Saquinavir_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Saquinavir perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Saquinavir_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.211478
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.112357
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.103747
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0828042
TPT1 tumor protein, translationally-controlled 1 0.0812229
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0773784
WSB1 WD repeat and SOCS box containing 1 0.0737715
RPLP0 ribosomal protein, large, P0 0.0683566
RPS8 ribosomal protein S8 0.0634815
RPS12 ribosomal protein S12 0.062606
SQSTM1 sequestosome 1 0.0611399
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0609301
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0582578
DSCAM Down syndrome cell adhesion molecule 0.0577734
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0565129
IFI6 interferon, alpha-inducible protein 6 0.0527455
RPS3 ribosomal protein S3 0.0513952
FAM13A family with sequence similarity 13, member A 0.0513816
GRB10 growth factor receptor-bound protein 10 0.0493619
BZW1 basic leucine zipper and W2 domains 1 0.0473846
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0453217
IFI16 interferon, gamma-inducible protein 16 0.0439221
PTK2 protein tyrosine kinase 2 0.0437765
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0420043
NAMPT nicotinamide phosphoribosyltransferase 0.0415959
RPS24 ribosomal protein S24 0.0414635
LAMC2 laminin, gamma 2 0.0414374
RPS27A ribosomal protein S27a 0.0413509
PGK1 phosphoglycerate kinase 1 0.0411974
FHIT fragile histidine triad 0.0400687
NAV2 neuron navigator 2 0.0399192
VIM vimentin 0.0393933
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0389277
LPP LIM domain containing preferred translocation partner in lipoma 0.0386867
LDHA lactate dehydrogenase A 0.0379911
EFNA5 ephrin-A5 0.0374549
RACK1 receptor for activated C kinase 1 0.0371291
SOX4 SRY (sex determining region Y)-box 4 0.0370272
SAMD4A sterile alpha motif domain containing 4A 0.0369599
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0362051
ZFP36L1 ZFP36 ring finger protein-like 1 0.0360613
SOD2 superoxide dismutase 2, mitochondrial 0.0354541
DSPP dentin sialophosphoprotein 0.0342416
DUSP6 dual specificity phosphatase 6 0.0341788
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0325059
HILPDA hypoxia inducible lipid droplet-associated 0.0307369
ARRDC3 arrestin domain containing 3 0.0303782
NAP1L1 nucleosome assembly protein 1-like 1 0.0302388
ZNF292 zinc finger protein 292 0.0299503
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0298294
RPL30 ribosomal protein L30 0.0298269
CSNK1A1 casein kinase 1, alpha 1 0.0297142
IFI27 interferon, alpha-inducible protein 27 0.0296689
FBXO32 F-box protein 32 0.0295829
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0294912
RPS25 ribosomal protein S25 0.0290808
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0287194
RYBP RING1 and YY1 binding protein 0.0283311
MX2 MX dynamin-like GTPase 2 0.0282298
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0282137
H1-0 H1.0 linker histone 0.0280359
NF1 neurofibromin 1 0.027939
TMSB4X thymosin beta 4, X-linked 0.0278183
RPL37A ribosomal protein L37a 0.0277948
HMGB2 high mobility group box 2 0.0276237
BAZ1A bromodomain adjacent to zinc finger domain, 1A 0.0275133
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0272989
SET SET nuclear proto-oncogene 0.0272897
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0270061
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0267343
PGBD5 piggyBac transposable element derived 5 0.0265635
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0265473
ENO1 enolase 1, (alpha) 0.0261644
IRF2BP2 interferon regulatory factor 2 binding protein 2 0.0260358
ATXN1 ataxin 1 0.0259396
CANX calnexin 0.0249926
RPS17 ribosomal protein S17 0.0249922
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0248894
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0248495
BBX bobby sox homolog (Drosophila) 0.0246812
RPL26 ribosomal protein L26 0.0244246
USP9X ubiquitin specific peptidase 9, X-linked 0.0243348
ITGAV integrin, alpha V 0.0243051
ARHGAP5 Rho GTPase activating protein 5 0.0241467
RAD51B RAD51 paralog B 0.0240654
AHNAK AHNAK nucleoprotein 0.0239594
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0235616
CTSS cathepsin S 0.0235221
ETV6 ets variant 6 0.0234895
NR1D2 nuclear receptor subfamily 1, group D, member 2 0.0233935
TNRC6B trinucleotide repeat containing 6B 0.0231906
ELL2 elongation factor, RNA polymerase II, 2 0.0231088
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.02308
LIMCH1 LIM and calponin homology domains 1 0.0230584
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0229495
OSMR oncostatin M receptor 0.0227187
MACF1 microtubule-actin crosslinking factor 1 0.0225176
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0222423
C6ORF62 chromosome 6 open reading frame 62 0.0221811
EXT1 exostosin glycosyltransferase 1 0.0221587

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.320928
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.254749
POTEF POTE ankyrin domain family, member F -0.164155
ACTG1 actin gamma 1 -0.150514
TMSB10 thymosin beta 10 -0.144149
FTL ferritin, light polypeptide -0.12155
NDRG1 N-myc downstream regulated 1 -0.102509
RPS23 ribosomal protein S23 -0.0688621
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0653352
ALCAM activated leukocyte cell adhesion molecule -0.0651858
HMGA1 high mobility group AT-hook 1 -0.0605438
LOC112694756 uncharaterized LOC112694756 -0.0555314
RPL8 ribosomal protein L8 -0.0540553
KRT7 keratin 7, type II -0.0538788
EEF2 eukaryotic translation elongation factor 2 -0.0493959
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0479966
RPS29 ribosomal protein S29 -0.0470369
RPL34 ribosomal protein L34 -0.0467573
WASF2 WAS protein family, member 2 -0.0460634
G0S2 G0/G1 switch 2 -0.0459442
SLC38A1 solute carrier family 38, member 1 -0.0456121
FAM3C family with sequence similarity 3, member C -0.042154
MYH9 myosin, heavy chain 9, non-muscle -0.0411684
GOLGA4 golgin A4 -0.0380186
CCNL1 cyclin L1 -0.0376923
AREG amphiregulin -0.0373768
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0373034
S100A10 S100 calcium binding protein A10 -0.0372115
RPL32 ribosomal protein L32 -0.0371452
MT2A metallothionein 2A -0.036218
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0359712
IFITM1 interferon induced transmembrane protein 1 -0.0350927
RNF145 ring finger protein 145 -0.0346271
MDK midkine (neurite growth-promoting factor 2) -0.0342592
RPLP2 ribosomal protein, large, P2 -0.0339978
TUBB4B tubulin, beta 4B class IVb -0.0338542
ITCH itchy E3 ubiquitin protein ligase -0.0334689
CDCP1 CUB domain containing protein 1 -0.033453
CLDN4 claudin 4 -0.0332331
HLA-B major histocompatibility complex, class I, B -0.0331257
ADAM9 ADAM metallopeptidase domain 9 -0.0330688
PLEC plectin -0.0329808
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0323818
RPS21 ribosomal protein S21 -0.0310045
LMAN1 lectin, mannose-binding, 1 -0.0309327
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.0309226
IGFBP3 insulin-like growth factor binding protein 3 -0.0304056
MKI67 marker of proliferation Ki-67 -0.0302789
EGR1 early growth response 1 -0.0294232
RPL5 ribosomal protein L5 -0.0286532
ACTN4 actinin, alpha 4 -0.0284116
ENO2 enolase 2 (gamma, neuronal) -0.0282169
RPS19 ribosomal protein S19 -0.027504
MAP4 microtubule-associated protein 4 -0.0274517
CCND1 cyclin D1 -0.0271087
RIOK3 RIO kinase 3 -0.02695
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0268155
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 -0.0268142
SDC4 syndecan 4 -0.0265573
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.0265426
KMT2E lysine (K)-specific methyltransferase 2E -0.026288
TFG TRK-fused gene -0.026216
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) -0.0260575
RPS15 ribosomal protein S15 -0.0259971
MARCHF6 membrane associated ring-CH-type finger 6 -0.0255052
TXNRD1 thioredoxin reductase 1 -0.0252736
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0252518
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0251451
CAPN2 calpain 2, (m/II) large subunit -0.0250534
RPS6 ribosomal protein S6 -0.0249131
EZR ezrin -0.0248712
UBE2H ubiquitin-conjugating enzyme E2H -0.0246935
TMEM165 transmembrane protein 165 -0.0246531
NDFIP1 Nedd4 family interacting protein 1 -0.024155
DEK DEK proto-oncogene -0.0240574
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 -0.0228502
VEGFA vascular endothelial growth factor A -0.0227717
ARHGAP29 Rho GTPase activating protein 29 -0.0227687
CALU calumenin -0.0220746
FOSL1 FOS-like antigen 1 -0.0219198
RBM39 RNA binding motif protein 39 -0.0217142
MEF2D myocyte enhancer factor 2D -0.0211969
RAB1A RAB1A, member RAS oncogene family -0.0211505
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0210878
S100A11 S100 calcium binding protein A11 -0.0209309
CLINT1 clathrin interactor 1 -0.0207675
RPL21 ribosomal protein L21 -0.0206215
RPL28 ribosomal protein L28 -0.0205657
DDX24 DEAD (Asp-Glu-Ala-Asp) box helicase 24 -0.020415
HSPB1 heat shock 27kDa protein 1 -0.0202429
TMOD3 tropomodulin 3 (ubiquitous) -0.0202279
PDLIM5 PDZ and LIM domain 5 -0.0200841
HDLBP high density lipoprotein binding protein -0.0199032
FLNB filamin B, beta -0.0196396
TXNIP thioredoxin interacting protein -0.0195373
KLF6 Kruppel-like factor 6 -0.0191197
FLNA filamin A, alpha -0.0189247
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0186663
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0186309
MXD1 MAX dimerization protein 1 -0.0185121