| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Saquinavir perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Saquinavir_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | 0.148621 |
| PCDH7 | protocadherin 7 | 0.086146 |
| CCN2 | cellular communication network factor 2 | 0.0835661 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0798113 |
| RRM2 | ribonucleotide reductase M2 | 0.074991 |
| NLGN1 | neuroligin 1 | 0.0704485 |
| YAP1 | Yes-associated protein 1 | 0.0700248 |
| RPS12 | ribosomal protein S12 | 0.060449 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0577091 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0544782 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0496058 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0492166 |
| CLDN1 | claudin 1 | 0.0487838 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0478934 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0462625 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 0.0452097 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.044136 |
| CELF2 | CUGBP, Elav-like family member 2 | 0.0431401 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.042207 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0418427 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | 0.0397097 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0388197 |
| TUBA1B | tubulin, alpha 1b | 0.0379367 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0379126 |
| ERBIN | erbb2 interacting protein | 0.0377042 |
| PDGFC | platelet derived growth factor C | 0.037415 |
| RSRC1 | arginine/serine-rich coiled-coil 1 | 0.03685 |
| YBX3 | Y box binding protein 3 | 0.0363411 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.0358714 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0332942 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | 0.0322822 |
| EDARADD | EDAR-associated death domain | 0.0313184 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0305456 |
| RAPGEF6 | Rap guanine nucleotide exchange factor (GEF) 6 | 0.0298081 |
| CCDC88A | coiled-coil domain containing 88A | 0.0297649 |
| SMYD3 | SET and MYND domain containing 3 | 0.0293548 |
| CCSER1 | coiled-coil serine-rich protein 1 | 0.0289831 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0286623 |
| RPL9 | ribosomal protein L9 | 0.0285668 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | 0.0284903 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.027726 |
| NHSL1 | NHS-like 1 | 0.0275247 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | 0.0272987 |
| DUSP6 | dual specificity phosphatase 6 | 0.0272147 |
| ADAM10 | ADAM metallopeptidase domain 10 | 0.0270932 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.025306 |
| LDHA | lactate dehydrogenase A | 0.0250417 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0250397 |
| IL6ST | interleukin 6 signal transducer | 0.0246779 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0245473 |
| DST | dystonin | 0.0242194 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0241967 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.024017 |
| FHIT | fragile histidine triad | 0.0235773 |
| ETV6 | ets variant 6 | 0.0233408 |
| RPS3 | ribosomal protein S3 | 0.0229441 |
| CEP192 | centrosomal protein 192kDa | 0.0229273 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0228941 |
| TUBA1C | tubulin, alpha 1c | 0.0220523 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0215864 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | 0.0213708 |
| TPM3 | tropomyosin 3 | 0.0213638 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | 0.0212507 |
| NEK7 | NIMA-related kinase 7 | 0.0210939 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0206764 |
| CSMD3 | CUB and Sushi multiple domains 3 | 0.0206223 |
| C6ORF62 | chromosome 6 open reading frame 62 | 0.0198994 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.0195992 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0195598 |
| TMCC1 | transmembrane and coiled-coil domain family 1 | 0.0194982 |
| XRN1 | 5'-3' exoribonuclease 1 | 0.019496 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0194825 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0194636 |
| BIRC2 | baculoviral IAP repeat containing 2 | 0.0194435 |
| TRA2B | transformer 2 beta homolog (Drosophila) | 0.0193853 |
| ATP11A | ATPase, class VI, type 11A | 0.0189499 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.0189412 |
| ATL2 | atlastin GTPase 2 | 0.0188642 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0188316 |
| NDC80 | NDC80 kinetochore complex component | 0.0185993 |
| RASAL2 | RAS protein activator like 2 | 0.0184358 |
| YLPM1 | YLP motif containing 1 | 0.0184311 |
| ROCK1 | Rho-associated, coiled-coil containing protein kinase 1 | 0.0184295 |
| TEAD4 | TEA domain family member 4 | 0.0183568 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0182439 |
| BLZF1 | basic leucine zipper nuclear factor 1 | 0.0181967 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0180299 |
| COX6C | cytochrome c oxidase subunit VIc | 0.0180153 |
| TMEM50A | transmembrane protein 50A | 0.01795 |
| EZH2 | enhancer of zeste 2 polycomb repressive complex 2 subunit | 0.0177944 |
| PRIM2 | primase, DNA, polypeptide 2 (58kDa) | 0.0176728 |
| EXOC4 | exocyst complex component 4 | 0.0175437 |
| BCAS3 | breast carcinoma amplified sequence 3 | 0.0174029 |
| EML4 | echinoderm microtubule associated protein like 4 | 0.0172488 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | 0.0172159 |
| RPL37A | ribosomal protein L37a | 0.0172111 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | 0.0171894 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0171397 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0170629 |
| PPP2CA | protein phosphatase 2, catalytic subunit, alpha isozyme | 0.0169754 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.38987 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.217918 |
| ACTG1 | actin gamma 1 | -0.0893717 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0798828 |
| RPS6 | ribosomal protein S6 | -0.078598 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.078355 |
| PTMA | prothymosin, alpha | -0.0773769 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0765629 |
| MMP12 | matrix metallopeptidase 12 | -0.0755474 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0726519 |
| AREG | amphiregulin | -0.0636251 |
| AHNAK | AHNAK nucleoprotein | -0.061925 |
| TXNRD1 | thioredoxin reductase 1 | -0.0615672 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0563104 |
| CANX | calnexin | -0.0550444 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | -0.0544267 |
| RPL35A | ribosomal protein L35a | -0.0539346 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0526244 |
| RPL34 | ribosomal protein L34 | -0.0493414 |
| RPL36 | ribosomal protein L36 | -0.0491631 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0486228 |
| RPL8 | ribosomal protein L8 | -0.0484173 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | -0.0458676 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0444903 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | -0.0444069 |
| RPLP2 | ribosomal protein, large, P2 | -0.0441248 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0435873 |
| RPS21 | ribosomal protein S21 | -0.0432335 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0424618 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.0423796 |
| RPS15 | ribosomal protein S15 | -0.0422978 |
| LDHB | lactate dehydrogenase B | -0.0420221 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0415849 |
| RPL12 | ribosomal protein L12 | -0.0396618 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0387357 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0371376 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | -0.036673 |
| TPI1 | triosephosphate isomerase 1 | -0.0356305 |
| CCND1 | cyclin D1 | -0.0351516 |
| KIF5B | kinesin family member 5B | -0.0347608 |
| TMSB10 | thymosin beta 10 | -0.0346609 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0343112 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0340813 |
| EIF4B | eukaryotic translation initiation factor 4B | -0.0335612 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0333602 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0332481 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | -0.0327356 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | -0.0320152 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | -0.0319114 |
| RPS26 | ribosomal protein S26 | -0.0316047 |
| RPS19 | ribosomal protein S19 | -0.0312547 |
| RPL3 | ribosomal protein L3 | -0.0310187 |
| NOLC1 | nucleolar and coiled-body phosphoprotein 1 | -0.0305892 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0301691 |
| RPS23 | ribosomal protein S23 | -0.0301205 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.030087 |
| SRRM2 | serine/arginine repetitive matrix 2 | -0.02988 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | -0.0296858 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0294403 |
| TUBB | tubulin, beta class I | -0.0293156 |
| KRR1 | KRR1, small subunit (SSU) processome component, homolog (yeast) | -0.0291581 |
| SCAF11 | SR-related CTD-associated factor 11 | -0.0288435 |
| MKI67 | marker of proliferation Ki-67 | -0.028785 |
| HDLBP | high density lipoprotein binding protein | -0.0286231 |
| YBX1 | Y box binding protein 1 | -0.0285426 |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | -0.0283191 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.028073 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0278547 |
| HMGA1 | high mobility group AT-hook 1 | -0.0277223 |
| S100A6 | S100 calcium binding protein A6 | -0.0274473 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0272734 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | -0.0271176 |
| EIF2AK1 | eukaryotic translation initiation factor 2-alpha kinase 1 | -0.0270316 |
| RPS16 | ribosomal protein S16 | -0.0270258 |
| S100A10 | S100 calcium binding protein A10 | -0.0267422 |
| LARP1 | La ribonucleoprotein domain family, member 1 | -0.0266829 |
| NACA | nascent polypeptide-associated complex alpha subunit | -0.0263986 |
| FUS | FUS RNA binding protein | -0.0262554 |
| RPL32 | ribosomal protein L32 | -0.0260194 |
| H1-0 | H1.0 linker histone | -0.0259358 |
| PCNP | PEST proteolytic signal containing nuclear protein | -0.0257731 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | -0.0256371 |
| HMGB1 | high mobility group box 1 | -0.0255291 |
| ACACA | acetyl-CoA carboxylase alpha | -0.0254333 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0253921 |
| FDPS | farnesyl diphosphate synthase | -0.0247607 |
| ACLY | ATP citrate lyase | -0.0247481 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0247281 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0245131 |
| TMEM131 | transmembrane protein 131 | -0.02449 |
| TMEM123 | transmembrane protein 123 | -0.0242445 |
| IGF2BP1 | insulin-like growth factor 2 mRNA binding protein 1 | -0.0241682 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | -0.024074 |
| DSPP | dentin sialophosphoprotein | -0.0237475 |
| RPS8 | ribosomal protein S8 | -0.0235323 |
| DEK | DEK proto-oncogene | -0.0233079 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0232981 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0232048 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | -0.0229219 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | -0.0228359 |
