Saquinavir_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Saquinavir perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Saquinavir_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LSAMP limbic system-associated membrane protein 0.0870034
LINGO2 leucine rich repeat and Ig domain containing 2 0.0732089
FMN1 formin 1 0.065826
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0649307
ZBTB20 zinc finger and BTB domain containing 20 0.0639145
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0634425
EXT1 exostosin glycosyltransferase 1 0.0554196
TAS2R14 taste receptor, type 2, member 14 0.0554065
PTPRD protein tyrosine phosphatase, receptor type, D 0.053224
DST dystonin 0.0531526
ENAH enabled homolog (Drosophila) 0.0500965
PLAT plasminogen activator, tissue 0.0467909
VCL vinculin 0.0458108
NAMPT nicotinamide phosphoribosyltransferase 0.0456144
TLE4 transducin-like enhancer of split 4 0.0438318
PDE4D phosphodiesterase 4D, cAMP-specific 0.0417192
PLPP1 phospholipid phosphatase 1 0.0411044
BPTF bromodomain PHD finger transcription factor 0.0390775
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0365457
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0364145
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0355477
ZSWIM6 zinc finger, SWIM-type containing 6 0.0348247
AEBP2 AE binding protein 2 0.0344249
NRIP1 nuclear receptor interacting protein 1 0.0339377
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.033492
ZFC3H1 zinc finger, C3H1-type containing 0.0331058
ANTXR1 anthrax toxin receptor 1 0.0326636
PGK1 phosphoglycerate kinase 1 0.0323846
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 0.032078
NAP1L1 nucleosome assembly protein 1-like 1 0.031703
CEMIP cell migration inducing protein, hyaluronan binding 0.0316845
VMP1 vacuole membrane protein 1 0.0313207
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0313004
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.030764
MED13 mediator complex subunit 13 0.0306493
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0299558
MYO1E myosin IE 0.0295158
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0291766
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0289881
MEF2A myocyte enhancer factor 2A 0.0289406
GAB2 GRB2-associated binding protein 2 0.0287705
BCAS3 breast carcinoma amplified sequence 3 0.028691
MEIS2 Meis homeobox 2 0.0286775
PSD3 pleckstrin and Sec7 domain containing 3 0.028496
ITGAV integrin, alpha V 0.0284775
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.0283552
PTEN phosphatase and tensin homolog 0.0281843
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0274136
ADARB1 adenosine deaminase, RNA-specific, B1 0.0272104
ZNF804A zinc finger protein 804A 0.0272093
MAP1B microtubule-associated protein 1B 0.0267856
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0265944
SPAG9 sperm associated antigen 9 0.0264561
ADGRB3 adhesion G protein-coupled receptor B3 0.0261842
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0261603
ANO6 anoctamin 6 0.0261515
CCNH cyclin H 0.0259382
KAT6B K(lysine) acetyltransferase 6B 0.0257873
PTPRE protein tyrosine phosphatase, receptor type, E 0.0257705
AHR aryl hydrocarbon receptor 0.0257466
MBD5 methyl-CpG binding domain protein 5 0.0253435
PEAK1 pseudopodium-enriched atypical kinase 1 0.0252095
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0249921
FRMD5 FERM domain containing 5 0.0248922
PACS1 phosphofurin acidic cluster sorting protein 1 0.0248123
TOP1 topoisomerase (DNA) I 0.0248092
CDK19 cyclin-dependent kinase 19 0.0247215
SEC31A SEC31 homolog A (S. cerevisiae) 0.0246208
PHF3 PHD finger protein 3 0.024601
HMBOX1 homeobox containing 1 0.0245341
FNDC3B fibronectin type III domain containing 3B 0.0244935
ADGRG6 adhesion G protein-coupled receptor G6 0.0242615
PRKCA protein kinase C, alpha 0.023991
NPAS2 neuronal PAS domain protein 2 0.0238629
ARID5B AT rich interactive domain 5B (MRF1-like) 0.0237562
EIF1 eukaryotic translation initiation factor 1 0.0234714
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 0.0234542
ZNF292 zinc finger protein 292 0.0234021
PARD3 par-3 family cell polarity regulator 0.0233669
INTS6 integrator complex subunit 6 0.0232746
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.0231973
KDM4C lysine (K)-specific demethylase 4C 0.0231403
DENND4C DENN/MADD domain containing 4C 0.0231186
AFF4 AF4/FMR2 family, member 4 0.0229315
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0229117
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 0.022841
PPP1R13B protein phosphatase 1, regulatory subunit 13B 0.0224591
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0224261
STXBP4 syntaxin binding protein 4 0.0224083
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0221388
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 0.021922
DYNC2I1 dynein 2 intermediate chain 1 0.0218248
RBMS1 RNA binding motif, single stranded interacting protein 1 0.0218187
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 0.0218113
HDAC8 histone deacetylase 8 0.0217786
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0216538
CEMIP2 cell migration inducing hyaluronidase 2 0.0215372
SMYD3 SET and MYND domain containing 3 0.0214647
ITPRID2 ITPR interacting domain containing 2 0.0214125
CD36 CD36 molecule (thrombospondin receptor) 0.0213453

decreased expression

Symbol Name Standardized Value
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.193711
IGF2 insulin-like growth factor 2 -0.191303
PTMA prothymosin, alpha -0.092331
RPL23 ribosomal protein L23 -0.0699789
CENPF centromere protein F, 350/400kDa -0.0607577
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0511204
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0482816
TMSB10 thymosin beta 10 -0.0458132
VIM vimentin -0.0427365
S100A9 S100 calcium binding protein A9 -0.0378264
FTL ferritin, light polypeptide -0.0365567
AKAP12 A kinase (PRKA) anchor protein 12 -0.0356319
RPLP1 ribosomal protein, large, P1 -0.0323947
RPL35A ribosomal protein L35a -0.0312857
PRRC2C proline-rich coiled-coil 2C -0.0309192
RPL34 ribosomal protein L34 -0.0306229
RPS6 ribosomal protein S6 -0.0301442
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0300715
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0296544
RPS14 ribosomal protein S14 -0.0288796
PDIA3 protein disulfide isomerase family A, member 3 -0.0286709
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0284198
RPL12 ribosomal protein L12 -0.0279292
RPS29 ribosomal protein S29 -0.027486
RPL18 ribosomal protein L18 -0.0271187
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0269541
AHNAK AHNAK nucleoprotein -0.0269456
CALR calreticulin -0.024929
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.024481
DACH2 dachshund family transcription factor 2 -0.0241027
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0240157
MKI67 marker of proliferation Ki-67 -0.023285
B2M beta-2-microglobulin -0.0228023
RPL36A ribosomal protein L36a -0.0227586
CLTC clathrin, heavy chain (Hc) -0.0227344
RPL37 ribosomal protein L37 -0.022232
POTEF POTE ankyrin domain family, member F -0.0219928
PKM pyruvate kinase, muscle -0.0218367
SMC4 structural maintenance of chromosomes 4 -0.0217605
GARS1 glycyl-tRNA synthetase 1 -0.021535
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.02148
LIMCH1 LIM and calponin homology domains 1 -0.021368
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0212175
PCBP2 poly(rC) binding protein 2 -0.0211936
NPEPPS aminopeptidase puromycin sensitive -0.0209923
COPA coatomer protein complex, subunit alpha -0.0203071
MATR3 matrin 3 -0.0202409
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.020135
FOXK2 forkhead box K2 -0.0199237
SEPTIN2 septin 2 -0.0197277
ANKRD17 ankyrin repeat domain 17 -0.0197253
RPLP2 ribosomal protein, large, P2 -0.0196941
RPS17 ribosomal protein S17 -0.0196194
HDGF hepatoma-derived growth factor -0.0190629
RPL27 ribosomal protein L27 -0.0190046
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.018976
JPT1 Jupiter microtubule associated homolog 1 -0.0188593
COL1A1 collagen, type I, alpha 1 -0.0184423
NACA nascent polypeptide-associated complex alpha subunit -0.0184014
RAB7A RAB7A, member RAS oncogene family -0.0183596
RPS21 ribosomal protein S21 -0.0183074
LPIN1 lipin 1 -0.0182614
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0181949
RPL19 ribosomal protein L19 -0.0180147
TOR1AIP2 torsin A interacting protein 2 -0.0176378
RPS23 ribosomal protein S23 -0.0176337
TPI1 triosephosphate isomerase 1 -0.01755
CRH corticotropin releasing hormone -0.0174844
RPL8 ribosomal protein L8 -0.017463
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0168928
RPS5 ribosomal protein S5 -0.0166082
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) -0.0166026
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0165657
WDR43 WD repeat domain 43 -0.0163027
RPL21 ribosomal protein L21 -0.016181
RPL36 ribosomal protein L36 -0.0161781
RGS5 regulator of G-protein signaling 5 -0.0160425
CCND1 cyclin D1 -0.0159119
ATP5F1E ATP synthase F1 subunit epsilon -0.0157786
RPS19 ribosomal protein S19 -0.015768
IGFBP4 insulin-like growth factor binding protein 4 -0.015744
ZNF207 zinc finger protein 207 -0.0157116
DEK DEK proto-oncogene -0.0156157
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0155554
WSB1 WD repeat and SOCS box containing 1 -0.0155062
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0153936
SH3PXD2A SH3 and PX domains 2A -0.0153583
NOP56 NOP56 ribonucleoprotein -0.0153506
RPS2 ribosomal protein S2 -0.0153397
CHD6 chromodomain helicase DNA binding protein 6 -0.0152981
ANKHD1 ankyrin repeat and KH domain containing 1 -0.015011
CDH13 cadherin 13 -0.0148832
RPS12 ribosomal protein S12 -0.0147778
MAP4 microtubule-associated protein 4 -0.0147471
TTC17 tetratricopeptide repeat domain 17 -0.0146872
HMGB1 high mobility group box 1 -0.0146751
ATP5F1B ATP synthase F1 subunit beta -0.0146172
RAB5C RAB5C, member RAS oncogene family -0.0146136
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0145817
TPM1 tropomyosin 1 (alpha) -0.0144808