| TMEM123 | transmembrane protein 123 | -0.0189642 |
| SETD5 | SET domain containing 5 | -0.018958 |
| AKAP10 | A kinase (PRKA) anchor protein 10 | -0.0189406 |
| CENPF | centromere protein F, 350/400kDa | -0.0188301 |
| ECT2 | epithelial cell transforming 2 | -0.0183514 |
| OGA | O-GlcNAcase | -0.0182945 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0182218 |
| ATF7IP | activating transcription factor 7 interacting protein | -0.0181935 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | -0.0181444 |
| GNAS | GNAS complex locus | -0.0180817 |
| BBX | bobby sox homolog (Drosophila) | -0.017961 |
| CKAP5 | cytoskeleton associated protein 5 | -0.0177371 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | -0.0167909 |
| KIF20B | kinesin family member 20B | -0.0164768 |
| NSD2 | nuclear receptor binding SET domain protein 2 | -0.0161842 |
| USP3 | ubiquitin specific peptidase 3 | -0.0161836 |
| TTK | TTK protein kinase | -0.016064 |
| AHCTF1 | AT hook containing transcription factor 1 | -0.0160184 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0159411 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | -0.0158652 |
| PDS5B | PDS5 cohesin associated factor B | -0.015823 |
| KIF4A | kinesin family member 4A | -0.015744 |
| YAP1 | Yes-associated protein 1 | -0.0156475 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0154435 |
| KIAA1958 | KIAA1958 | -0.0154109 |
| KIF23 | kinesin family member 23 | -0.0153647 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0152963 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0152825 |
| PRC1 | protein regulator of cytokinesis 1 | -0.0150423 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0149569 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0149319 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0149152 |
| GOLT1B | golgi transport 1B | -0.0148396 |
| SYCP2 | synaptonemal complex protein 2 | -0.0146938 |
| WBP11 | WW domain binding protein 11 | -0.0145791 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0144997 |
| XPO1 | exportin 1 | -0.0144756 |
| HMGB2 | high mobility group box 2 | -0.0144371 |
| MTF2 | metal response element binding transcription factor 2 | -0.0144078 |
| PIAS2 | protein inhibitor of activated STAT, 2 | -0.0140753 |
| ZFR | zinc finger RNA binding protein | -0.0138608 |
| KLHL24 | kelch-like family member 24 | -0.0138197 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | -0.0137506 |
| RHEB | Ras homolog enriched in brain | -0.0136543 |
| NCAPG2 | non-SMC condensin II complex, subunit G2 | -0.0136354 |
| SRSF11 | serine/arginine-rich splicing factor 11 | -0.0135538 |
| ZFAND6 | zinc finger, AN1-type domain 6 | -0.013504 |
| IFRD1 | interferon-related developmental regulator 1 | -0.0134117 |
| TBC1D23 | TBC1 domain family, member 23 | -0.0133061 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0132852 |
| WDR45B | WD repeat domain 45B | -0.0132575 |
| GAS2L3 | growth arrest-specific 2 like 3 | -0.0131908 |
| CANX | calnexin | -0.0130864 |
| CDK19 | cyclin-dependent kinase 19 | -0.0130669 |
| NUP54 | nucleoporin 54kDa | -0.0130081 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0128959 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0127781 |
| NKTR | natural killer cell triggering receptor | -0.0127513 |
| PRR11 | proline rich 11 | -0.0127088 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | -0.0126821 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | -0.0126798 |
| MORF4L2 | mortality factor 4 like 2 | -0.0126197 |
| PLEKHB2 | pleckstrin homology domain containing, family B (evectins) member 2 | -0.0125742 |
| TUBA1B | tubulin, alpha 1b | -0.0124942 |
| TENT2 | terminal nucleotidyltransferase 2 | -0.0124522 |
| FUS | FUS RNA binding protein | -0.0123944 |
| INSIG1 | insulin induced gene 1 | -0.0123925 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0123063 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | -0.0122332 |
| WDR48 | WD repeat domain 48 | -0.0122227 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0122194 |
| BCLAF1 | BCL2-associated transcription factor 1 | -0.0121313 |
| CCNB1 | cyclin B1 | -0.0121255 |
