Saquinavir_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Saquinavir perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Saquinavir_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LMO7 LIM domain 7 0.323583
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.130831
SMAD3 SMAD family member 3 0.11034
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0944907
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0904959
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0827146
TMC5 transmembrane channel-like 5 0.0780886
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0776305
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0771084
GCLC glutamate-cysteine ligase, catalytic subunit 0.0715148
SPATA13 spermatogenesis associated 13 0.0711746
AKAP13 A kinase (PRKA) anchor protein 13 0.0711378
EPS8 epidermal growth factor receptor pathway substrate 8 0.0686162
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0681972
ETV6 ets variant 6 0.0679298
SIPA1L2 signal-induced proliferation-associated 1 like 2 0.066459
BAIAP2L1 BAI1-associated protein 2-like 1 0.0624669
EXT1 exostosin glycosyltransferase 1 0.0606627
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0587728
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0585261
EPSTI1 epithelial stromal interaction 1 (breast) 0.0579815
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0571233
MBNL2 muscleblind-like splicing regulator 2 0.0563078
HKDC1 hexokinase domain containing 1 0.0559879
FNDC3A fibronectin type III domain containing 3A 0.0557219
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0553177
AHI1 Abelson helper integration site 1 0.0528381
TRIM2 tripartite motif containing 2 0.0526509
ITGA6 integrin, alpha 6 0.0514688
UBC ubiquitin C 0.0514619
TJP1 tight junction protein 1 0.0510479
LIMA1 LIM domain and actin binding 1 0.0507078
PTBP3 polypyrimidine tract binding protein 3 0.0503125
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0493797
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0488892
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0480469
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0478156
MAP7 microtubule-associated protein 7 0.0477301
NT5C3A 5'-nucleotidase, cytosolic IIIA 0.0463195
MCU mitochondrial calcium uniporter 0.0455358
ABHD2 abhydrolase domain containing 2 0.0455136
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.0453244
IFNGR1 interferon gamma receptor 1 0.0449791
FNIP1 folliculin interacting protein 1 0.0448219
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0443812
FAT1 FAT atypical cadherin 1 0.0443431
TOX3 TOX high mobility group box family member 3 0.0439604
C6ORF132 chromosome 6 open reading frame 132 0.0427614
MED13 mediator complex subunit 13 0.0420505
ARHGAP5 Rho GTPase activating protein 5 0.0419219
ADAM10 ADAM metallopeptidase domain 10 0.0411438
ERBIN erbb2 interacting protein 0.0403876
TSC22D1 TSC22 domain family, member 1 0.0403121
TM4SF19 transmembrane 4 L six family member 19 0.0402284
SIK3 SIK family kinase 3 0.0401683
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0398895
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0394078
IQGAP1 IQ motif containing GTPase activating protein 1 0.0389682
TMEM65 transmembrane protein 65 0.0387734
B2M beta-2-microglobulin 0.0386093
TMEM123 transmembrane protein 123 0.0377013
LURAP1L leucine rich adaptor protein 1-like 0.0373326
RUNX1 runt-related transcription factor 1 0.0371617
ANXA2 annexin A2 0.0367311
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.036497
N4BP2L2 NEDD4 binding protein 2-like 2 0.0361575
PGK1 phosphoglycerate kinase 1 0.0360263
RABGAP1L RAB GTPase activating protein 1-like 0.0356132
RHOBTB3 Rho-related BTB domain containing 3 0.0355478
KYNU kynureninase 0.0349984
FNDC3B fibronectin type III domain containing 3B 0.0348697
MYO1E myosin IE 0.0345882
SOX9 SRY (sex determining region Y)-box 9 0.0334764
PIBF1 progesterone immunomodulatory binding factor 1 0.0332173
PDIA3 protein disulfide isomerase family A, member 3 0.0331462
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 0.0328209
COPA coatomer protein complex, subunit alpha 0.0326802
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0325935
SEC31A SEC31 homolog A (S. cerevisiae) 0.0324077
PERP PERP, TP53 apoptosis effector 0.0322112
CTSB cathepsin B 0.031806
SEC24D SEC24 family member D 0.0313771
BCL2L1 BCL2-like 1 0.0308386
LPP LIM domain containing preferred translocation partner in lipoma 0.0302523
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0300965
CMPK1 cytidine monophosphate (UMP-CMP) kinase 1, cytosolic 0.0292763
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.029242
ABLIM1 actin binding LIM protein 1 0.029197
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.0291942
MACC1 metastasis associated in colon cancer 1 0.0290413
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.0289656
ANXA1 annexin A1 0.0287711
NCEH1 neutral cholesterol ester hydrolase 1 0.0286009
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.0284314
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0284262
YAP1 Yes-associated protein 1 0.0284102
KLF5 Kruppel-like factor 5 (intestinal) 0.0284101
CEMIP cell migration inducing protein, hyaluronan binding 0.0283182
FAM120A family with sequence similarity 120A 0.0280871
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0279449

decreased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 -0.125996
PTMA prothymosin, alpha -0.108615
INTS6 integrator complex subunit 6 -0.0943028
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0789231
VCL vinculin -0.0692749
RPL35A ribosomal protein L35a -0.0688458
TRIO trio Rho guanine nucleotide exchange factor -0.0661861
EGR1 early growth response 1 -0.0629888
MT2A metallothionein 2A -0.0611679
NPSR1 neuropeptide S receptor 1 -0.0611385
RPL23 ribosomal protein L23 -0.0604856
FTL ferritin, light polypeptide -0.0594818
GMDS GDP-mannose 4,6-dehydratase -0.0591867
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.0582044
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0574467
TMSB10 thymosin beta 10 -0.0574005
LOC102724023 ES1 protein homolog, mitochondrial -0.0529749
NDRG1 N-myc downstream regulated 1 -0.0514068
XAF1 XIAP associated factor 1 -0.0484817
LCN2 lipocalin 2 -0.0467679
STS steroid sulfatase (microsomal), isozyme S -0.0463213
PLSCR2 phospholipid scramblase 2 -0.0456053
WSB1 WD repeat and SOCS box containing 1 -0.045457
RAD51B RAD51 paralog B -0.0445537
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0438386
RNF213 ring finger protein 213 -0.0424947
SAMD12 sterile alpha motif domain containing 12 -0.0420414
MUC20 mucin 20, cell surface associated -0.0419567
PRRC2C proline-rich coiled-coil 2C -0.0384005
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.038357
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0379413
RIGI RNA sensor RIG-I -0.0373265
RPL37A ribosomal protein L37a -0.0368608
RPL31 ribosomal protein L31 -0.0368236
RPL34 ribosomal protein L34 -0.0367315
SQSTM1 sequestosome 1 -0.0366071
S100P S100 calcium binding protein P -0.0353447
HLA-B major histocompatibility complex, class I, B -0.0352401
ANKRD10 ankyrin repeat domain 10 -0.0346275
ZMYND8 zinc finger, MYND-type containing 8 -0.0342097
RPL26 ribosomal protein L26 -0.0335518
SP100 SP100 nuclear antigen -0.0334451
BABAM2 BRISC and BRCA1 A complex member 2 -0.033074
RPS3 ribosomal protein S3 -0.0327666
STK39 serine threonine kinase 39 -0.0325623
DSCAML1 Down syndrome cell adhesion molecule like 1 -0.032502
RPS29 ribosomal protein S29 -0.0324497
ARHGAP26 Rho GTPase activating protein 26 -0.0324374
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0322628
IGF1R insulin-like growth factor 1 receptor -0.032057
MYH9 myosin, heavy chain 9, non-muscle -0.0319709
RPL19 ribosomal protein L19 -0.0308871
MPHOSPH8 M-phase phosphoprotein 8 -0.030524
PATJ PATJ crumbs cell polarity complex component -0.0305133
NCOA7 nuclear receptor coactivator 7 -0.0303857
CCNL1 cyclin L1 -0.0298748
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0295177
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 -0.0290214
RPS27 ribosomal protein S27 -0.0289232
CLYBL citrate lyase beta like -0.0289128
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0281946
TUFT1 tuftelin 1 -0.0280993
HDAC4 histone deacetylase 4 -0.0280709
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -0.0278751
RPL9 ribosomal protein L9 -0.0274632
RPLP2 ribosomal protein, large, P2 -0.0272642
RPS19 ribosomal protein S19 -0.0269425
RPS24 ribosomal protein S24 -0.0268888
FUS FUS RNA binding protein -0.0264149
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0263523
TBC1D22A TBC1 domain family, member 22A -0.0262209
TRA2B transformer 2 beta homolog (Drosophila) -0.0258611
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0257108
RPS6 ribosomal protein S6 -0.0255339
ATF4 activating transcription factor 4 -0.0251027
RPLP1 ribosomal protein, large, P1 -0.0248181
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0246881
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -0.0246751
RPS27A ribosomal protein S27a -0.024516
RPL36 ribosomal protein L36 -0.0243791
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa -0.0241502
NKD1 naked cuticle homolog 1 (Drosophila) -0.0241227
RPL13A ribosomal protein L13a -0.0241171
VEGFA vascular endothelial growth factor A -0.0239657
LMNA lamin A/C -0.0239185
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa -0.0237602
TNS3 tensin 3 -0.0237374
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like -0.0237363
PDE4D phosphodiesterase 4D, cAMP-specific -0.0237276
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0233447
SPTAN1 spectrin, alpha, non-erythrocytic 1 -0.0231354
AHNAK AHNAK nucleoprotein -0.0230362
RPS16 ribosomal protein S16 -0.0228946
SRSF6 serine/arginine-rich splicing factor 6 -0.0224758
DDIT3 DNA-damage-inducible transcript 3 -0.0222566
RPS21 ribosomal protein S21 -0.0221955
RPL36A ribosomal protein L36a -0.0221772
UBE2B ubiquitin-conjugating enzyme E2B -0.0219694
RPS12 ribosomal protein S12 -0.0219201
ACTG1 actin gamma 1 -0.0217917