Saquinavir_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Saquinavir perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Saquinavir_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.0995798
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0909487
SOD2 superoxide dismutase 2, mitochondrial 0.0815341
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0779496
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0768263
CXCL8 chemokine (C-X-C motif) ligand 8 0.0758814
FNDC3B fibronectin type III domain containing 3B 0.0742101
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0719479
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0700177
TRIO trio Rho guanine nucleotide exchange factor 0.0627722
LDHA lactate dehydrogenase A 0.0605828
NKAIN3 Na+/K+ transporting ATPase interacting 3 0.055358
FMNL2 formin-like 2 0.055289
ZSWIM6 zinc finger, SWIM-type containing 6 0.050156
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.048089
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0461655
ALCAM activated leukocyte cell adhesion molecule 0.0460402
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0459241
UBC ubiquitin C 0.0453714
ZFAND3 zinc finger, AN1-type domain 3 0.0450815
CAMTA1 calmodulin binding transcription activator 1 0.0440564
BBX bobby sox homolog (Drosophila) 0.0434391
B2M beta-2-microglobulin 0.0415003
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0413084
SPAG9 sperm associated antigen 9 0.0398971
MRTFA myocardin related transcription factor A 0.0396667
MBNL1 muscleblind-like splicing regulator 1 0.0385492
CD44 CD44 molecule (Indian blood group) 0.0384307
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0383731
HMGA2 high mobility group AT-hook 2 0.0373544
LPP LIM domain containing preferred translocation partner in lipoma 0.0372715
EXT1 exostosin glycosyltransferase 1 0.0364008
HDAC9 histone deacetylase 9 0.036066
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0356995
ELL2 elongation factor, RNA polymerase II, 2 0.0354331
NAV2 neuron navigator 2 0.0345842
SQSTM1 sequestosome 1 0.0341751
ADAM17 ADAM metallopeptidase domain 17 0.0334617
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0327995
TRAM1 translocation associated membrane protein 1 0.0327555
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0318798
CADM1 cell adhesion molecule 1 0.0314325
AKAP9 A kinase (PRKA) anchor protein 9 0.0312496
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0309049
IGFBP7 insulin-like growth factor binding protein 7 0.0309005
ZCCHC7 zinc finger, CCHC domain containing 7 0.0306701
KMT2E lysine (K)-specific methyltransferase 2E 0.0304824
NAP1L1 nucleosome assembly protein 1-like 1 0.0303681
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0302367
HIP1 huntingtin interacting protein 1 0.0296528
COG5 component of oligomeric golgi complex 5 0.0295482
ENO1 enolase 1, (alpha) 0.0291486
DPYSL2 dihydropyrimidinase-like 2 0.0289753
EIF1 eukaryotic translation initiation factor 1 0.0289368
COPA coatomer protein complex, subunit alpha 0.0288724
MLF1 myeloid leukemia factor 1 0.0285362
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) 0.0283949
SP100 SP100 nuclear antigen 0.0279648
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0278766
TRA2A transformer 2 alpha homolog (Drosophila) 0.0277915
ZBTB20 zinc finger and BTB domain containing 20 0.0273014
ESYT2 extended synaptotagmin-like protein 2 0.0272851
RASA2 RAS p21 protein activator 2 0.0271534
TRAM2 translocation associated membrane protein 2 0.02705
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0267631
FAM107B family with sequence similarity 107, member B 0.0265439
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0262332
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0262137
WWTR1 WW domain containing transcription regulator 1 0.0261039
ZNF292 zinc finger protein 292 0.0260614
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0259738
GSK3B glycogen synthase kinase 3 beta 0.0259108
JMJD1C jumonji domain containing 1C 0.025651
OGA O-GlcNAcase 0.0256094
RND3 Rho family GTPase 3 0.0254747
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0254102
PICALM phosphatidylinositol binding clathrin assembly protein 0.0251453
JUN jun proto-oncogene 0.0250791
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0247222
RPL7 ribosomal protein L7 0.0246008
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0245009
RPL30 ribosomal protein L30 0.0242326
INHBA inhibin, beta A 0.0238828
PPP3CC protein phosphatase 3, catalytic subunit, gamma isozyme 0.0238567
SEC31A SEC31 homolog A (S. cerevisiae) 0.0238517
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0235634
SQLE squalene epoxidase 0.0235408
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.0235403
NKTR natural killer cell triggering receptor 0.0232868
RACK1 receptor for activated C kinase 1 0.0230838
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0228762
PDIA6 protein disulfide isomerase family A, member 6 0.0228339
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0228111
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 0.0227598
TTC17 tetratricopeptide repeat domain 17 0.0227429
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0226934
PEAK1 pseudopodium-enriched atypical kinase 1 0.0225992
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0225565
QKI QKI, KH domain containing, RNA binding 0.0224377
DLG1 discs, large homolog 1 (Drosophila) 0.0221085

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.358544
COL1A1 collagen, type I, alpha 1 -0.33684
FN1 fibronectin 1 -0.18182
COL1A2 collagen, type I, alpha 2 -0.145705
TIMP3 TIMP metallopeptidase inhibitor 3 -0.132872
COL6A3 collagen, type VI, alpha 3 -0.0893989
COL5A1 collagen, type V, alpha 1 -0.0818768
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0606001
LOXL2 lysyl oxidase-like 2 -0.0567345
IER3 immediate early response 3 -0.0554929
RRBP1 ribosome binding protein 1 -0.0539051
CDH13 cadherin 13 -0.0527757
TMSB10 thymosin beta 10 -0.0511841
F3 coagulation factor III (thromboplastin, tissue factor) -0.0489906
TGFBI transforming growth factor, beta-induced, 68kDa -0.0477444
LOX lysyl oxidase -0.0463702
COL6A2 collagen, type VI, alpha 2 -0.0454944
TPM4 tropomyosin 4 -0.0441202
CALD1 caldesmon 1 -0.0423678
NDRG1 N-myc downstream regulated 1 -0.0400159
COL7A1 collagen, type VII, alpha 1 -0.038981
TRPS1 trichorhinophalangeal syndrome I -0.0376178
DPYD dihydropyrimidine dehydrogenase -0.0351488
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0350413
VCAN versican -0.0350085
ZMYND8 zinc finger, MYND-type containing 8 -0.0329135
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0302842
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 -0.0293239
PSD3 pleckstrin and Sec7 domain containing 3 -0.0291498
CAVIN1 caveolae associated protein 1 -0.0289047
FBN1 fibrillin 1 -0.0286583
ADAM12 ADAM metallopeptidase domain 12 -0.0276906
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0268618
FRMD4A FERM domain containing 4A -0.0268431
GNAS GNAS complex locus -0.0263369
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.026103
VIM vimentin -0.0259597
BNC2 basonuclin 2 -0.0253396
PDE10A phosphodiesterase 10A -0.024862
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -0.0239551
GARS1 glycyl-tRNA synthetase 1 -0.0235859
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.023037
ZFHX3 zinc finger homeobox 3 -0.022635
TPM2 tropomyosin 2 (beta) -0.02242
CLMP CXADR-like membrane protein -0.0222759
ACTG1 actin gamma 1 -0.0222101
ASPH aspartate beta-hydroxylase -0.0221474
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.02199
ENO2 enolase 2 (gamma, neuronal) -0.0218198
LTBP1 latent transforming growth factor beta binding protein 1 -0.0212829
LMAN1 lectin, mannose-binding, 1 -0.0205928
COL6A1 collagen, type VI, alpha 1 -0.020318
NRP1 neuropilin 1 -0.0202642
LAMB3 laminin, beta 3 -0.0201227
FTH1 ferritin, heavy polypeptide 1 -0.0201213
HLA-B major histocompatibility complex, class I, B -0.0196413
KPNB1 karyopherin (importin) beta 1 -0.0191121
PRRX1 paired related homeobox 1 -0.0189608
PLEC plectin -0.0183951
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0183025
ABI3BP ABI family, member 3 (NESH) binding protein -0.0181761
RPS21 ribosomal protein S21 -0.0181363
SMC4 structural maintenance of chromosomes 4 -0.0171326
VEPH1 ventricular zone expressed PH domain-containing 1 -0.0171153
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 -0.0167786
SH3KBP1 SH3-domain kinase binding protein 1 -0.0167502
KLF6 Kruppel-like factor 6 -0.0161463
GLIS3 GLIS family zinc finger 3 -0.0160886
PXDN peroxidasin -0.0159607
OSMR oncostatin M receptor -0.0159375
RNF168 ring finger protein 168, E3 ubiquitin protein ligase -0.015886
MMP14 matrix metallopeptidase 14 (membrane-inserted) -0.0156817
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 -0.0155286
RPL35A ribosomal protein L35a -0.0154719
MAML2 mastermind-like 2 (Drosophila) -0.015457
DEK DEK proto-oncogene -0.0154191
APOLD1 apolipoprotein L domain containing 1 -0.0153848
SULF1 sulfatase 1 -0.0152977
STC2 stanniocalcin 2 -0.0152846
RPL38 ribosomal protein L38 -0.0152383
SORBS2 sorbin and SH3 domain containing 2 -0.0152227
COL4A2 collagen, type IV, alpha 2 -0.0150279
ANKH ANKH inorganic pyrophosphate transport regulator -0.0150045
APCDD1L adenomatosis polyposis coli down-regulated 1-like -0.0147685
CD99 CD99 molecule -0.0147424
THY1 Thy-1 cell surface antigen -0.0143174
FKBP10 FK506 binding protein 10, 65 kDa -0.0140681
TUBB6 tubulin, beta 6 class V -0.0139657
CENPF centromere protein F, 350/400kDa -0.0138924
RNF213 ring finger protein 213 -0.0138705
DST dystonin -0.0138661
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) -0.0138354
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0138127
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0136087
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0133498
CCDC91 coiled-coil domain containing 91 -0.0129229
NALF1 NALCN channel auxiliary factor 1 -0.0129149
MYH9 myosin, heavy chain 9, non-muscle -0.0128969
IGFBP5 insulin-like growth factor binding protein 5 -0.0128265
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 -0.0127774