| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Saquinavir perturbation in LS 180 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Saquinavir_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.299703 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.174159 |
| LMO7 | LIM domain 7 | 0.138071 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.127994 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.119587 |
| NDRG1 | N-myc downstream regulated 1 | 0.0841693 |
| FTL | ferritin, light polypeptide | 0.0744157 |
| MYO1E | myosin IE | 0.0735809 |
| LGR4 | leucine-rich repeat containing G protein-coupled receptor 4 | 0.0696215 |
| TXNIP | thioredoxin interacting protein | 0.0676544 |
| RPS12 | ribosomal protein S12 | 0.0667862 |
| LDHA | lactate dehydrogenase A | 0.0654955 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0651695 |
| RNF145 | ring finger protein 145 | 0.0629726 |
| AREG | amphiregulin | 0.0592047 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0581617 |
| RPLP0 | ribosomal protein, large, P0 | 0.0578857 |
| B2M | beta-2-microglobulin | 0.0577156 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0560811 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0548301 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0541786 |
| CALR | calreticulin | 0.0504621 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0490548 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | 0.0479228 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0459872 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0441656 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | 0.0439003 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0426137 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0422862 |
| FBXO11 | F-box protein 11 | 0.0422077 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0422006 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0416842 |
| ISG15 | ISG15 ubiquitin-like modifier | 0.0412152 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0410853 |
| GAREM1 | GRB2 associated regulator of MAPK1 subtype 1 | 0.0406316 |
| ANXA1 | annexin A1 | 0.0405079 |
| MT2A | metallothionein 2A | 0.0398396 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0391326 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0374735 |
| MUC13 | mucin 13, cell surface associated | 0.0366477 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0365467 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.035983 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0358359 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0345546 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0342347 |
| RPL27A | ribosomal protein L27a | 0.0341702 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0340529 |
| MED13 | mediator complex subunit 13 | 0.0336482 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0330517 |
| TGFBR3 | transforming growth factor, beta receptor III | 0.0329851 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0329784 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0321856 |
| PARD3 | par-3 family cell polarity regulator | 0.0320152 |
| TFG | TRK-fused gene | 0.0320059 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.0318336 |
| FAM13A | family with sequence similarity 13, member A | 0.0318163 |
| UBC | ubiquitin C | 0.0315689 |
| MYO5B | myosin VB | 0.0310984 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0309144 |
| RPS3 | ribosomal protein S3 | 0.0308864 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0305237 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.030247 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0292343 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0292283 |
| RPL37A | ribosomal protein L37a | 0.0282183 |
| TRIB1 | tribbles pseudokinase 1 | 0.0280367 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0277341 |
| RPS8 | ribosomal protein S8 | 0.0277292 |
| RPLP1 | ribosomal protein, large, P1 | 0.0277027 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0276079 |
| INTS6 | integrator complex subunit 6 | 0.0275885 |
| SPAG9 | sperm associated antigen 9 | 0.0275043 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0272063 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | 0.0271817 |
| MARCHF3 | membrane associated ring-CH-type finger 3 | 0.0271349 |
| WDR45B | WD repeat domain 45B | 0.0268553 |
| MT1X | metallothionein 1X | 0.026564 |
| UBE2B | ubiquitin-conjugating enzyme E2B | 0.0265405 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0264558 |
| COPA | coatomer protein complex, subunit alpha | 0.0264403 |
| SIK3 | SIK family kinase 3 | 0.0264219 |
| TMC5 | transmembrane channel-like 5 | 0.0262825 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0261013 |
| RORA | RAR-related orphan receptor A | 0.0260981 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | 0.0259483 |
| EMP1 | epithelial membrane protein 1 | 0.0258746 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0252213 |
| ATF3 | activating transcription factor 3 | 0.0251985 |
| MAGT1 | magnesium transporter 1 | 0.0251891 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.0250694 |
| RPS19 | ribosomal protein S19 | 0.025023 |
| MT1E | metallothionein 1E | 0.024947 |
| DNAJC1 | DnaJ (Hsp40) homolog, subfamily C, member 1 | 0.0246488 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | 0.0245399 |
| CLDN4 | claudin 4 | 0.0245339 |
| DDIT3 | DNA-damage-inducible transcript 3 | 0.0241972 |
| RPL31 | ribosomal protein L31 | 0.024049 |
| ARHGAP42 | Rho GTPase activating protein 42 | 0.02401 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0239959 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0235997 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NPSR1 | neuropeptide S receptor 1 | -0.218342 |
| KRT8 | keratin 8, type II | -0.0995499 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.090466 |
| AHNAK | AHNAK nucleoprotein | -0.0893383 |
| KRT18 | keratin 18, type I | -0.0878136 |
| ONECUT3 | one cut homeobox 3 | -0.0836198 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0807589 |
| TNS4 | tensin 4 | -0.07923 |
| FLNB | filamin B, beta | -0.0750602 |
| ANXA2 | annexin A2 | -0.0686598 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0615835 |
| PRSS3 | protease, serine, 3 | -0.0603794 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0580133 |
| GPHN | gephyrin | -0.0571911 |
| RPS6 | ribosomal protein S6 | -0.0527533 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.052442 |
| ACTN4 | actinin, alpha 4 | -0.049421 |
| KIF5B | kinesin family member 5B | -0.0477643 |
| RNF43 | ring finger protein 43 | -0.0457155 |
| HSD17B12 | hydroxysteroid (17-beta) dehydrogenase 12 | -0.0455482 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0450452 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0447823 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0447727 |
| PTPRR | protein tyrosine phosphatase, receptor type, R | -0.0430325 |
| PTMA | prothymosin, alpha | -0.0413091 |
| HMGB1 | high mobility group box 1 | -0.0406452 |
| TPM4 | tropomyosin 4 | -0.0402136 |
| MUC5AC | mucin 5AC, oligomeric mucus/gel-forming | -0.0393568 |
| CALB1 | calbindin 1, 28kDa | -0.0392457 |
| NFIA | nuclear factor I/A | -0.038736 |
| DSG2 | desmoglein 2 | -0.0384614 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | -0.0380732 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | -0.0380041 |
| TMEM45B | transmembrane protein 45B | -0.0376085 |
| DEK | DEK proto-oncogene | -0.0369231 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0365697 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.03604 |
| KLF3 | Kruppel-like factor 3 (basic) | -0.0355853 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0352381 |
| FERMT1 | fermitin family member 1 | -0.0350473 |
| PIGR | polymeric immunoglobulin receptor | -0.0343429 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0338195 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | -0.0330898 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0330297 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0328356 |
| GOLGA4 | golgin A4 | -0.0326865 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0320968 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0320582 |
| TMSB10 | thymosin beta 10 | -0.0320553 |
| SBF2 | SET binding factor 2 | -0.0318045 |
| BAZ2B | bromodomain adjacent to zinc finger domain, 2B | -0.0317512 |
| RPL23 | ribosomal protein L23 | -0.0317142 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | -0.03169 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | -0.0316594 |
| FAT1 | FAT atypical cadherin 1 | -0.0304171 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0303856 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0299787 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | -0.0285531 |
| ITGB4 | integrin, beta 4 | -0.0279071 |
| FRMD5 | FERM domain containing 5 | -0.0273794 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0267716 |
| SAMD5 | sterile alpha motif domain containing 5 | -0.0266676 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0264273 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -0.0262933 |
| VDR | vitamin D (1,25- dihydroxyvitamin D3) receptor | -0.0262821 |
| TXNRD1 | thioredoxin reductase 1 | -0.0260865 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | -0.0260157 |
| VCL | vinculin | -0.0259633 |
| RPL14 | ribosomal protein L14 | -0.0258688 |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | -0.0257141 |
| CD46 | CD46 molecule, complement regulatory protein | -0.0256404 |
| KRT19 | keratin 19, type I | -0.0256358 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.0254752 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0252775 |
| SMYD3 | SET and MYND domain containing 3 | -0.0252276 |
| GRIN2B | glutamate receptor, ionotropic, N-methyl D-aspartate 2B | -0.0250616 |
| HNRNPK | heterogeneous nuclear ribonucleoprotein K | -0.0248085 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | -0.0246321 |
| GPA33 | glycoprotein A33 (transmembrane) | -0.024445 |
| RPL34 | ribosomal protein L34 | -0.0242741 |
| HNRNPAB | heterogeneous nuclear ribonucleoprotein A/B | -0.0242591 |
| MATR3 | matrin 3 | -0.0241734 |
| PRELID2 | PRELI domain containing 2 | -0.0241254 |
| SEPTIN10 | septin 10 | -0.0239138 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.023665 |
| KDM7A | lysine (K)-specific demethylase 7A | -0.0235377 |
| HMGA1 | high mobility group AT-hook 1 | -0.0233904 |
| EXOC4 | exocyst complex component 4 | -0.0231671 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0230344 |
| TBC1D5 | TBC1 domain family, member 5 | -0.022987 |
| PCDHB16 | protocadherin beta 16 | -0.0229656 |
| DENND1A | DENN/MADD domain containing 1A | -0.0229047 |
| MUC17 | mucin 17, cell surface associated | -0.0227125 |
| BCKDHB | branched chain keto acid dehydrogenase E1, beta polypeptide | -0.0226196 |
| TCF12 | transcription factor 12 | -0.0224622 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0223577 |
| GOLGB1 | golgin B1 | -0.0223176 |
| ASPH | aspartate beta-hydroxylase | -0.0223028 |
| FHIT | fragile histidine triad | -0.0221706 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.022164 |
