Saquinavir_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Saquinavir perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Saquinavir_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.235867
MT2A metallothionein 2A 0.175747
VIM vimentin 0.139849
SAMD4A sterile alpha motif domain containing 4A 0.116014
IGFBP3 insulin-like growth factor binding protein 3 0.115346
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.10802
PYGL phosphorylase, glycogen, liver 0.106367
DOCK4 dedicator of cytokinesis 4 0.0998967
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0856882
FMNL2 formin-like 2 0.084749
S100A6 S100 calcium binding protein A6 0.0830548
PDE4D phosphodiesterase 4D, cAMP-specific 0.0824768
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0812654
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0707231
DOCK5 dedicator of cytokinesis 5 0.0690381
NDRG1 N-myc downstream regulated 1 0.0654296
FNDC3B fibronectin type III domain containing 3B 0.0650696
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0604333
BIRC6 baculoviral IAP repeat containing 6 0.0601778
TRIO trio Rho guanine nucleotide exchange factor 0.0595637
SVIL supervillin 0.0583832
EGFR epidermal growth factor receptor 0.0579689
FLNB filamin B, beta 0.0573696
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0571705
THSD4 thrombospondin, type I, domain containing 4 0.0568989
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0566872
MACF1 microtubule-actin crosslinking factor 1 0.0565662
RICTOR RPTOR independent companion of MTOR, complex 2 0.0562664
CMIP c-Maf inducing protein 0.0552192
TPD52 tumor protein D52 0.0540521
FAM107B family with sequence similarity 107, member B 0.0534603
ERBIN erbb2 interacting protein 0.053234
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0529607
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0523548
WAC WW domain containing adaptor with coiled-coil 0.0519147
STC1 stanniocalcin 1 0.0517369
EIF1 eukaryotic translation initiation factor 1 0.0514088
AKAP13 A kinase (PRKA) anchor protein 13 0.0507067
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.048669
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0460135
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0452317
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0452019
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 0.0450967
HLA-B major histocompatibility complex, class I, B 0.0449415
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0433714
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0432324
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0430539
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0420286
EXT1 exostosin glycosyltransferase 1 0.0408131
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0407292
HLA-A major histocompatibility complex, class I, A 0.0402571
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0401622
SOD2 superoxide dismutase 2, mitochondrial 0.0401066
PARD3 par-3 family cell polarity regulator 0.0397359
RUNX1 runt-related transcription factor 1 0.0396183
SBF2 SET binding factor 2 0.0383183
UBASH3B ubiquitin associated and SH3 domain containing B 0.0378038
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.037173
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0363844
TTC28 tetratricopeptide repeat domain 28 0.0360587
RPLP0 ribosomal protein, large, P0 0.0357003
NEBL nebulette 0.0354889
ITCH itchy E3 ubiquitin protein ligase 0.0353688
SLMAP sarcolemma associated protein 0.0349789
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0346164
CUX1 cut-like homeobox 1 0.0346027
KDM3A lysine (K)-specific demethylase 3A 0.0345541
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0342126
KTN1 kinectin 1 (kinesin receptor) 0.0341572
MAP3K20 mitogen-activated protein kinase kinase kinase 20 0.0339897
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0335237
RPS8 ribosomal protein S8 0.0333612
LDHA lactate dehydrogenase A 0.0333328
ZMYND8 zinc finger, MYND-type containing 8 0.0329519
HLA-E major histocompatibility complex, class I, E 0.0324873
ALCAM activated leukocyte cell adhesion molecule 0.0319471
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0318473
ELL2 elongation factor, RNA polymerase II, 2 0.0316917
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0315682
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial) 0.0314174
MAML3 mastermind-like 3 (Drosophila) 0.0313124
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0310263
COPA coatomer protein complex, subunit alpha 0.0309516
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0306722
BCAR3 breast cancer anti-estrogen resistance 3 0.0306386
NEK7 NIMA-related kinase 7 0.0306157
OSMR oncostatin M receptor 0.0299503
ARHGAP26 Rho GTPase activating protein 26 0.0298988
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.029563
EHBP1 EH domain binding protein 1 0.0294819
PTPRM protein tyrosine phosphatase, receptor type, M 0.0292615
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.029226
ZEB1 zinc finger E-box binding homeobox 1 0.0290284
SMAD3 SMAD family member 3 0.02899
NPEPPS aminopeptidase puromycin sensitive 0.0289857
USP34 ubiquitin specific peptidase 34 0.0289556
DHRSX dehydrogenase/reductase (SDR family) X-linked 0.0287666
C15ORF48 chromosome 15 open reading frame 48 0.0286007
HMGA2 high mobility group AT-hook 2 0.0285727
APP amyloid beta (A4) precursor protein 0.0285089

decreased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.17375
TMSB10 thymosin beta 10 -0.167875
TXNRD1 thioredoxin reductase 1 -0.104432
PM20D1 peptidase M20 domain containing 1 -0.0768655
EGR1 early growth response 1 -0.0753833
RPS21 ribosomal protein S21 -0.0705946
TFPI2 tissue factor pathway inhibitor 2 -0.0699197
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0661974
FTH1 ferritin, heavy polypeptide 1 -0.0638806
RPS19 ribosomal protein S19 -0.0611554
RPL19 ribosomal protein L19 -0.0529316
RPLP1 ribosomal protein, large, P1 -0.0511418
RPL23 ribosomal protein L23 -0.0505387
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0493877
SLC38A2 solute carrier family 38, member 2 -0.0483143
PTMA prothymosin, alpha -0.0482338
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0465102
MKI67 marker of proliferation Ki-67 -0.0439184
CENPF centromere protein F, 350/400kDa -0.0411995
RPL36 ribosomal protein L36 -0.038639
NQO1 NAD(P)H dehydrogenase, quinone 1 -0.0378393
ATP5F1E ATP synthase F1 subunit epsilon -0.0367506
RTN4 reticulon 4 -0.0366526
PKM pyruvate kinase, muscle -0.0352323
HSPA8 heat shock 70kDa protein 8 -0.0336912
IGF2 insulin-like growth factor 2 -0.0333448
EEF2 eukaryotic translation elongation factor 2 -0.0329936
RPLP2 ribosomal protein, large, P2 -0.03232
KLF6 Kruppel-like factor 6 -0.0322844
WDR43 WD repeat domain 43 -0.0320658
PFDN2 prefoldin subunit 2 -0.032037
PFN1 profilin 1 -0.0314782
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0309154
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0297156
FGB fibrinogen beta chain -0.0290367
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) -0.0287105
RPS23 ribosomal protein S23 -0.0284738
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0276988
RPL28 ribosomal protein L28 -0.027555
EEF1G eukaryotic translation elongation factor 1 gamma -0.0269985
TM4SF1 transmembrane 4 L six family member 1 -0.0266352
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0264859
FTL ferritin, light polypeptide -0.0264646
YBX3 Y box binding protein 3 -0.025429
ATP5F1B ATP synthase F1 subunit beta -0.0249397
RPS5 ribosomal protein S5 -0.0248233
SLC38A1 solute carrier family 38, member 1 -0.0242136
RPS29 ribosomal protein S29 -0.0240485
NR4A2 nuclear receptor subfamily 4, group A, member 2 -0.0235532
RPL18 ribosomal protein L18 -0.0234013
RPS15 ribosomal protein S15 -0.0233951
PAPOLA poly(A) polymerase alpha -0.0225358
POTEF POTE ankyrin domain family, member F -0.0224365
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.022364
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.022333
RPL35A ribosomal protein L35a -0.0221435
RPS17 ribosomal protein S17 -0.0220925
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0220904
HMGB1 high mobility group box 1 -0.0216281
GARS1 glycyl-tRNA synthetase 1 -0.0213753
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0208836
RPS27A ribosomal protein S27a -0.020802
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0207931
VMP1 vacuole membrane protein 1 -0.0207816
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0204612
OAZ1 ornithine decarboxylase antizyme 1 -0.0204455
EIF5B eukaryotic translation initiation factor 5B -0.0203836
PDLIM5 PDZ and LIM domain 5 -0.0202618
YBX1 Y box binding protein 1 -0.0201527
TPI1 triosephosphate isomerase 1 -0.0200943
FUS FUS RNA binding protein -0.0199301
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0198718
RPS20 ribosomal protein S20 -0.0198128
AREG amphiregulin -0.019694
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0194479
DEK DEK proto-oncogene -0.0193313
MYH9 myosin, heavy chain 9, non-muscle -0.0190123
PDIA3 protein disulfide isomerase family A, member 3 -0.0187751
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0186923
SFTPA2 surfactant protein A2 -0.0185981
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0185018
NNMT nicotinamide N-methyltransferase -0.0184658
IGF1R insulin-like growth factor 1 receptor -0.0183731
AGO2 argonaute RISC catalytic component 2 -0.0181693
ACACA acetyl-CoA carboxylase alpha -0.0181633
CANX calnexin -0.0181583
TPM4 tropomyosin 4 -0.0179075
RPL8 ribosomal protein L8 -0.0177324
SPAG9 sperm associated antigen 9 -0.0176899
RPL3 ribosomal protein L3 -0.0176409
PLS3 plastin 3 -0.0176037
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.0175975
RPS11 ribosomal protein S11 -0.0173374
PARK7 parkinson protein 7 -0.0172556
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 -0.0170692
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 -0.0169828
TDP2 tyrosyl-DNA phosphodiesterase 2 -0.0169114
RPL32 ribosomal protein L32 -0.0168882
ZFP91 ZFP91 zinc finger protein -0.0168405
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0168339