| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Saquinavir perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Saquinavir_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.171618 |
| VIM | vimentin | 0.130734 |
| MCL1 | myeloid cell leukemia 1 | 0.108684 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0972178 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.093603 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0909058 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0768406 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | 0.0738915 |
| RPS8 | ribosomal protein S8 | 0.0731583 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0632881 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.061349 |
| AFF3 | AF4/FMR2 family, member 3 | 0.0602119 |
| AEBP2 | AE binding protein 2 | 0.0548283 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0539578 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0537808 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0528584 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0526408 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0520878 |
| COPA | coatomer protein complex, subunit alpha | 0.0519145 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0482311 |
| LDHA | lactate dehydrogenase A | 0.047607 |
| UBC | ubiquitin C | 0.047047 |
| INTS6 | integrator complex subunit 6 | 0.0463563 |
| PRKCE | protein kinase C, epsilon | 0.0459668 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0457153 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0452456 |
| RPS3 | ribosomal protein S3 | 0.0446308 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0441306 |
| RPL37 | ribosomal protein L37 | 0.0438396 |
| FBXO11 | F-box protein 11 | 0.0425882 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0405171 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.040123 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0396097 |
| RACK1 | receptor for activated C kinase 1 | 0.0393782 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0380634 |
| RPL37A | ribosomal protein L37a | 0.0378567 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0373708 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0371954 |
| WNT2B | wingless-type MMTV integration site family, member 2B | 0.0369015 |
| SCFD1 | sec1 family domain containing 1 | 0.0367828 |
| GOLGB1 | golgin B1 | 0.0364413 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | 0.0352674 |
| RPS12 | ribosomal protein S12 | 0.0352368 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.0348946 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0347138 |
| JMJD1C | jumonji domain containing 1C | 0.034601 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.034319 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0342963 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0341338 |
| SQSTM1 | sequestosome 1 | 0.0335099 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0332437 |
| HOMER1 | homer scaffolding protein 1 | 0.0331974 |
| MYO9A | myosin IXA | 0.0331217 |
| R3HDM2 | R3H domain containing 2 | 0.0328045 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0326796 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0325267 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.032485 |
| RSF1 | remodeling and spacing factor 1 | 0.0313654 |
| NDRG1 | N-myc downstream regulated 1 | 0.0313284 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0310133 |
| ADIPOR2 | adiponectin receptor 2 | 0.0305917 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0303266 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0298716 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | 0.0297541 |
| CALR | calreticulin | 0.0295787 |
| EGFR | epidermal growth factor receptor | 0.0292886 |
| TPM3 | tropomyosin 3 | 0.0292563 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0291999 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0287844 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0283083 |
| C6ORF62 | chromosome 6 open reading frame 62 | 0.0282651 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0281314 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0280268 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | 0.0277378 |
| RPL30 | ribosomal protein L30 | 0.0274381 |
| EXOC6B | exocyst complex component 6B | 0.0272649 |
| ARFGEF3 | ARFGEF family member 3 | 0.0270875 |
| STK4 | serine/threonine kinase 4 | 0.0270342 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0266399 |
| CAMKMT | calmodulin-lysine N-methyltransferase | 0.0265311 |
| RPLP0 | ribosomal protein, large, P0 | 0.026479 |
| PIBF1 | progesterone immunomodulatory binding factor 1 | 0.0264386 |
| DDX39B | DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B | 0.0262893 |
| LRCH3 | leucine-rich repeats and calponin homology (CH) domain containing 3 | 0.0260446 |
| RPL39 | ribosomal protein L39 | 0.0258665 |
| SETX | senataxin | 0.0258331 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0255171 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0254533 |
| USP34 | ubiquitin specific peptidase 34 | 0.0251783 |
| FMNL2 | formin-like 2 | 0.024959 |
| SLC9A1 | solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 | 0.0247657 |
| EIF2AK3 | eukaryotic translation initiation factor 2-alpha kinase 3 | 0.0246686 |
| DDIT3 | DNA-damage-inducible transcript 3 | 0.0245006 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.024498 |
| HLA-B | major histocompatibility complex, class I, B | 0.0242847 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | 0.0241988 |
| BPTF | bromodomain PHD finger transcription factor | 0.0237708 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0235938 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0233944 |
| GPATCH2L | G patch domain containing 2-like | 0.0231553 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GRAMD1B | GRAM domain containing 1B | -0.129373 |
| TMSB10 | thymosin beta 10 | -0.118466 |
| TXNRD1 | thioredoxin reductase 1 | -0.0965688 |
| PTMA | prothymosin, alpha | -0.0871591 |
| RPS21 | ribosomal protein S21 | -0.0809593 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0691478 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0686215 |
| OSMR | oncostatin M receptor | -0.0670009 |
| CSDE1 | cold shock domain containing E1, RNA-binding | -0.0636797 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0611449 |
| RBM39 | RNA binding motif protein 39 | -0.056961 |
| MKI67 | marker of proliferation Ki-67 | -0.0553575 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0535396 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0531927 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0520706 |
| CCND2 | cyclin D2 | -0.0498275 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0483552 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0482899 |
| TUBB | tubulin, beta class I | -0.0479462 |
| KLF6 | Kruppel-like factor 6 | -0.0476241 |
| ADAR | adenosine deaminase, RNA-specific | -0.0469649 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0469116 |
| H1-0 | H1.0 linker histone | -0.0454429 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0452631 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0451538 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0447722 |
| LATS2 | large tumor suppressor kinase 2 | -0.0442091 |
| PDE10A | phosphodiesterase 10A | -0.0415917 |
| ZNF217 | zinc finger protein 217 | -0.0411711 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0404571 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0403294 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0400614 |
| SMAD3 | SMAD family member 3 | -0.0399129 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0386324 |
| TPI1 | triosephosphate isomerase 1 | -0.0385059 |
| CDCP1 | CUB domain containing protein 1 | -0.0378685 |
| IGF2BP1 | insulin-like growth factor 2 mRNA binding protein 1 | -0.0374208 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0372186 |
| RNF213 | ring finger protein 213 | -0.0371517 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0359621 |
| PNPT1 | polyribonucleotide nucleotidyltransferase 1 | -0.0353704 |
| LUC7L2 | LUC7-like 2 (S. cerevisiae) | -0.0352736 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | -0.0347699 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0341221 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | -0.0341114 |
| RYR3 | ryanodine receptor 3 | -0.03409 |
| MATR3 | matrin 3 | -0.0336429 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0335784 |
| SSH2 | slingshot protein phosphatase 2 | -0.0335704 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0332282 |
| CDK17 | cyclin-dependent kinase 17 | -0.0329472 |
| FLOT1 | flotillin 1 | -0.0327123 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.031889 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | -0.0308307 |
| SINHCAF | SIN3-HDAC complex associated factor | -0.0306152 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0303085 |
| GATAD2B | GATA zinc finger domain containing 2B | -0.0301472 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0299217 |
| RPS29 | ribosomal protein S29 | -0.029718 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0294991 |
| CENPF | centromere protein F, 350/400kDa | -0.0293494 |
| YBX3 | Y box binding protein 3 | -0.0291776 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | -0.0288539 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0279904 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.027803 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0277448 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0275595 |
| ZFR | zinc finger RNA binding protein | -0.0271997 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0270296 |
| KIF18B | kinesin family member 18B | -0.026961 |
| PTK2 | protein tyrosine kinase 2 | -0.026879 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0267591 |
| AHNAK | AHNAK nucleoprotein | -0.0267399 |
| CD2AP | CD2-associated protein | -0.0265442 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | -0.0265026 |
| COL5A2 | collagen, type V, alpha 2 | -0.0263477 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0260011 |
| HIBADH | 3-hydroxyisobutyrate dehydrogenase | -0.0257828 |
| U2SURP | U2 snRNP-associated SURP domain containing | -0.0255765 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0255489 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0255007 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.0254514 |
| MT1X | metallothionein 1X | -0.025406 |
| APP | amyloid beta (A4) precursor protein | -0.025318 |
| IGF1R | insulin-like growth factor 1 receptor | -0.025201 |
| CCND1 | cyclin D1 | -0.0250184 |
| TMEM131 | transmembrane protein 131 | -0.0249283 |
| IGF2 | insulin-like growth factor 2 | -0.024587 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0244886 |
| SIN3A | SIN3 transcription regulator family member A | -0.0244658 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0242598 |
| TAGLN2 | transgelin 2 | -0.024127 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | -0.0239963 |
| RBL1 | retinoblastoma-like 1 | -0.0238255 |
| TMPO | thymopoietin | -0.0237649 |
| LDHB | lactate dehydrogenase B | -0.0237543 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0236212 |
| FOXJ3 | forkhead box J3 | -0.0235403 |
| CSE1L | CSE1 chromosome segregation 1-like (yeast) | -0.0234692 |
| SBF2 | SET binding factor 2 | -0.0234262 |
