Scoliosis Gene Set

Dataset DISEASES Experimental Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
Description An appreciable lateral deviation in the normally straight vertical line of the spine. (Dorland, 27th ed) (Experimental Factor Ontology, EFO_0004273)
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Genes

84 genes associated with the disease Scoliosis in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
LBX1 ladybird homeobox 1 1.993
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 1.986
ADGRG6 adhesion G protein-coupled receptor G6 1.986
BNC2 basonuclin 2 1.962
CDH13 cadherin 13 1.86
MEIS1 Meis homeobox 1 1.646
KDSR 3-ketodihydrosphingosine reductase 1.586
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 1.586
BCL2 B-cell CLL/lymphoma 2 1.586
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1 1.566
TNIK TRAF2 and NCK interacting kinase 1.498
TLX1 T-cell leukemia homeobox 1 1.428
IBA57 IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae) 1.379
C1ORF35 chromosome 1 open reading frame 35 1.379
GUK1 guanylate kinase 1 1.379
GJC2 gap junction protein, gamma 2, 47kDa 1.379
WNT3A wingless-type MMTV integration site family, member 3A 1.379
ARF1 ADP-ribosylation factor 1 1.379
MRPL55 mitochondrial ribosomal protein L55 1.379
NKX6-1 NK6 homeobox 1 1.365
CNTFR ciliary neurotrophic factor receptor 1.34
GALT galactose-1-phosphate uridylyltransferase 1.34
DNAI1 dynein, axonemal, intermediate chain 1 1.34
IL11RA interleukin 11 receptor, alpha 1.34
BOLA1 bolA family member 1 1.34
MTMR11 myotubularin related protein 11 1.34
ARID3C AT rich interactive domain 3C (BRIGHT-like) 1.34
H2AC20 H2A clustered histone 20 1.34
SF3B4 splicing factor 3b, subunit 4, 49kDa 1.34
RPP25L ribonuclease P/MRP 25kDa subunit-like 1.34
H3C14 H3 clustered histone 14 1.34
H3C15 H3 clustered histone 15 1.34
H2BC21 H2B clustered histone 21 1.34
OTUD7B OTU deubiquitinase 7B 1.34
SV2A synaptic vesicle glycoprotein 2A 1.34
DCTN3 dynactin 3 (p22) 1.34
PHF24 PHD finger protein 24 1.34
H4C14 H4 clustered histone 14 1.34
H4C15 H4 clustered histone 15 1.34
CCL27 chemokine (C-C motif) ligand 27 1.34
SIGMAR1 sigma non-opioid intracellular receptor 1 1.34
ENHO energy homeostasis associated 1.34
H2AC21 H2A clustered histone 21 1.34
MED22 mediator complex subunit 22 1.275
RPL7A ribosomal protein L7a 1.275
OBP2B odorant binding protein 2B 1.275
GBGT1 globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 1.275
SURF6 surfeit 6 1.275
SURF4 surfeit 4 1.275
SURF2 surfeit 2 1.275
SURF1 surfeit 1 1.275
SEPTIN5 septin 5 1.256
RTL10 retrotransposon Gag like 10 1.256
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like 1.256
GP1BB glycoprotein Ib (platelet), beta polypeptide 1.256
TBX1 T-box 1 1.256
CSMD1 CUB and Sushi multiple domains 1 1.244
KIF24 kinesin family member 24 1.156
NUDT2 nudix (nucleoside diphosphate linked moiety X)-type motif 2 1.156
MYORG myogenesis regulating glycosidase (putative) 1.156
FAM219A family with sequence similarity 219, member A 1.156
UBAP1 ubiquitin associated protein 1 1.156
CFAP44 cilia and flagella associated protein 44 1.145
BOC BOC cell adhesion associated, oncogene regulated 1.145
SEC16B SEC16 homolog B (S. cerevisiae) 1.058
CREB5 cAMP responsive element binding protein 5 1.043
TRIL TLR4 interactor with leucine-rich repeats 1.043
SOX6 SRY (sex determining region Y)-box 6 1.034
NT5DC1 5'-nucleotidase domain containing 1 1.005
COL10A1 collagen, type X, alpha 1 1.005
FRK fyn-related Src family tyrosine kinase 1.005
PLXNA2 plexin A2 0.985
FTO fat mass and obesity associated 0.929
RPGRIP1L RPGRIP1-like 0.929
TENT5A terminal nucleotidyltransferase 5A 0.575
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide 0.558
ZFAND2A zinc finger, AN1-type domain 2A 0.548
UNCX UNC homeobox 0.548
SH2D1B SH2 domain containing 1B 0.526
UHMK1 U2AF homology motif (UHM) kinase 1 0.526
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.526
C1ORF226 chromosome 1 open reading frame 226 0.526
MEOX2 mesenchyme homeobox 2 0.511
AGMO alkylglycerol monooxygenase 0.511