Saquinavir_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Saquinavir perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Saquinavir_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FNDC3B fibronectin type III domain containing 3B 0.144489
MACF1 microtubule-actin crosslinking factor 1 0.0951221
FMNL2 formin-like 2 0.0612934
CD44 CD44 molecule (Indian blood group) 0.0586065
DSCAM Down syndrome cell adhesion molecule 0.0582653
DST dystonin 0.056303
RORA RAR-related orphan receptor A 0.0562133
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0552108
TAS2R14 taste receptor, type 2, member 14 0.0546283
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0522945
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0513657
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0503399
BIRC6 baculoviral IAP repeat containing 6 0.0498155
DTNA dystrobrevin, alpha 0.0497631
TRIO trio Rho guanine nucleotide exchange factor 0.0485412
JMJD1C jumonji domain containing 1C 0.0467236
PRKCA protein kinase C, alpha 0.0457739
SVIL supervillin 0.0442678
RAD51B RAD51 paralog B 0.0442449
SMYD3 SET and MYND domain containing 3 0.0438518
ZBTB20 zinc finger and BTB domain containing 20 0.0428329
ITCH itchy E3 ubiquitin protein ligase 0.0420222
KLF12 Kruppel-like factor 12 0.0416841
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0389337
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0386633
MBNL2 muscleblind-like splicing regulator 2 0.0385539
DPYD dihydropyrimidine dehydrogenase 0.0385375
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0384141
ERRFI1 ERBB receptor feedback inhibitor 1 0.0374453
YAP1 Yes-associated protein 1 0.0363108
ARHGAP21 Rho GTPase activating protein 21 0.035984
SLC38A2 solute carrier family 38, member 2 0.035876
ELL2 elongation factor, RNA polymerase II, 2 0.0355037
WWOX WW domain containing oxidoreductase 0.0347288
LPP LIM domain containing preferred translocation partner in lipoma 0.0345743
BICD1 bicaudal D homolog 1 (Drosophila) 0.0345513
HMGA2 high mobility group AT-hook 2 0.034469
ASXL1 additional sex combs like transcriptional regulator 1 0.0344251
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0344231
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0332938
N4BP2L2 NEDD4 binding protein 2-like 2 0.0332251
ANO6 anoctamin 6 0.0332073
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0318015
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.0315934
ZEB1 zinc finger E-box binding homeobox 1 0.0312408
PRR16 proline rich 16 0.0309149
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0305973
PGK1 phosphoglycerate kinase 1 0.0304665
AK1 adenylate kinase 1 0.0301926
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase 0.0301049
RASAL2 RAS protein activator like 2 0.0295131
EXOC4 exocyst complex component 4 0.0291507
ATXN1 ataxin 1 0.0291083
SMAD3 SMAD family member 3 0.0290488
PBX3 pre-B-cell leukemia homeobox 3 0.0289632
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0288989
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0287105
NFE2L2 nuclear factor, erythroid 2-like 2 0.0280812
MBNL1 muscleblind-like splicing regulator 1 0.0278613
NAV2 neuron navigator 2 0.0276824
IFRD1 interferon-related developmental regulator 1 0.027649
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.0275727
USP34 ubiquitin specific peptidase 34 0.0275025
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0274652
TTC3 tetratricopeptide repeat domain 3 0.0273203
GPC6 glypican 6 0.0272208
KIAA1328 KIAA1328 0.0271482
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0270403
NALCN sodium leak channel, non selective 0.0268733
FNDC3A fibronectin type III domain containing 3A 0.0268232
SMC5 structural maintenance of chromosomes 5 0.0267297
DGKD diacylglycerol kinase, delta 130kDa 0.0264172
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0262036
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0261819
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0258525
TXNRD1 thioredoxin reductase 1 0.0254974
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0254393
FBXL17 F-box and leucine-rich repeat protein 17 0.0253993
ATP9B ATPase, class II, type 9B 0.0252772
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0251759
UBR2 ubiquitin protein ligase E3 component n-recognin 2 0.0250984
AFF4 AF4/FMR2 family, member 4 0.025091
AKAP12 A kinase (PRKA) anchor protein 12 0.0249499
NPAS2 neuronal PAS domain protein 2 0.0247447
CAPRIN2 caprin family member 2 0.0242742
ESYT2 extended synaptotagmin-like protein 2 0.024271
AKAP9 A kinase (PRKA) anchor protein 9 0.0241493
RDX radixin 0.0240751
CCDC88A coiled-coil domain containing 88A 0.023848
ATM ATM serine/threonine kinase 0.0237901
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0237242
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.0227472
CDK17 cyclin-dependent kinase 17 0.0225606
PHF3 PHD finger protein 3 0.02256
SAMD4A sterile alpha motif domain containing 4A 0.0225417
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0224074
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0223772
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.0219635
SEPTIN2 septin 2 0.0217284
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.0216546

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.254368
PTMA prothymosin, alpha -0.173098
TMSB10 thymosin beta 10 -0.0911682
TPT1 tumor protein, translationally-controlled 1 -0.0794864
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0675515
GNAS GNAS complex locus -0.0612185
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0561562
RPS8 ribosomal protein S8 -0.05388
UBC ubiquitin C -0.0530067
VIM vimentin -0.051619
OASL 2'-5'-oligoadenylate synthetase-like -0.0502914
RPLP1 ribosomal protein, large, P1 -0.0493429
RPS6 ribosomal protein S6 -0.0488943
RPS13 ribosomal protein S13 -0.0479415
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0465115
RPL31 ribosomal protein L31 -0.0442595
S100A9 S100 calcium binding protein A9 -0.0439874
RPL23 ribosomal protein L23 -0.0433621
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0424786
DEK DEK proto-oncogene -0.0424223
RPS23 ribosomal protein S23 -0.0420517
RPS27A ribosomal protein S27a -0.0398694
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0394614
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.039165
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0385088
EEF2 eukaryotic translation elongation factor 2 -0.037539
RPL27A ribosomal protein L27a -0.03734
ENO2 enolase 2 (gamma, neuronal) -0.0368488
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0364456
POTEF POTE ankyrin domain family, member F -0.0363807
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0356679
RPS3 ribosomal protein S3 -0.0355822
FTL ferritin, light polypeptide -0.0348886
RPL26 ribosomal protein L26 -0.0346905
RPL37 ribosomal protein L37 -0.0339773
RPS25 ribosomal protein S25 -0.0338739
EGR1 early growth response 1 -0.0333782
RPS29 ribosomal protein S29 -0.0332568
PCBP2 poly(rC) binding protein 2 -0.0332064
RPL35A ribosomal protein L35a -0.0331172
PNISR PNN-interacting serine/arginine-rich protein -0.0329341
H3-3B H3.3 histone B -0.0329285
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0317552
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0313596
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0310018
RPL36 ribosomal protein L36 -0.0307543
RPL4 ribosomal protein L4 -0.0304682
RPL37A ribosomal protein L37a -0.0298151
RPL19 ribosomal protein L19 -0.0297104
TPX2 TPX2, microtubule-associated -0.029563
RPS16 ribosomal protein S16 -0.0294034
PKM pyruvate kinase, muscle -0.0293888
RPS15 ribosomal protein S15 -0.0292253
IFITM3 interferon induced transmembrane protein 3 -0.0285347
LOC102724023 ES1 protein homolog, mitochondrial -0.0284089
SAFB scaffold attachment factor B -0.0279368
ENO1 enolase 1, (alpha) -0.0274273
CELF1 CUGBP, Elav-like family member 1 -0.0269176
B2M beta-2-microglobulin -0.0265087
RPS17 ribosomal protein S17 -0.0265073
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0264442
RPS21 ribosomal protein S21 -0.0263067
AUH AU RNA binding protein/enoyl-CoA hydratase -0.0259675
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0257357
AOPEP aminopeptidase O (putative) -0.0257313
RIGI RNA sensor RIG-I -0.0257048
TUBB4B tubulin, beta 4B class IVb -0.0255759
RPL34 ribosomal protein L34 -0.0252713
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0252377
RBM27 RNA binding motif protein 27 -0.0250675
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0250546
RPL12 ribosomal protein L12 -0.0245978
RPL5 ribosomal protein L5 -0.0245813
CHSY1 chondroitin sulfate synthase 1 -0.0245187
CALU calumenin -0.0239484
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0238587
NAMPT nicotinamide phosphoribosyltransferase -0.0235956
RPLP0 ribosomal protein, large, P0 -0.0233709
HLA-B major histocompatibility complex, class I, B -0.0232808
SCFD1 sec1 family domain containing 1 -0.0230937
OPTN optineurin -0.0228936
RPS10 ribosomal protein S10 -0.0228602
EIF4A1 eukaryotic translation initiation factor 4A1 -0.022772
S100A10 S100 calcium binding protein A10 -0.022583
KHSRP KH-type splicing regulatory protein -0.0225725
KIF20B kinesin family member 20B -0.0224298
DLG1 discs, large homolog 1 (Drosophila) -0.022329
RPL32 ribosomal protein L32 -0.0221112
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0220968
YBX1 Y box binding protein 1 -0.0219705
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0219115
NOL7 nucleolar protein 7, 27kDa -0.0219054
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0218429
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 -0.0217783
NF1 neurofibromin 1 -0.021769
WDR43 WD repeat domain 43 -0.0213764
RAB7A RAB7A, member RAS oncogene family -0.0213616
TRIM5 tripartite motif containing 5 -0.021189
IER3 immediate early response 3 -0.0211061
RPL28 ribosomal protein L28 -0.0210765