Schizophrenia Gene Set

Dataset dbGAP Gene-Trait Associations
Category disease or phenotype associations
Type trait
Description A major psychotic disorder characterized by abnormalities in the perception or expression of reality. It affects the cognitive and psychomotor functions. Common clinical signs and symptoms include delusions, hallucinations, disorganized thinking, and retreat from reality.|A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, HALLUCINATIONS, emotional disharmony, and regressive behavior. (Experimental Factor Ontology, EFO_0000692)
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Genes

82 genes associated with the trait Schizophrenia in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.

Symbol Name Standardized Value
TRIM26 tripartite motif containing 26 1.0562
NKAPL NFKB activating protein-like 1.02473
TSPAN18 tetraspanin 18 1.01477
LSM1 LSM1, U6 small nuclear RNA associated 0.944178
NOTCH4 notch 4 0.922056
TCF4 transcription factor 4 0.807263
MPC2 mitochondrial pyruvate carrier 2 0.763999
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 0.731179
CSMD1 CUB and Sushi multiple domains 1 0.731179
NT5C2 5'-nucleotidase, cytosolic II 0.711358
SDCCAG8 serologically defined colon cancer antigen 8 0.685324
ITIH4 inter-alpha-trypsin inhibitor heavy chain family, member 4 0.67572
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.64828
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.609816
ZNF804A zinc finger protein 804A 0.609816
RELN reelin 0.50886
CCDC60 coiled-coil domain containing 60 0.50084
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic) 0.50084
FAM69A family with sequence similarity 69, member A 0.497798
PLAA phospholipase A2-activating protein 0.443956
CALN1 calneuron 1 0.443956
PTPRG protein tyrosine phosphatase, receptor type, G 0.443956
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 0.443956
AGBL1 ATP/GTP binding protein-like 1 0.443956
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) 0.435233
ACSM1 acyl-CoA synthetase medium-chain family member 1 0.406869
RUNDC3B RUN domain containing 3B 0.406869
RERE arginine-glutamic acid dipeptide (RE) repeats 0.406869
PLCB2 phospholipase C, beta 2 0.406869
MSRA methionine sulfoxide reductase A 0.378873
RNLS renalase, FAD-dependent amine oxidase 0.366472
TRAF3 TNF receptor-associated factor 3 0.356676
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.356676
ERBB4 erb-b2 receptor tyrosine kinase 4 0.354498
TNIK TRAF2 and NCK interacting kinase 0.33862
SHISA9 shisa family member 9 0.33862
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.33862
RPL5 ribosomal protein L5 0.318735
CBX2 chromobox homolog 2 0.294905
KIAA0391 KIAA0391 0.280395
NALCN sodium leak channel, non selective 0.264819
PPP1R36 protein phosphatase 1, regulatory subunit 36 0.246291
SMARCAD1 SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1 0.242118
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor 0.242118
OPCML opioid binding protein/cell adhesion molecule-like 0.226067
CDH13 cadherin 13 0.221103
SLC35A5 solute carrier family 35, member A5 0.202915
NRG1 neuregulin 1 0.199315
TC2N tandem C2 domains, nuclear 0.198924
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.182006
KMT2C lysine (K)-specific methyltransferase 2C 0.17671
ANKRD11 ankyrin repeat domain 11 0.173256
CAPN14 calpain 14 0.171576
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31 0.167665
BTLA B and T lymphocyte associated 0.167029
PGPEP1 pyroglutamyl-peptidase I 0.161199
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.157131
SPTBN1 spectrin, beta, non-erythrocytic 1 0.153785
GTF3C4 general transcription factor IIIC, polypeptide 4, 90kDa 0.153511
KDM4C lysine (K)-specific demethylase 4C 0.149441
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 0.140513
ELP3 elongator acetyltransferase complex subunit 3 0.138406
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.131621
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1 0.128991
KYNU kynureninase 0.128991
NREP neuronal regeneration related protein 0.128991
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein 0.127124
HPGDS hematopoietic prostaglandin D synthase 0.126433
ARSG arylsulfatase G 0.125748
CERCAM cerebral endothelial cell adhesion molecule 0.125067
CCDC13 coiled-coil domain containing 13 0.111476
MACROD2 MACRO domain containing 2 0.104855
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.102995
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2 0.092657
WWOX WW domain containing oxidoreductase 0.08923
ANO3 anoctamin 3 0.07985
NRCAM neuronal cell adhesion molecule 0.067999
PRMT7 protein arginine methyltransferase 7 0.067633
EMC2 ER membrane protein complex subunit 2 0.065921
CCSER1 coiled-coil serine-rich protein 1 0.063303
FHIT fragile histidine triad 0.059235
NINJ2 ninjurin 2 0.058196