Saquinavir_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Saquinavir perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Saquinavir_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SLTM SAFB-like, transcription modulator 0.0991102
NSUN6 NOP2/Sun domain family, member 6 0.0877014
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0787206
ASPH aspartate beta-hydroxylase 0.076442
CXCL8 chemokine (C-X-C motif) ligand 8 0.0758042
STAT1 signal transducer and activator of transcription 1, 91kDa 0.064105
DSCAM Down syndrome cell adhesion molecule 0.0617404
LMO7 LIM domain 7 0.0560732
BLZF1 basic leucine zipper nuclear factor 1 0.0544371
ELL2 elongation factor, RNA polymerase II, 2 0.0540011
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0538028
STC1 stanniocalcin 1 0.0515682
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0493161
SAMD4A sterile alpha motif domain containing 4A 0.0460461
CSNK1A1 casein kinase 1, alpha 1 0.0455022
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0447954
CEMIP cell migration inducing protein, hyaluronan binding 0.0440928
TPT1 tumor protein, translationally-controlled 1 0.0427912
PM20D1 peptidase M20 domain containing 1 0.0424289
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0422023
HOMER1 homer scaffolding protein 1 0.0391127
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 0.0387314
TBC1D22A TBC1 domain family, member 22A 0.0375702
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.037388
MCL1 myeloid cell leukemia 1 0.0373599
RAD51B RAD51 paralog B 0.0372062
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.0367343
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0367095
SOD2 superoxide dismutase 2, mitochondrial 0.0363768
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0357729
EXT1 exostosin glycosyltransferase 1 0.0348216
SP100 SP100 nuclear antigen 0.0344103
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.033899
DOCK1 dedicator of cytokinesis 1 0.0333913
TRAPPC9 trafficking protein particle complex 9 0.033326
SMYD3 SET and MYND domain containing 3 0.0330655
AREG amphiregulin 0.0329797
DOCK5 dedicator of cytokinesis 5 0.0328086
TES testin LIM domain protein 0.0325226
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0316144
PTPRD protein tyrosine phosphatase, receptor type, D 0.0312842
FOXP1 forkhead box P1 0.0311519
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.029969
LAMB3 laminin, beta 3 0.0298775
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0286496
BZW1 basic leucine zipper and W2 domains 1 0.02832
TAS2R14 taste receptor, type 2, member 14 0.0281415
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0281149
TRIP12 thyroid hormone receptor interactor 12 0.0273472
EXOC6B exocyst complex component 6B 0.0272408
TJP1 tight junction protein 1 0.0267477
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0259472
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0258196
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric 0.0254344
ATF6 activating transcription factor 6 0.0254274
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0246553
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0245526
AEBP2 AE binding protein 2 0.024457
FRMD4B FERM domain containing 4B 0.0243919
EGFR epidermal growth factor receptor 0.024312
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) 0.0242286
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0241527
AGO2 argonaute RISC catalytic component 2 0.0239442
ZSWIM6 zinc finger, SWIM-type containing 6 0.0237996
XRRA1 X-ray radiation resistance associated 1 0.0236388
UBR1 ubiquitin protein ligase E3 component n-recognin 1 0.0236067
SIK3 SIK family kinase 3 0.0235751
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) 0.023575
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0235025
KYNU kynureninase 0.0231608
FAF1 Fas (TNFRSF6) associated factor 1 0.0231226
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0229092
PRELID2 PRELI domain containing 2 0.0227697
VCL vinculin 0.0226868
SUMF1 sulfatase modifying factor 1 0.0226129
SLC35F5 solute carrier family 35, member F5 0.0225653
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 0.0222691
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0221638
IFI6 interferon, alpha-inducible protein 6 0.0221228
LRP12 low density lipoprotein receptor-related protein 12 0.0215514
MAP3K20 mitogen-activated protein kinase kinase kinase 20 0.0215462
SDC4 syndecan 4 0.0215413
KIAA1328 KIAA1328 0.0215311
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0213217
LDHA lactate dehydrogenase A 0.0212617
HDAC8 histone deacetylase 8 0.021243
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides 0.0203418
MYO9A myosin IXA 0.0200526
USP34 ubiquitin specific peptidase 34 0.0199715
BMAL2 basic helix-loop-helix ARNT like 2 0.0199287
ATXN1 ataxin 1 0.0199183
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0198819
ZC3H12B zinc finger CCCH-type containing 12B 0.0198112
BABAM2 BRISC and BRCA1 A complex member 2 0.0196893
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0195968
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0194298
OSMR oncostatin M receptor 0.0193715
CTNND1 catenin (cadherin-associated protein), delta 1 0.0193223
GRAMD1B GRAM domain containing 1B 0.0192551
MTERF1 mitochondrial transcription termination factor 1 0.0191018

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.189683
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.184821
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.17759
FTH1 ferritin, heavy polypeptide 1 -0.148664
PTMA prothymosin, alpha -0.0974096
TXNRD1 thioredoxin reductase 1 -0.0959183
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0812727
CES1 carboxylesterase 1 -0.0806752
CAV1 caveolin 1, caveolae protein, 22kDa -0.0725477
FAM13A family with sequence similarity 13, member A -0.0661528
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 -0.0646163
MT2A metallothionein 2A -0.062774
PKM pyruvate kinase, muscle -0.0602777
NDRG1 N-myc downstream regulated 1 -0.0573628
WASF2 WAS protein family, member 2 -0.0549052
IGFBP3 insulin-like growth factor binding protein 3 -0.0533902
CST3 cystatin C -0.0532479
TMEM165 transmembrane protein 165 -0.0526351
AKR1C1 aldo-keto reductase family 1, member C1 -0.0515819
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0511866
RPS6 ribosomal protein S6 -0.0482342
LRP1B low density lipoprotein receptor-related protein 1B -0.0474352
RNF145 ring finger protein 145 -0.0465678
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0463948
KCMF1 potassium channel modulatory factor 1 -0.0443492
FTL ferritin, light polypeptide -0.0442792
KRT7 keratin 7, type II -0.0407345
RPL35A ribosomal protein L35a -0.0401688
TPD52 tumor protein D52 -0.0401552
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0397822
PTPRM protein tyrosine phosphatase, receptor type, M -0.0397725
ZMYND8 zinc finger, MYND-type containing 8 -0.0395229
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0395015
LOC112694756 uncharaterized LOC112694756 -0.0394391
PDE8A phosphodiesterase 8A -0.0394303
PDIA3 protein disulfide isomerase family A, member 3 -0.0378637
GCLC glutamate-cysteine ligase, catalytic subunit -0.0378373
RPL34 ribosomal protein L34 -0.0339061
H1-0 H1.0 linker histone -0.0333803
HDLBP high density lipoprotein binding protein -0.0326008
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0322648
PTPRJ protein tyrosine phosphatase, receptor type, J -0.031909
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0313786
SREBF2 sterol regulatory element binding transcription factor 2 -0.0310385
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0299325
WDR45B WD repeat domain 45B -0.0296654
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0286762
RPS21 ribosomal protein S21 -0.0285272
ANXA2 annexin A2 -0.0278565
AKAP12 A kinase (PRKA) anchor protein 12 -0.0273428
S100A10 S100 calcium binding protein A10 -0.0273206
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0273002
MCTP1 multiple C2 domains, transmembrane 1 -0.0272419
DSPP dentin sialophosphoprotein -0.0271796
NCOA3 nuclear receptor coactivator 3 -0.0271258
RPLP1 ribosomal protein, large, P1 -0.0269446
EGLN3 egl-9 family hypoxia-inducible factor 3 -0.0257178
ACTG1 actin gamma 1 -0.0254409
LAMC2 laminin, gamma 2 -0.0252665
S100A9 S100 calcium binding protein A9 -0.0252541
HYOU1 hypoxia up-regulated 1 -0.0246483
RPS23 ribosomal protein S23 -0.0244596
SERF2 small EDRK-rich factor 2 -0.0244294
KDM2A lysine (K)-specific demethylase 2A -0.0242115
RAP1B RAP1B, member of RAS oncogene family -0.0241127
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0239445
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 -0.0234306
RPS14 ribosomal protein S14 -0.0233402
MATR3 matrin 3 -0.0231199
VEGFA vascular endothelial growth factor A -0.0230983
KRT18 keratin 18, type I -0.0229889
RPS25 ribosomal protein S25 -0.0227751
ANKRD37 ankyrin repeat domain 37 -0.0227546
RPL8 ribosomal protein L8 -0.0225061
POTEF POTE ankyrin domain family, member F -0.0224175
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0222953
HILPDA hypoxia inducible lipid droplet-associated -0.0221961
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0221335
KMT2E lysine (K)-specific methyltransferase 2E -0.0220945
RPL19 ribosomal protein L19 -0.021734
RPL36 ribosomal protein L36 -0.0214881
RPL31 ribosomal protein L31 -0.0212915
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0211136
HMGA1 high mobility group AT-hook 1 -0.0210676
CD99 CD99 molecule -0.020922
FLNB filamin B, beta -0.020881
BIRC3 baculoviral IAP repeat containing 3 -0.0208765
KDM5B lysine (K)-specific demethylase 5B -0.0205188
CDKN2A cyclin-dependent kinase inhibitor 2A -0.0204927
CCND1 cyclin D1 -0.0202915
BRWD1 bromodomain and WD repeat domain containing 1 -0.0202437
RAB10 RAB10, member RAS oncogene family -0.020221
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa -0.0200915
RPS27 ribosomal protein S27 -0.0198441
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0195977
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0195797
BBX bobby sox homolog (Drosophila) -0.0193792
RPLP2 ribosomal protein, large, P2 -0.0193655
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0190954
TNS3 tensin 3 -0.0189595