| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Saquinavir perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Saquinavir_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | 0.166889 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.162601 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.126144 |
| RUNX1 | runt-related transcription factor 1 | 0.125166 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.122156 |
| VIM | vimentin | 0.114438 |
| FMNL2 | formin-like 2 | 0.0998489 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0992724 |
| RAI1 | retinoic acid induced 1 | 0.0806795 |
| CAPRIN2 | caprin family member 2 | 0.0800911 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0729328 |
| TSC22D1 | TSC22 domain family, member 1 | 0.0727972 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0670566 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0667067 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0660943 |
| EREG | epiregulin | 0.0654365 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0652063 |
| CD44 | CD44 molecule (Indian blood group) | 0.0648264 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0646649 |
| MT1E | metallothionein 1E | 0.0640927 |
| JMJD1C | jumonji domain containing 1C | 0.0630067 |
| HMGA1 | high mobility group AT-hook 1 | 0.0616886 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0596194 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0593034 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.057173 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0562297 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0546866 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0544149 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0517405 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0509112 |
| DPYD | dihydropyrimidine dehydrogenase | 0.047609 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0461863 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0458978 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0454694 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0449224 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0437641 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0431056 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0422336 |
| RPLP0 | ribosomal protein, large, P0 | 0.0421413 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0419689 |
| DNER | delta/notch-like EGF repeat containing | 0.041609 |
| DPYSL2 | dihydropyrimidinase-like 2 | 0.0412586 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.041017 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0404019 |
| PATJ | PATJ crumbs cell polarity complex component | 0.0400285 |
| DST | dystonin | 0.0400092 |
| EMP1 | epithelial membrane protein 1 | 0.039788 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0394108 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0392009 |
| LDHA | lactate dehydrogenase A | 0.038762 |
| HDAC9 | histone deacetylase 9 | 0.038404 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.0381598 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0380595 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0379426 |
| MT1X | metallothionein 1X | 0.0370485 |
| ZDHHC14 | zinc finger, DHHC-type containing 14 | 0.0365466 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0365392 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | 0.0364369 |
| SMYD3 | SET and MYND domain containing 3 | 0.0362764 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0362271 |
| FLNB | filamin B, beta | 0.0360192 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0355466 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0354383 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0352986 |
| SDCCAG8 | serologically defined colon cancer antigen 8 | 0.0352718 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0352354 |
| ERBIN | erbb2 interacting protein | 0.0352268 |
| PDE10A | phosphodiesterase 10A | 0.0344848 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0336363 |
| SEC24A | SEC24 family member A | 0.0334582 |
| ANGPTL4 | angiopoietin-like 4 | 0.0330678 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.032868 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.032395 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0323701 |
| NAV2 | neuron navigator 2 | 0.0323028 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | 0.0321978 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0320529 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0319792 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.0319113 |
| PTK2 | protein tyrosine kinase 2 | 0.0317483 |
| FOXP1 | forkhead box P1 | 0.0313045 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0310429 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0310304 |
| NDRG1 | N-myc downstream regulated 1 | 0.0309577 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0304798 |
| OFD1 | oral-facial-digital syndrome 1 | 0.0303709 |
| UBC | ubiquitin C | 0.0302642 |
| CDK6 | cyclin-dependent kinase 6 | 0.0297649 |
| ATXN2 | ataxin 2 | 0.0294797 |
| CFAP299 | cilia and flagella associated protein 299 | 0.0289529 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0284721 |
| UBE2E3 | ubiquitin-conjugating enzyme E2E 3 | 0.0282264 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | 0.0282194 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | 0.0279835 |
| VEGFC | vascular endothelial growth factor C | 0.0278913 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | 0.0278558 |
| UBAP2 | ubiquitin associated protein 2 | 0.0278554 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.027807 |
| TP63 | tumor protein p63 | 0.0277239 |
| RAD51B | RAD51 paralog B | 0.0277147 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.113533 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0831895 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0703532 |
| PTMA | prothymosin, alpha | -0.0699684 |
| AHNAK | AHNAK nucleoprotein | -0.0695109 |
| TMSB4X | thymosin beta 4, X-linked | -0.0642149 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0592764 |
| RPL23 | ribosomal protein L23 | -0.0592283 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0518611 |
| RPLP2 | ribosomal protein, large, P2 | -0.0504842 |
| RPL35A | ribosomal protein L35a | -0.0502224 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0450843 |
| ZNF217 | zinc finger protein 217 | -0.043447 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0431529 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0431341 |
| RPS21 | ribosomal protein S21 | -0.0395068 |
| RPL35 | ribosomal protein L35 | -0.0375754 |
| RPL19 | ribosomal protein L19 | -0.0375484 |
| RPS19 | ribosomal protein S19 | -0.0359865 |
| MKI67 | marker of proliferation Ki-67 | -0.0358398 |
| RPL34 | ribosomal protein L34 | -0.035537 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0348607 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.0344742 |
| NT5E | 5'-nucleotidase, ecto (CD73) | -0.0338734 |
| RPL12 | ribosomal protein L12 | -0.0315154 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0314201 |
| CENPF | centromere protein F, 350/400kDa | -0.031135 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0310797 |
| S100A9 | S100 calcium binding protein A9 | -0.0307906 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0304603 |
| RPL27 | ribosomal protein L27 | -0.0301393 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.029623 |
| RPS6 | ribosomal protein S6 | -0.0292234 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0288948 |
| YBX1 | Y box binding protein 1 | -0.0286785 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | -0.0284535 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.028402 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0276603 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0267842 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0265892 |
| RPL26 | ribosomal protein L26 | -0.0265053 |
| DNTTIP2 | deoxynucleotidyltransferase, terminal, interacting protein 2 | -0.0263311 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0263245 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | -0.0262108 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0258451 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0255849 |
| AHNAK2 | AHNAK nucleoprotein 2 | -0.025404 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0248763 |
| RPL36 | ribosomal protein L36 | -0.0240524 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | -0.0237658 |
| PHF3 | PHD finger protein 3 | -0.0235246 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | -0.0231538 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0227636 |
| RPL36A | ribosomal protein L36a | -0.0227558 |
| TNFAIP2 | tumor necrosis factor, alpha-induced protein 2 | -0.022731 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0224676 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0213847 |
| RPL4 | ribosomal protein L4 | -0.0211197 |
| RPL13A | ribosomal protein L13a | -0.0210805 |
| FTL | ferritin, light polypeptide | -0.0209233 |
| RPS29 | ribosomal protein S29 | -0.020894 |
| LARP1 | La ribonucleoprotein domain family, member 1 | -0.0206453 |
| VCL | vinculin | -0.0205189 |
| DHX9 | DEAH (Asp-Glu-Ala-His) box helicase 9 | -0.0204575 |
| SUB1 | SUB1 homolog (S. cerevisiae) | -0.0201847 |
| KIF5B | kinesin family member 5B | -0.0200594 |
| MATR3 | matrin 3 | -0.0199261 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0197007 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | -0.0194267 |
| SDC4 | syndecan 4 | -0.019273 |
| SLK | STE20-like kinase | -0.0191983 |
| HLA-C | major histocompatibility complex, class I, C | -0.0189836 |
| NEK10 | NIMA-related kinase 10 | -0.0186955 |
| EIF4H | eukaryotic translation initiation factor 4H | -0.0186622 |
| ANLN | anillin, actin binding protein | -0.0180047 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0179715 |
| FDPS | farnesyl diphosphate synthase | -0.017742 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | -0.0177006 |
| RPL5 | ribosomal protein L5 | -0.017661 |
| HMGB1 | high mobility group box 1 | -0.0176363 |
| EFNA5 | ephrin-A5 | -0.0173888 |
| RPL14 | ribosomal protein L14 | -0.0173678 |
| RPS27 | ribosomal protein S27 | -0.017327 |
| RPS15A | ribosomal protein S15a | -0.0172966 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0172176 |
| CEP95 | centrosomal protein 95kDa | -0.0172168 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0171848 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0171383 |
| PTPN1 | protein tyrosine phosphatase, non-receptor type 1 | -0.016968 |
| SERINC1 | serine incorporator 1 | -0.0167977 |
| HOOK2 | hook microtubule-tethering protein 2 | -0.0167801 |
| PLEC | plectin | -0.0167665 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -0.016753 |
| RPS18 | ribosomal protein S18 | -0.0167503 |
| RPL36AL | ribosomal protein L36a-like | -0.0165675 |
| RPLP1 | ribosomal protein, large, P1 | -0.0164244 |
| UBE2I | ubiquitin-conjugating enzyme E2I | -0.0163369 |
| PRRC2B | proline-rich coiled-coil 2B | -0.0163138 |
| ESF1 | ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) | -0.0160863 |
| PNN | pinin, desmosome associated protein | -0.0159065 |
