Saquinavir_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Saquinavir perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Saquinavir_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CD44 CD44 molecule (Indian blood group) 0.109555
SOD2 superoxide dismutase 2, mitochondrial 0.105964
GRB10 growth factor receptor-bound protein 10 0.100696
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0975121
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0814446
SMAD3 SMAD family member 3 0.0730631
PDE4D phosphodiesterase 4D, cAMP-specific 0.0721381
EFNA5 ephrin-A5 0.0657565
NAV2 neuron navigator 2 0.0593895
RAD51B RAD51 paralog B 0.0504848
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0481462
ANKRD28 ankyrin repeat domain 28 0.0464812
EHBP1 EH domain binding protein 1 0.0456928
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0428339
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.0428306
EXOC6B exocyst complex component 6B 0.0406717
RUNX1 runt-related transcription factor 1 0.0403119
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0401119
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0398372
ELL2 elongation factor, RNA polymerase II, 2 0.0382605
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0374836
NCOA7 nuclear receptor coactivator 7 0.0359788
TRIO trio Rho guanine nucleotide exchange factor 0.0350547
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0348953
FAM107B family with sequence similarity 107, member B 0.0346694
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0341796
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0340814
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0336741
LPP LIM domain containing preferred translocation partner in lipoma 0.0331
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0330625
DSCAM Down syndrome cell adhesion molecule 0.0326603
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0316187
BACE2 beta-site APP-cleaving enzyme 2 0.03142
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0312406
TAS2R14 taste receptor, type 2, member 14 0.0309572
FAM20C family with sequence similarity 20, member C 0.0309251
MAML2 mastermind-like 2 (Drosophila) 0.0307398
LRMDA leucine rich melanocyte differentiation associated 0.0304625
MYO10 myosin X 0.0302295
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0298592
KYNU kynureninase 0.0298509
ZNF638 zinc finger protein 638 0.0297745
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.029574
HMGA2 high mobility group AT-hook 2 0.0278064
MEIS1 Meis homeobox 1 0.02776
ZEB1 zinc finger E-box binding homeobox 1 0.0274969
TBC1D5 TBC1 domain family, member 5 0.0272489
FNDC3B fibronectin type III domain containing 3B 0.0270811
WDPCP WD repeat containing planar cell polarity effector 0.0266516
SYAP1 synapse associated protein 1 0.0263767
MBNL1 muscleblind-like splicing regulator 1 0.0263355
USP34 ubiquitin specific peptidase 34 0.0262223
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0260244
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0259259
EXOC4 exocyst complex component 4 0.0257819
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0256326
ZSWIM6 zinc finger, SWIM-type containing 6 0.0255466
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0250814
PTPRM protein tyrosine phosphatase, receptor type, M 0.0250538
FBXL13 F-box and leucine-rich repeat protein 13 0.024743
AKAP13 A kinase (PRKA) anchor protein 13 0.0246266
ALCAM activated leukocyte cell adhesion molecule 0.0243345
EXT1 exostosin glycosyltransferase 1 0.0242784
PRELID2 PRELI domain containing 2 0.0241696
WWTR1 WW domain containing transcription regulator 1 0.0237412
ATXN1 ataxin 1 0.0237263
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.0231692
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0231581
ANGPTL4 angiopoietin-like 4 0.022832
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0227696
SMYD3 SET and MYND domain containing 3 0.0227439
SOS1 son of sevenless homolog 1 (Drosophila) 0.0225019
CTNND1 catenin (cadherin-associated protein), delta 1 0.0221232
CCSER1 coiled-coil serine-rich protein 1 0.0219147
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0218558
ETV6 ets variant 6 0.0218427
LOXL2 lysyl oxidase-like 2 0.0218405
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0218078
SP100 SP100 nuclear antigen 0.0214911
TGM2 transglutaminase 2 0.0212902
OFD1 oral-facial-digital syndrome 1 0.0212342
FHL2 four and a half LIM domains 2 0.0212281
INTS6 integrator complex subunit 6 0.021046
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0210289
DOCK4 dedicator of cytokinesis 4 0.0209289
EGFR epidermal growth factor receptor 0.0208425
MX2 MX dynamin-like GTPase 2 0.0208199
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9 0.0204572
OSMR oncostatin M receptor 0.0203856
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1 0.0202506
ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif, 14 0.0201567
ANXA2 annexin A2 0.0201183
MYO9A myosin IXA 0.0200153
NAMPT nicotinamide phosphoribosyltransferase 0.0199802
CAPRIN2 caprin family member 2 0.0199429
LHFPL2 lipoma HMGIC fusion partner-like 2 0.019717
SIK3 SIK family kinase 3 0.019596
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0195605
DPYSL3 dihydropyrimidinase-like 3 0.0195489
CCNY cyclin Y 0.0193832

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.248799
FN1 fibronectin 1 -0.170774
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.123422
AKAP12 A kinase (PRKA) anchor protein 12 -0.121392
VIM vimentin -0.105024
FTL ferritin, light polypeptide -0.0921921
IGFBP3 insulin-like growth factor binding protein 3 -0.0851588
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0787691
CXCL8 chemokine (C-X-C motif) ligand 8 -0.078705
PTMA prothymosin, alpha -0.0752808
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0699657
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0665596
TFPI2 tissue factor pathway inhibitor 2 -0.0654878
RPLP1 ribosomal protein, large, P1 -0.0605885
GOLGA4 golgin A4 -0.0601659
RPS6 ribosomal protein S6 -0.0577491
ENO2 enolase 2 (gamma, neuronal) -0.0571094
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0550393
RPS19 ribosomal protein S19 -0.054967
VEGFA vascular endothelial growth factor A -0.0548039
RPL35A ribosomal protein L35a -0.0517407
RPS21 ribosomal protein S21 -0.0495944
RPL36 ribosomal protein L36 -0.0490238
POTEF POTE ankyrin domain family, member F -0.0442355
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.04038
MTSS1 metastasis suppressor 1 -0.0378836
HMGA1 high mobility group AT-hook 1 -0.037404
FTH1 ferritin, heavy polypeptide 1 -0.037106
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0370348
RPLP2 ribosomal protein, large, P2 -0.0370045
RPS29 ribosomal protein S29 -0.0368117
GLCCI1 glucocorticoid induced 1 -0.0364129
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0362859
PDIA3 protein disulfide isomerase family A, member 3 -0.036282
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0357415
RPL34 ribosomal protein L34 -0.0346423
BASP1 brain abundant, membrane attached signal protein 1 -0.0346097
TMEM165 transmembrane protein 165 -0.0343835
RPL23 ribosomal protein L23 -0.0334601
ANKRD12 ankyrin repeat domain 12 -0.0334126
LOX lysyl oxidase -0.0332902
NRP1 neuropilin 1 -0.0330903
SOX4 SRY (sex determining region Y)-box 4 -0.0314998
RPS23 ribosomal protein S23 -0.0312716
S100A9 S100 calcium binding protein A9 -0.031026
IL1B interleukin 1, beta -0.0306379
PRRC2C proline-rich coiled-coil 2C -0.0302559
TPT1 tumor protein, translationally-controlled 1 -0.0300784
MRPS6 mitochondrial ribosomal protein S6 -0.0297587
S100A6 S100 calcium binding protein A6 -0.028995
LOC112694756 uncharaterized LOC112694756 -0.0279452
CLMP CXADR-like membrane protein -0.0277323
RPS13 ribosomal protein S13 -0.0272993
EGR1 early growth response 1 -0.0270386
RPL19 ribosomal protein L19 -0.0270027
B2M beta-2-microglobulin -0.026939
RPS27 ribosomal protein S27 -0.0266685
BTG1 B-cell translocation gene 1, anti-proliferative -0.0263128
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0261747
PDGFA platelet-derived growth factor alpha polypeptide -0.0259797
MT2A metallothionein 2A -0.0259152
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -0.0256647
SNX9 sorting nexin 9 -0.0253869
PLIN2 perilipin 2 -0.0253818
MAP1B microtubule-associated protein 1B -0.0249268
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0248764
ZMYND8 zinc finger, MYND-type containing 8 -0.0248401
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0248325
RAB1A RAB1A, member RAS oncogene family -0.0247489
RPL31 ribosomal protein L31 -0.0246526
PKM pyruvate kinase, muscle -0.0246315
RPS11 ribosomal protein S11 -0.0246185
DDIT3 DNA-damage-inducible transcript 3 -0.0240984
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 -0.0239836
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0239494
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0237802
ENO1 enolase 1, (alpha) -0.0237722
KTN1 kinectin 1 (kinesin receptor) -0.0237558
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0235919
ATF4 activating transcription factor 4 -0.023245
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0232105
TMSB4X thymosin beta 4, X-linked -0.0231559
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0226133
AHNAK AHNAK nucleoprotein -0.0226023
RPL32 ribosomal protein L32 -0.0225836
INSIG1 insulin induced gene 1 -0.0225255
RPS25 ribosomal protein S25 -0.0223854
RPL28 ribosomal protein L28 -0.0223463
HLA-B major histocompatibility complex, class I, B -0.0222413
GOLGB1 golgin B1 -0.0222365
RPL38 ribosomal protein L38 -0.0221599
CALR calreticulin -0.0220543
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.022045
POLD4 polymerase (DNA-directed), delta 4, accessory subunit -0.0216348
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0213629
LMAN1 lectin, mannose-binding, 1 -0.0212313
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0210575
RPL37 ribosomal protein L37 -0.0208496
C1R complement component 1, r subcomponent -0.0208387
PRRX1 paired related homeobox 1 -0.0207289