Saquinavir_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Saquinavir perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Saquinavir_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EXT1 exostosin glycosyltransferase 1 0.142852
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0655696
FNDC3B fibronectin type III domain containing 3B 0.0642949
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0634485
VCL vinculin 0.0622361
ZSWIM6 zinc finger, SWIM-type containing 6 0.0584978
NPAS2 neuronal PAS domain protein 2 0.0546909
FNDC3A fibronectin type III domain containing 3A 0.0536962
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0469771
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0455047
TOP1 topoisomerase (DNA) I 0.0451996
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0449125
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0448489
ANKRD28 ankyrin repeat domain 28 0.04432
ELL2 elongation factor, RNA polymerase II, 2 0.044093
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0400242
BIRC6 baculoviral IAP repeat containing 6 0.0383328
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0381708
GLIS3 GLIS family zinc finger 3 0.0381149
GRB10 growth factor receptor-bound protein 10 0.0360539
NTN4 netrin 4 0.0359072
ATXN1 ataxin 1 0.0356196
KSR1 kinase suppressor of ras 1 0.0350389
CSNK1A1 casein kinase 1, alpha 1 0.0341799
SVIL supervillin 0.0332687
PDLIM5 PDZ and LIM domain 5 0.0329837
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0323781
SIK3 SIK family kinase 3 0.0321224
INTS6 integrator complex subunit 6 0.0321094
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0319905
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0317871
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0316555
SMAD3 SMAD family member 3 0.0309009
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0307327
CLIP2 CAP-GLY domain containing linker protein 2 0.0306706
NFE2L2 nuclear factor, erythroid 2-like 2 0.0303638
RAB10 RAB10, member RAS oncogene family 0.0295897
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0295394
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0291726
ERBIN erbb2 interacting protein 0.0290432
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0286931
DSCAM Down syndrome cell adhesion molecule 0.0282906
EFNA5 ephrin-A5 0.0282339
PALLD palladin, cytoskeletal associated protein 0.0281775
ATF6 activating transcription factor 6 0.0278929
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0271906
SOD2 superoxide dismutase 2, mitochondrial 0.0267292
FHL2 four and a half LIM domains 2 0.0266754
SEPTIN9 septin 9 0.0264977
WWTR1 WW domain containing transcription regulator 1 0.0264637
KMT2E lysine (K)-specific methyltransferase 2E 0.0259531
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0259385
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0258149
IL6ST interleukin 6 signal transducer 0.0257583
OSMR oncostatin M receptor 0.0255553
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0255453
COPA coatomer protein complex, subunit alpha 0.0253416
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0250969
LTBP1 latent transforming growth factor beta binding protein 1 0.0250619
SDC2 syndecan 2 0.0249744
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 0.0249496
DOCK5 dedicator of cytokinesis 5 0.024577
NXN nucleoredoxin 0.0245455
MACF1 microtubule-actin crosslinking factor 1 0.024306
FBXW11 F-box and WD repeat domain containing 11 0.0240848
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 0.0239836
RBMS1 RNA binding motif, single stranded interacting protein 1 0.0239434
RUNX1 runt-related transcription factor 1 0.0237869
GPC6 glypican 6 0.0234601
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0231716
SMYD3 SET and MYND domain containing 3 0.023041
AOPEP aminopeptidase O (putative) 0.0228517
LOXL2 lysyl oxidase-like 2 0.022849
TTC3 tetratricopeptide repeat domain 3 0.0226165
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0224736
SHB Src homology 2 domain containing adaptor protein B 0.0223945
RAB31 RAB31, member RAS oncogene family 0.0223273
ABLIM1 actin binding LIM protein 1 0.0222529
ENAH enabled homolog (Drosophila) 0.0221463
GPATCH2L G patch domain containing 2-like 0.0218198
SIRT1 sirtuin 1 0.0216789
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0214542
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.0212659
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.021105
DUSP5 dual specificity phosphatase 5 0.0210855
SHOC2 soc-2 suppressor of clear homolog (C. elegans) 0.0210246
TPR translocated promoter region, nuclear basket protein 0.0209373
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0208896
SMOC1 SPARC related modular calcium binding 1 0.0208585
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0208126
ATOSA atos homolog A 0.0207914
FOXP1 forkhead box P1 0.0206916
TNRC6B trinucleotide repeat containing 6B 0.0206675
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.0205631
AGO2 argonaute RISC catalytic component 2 0.020522
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0205131
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.020447
ETNK1 ethanolamine kinase 1 0.0204013
PELO pelota homolog (Drosophila) 0.02028
PELI1 pellino E3 ubiquitin protein ligase 1 0.0201837

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.250288
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.215111
NRG1 neuregulin 1 -0.155148
PTMA prothymosin, alpha -0.147768
IFI27 interferon, alpha-inducible protein 27 -0.117521
P4HB prolyl 4-hydroxylase, beta polypeptide -0.110752
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.102052
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0999046
TMSB10 thymosin beta 10 -0.0956072
S100A6 S100 calcium binding protein A6 -0.091422
HLA-B major histocompatibility complex, class I, B -0.0863996
AKAP12 A kinase (PRKA) anchor protein 12 -0.0800711
ENO1 enolase 1, (alpha) -0.0793037
STC2 stanniocalcin 2 -0.0759309
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0692565
MAP1B microtubule-associated protein 1B -0.0677587
POTEF POTE ankyrin domain family, member F -0.0673942
UBC ubiquitin C -0.0658822
TMEM156 transmembrane protein 156 -0.062458
HMGA2 high mobility group AT-hook 2 -0.0614957
TMSB4X thymosin beta 4, X-linked -0.061222
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0586919
ITGA1 integrin, alpha 1 -0.0578844
B2M beta-2-microglobulin -0.0559606
ACTG1 actin gamma 1 -0.0558182
VEGFA vascular endothelial growth factor A -0.051544
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0498752
PKM pyruvate kinase, muscle -0.0497444
SQSTM1 sequestosome 1 -0.047817
SYT1 synaptotagmin I -0.047607
KLHL5 kelch-like family member 5 -0.047524
HMGA1 high mobility group AT-hook 1 -0.0472349
TMEM165 transmembrane protein 165 -0.0469894
LOC112694756 uncharaterized LOC112694756 -0.0469286
RPS27A ribosomal protein S27a -0.0455718
ZFP36L1 ZFP36 ring finger protein-like 1 -0.044044
RPS19 ribosomal protein S19 -0.0427254
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0420441
PLIN2 perilipin 2 -0.0419299
PDIA3 protein disulfide isomerase family A, member 3 -0.0413876
MRPS6 mitochondrial ribosomal protein S6 -0.0402583
TFPI2 tissue factor pathway inhibitor 2 -0.0401861
RPS6 ribosomal protein S6 -0.0399486
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0394868
SOX4 SRY (sex determining region Y)-box 4 -0.0392561
PRRC2C proline-rich coiled-coil 2C -0.039111
HLA-A major histocompatibility complex, class I, A -0.039017
RPS21 ribosomal protein S21 -0.0389429
RPL35A ribosomal protein L35a -0.0382365
SFTPA2 surfactant protein A2 -0.0378008
HDGF hepatoma-derived growth factor -0.0374736
RPL31 ribosomal protein L31 -0.0371892
DNAH5 dynein, axonemal, heavy chain 5 -0.0364552
HIPK2 homeodomain interacting protein kinase 2 -0.0363953
S100A10 S100 calcium binding protein A10 -0.0361646
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0356971
AHNAK AHNAK nucleoprotein -0.0356041
CALU calumenin -0.0351002
TM4SF1 transmembrane 4 L six family member 1 -0.0349605
RPS27 ribosomal protein S27 -0.0348602
MT2A metallothionein 2A -0.034769
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.034525
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0341067
CANX calnexin -0.0338783
EEF2 eukaryotic translation elongation factor 2 -0.0336849
CD63 CD63 molecule -0.0334311
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0332326
TPI1 triosephosphate isomerase 1 -0.0331125
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0330393
ENO2 enolase 2 (gamma, neuronal) -0.0316991
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0316921
MYOF myoferlin -0.0316258
LOC102724023 ES1 protein homolog, mitochondrial -0.0306227
FTH1 ferritin, heavy polypeptide 1 -0.030116
RPL28 ribosomal protein L28 -0.0299591
RPS5 ribosomal protein S5 -0.0296464
TRIO trio Rho guanine nucleotide exchange factor -0.0292516
FOSL1 FOS-like antigen 1 -0.0291847
IGFBP3 insulin-like growth factor binding protein 3 -0.0290089
CENPF centromere protein F, 350/400kDa -0.0288673
RPS23 ribosomal protein S23 -0.0278831
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0277645
RPL34 ribosomal protein L34 -0.0276048
RPS8 ribosomal protein S8 -0.027424
CCND1 cyclin D1 -0.0269532
RPL8 ribosomal protein L8 -0.0266317
CYBA cytochrome b-245, alpha polypeptide -0.0260346
RAI14 retinoic acid induced 14 -0.0259263
FTL ferritin, light polypeptide -0.0257989
LY6E lymphocyte antigen 6 complex, locus E -0.0255533
FDPS farnesyl diphosphate synthase -0.0255359
CALR calreticulin -0.0254949
SFRP1 secreted frizzled-related protein 1 -0.025388
DDX24 DEAD (Asp-Glu-Ala-Asp) box helicase 24 -0.0253044
BASP1 brain abundant, membrane attached signal protein 1 -0.0251164
ZMYND8 zinc finger, MYND-type containing 8 -0.0250352
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0244515
S100A9 S100 calcium binding protein A9 -0.0244499
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0244225
RACK1 receptor for activated C kinase 1 -0.0242396