Selinexor _A498 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Selinexor perturbation in A498 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Selinexor _A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FRMD4A FERM domain containing 4A 0.166826
PCLO piccolo presynaptic cytomatrix protein 0.148571
IGFBP3 insulin-like growth factor binding protein 3 0.138223
VIM vimentin 0.108726
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.067079
RND3 Rho family GTPase 3 0.062742
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0434365
CA12 carbonic anhydrase XII 0.0421106
GOLGB1 golgin B1 0.0362456
EXT1 exostosin glycosyltransferase 1 0.0354099
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0343994
NDRG1 N-myc downstream regulated 1 0.0339708
CP ceruloplasmin (ferroxidase) 0.0335736
IFI44L interferon-induced protein 44-like 0.0322197
MYADM myeloid-associated differentiation marker 0.0314254
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0314202
VMP1 vacuole membrane protein 1 0.0304343
PLIN2 perilipin 2 0.0300761
XPO1 exportin 1 0.0288524
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0287137
TXNRD1 thioredoxin reductase 1 0.0278392
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0276957
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0276331
GPC5 glypican 5 0.027628
HM13 histocompatibility (minor) 13 0.0271625
SEC31A SEC31 homolog A (S. cerevisiae) 0.0270857
HDAC9 histone deacetylase 9 0.0269587
AKAP9 A kinase (PRKA) anchor protein 9 0.0261543
MBNL2 muscleblind-like splicing regulator 2 0.0258834
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0257758
TPM4 tropomyosin 4 0.0253593
OPTN optineurin 0.0246941
CALR calreticulin 0.0244222
APOL1 apolipoprotein L, 1 0.0242505
SEPTIN9 septin 9 0.0237334
PDIA3 protein disulfide isomerase family A, member 3 0.0234111
FAM114A1 family with sequence similarity 114, member A1 0.0230882
TMED2 transmembrane emp24 domain trafficking protein 2 0.0228587
LYST lysosomal trafficking regulator 0.022595
MYOF myoferlin 0.0223814
FTH1 ferritin, heavy polypeptide 1 0.0220674
LDHA lactate dehydrogenase A 0.021709
ANXA2 annexin A2 0.0217073
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0216127
RNF213 ring finger protein 213 0.0215436
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0214399
DOCK5 dedicator of cytokinesis 5 0.0207181
SLC39A11 solute carrier family 39, member 11 0.0199945
SMYD3 SET and MYND domain containing 3 0.0199421
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0198119
PDIA6 protein disulfide isomerase family A, member 6 0.0197149
ZCCHC7 zinc finger, CCHC domain containing 7 0.0190951
FNIP1 folliculin interacting protein 1 0.0190267
SPTY2D1 SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae) 0.0188376
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0182514
HLA-E major histocompatibility complex, class I, E 0.0181833
ZBTB20 zinc finger and BTB domain containing 20 0.0178381
ATF3 activating transcription factor 3 0.0178055
BPTF bromodomain PHD finger transcription factor 0.0176218
NFE2L1 nuclear factor, erythroid 2-like 1 0.0173196
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0173059
EHBP1 EH domain binding protein 1 0.0172214
SP100 SP100 nuclear antigen 0.0169285
MCL1 myeloid cell leukemia 1 0.0167853
ANXA4 annexin A4 0.0166913
CD44 CD44 molecule (Indian blood group) 0.0162773
EGR1 early growth response 1 0.016193
ACBD3 acyl-CoA binding domain containing 3 0.0160588
SKAP2 src kinase associated phosphoprotein 2 0.0159742
MLF1 myeloid leukemia factor 1 0.0158513
ESYT2 extended synaptotagmin-like protein 2 0.0155426
ARRDC3 arrestin domain containing 3 0.0154997
TTC3 tetratricopeptide repeat domain 3 0.0154807
TPM3 tropomyosin 3 0.0152944
PDE4D phosphodiesterase 4D, cAMP-specific 0.015224
IFITM1 interferon induced transmembrane protein 1 0.0150728
BLZF1 basic leucine zipper nuclear factor 1 0.0150276
PCBP3 poly(rC) binding protein 3 0.0148888
NBEAL1 neurobeachin-like 1 0.014819
ANO10 anoctamin 10 0.0148059
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0147634
UMAD1 UBAP1-MVB12-associated (UMA) domain containing 1 0.0147408
FAM13A family with sequence similarity 13, member A 0.014717
UBC ubiquitin C 0.0145966
CDCP1 CUB domain containing protein 1 0.0145948
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0145238
PGM3 phosphoglucomutase 3 0.0144586
STK32A serine/threonine kinase 32A 0.0144094
UBAP2 ubiquitin associated protein 2 0.0143992
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0143515
LOXL2 lysyl oxidase-like 2 0.0142526
CCNG2 cyclin G2 0.0142236
CD68 CD68 molecule 0.0142191
RNF150 ring finger protein 150 0.014128
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A 0.013929
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.013844
MYO1E myosin IE 0.0137896
SLC16A4 solute carrier family 16, member 4 0.0137316
KATNIP katanin interacting protein 0.0136583
PLSCR1 phospholipid scramblase 1 0.0134641

decreased expression

Symbol Name Standardized Value
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0891617
ATP13A3 ATPase type 13A3 -0.0821198
FTL ferritin, light polypeptide -0.0732346
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0650722
ASPH aspartate beta-hydroxylase -0.0628003
CADM1 cell adhesion molecule 1 -0.0601353
PTBP3 polypyrimidine tract binding protein 3 -0.0594935
TMSB10 thymosin beta 10 -0.0588055
PRRC2C proline-rich coiled-coil 2C -0.0575051
CCL2 chemokine (C-C motif) ligand 2 -0.0504455
SPAG9 sperm associated antigen 9 -0.0500951
TRIO trio Rho guanine nucleotide exchange factor -0.0493147
GPC6 glypican 6 -0.0476428
PTK2 protein tyrosine kinase 2 -0.0473344
NAP1L1 nucleosome assembly protein 1-like 1 -0.0463657
POTEF POTE ankyrin domain family, member F -0.0456636
QKI QKI, KH domain containing, RNA binding -0.0431033
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0422739
PALS2 protein associated with LIN7 2, MAGUK p55 family member -0.0417256
ALCAM activated leukocyte cell adhesion molecule -0.0416042
ANKRD33B ankyrin repeat domain 33B -0.0405382
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0396401
MARCHF6 membrane associated ring-CH-type finger 6 -0.0395799
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.039304
GLS2 glutaminase 2 (liver, mitochondrial) -0.0388056
USP3 ubiquitin specific peptidase 3 -0.0385375
NAMPT nicotinamide phosphoribosyltransferase -0.0384448
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 -0.038424
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0379102
OSBPL3 oxysterol binding protein-like 3 -0.0375365
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0375346
TSHZ2 teashirt zinc finger homeobox 2 -0.0369502
ZFAND3 zinc finger, AN1-type domain 3 -0.0365346
RBM39 RNA binding motif protein 39 -0.0364769
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0358015
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0352393
FMNL2 formin-like 2 -0.0338681
KMT2C lysine (K)-specific methyltransferase 2C -0.0334444
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 -0.0333194
G0S2 G0/G1 switch 2 -0.0332699
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0330768
CXCL3 chemokine (C-X-C motif) ligand 3 -0.0328409
RPL23 ribosomal protein L23 -0.0327884
CD70 CD70 molecule -0.0324497
GDF15 growth differentiation factor 15 -0.0321609
PTPRJ protein tyrosine phosphatase, receptor type, J -0.0321587
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta -0.0318509
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0315024
CSF1 colony stimulating factor 1 (macrophage) -0.0314213
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0312506
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0308824
ANKRD11 ankyrin repeat domain 11 -0.0306619
RHEB Ras homolog enriched in brain -0.0302204
DENND4A DENN/MADD domain containing 4A -0.0300366
CXCL2 chemokine (C-X-C motif) ligand 2 -0.0297984
TSC22D2 TSC22 domain family, member 2 -0.0295262
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -0.0294037
NRIP1 nuclear receptor interacting protein 1 -0.0292134
GARS1 glycyl-tRNA synthetase 1 -0.0290162
HLA-B major histocompatibility complex, class I, B -0.02898
DENND2B DENN domain containing 2B -0.0287566
KMT2E lysine (K)-specific methyltransferase 2E -0.0285814
SRPK2 SRSF protein kinase 2 -0.0285589
WAC WW domain containing adaptor with coiled-coil -0.0283861
RPS24 ribosomal protein S24 -0.0281799
RAD21 RAD21 homolog (S. pombe) -0.0280152
ANKRD10 ankyrin repeat domain 10 -0.0278487
OLA1 Obg-like ATPase 1 -0.0274963
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0273827
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0269822
SMG7 SMG7 nonsense mediated mRNA decay factor -0.0268312
ARHGAP26 Rho GTPase activating protein 26 -0.026781
PTMA prothymosin, alpha -0.0267635
VCAM1 vascular cell adhesion molecule 1 -0.0267569
UGCG UDP-glucose ceramide glucosyltransferase -0.0267469
JAK1 Janus kinase 1 -0.0264969
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -0.0264338
TPT1 tumor protein, translationally-controlled 1 -0.0263424
UBE2G1 ubiquitin-conjugating enzyme E2G 1 -0.0257621
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.025718
KLF10 Kruppel-like factor 10 -0.0256382
WDR43 WD repeat domain 43 -0.0255518
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -0.0255014
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0251113
RPS19 ribosomal protein S19 -0.0250607
DLG1 discs, large homolog 1 (Drosophila) -0.0249525
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.0249242
AZIN1 antizyme inhibitor 1 -0.0247689
MORF4L2 mortality factor 4 like 2 -0.0247142
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0246389
NPEPPS aminopeptidase puromycin sensitive -0.0246205
MARCKS myristoylated alanine-rich protein kinase C substrate -0.024618
RPS6 ribosomal protein S6 -0.0245999
ICAM1 intercellular adhesion molecule 1 -0.0244775
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0244507
ECT2 epithelial cell transforming 2 -0.0243207
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0242685
ABTB3 ankyrin repeat and BTB domain containing 3 -0.0242139
RPL35A ribosomal protein L35a -0.0241659
CHD1 chromodomain helicase DNA binding protein 1 -0.0240406