Saquinavir_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Saquinavir perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Saquinavir_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.117115
EHBP1 EH domain binding protein 1 0.111347
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.093316
RERE arginine-glutamic acid dipeptide (RE) repeats 0.086491
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0791429
GPC3 glypican 3 0.0752417
TPT1 tumor protein, translationally-controlled 1 0.0725689
MAML2 mastermind-like 2 (Drosophila) 0.0700501
NAP1L1 nucleosome assembly protein 1-like 1 0.0689136
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0642829
ASPH aspartate beta-hydroxylase 0.0591296
GK glycerol kinase 0.0571899
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0566694
FOXP1 forkhead box P1 0.0518788
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0508297
CP ceruloplasmin (ferroxidase) 0.0496966
GPC6 glypican 6 0.0487026
ELL2 elongation factor, RNA polymerase II, 2 0.0485857
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.0476401
ENO1 enolase 1, (alpha) 0.046401
RPLP0 ribosomal protein, large, P0 0.0428157
RPL26 ribosomal protein L26 0.0411204
FNDC3B fibronectin type III domain containing 3B 0.0400558
KDM3A lysine (K)-specific demethylase 3A 0.0396086
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0380476
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0374225
RPS8 ribosomal protein S8 0.0374167
MALRD1 MAM and LDL receptor class A domain containing 1 0.0367767
TAS2R14 taste receptor, type 2, member 14 0.0354522
DUSP6 dual specificity phosphatase 6 0.0354235
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0352834
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0349715
EXT1 exostosin glycosyltransferase 1 0.0342969
ATXN1 ataxin 1 0.0341977
GMDS GDP-mannose 4,6-dehydratase 0.0341924
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0339376
MBNL2 muscleblind-like splicing regulator 2 0.0336693
SAMD4A sterile alpha motif domain containing 4A 0.0334022
TBC1D22A TBC1 domain family, member 22A 0.0329855
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0325118
RPL11 ribosomal protein L11 0.0324918
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0305104
RPS24 ribosomal protein S24 0.0304972
EPAS1 endothelial PAS domain protein 1 0.0296892
LDHA lactate dehydrogenase A 0.0294941
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0293774
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0291352
KLF6 Kruppel-like factor 6 0.0285834
GRB10 growth factor receptor-bound protein 10 0.0281152
ARFGEF3 ARFGEF family member 3 0.028059
TM4SF1 transmembrane 4 L six family member 1 0.0278867
RPS12 ribosomal protein S12 0.0277384
RIGI RNA sensor RIG-I 0.0273343
OSBPL10 oxysterol binding protein-like 10 0.0270455
MACF1 microtubule-actin crosslinking factor 1 0.026724
PARD3 par-3 family cell polarity regulator 0.0266651
RPL30 ribosomal protein L30 0.0265546
TNS1 tensin 1 0.0264425
SVIL supervillin 0.0264332
RPS27A ribosomal protein S27a 0.0262377
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.025837
ATP10A ATPase, class V, type 10A 0.0257645
RPL37A ribosomal protein L37a 0.0257093
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0256675
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.025602
ZFAND3 zinc finger, AN1-type domain 3 0.0255394
USP34 ubiquitin specific peptidase 34 0.0255258
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0254764
CRY1 cryptochrome circadian clock 1 0.0250366
IRF2BP2 interferon regulatory factor 2 binding protein 2 0.0246827
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0246799
LPP LIM domain containing preferred translocation partner in lipoma 0.0245151
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0245121
SP100 SP100 nuclear antigen 0.0244255
ACSL4 acyl-CoA synthetase long-chain family member 4 0.0243861
DSCAM Down syndrome cell adhesion molecule 0.024374
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0243542
BIRC6 baculoviral IAP repeat containing 6 0.0243428
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0241156
DNAAF9 dynein axonemal assembly factor 9 0.0239474
RACK1 receptor for activated C kinase 1 0.0235458
RUNX1 runt-related transcription factor 1 0.0234711
GCLC glutamate-cysteine ligase, catalytic subunit 0.0234552
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0232987
TNRC6B trinucleotide repeat containing 6B 0.0232817
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0232164
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0231485
FAM107B family with sequence similarity 107, member B 0.0231049
FERMT1 fermitin family member 1 0.0230808
RNASET2 ribonuclease T2 0.0228397
ENKUR enkurin, TRPC channel interacting protein 0.0228318
RPL35A ribosomal protein L35a 0.0227748
STAU1 staufen double-stranded RNA binding protein 1 0.0225549
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.0225204
LAMA4 laminin, alpha 4 0.0222845
MTSS1 metastasis suppressor 1 0.0220188
IGF1R insulin-like growth factor 1 receptor 0.0219394
SYNE1 spectrin repeat containing, nuclear envelope 1 0.0219393
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0219137
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.021682

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.39943
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.246679
C3 complement component 3 -0.119153
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.119002
AKAP12 A kinase (PRKA) anchor protein 12 -0.0989168
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0856903
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0553494
IGFBP1 insulin-like growth factor binding protein 1 -0.0539817
FN1 fibronectin 1 -0.0514307
TMSB10 thymosin beta 10 -0.0423629
APOA2 apolipoprotein A-II -0.0389085
RPS6 ribosomal protein S6 -0.0376782
VEGFA vascular endothelial growth factor A -0.0345597
POTEF POTE ankyrin domain family, member F -0.0339443
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide -0.0290552
PDIA3 protein disulfide isomerase family A, member 3 -0.0281373
MYH9 myosin, heavy chain 9, non-muscle -0.0263874
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0255228
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0238816
ITGAV integrin, alpha V -0.0236269
LYZ lysozyme -0.0233726
HMGA1 high mobility group AT-hook 1 -0.0230783
APOA1 apolipoprotein A-I -0.0226786
TPM4 tropomyosin 4 -0.0226607
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1 -0.0226569
ACTN4 actinin, alpha 4 -0.0219726
MT2A metallothionein 2A -0.0212954
S100A9 S100 calcium binding protein A9 -0.0200853
DST dystonin -0.0199364
PCBP2 poly(rC) binding protein 2 -0.0191443
PTPRM protein tyrosine phosphatase, receptor type, M -0.0191277
RPS23 ribosomal protein S23 -0.0191158
KIF1B kinesin family member 1B -0.0187625
CALD1 caldesmon 1 -0.018337
NCOR2 nuclear receptor corepressor 2 -0.0182037
CYB5R3 cytochrome b5 reductase 3 -0.0177857
MATR3 matrin 3 -0.0174225
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.017218
TPM1 tropomyosin 1 (alpha) -0.0171432
LRRTM4 leucine rich repeat transmembrane neuronal 4 -0.0171084
PPIG peptidylprolyl isomerase G (cyclophilin G) -0.0166867
ICAM1 intercellular adhesion molecule 1 -0.0165398
MYO1B myosin IB -0.0164221
CCNL1 cyclin L1 -0.0163947
GLS2 glutaminase 2 (liver, mitochondrial) -0.0160774
EIF5B eukaryotic translation initiation factor 5B -0.0158788
PKM pyruvate kinase, muscle -0.0157867
APOH apolipoprotein H (beta-2-glycoprotein I) -0.0156607
SOX5 SRY (sex determining region Y)-box 5 -0.0156538
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 -0.0155322
INSIG2 insulin induced gene 2 -0.0152785
GNAS GNAS complex locus -0.0151815
IWS1 IWS1 homolog (S. cerevisiae) -0.015116
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0150268
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein -0.0148875
LAMB1 laminin, beta 1 -0.0147354
YY1 YY1 transcription factor -0.0146425
BIRC3 baculoviral IAP repeat containing 3 -0.0143189
ADAM9 ADAM metallopeptidase domain 9 -0.0142799
YAP1 Yes-associated protein 1 -0.0142255
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.013852
RSF1 remodeling and spacing factor 1 -0.0138184
CST3 cystatin C -0.0137367
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0135953
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 -0.0135707
PFN1 profilin 1 -0.0135327
VIM vimentin -0.0135219
RNF43 ring finger protein 43 -0.0134788
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -0.0133699
RNASEH2A ribonuclease H2, subunit A -0.0131944
GOLGA4 golgin A4 -0.0131932
KRT19 keratin 19, type I -0.0131469
PUM2 pumilio RNA-binding family member 2 -0.013066
DDX24 DEAD (Asp-Glu-Ala-Asp) box helicase 24 -0.0130561
MARCHF7 membrane associated ring-CH-type finger 7 -0.0128948
KDM6B lysine (K)-specific demethylase 6B -0.0128774
BCLAF1 BCL2-associated transcription factor 1 -0.0128689
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -0.0128279
CDH2 cadherin 2, type 1, N-cadherin (neuronal) -0.0128119
PLIN2 perilipin 2 -0.0127905
FOSL1 FOS-like antigen 1 -0.0127427
UBXN4 UBX domain protein 4 -0.012633
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 -0.0125886
DIAPH1 diaphanous-related formin 1 -0.0124657
SRRM2 serine/arginine repetitive matrix 2 -0.01233
RAP1B RAP1B, member of RAS oncogene family -0.0122201
BRD2 bromodomain containing 2 -0.0121489
HSPG2 heparan sulfate proteoglycan 2 -0.0119223
RPL3 ribosomal protein L3 -0.0117894
TNIP1 TNFAIP3 interacting protein 1 -0.0117567
TAPBP TAP binding protein (tapasin) -0.0115959
PCM1 pericentriolar material 1 -0.0115435
GSE1 Gse1 coiled-coil protein -0.0115368
FKTN fukutin -0.0114619
ANXA3 annexin A3 -0.0114381
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 -0.0114354
CCT3 chaperonin containing TCP1, subunit 3 (gamma) -0.0113392
RPL8 ribosomal protein L8 -0.0112407
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0111769
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0111694