| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Sapanisertib perturbation in SW 900 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Sapanisertib_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FTH1 | ferritin, heavy polypeptide 1 | 0.217367 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.119898 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.111674 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.106095 |
| NDRG1 | N-myc downstream regulated 1 | 0.105705 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0982208 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0877671 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0850649 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0838628 |
| ITGA1 | integrin, alpha 1 | 0.0791625 |
| FTL | ferritin, light polypeptide | 0.0763146 |
| SFTPA2 | surfactant protein A2 | 0.0736351 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0736332 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | 0.0725927 |
| MT2A | metallothionein 2A | 0.0722967 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0708324 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.068959 |
| RFX2 | regulatory factor X, 2 (influences HLA class II expression) | 0.065009 |
| PLIN2 | perilipin 2 | 0.0633626 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0623977 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0605636 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0601652 |
| VIM | vimentin | 0.0587242 |
| AGPAT4 | 1-acylglycerol-3-phosphate O-acyltransferase 4 | 0.0578139 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0557249 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0539881 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0512322 |
| TMEM156 | transmembrane protein 156 | 0.0502366 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0493949 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.048879 |
| TXNIP | thioredoxin interacting protein | 0.0480877 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.047938 |
| B2M | beta-2-microglobulin | 0.0475589 |
| VEGFA | vascular endothelial growth factor A | 0.0471227 |
| FAM13A | family with sequence similarity 13, member A | 0.0465603 |
| PTMA | prothymosin, alpha | 0.0460071 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0456981 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | 0.0451193 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0448091 |
| STC2 | stanniocalcin 2 | 0.0446714 |
| RAI14 | retinoic acid induced 14 | 0.0444113 |
| CD109 | CD109 molecule | 0.0435378 |
| EMP1 | epithelial membrane protein 1 | 0.0423129 |
| FAT1 | FAT atypical cadherin 1 | 0.0417312 |
| HMGA1 | high mobility group AT-hook 1 | 0.0417031 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0410743 |
| RPS27 | ribosomal protein S27 | 0.0409605 |
| CTSB | cathepsin B | 0.0407502 |
| MAPKAPK2 | mitogen-activated protein kinase-activated protein kinase 2 | 0.0402102 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0400993 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.0396023 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0387487 |
| PARD3 | par-3 family cell polarity regulator | 0.0386911 |
| LMNA | lamin A/C | 0.037979 |
| SMAD3 | SMAD family member 3 | 0.0369906 |
| MYADM | myeloid-associated differentiation marker | 0.0368406 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | 0.0366464 |
| MRPS6 | mitochondrial ribosomal protein S6 | 0.0365993 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0365838 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0363391 |
| RACK1 | receptor for activated C kinase 1 | 0.0362729 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0354487 |
| SIRT1 | sirtuin 1 | 0.0353963 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0351207 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0347472 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0344297 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0343995 |
| S100A6 | S100 calcium binding protein A6 | 0.0343094 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0338433 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | 0.0335693 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.033281 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0323439 |
| IL6 | interleukin 6 | 0.0322076 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0309924 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0309477 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0308359 |
| CLIP2 | CAP-GLY domain containing linker protein 2 | 0.0307582 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.030638 |
| RND3 | Rho family GTPase 3 | 0.0305182 |
| YBX3 | Y box binding protein 3 | 0.030259 |
| SVIL | supervillin | 0.0302473 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0302302 |
| EZR | ezrin | 0.0294712 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0292211 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0290374 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0289061 |
| EGFR | epidermal growth factor receptor | 0.0288514 |
| DSTN | destrin (actin depolymerizing factor) | 0.028727 |
| MTMR3 | myotubularin related protein 3 | 0.0285825 |
| RASAL2 | RAS protein activator like 2 | 0.028558 |
| GOLGA4 | golgin A4 | 0.0285068 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0284728 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0282235 |
| LYST | lysosomal trafficking regulator | 0.0280842 |
| CSGALNACT2 | chondroitin sulfate N-acetylgalactosaminyltransferase 2 | 0.0280509 |
| SIK3 | SIK family kinase 3 | 0.0277828 |
| MTSS1 | metastasis suppressor 1 | 0.027534 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0272744 |
| SGMS2 | sphingomyelin synthase 2 | 0.0271229 |
| RNF145 | ring finger protein 145 | 0.0270697 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.256057 |
| VCL | vinculin | -0.151471 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.146993 |
| NRG1 | neuregulin 1 | -0.143851 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.124357 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.105979 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0867442 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0713321 |
| SYT1 | synaptotagmin I | -0.0664532 |
| ASPH | aspartate beta-hydroxylase | -0.065802 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0613321 |
| AEBP2 | AE binding protein 2 | -0.0560665 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0549303 |
| INTS6 | integrator complex subunit 6 | -0.0503848 |
| PRELID2 | PRELI domain containing 2 | -0.0490897 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.0477799 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0465798 |
| TUFT1 | tuftelin 1 | -0.046404 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0447592 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0439837 |
| LRRC23 | leucine rich repeat containing 23 | -0.0434745 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.041337 |
| GLIS3 | GLIS family zinc finger 3 | -0.0408565 |
| DST | dystonin | -0.040567 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0402582 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0401137 |
| RRBP1 | ribosome binding protein 1 | -0.0397999 |
| FAM20C | family with sequence similarity 20, member C | -0.0394857 |
| ACTN4 | actinin, alpha 4 | -0.039233 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0390165 |
| OGA | O-GlcNAcase | -0.0384839 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0384299 |
| PALLD | palladin, cytoskeletal associated protein | -0.0377616 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | -0.0343742 |
| H1-0 | H1.0 linker histone | -0.0341973 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0340475 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0340213 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0339186 |
| DNAH5 | dynein, axonemal, heavy chain 5 | -0.0337508 |
| RPH3AL | rabphilin 3A-like (without C2 domains) | -0.0327947 |
| AHNAK | AHNAK nucleoprotein | -0.0325703 |
| ETV6 | ets variant 6 | -0.0324426 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0322971 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0320341 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.032012 |
| RIGI | RNA sensor RIG-I | -0.0318464 |
| AHNAK2 | AHNAK nucleoprotein 2 | -0.0299564 |
| NABP1 | nucleic acid binding protein 1 | -0.0296474 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.0295736 |
| RNF213 | ring finger protein 213 | -0.0295053 |
| TNNC1 | troponin C type 1 (slow) | -0.0284843 |
| ETNK1 | ethanolamine kinase 1 | -0.028416 |
| RPS24 | ribosomal protein S24 | -0.0274681 |
| WDR1 | WD repeat domain 1 | -0.0267861 |
| HLA-B | major histocompatibility complex, class I, B | -0.0267743 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | -0.0263743 |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | -0.0262668 |
| CANX | calnexin | -0.0261384 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.0258579 |
| FERMT2 | fermitin family member 2 | -0.0257597 |
| GNAS | GNAS complex locus | -0.0250701 |
| TGFA | transforming growth factor, alpha | -0.0250111 |
| APOLD1 | apolipoprotein L domain containing 1 | -0.0244944 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0241718 |
| ADD3 | adducin 3 (gamma) | -0.0241262 |
| TFRC | transferrin receptor | -0.0240581 |
| SMYD3 | SET and MYND domain containing 3 | -0.0239946 |
| SP100 | SP100 nuclear antigen | -0.0238738 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0236396 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0232241 |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | -0.0231188 |
| RAD51B | RAD51 paralog B | -0.0229283 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0228753 |
| MAP1B | microtubule-associated protein 1B | -0.0227886 |
| HOMER1 | homer scaffolding protein 1 | -0.0227254 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0226509 |
| HDLBP | high density lipoprotein binding protein | -0.0225513 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0223598 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0223191 |
| GLIPR1 | GLI pathogenesis-related 1 | -0.0223188 |
| ARF1 | ADP-ribosylation factor 1 | -0.0222019 |
| FMN1 | formin 1 | -0.0220438 |
| FLNA | filamin A, alpha | -0.0219139 |
| KHDC4 | KH domain containing 4, pre-mRNA splicing factor | -0.0217749 |
| CAB39 | calcium binding protein 39 | -0.0213183 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0211511 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0209319 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.0207258 |
| ADIPOR2 | adiponectin receptor 2 | -0.0201557 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0201172 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | -0.0199769 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0199622 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | -0.0199041 |
| GOLGA3 | golgin A3 | -0.0198798 |
| ETV1 | ets variant 1 | -0.0198294 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.0197052 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | -0.0195925 |
| RNF220 | ring finger protein 220 | -0.0195492 |
| COL7A1 | collagen, type VII, alpha 1 | -0.0195488 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.0194562 |
