| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/135402045 |
| Similar Terms | |
| Downloads & Tools |
200 proteins with high or low expression in Sapropterin relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ARHGAP22 | Rho GTPase activating protein 22 | 2.89 |
| TTN | titin | 1.78 |
| KLHL23 | kelch-like family member 23 | 1.58 |
| KDM6B | lysine (K)-specific demethylase 6B | 1.34 |
| HBB | hemoglobin, beta | 1.14 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | 1.1 |
| SUGCT | succinyl-CoA:glutarate-CoA transferase | 1.07 |
| LRP5 | low density lipoprotein receptor-related protein 5 | 1.06 |
| RNF6 | ring finger protein (C3H2C3 type) 6 | 0.99 |
| NBEAL1 | neurobeachin-like 1 | 0.9 |
| CELSR3 | cadherin, EGF LAG seven-pass G-type receptor 3 | 0.83 |
| TRAF6 | TNF receptor-associated factor 6, E3 ubiquitin protein ligase | 0.77 |
| SBSN | suprabasin | 0.74 |
| RNF181 | ring finger protein 181 | 0.71 |
| INSR | insulin receptor | 0.68 |
| ACTBL2 | actin, beta-like 2 | 0.65 |
| HDAC11 | histone deacetylase 11 | 0.64 |
| WNT10B | wingless-type MMTV integration site family, member 10B | 0.59 |
| SEMA4D | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D | 0.58 |
| SET | SET nuclear proto-oncogene | 0.57 |
| FLNA | filamin A, alpha | 0.53 |
| ISYNA1 | inositol-3-phosphate synthase 1 | 0.52 |
| TTLL4 | tubulin tyrosine ligase-like family member 4 | 0.51 |
| FLII | flightless I homolog (Drosophila) | 0.51 |
| ALS2CL | ALS2 C-terminal like | 0.51 |
| DCLRE1A | DNA cross-link repair 1A | 0.49 |
| NEK4 | NIMA-related kinase 4 | 0.49 |
| UNC13D | unc-13 homolog D (C. elegans) | 0.48 |
| TCHP | trichoplein, keratin filament binding | 0.47 |
| NUDT16 | nudix (nucleoside diphosphate linked moiety X)-type motif 16 | 0.45 |
| NCKAP1L | NCK-associated protein 1-like | 0.45 |
| DR1 | down-regulator of transcription 1, TBP-binding (negative cofactor 2) | 0.43 |
| DNPH1 | 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 | 0.43 |
| BRF2 | BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit | 0.42 |
| KBTBD11 | kelch repeat and BTB (POZ) domain containing 11 | 0.42 |
| CDA | cytidine deaminase | 0.4 |
| YDJC | YdjC homolog (bacterial) | 0.39 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.39 |
| CYTH2 | cytohesin 2 | 0.39 |
| LAMP2 | lysosomal-associated membrane protein 2 | 0.39 |
| ASTE1 | asteroid homolog 1 (Drosophila) | 0.39 |
| AURKAIP1 | aurora kinase A interacting protein 1 | 0.37 |
| NEMP1 | nuclear envelope integral membrane protein 1 | 0.36 |
| SS18L1 | synovial sarcoma translocation gene on chromosome 18-like 1 | 0.36 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.36 |
| IP6K2 | inositol hexakisphosphate kinase 2 | 0.35 |
| PSMB9 | proteasome (prosome, macropain) subunit, beta type, 9 | 0.35 |
| RTEL1 | regulator of telomere elongation helicase 1 | 0.35 |
| PLA2G12A | phospholipase A2, group XIIA | 0.34 |
| C12ORF60 | chromosome 12 open reading frame 60 | 0.34 |
| LSM3 | LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae) | 0.33 |
| ACAD10 | acyl-CoA dehydrogenase family, member 10 | 0.33 |
| TIMM10B | translocase of inner mitochondrial membrane 10 homolog B (yeast) | 0.33 |
| ZBED5 | zinc finger, BED-type containing 5 | 0.33 |
| WASHC3 | WASH complex subunit 3 | 0.33 |
| FKBP1A | FK506 binding protein 1A, 12kDa | 0.33 |
| FLCN | folliculin | 0.33 |
| ALG13 | ALG13, UDP-N-acetylglucosaminyltransferase subunit | 0.33 |
| CRTC3 | CREB regulated transcription coactivator 3 | 0.32 |
| CCDC9 | coiled-coil domain containing 9 | 0.32 |
| PTPMT1 | protein tyrosine phosphatase, mitochondrial 1 | 0.32 |
| IQCB1 | IQ motif containing B1 | 0.32 |
| ONECUT3 | one cut homeobox 3 | 0.31 |
| TECPR1 | tectonin beta-propeller repeat containing 1 | 0.31 |
| F8A1 | coagulation factor VIII-associated 1 | 0.31 |
| R3HCC1L | R3H domain and coiled-coil containing 1-like | 0.3 |
| GLRX | glutaredoxin (thioltransferase) | 0.3 |
| SELENOF | selenoprotein F | 0.3 |
| H3-3A | H3.3 histone A | 0.3 |
| SYPL1 | synaptophysin-like 1 | 0.3 |
| F8 | coagulation factor VIII, procoagulant component | 0.3 |
| KPTN | kaptin (actin binding protein) | 0.3 |
| LASP1 | LIM and SH3 protein 1 | 0.29 |
| ENTPD2 | ectonucleoside triphosphate diphosphohydrolase 2 | 0.29 |
| AGFG2 | ArfGAP with FG repeats 2 | 0.29 |
| POLR2I | polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa | 0.29 |
| ELK3 | ELK3, ETS-domain protein (SRF accessory protein 2) | 0.29 |
| CD40 | CD40 molecule, TNF receptor superfamily member 5 | 0.29 |
| RPS12 | ribosomal protein S12 | 0.29 |
| TSC22D1 | TSC22 domain family, member 1 | 0.29 |
| PFKFB1 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 | 0.29 |
| PLEKHG6 | pleckstrin homology domain containing, family G (with RhoGef domain) member 6 | 0.28 |
| HIST2H2BF | histone cluster 2, H2bf | 0.28 |
| TRIB3 | tribbles pseudokinase 3 | 0.28 |
| HMGN4 | high mobility group nucleosomal binding domain 4 | 0.28 |
| METAP1D | methionyl aminopeptidase type 1D (mitochondrial) | 0.28 |
| PDCD2L | programmed cell death 2-like | 0.28 |
| TRIM15 | tripartite motif containing 15 | 0.28 |
| PLEKHG4 | pleckstrin homology domain containing, family G (with RhoGef domain) member 4 | 0.28 |
| TBC1D2B | TBC1 domain family, member 2B | 0.28 |
| ENO1 | enolase 1, (alpha) | 0.27 |
| XIRP1 | xin actin binding repeat containing 1 | 0.27 |
| VGLL4 | vestigial-like family member 4 | 0.27 |
| ADAM22 | ADAM metallopeptidase domain 22 | 0.27 |
| NOL3 | nucleolar protein 3 (apoptosis repressor with CARD domain) | 0.27 |
| TSSC4 | tumor suppressing subtransferable candidate 4 | 0.27 |
| MAX | MYC associated factor X | 0.27 |
| INPP5J | inositol polyphosphate-5-phosphatase J | 0.27 |
| TMEM184C | transmembrane protein 184C | 0.27 |
| NPHP1 | nephronophthisis 1 (juvenile) | 0.27 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ZFP37 | ZFP37 zinc finger protein | -2.31 |
| CCNDBP1 | cyclin D-type binding-protein 1 | -0.85 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | -0.8 |
| SYTL2 | synaptotagmin-like 2 | -0.69 |
| RNF113A | ring finger protein 113A | -0.68 |
| FAM241B | family with sequence similarity 241 member B | -0.65 |
| CYP4F22 | cytochrome P450, family 4, subfamily F, polypeptide 22 | -0.63 |
| ARHGAP44 | Rho GTPase activating protein 44 | -0.62 |
| ZNF623 | zinc finger protein 623 | -0.59 |
| CES3 | carboxylesterase 3 | -0.58 |
| CERK | ceramide kinase | -0.57 |
| HSPA1L | heat shock 70kDa protein 1-like | -0.57 |
| PSEN1 | presenilin 1 | -0.54 |
| AMPD1 | adenosine monophosphate deaminase 1 | -0.53 |
| TTC21B | tetratricopeptide repeat domain 21B | -0.5 |
| MAN1A2 | mannosidase, alpha, class 1A, member 2 | -0.46 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.44 |
| ZNF865 | zinc finger protein 865 | -0.42 |
| PHLDB3 | pleckstrin homology-like domain, family B, member 3 | -0.41 |
| PAK5 | p21 (RAC1) activated kinase 5 | -0.41 |
| SYN1 | synapsin I | -0.4 |
| NDFIP1 | Nedd4 family interacting protein 1 | -0.4 |
| MIPOL1 | mirror-image polydactyly 1 | -0.39 |
| CLTA | clathrin, light chain A | -0.38 |
| ZNF362 | zinc finger protein 362 | -0.37 |
| CCNF | cyclin F | -0.37 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.37 |
| LRRC49 | leucine rich repeat containing 49 | -0.37 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.37 |
| BAZ2B | bromodomain adjacent to zinc finger domain, 2B | -0.37 |
| RWDD3 | RWD domain containing 3 | -0.37 |
| PRKAA2 | protein kinase, AMP-activated, alpha 2 catalytic subunit | -0.37 |
| PRG4 | proteoglycan 4 | -0.37 |
| SPHK2 | sphingosine kinase 2 | -0.36 |
| PPM1H | protein phosphatase, Mg2+/Mn2+ dependent, 1H | -0.36 |
| CNTNAP1 | contactin associated protein 1 | -0.35 |
| ADCY9 | adenylate cyclase 9 | -0.35 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | -0.35 |
| ACE | angiotensin I converting enzyme | -0.35 |
| ALKBH5 | AlkB family member 5, RNA demethylase | -0.34 |
| MCL1 | myeloid cell leukemia 1 | -0.34 |
| RAB5IF | RAB5 interacting factor | -0.34 |
| MAP3K21 | mitogen-activated protein kinase kinase kinase 21 | -0.33 |
| SDCCAG8 | serologically defined colon cancer antigen 8 | -0.33 |
| CHST15 | carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 | -0.32 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | -0.32 |
| AXIN2 | axin 2 | -0.32 |
| EIF5A2 | eukaryotic translation initiation factor 5A2 | -0.32 |
| TRAPPC2 | trafficking protein particle complex 2 | -0.32 |
| ZNF354B | zinc finger protein 354B | -0.31 |
| MIF4GD | MIF4G domain containing | -0.31 |
| ACTN3 | actinin, alpha 3 (gene/pseudogene) | -0.3 |
| TMEM246 | transmembrane protein 246 | -0.3 |
| HM13 | histocompatibility (minor) 13 | -0.3 |
| FOXO1 | forkhead box O1 | -0.3 |
| SCYL3 | SCY1-like 3 (S. cerevisiae) | -0.3 |
| FAM126B | family with sequence similarity 126, member B | -0.3 |
| RPGR | retinitis pigmentosa GTPase regulator | -0.29 |
| EXT1 | exostosin glycosyltransferase 1 | -0.29 |
| ZNF587 | zinc finger protein 587 | -0.29 |
| PTBP1 | polypyrimidine tract binding protein 1 | -0.29 |
| CBARP | CACN subunit beta associated regulatory protein | -0.29 |
| NUCB2 | nucleobindin 2 | -0.29 |
| R3HDM4 | R3H domain containing 4 | -0.29 |
| TRAPPC9 | trafficking protein particle complex 9 | -0.28 |
| ZNF524 | zinc finger protein 524 | -0.28 |
| BMPR1A | bone morphogenetic protein receptor, type IA | -0.28 |
| UHMK1 | U2AF homology motif (UHM) kinase 1 | -0.27 |
| SLC25A44 | solute carrier family 25, member 44 | -0.27 |
| SNX25 | sorting nexin 25 | -0.27 |
| COL14A1 | collagen, type XIV, alpha 1 | -0.27 |
| COX16 | COX16 cytochrome c oxidase assembly homolog (S. cerevisiae) | -0.27 |
| HDDC3 | HD domain containing 3 | -0.27 |
| ATP8B1 | ATPase, aminophospholipid transporter, class I, type 8B, member 1 | -0.27 |
| CCDC73 | coiled-coil domain containing 73 | -0.26 |
| DENND2D | DENN/MADD domain containing 2D | -0.26 |
| HSCB | HscB mitochondrial iron-sulfur cluster co-chaperone | -0.26 |
| ZFHX2 | zinc finger homeobox 2 | -0.26 |
| BDH2 | 3-hydroxybutyrate dehydrogenase, type 2 | -0.26 |
| TADA2A | transcriptional adaptor 2A | -0.26 |
| TRIM41 | tripartite motif containing 41 | -0.26 |
| MFF | mitochondrial fission factor | -0.26 |
| FAM210B | family with sequence similarity 210, member B | -0.25 |
| SORBS1 | sorbin and SH3 domain containing 1 | -0.25 |
| CACNA2D2 | calcium channel, voltage-dependent, alpha 2/delta subunit 2 | -0.25 |
| ALG12 | ALG12, alpha-1,6-mannosyltransferase | -0.25 |
| BET1L | Bet1 golgi vesicular membrane trafficking protein-like | -0.25 |
| WDR25 | WD repeat domain 25 | -0.25 |
| RBKS | ribokinase | -0.25 |
| B3GNTL1 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1 | -0.25 |
| HSPA8 | heat shock 70kDa protein 8 | -0.25 |
| SVIP | small VCP/p97-interacting protein | -0.25 |
| ITPRIPL1 | inositol 1,4,5-trisphosphate receptor interacting protein-like 1 | -0.25 |
| FAM110C | family with sequence similarity 110, member C | -0.25 |
| CMC1 | C-x(9)-C motif containing 1 | -0.25 |
| HBA1 | hemoglobin, alpha 1 | -0.25 |
| ARL15 | ADP-ribosylation factor-like 15 | -0.25 |
| CPN1 | carboxypeptidase N, polypeptide 1 | -0.24 |
| DBNL | drebrin-like | -0.24 |
| COPRS | coordinator of PRMT5, differentiation stimulator | -0.24 |
