| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Selinexor perturbation in A549 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Selinexor _A549 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0914688 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.0612738 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0459362 |
| XPO1 | exportin 1 | 0.0418218 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0185618 |
| FAT1 | FAT atypical cadherin 1 | 0.0166829 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0166357 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0156168 |
| ANTXR1 | anthrax toxin receptor 1 | 0.0150293 |
| GPHN | gephyrin | 0.0137375 |
| PGM2L1 | phosphoglucomutase 2-like 1 | 0.0137228 |
| RNF150 | ring finger protein 150 | 0.0134352 |
| CXCL3 | chemokine (C-X-C motif) ligand 3 | 0.0133365 |
| ARL15 | ADP-ribosylation factor-like 15 | 0.0118926 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0116875 |
| SOCS5 | suppressor of cytokine signaling 5 | 0.011622 |
| SPPL3 | signal peptide peptidase like 3 | 0.0114941 |
| DNAH14 | dynein, axonemal, heavy chain 14 | 0.0114935 |
| SDC4 | syndecan 4 | 0.0114859 |
| ATF7IP2 | activating transcription factor 7 interacting protein 2 | 0.0114857 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0113111 |
| ASTN2 | astrotactin 2 | 0.0111078 |
| NGFR | nerve growth factor receptor | 0.0110055 |
| GNAI1 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | 0.0109049 |
| XPC | xeroderma pigmentosum, complementation group C | 0.0107699 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0106217 |
| FBN2 | fibrillin 2 | 0.0105955 |
| FDXR | ferredoxin reductase | 0.0104607 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | 0.0100328 |
| NOP56 | NOP56 ribonucleoprotein | 0.00988859 |
| PLK2 | polo-like kinase 2 | 0.00968882 |
| ARRDC3 | arrestin domain containing 3 | 0.0095527 |
| CADM1 | cell adhesion molecule 1 | 0.00946826 |
| HSPA4L | heat shock 70kDa protein 4-like | 0.00943561 |
| GALNT18 | polypeptide N-acetylgalactosaminyltransferase 18 | 0.00923069 |
| ZNF337 | zinc finger protein 337 | 0.00920269 |
| CSNK1G1 | casein kinase 1, gamma 1 | 0.00902561 |
| PLCL2 | phospholipase C-like 2 | 0.00872182 |
| SLC30A1 | solute carrier family 30 (zinc transporter), member 1 | 0.00864756 |
| CYFIP2 | cytoplasmic FMR1 interacting protein 2 | 0.0084114 |
| SPECC1 | sperm antigen with calponin homology and coiled-coil domains 1 | 0.00839967 |
| FHIT | fragile histidine triad | 0.00819854 |
| PREPL | prolyl endopeptidase-like | 0.00811949 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0080523 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | 0.0079909 |
| METTL8 | methyltransferase like 8 | 0.00796034 |
| ATF3 | activating transcription factor 3 | 0.00795524 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.00793894 |
| GAREM1 | GRB2 associated regulator of MAPK1 subtype 1 | 0.00781248 |
| PPM1D | protein phosphatase, Mg2+/Mn2+ dependent, 1D | 0.00779578 |
| EPDR1 | ependymin related 1 | 0.00766661 |
| HEXIM1 | hexamethylene bis-acetamide inducible 1 | 0.00760532 |
| PPME1 | protein phosphatase methylesterase 1 | 0.00760483 |
| MFHAS1 | malignant fibrous histiocytoma amplified sequence 1 | 0.00756762 |
| FBXO22 | F-box protein 22 | 0.00752725 |
| NARS2 | asparaginyl-tRNA synthetase 2, mitochondrial (putative) | 0.00743053 |
| MAP7 | microtubule-associated protein 7 | 0.00728193 |
| LGALS12 | lectin, galactoside-binding, soluble, 12 | 0.00721787 |
| SLC12A6 | solute carrier family 12 (potassium/chloride transporter), member 6 | 0.00709307 |
| RPS17 | ribosomal protein S17 | 0.00708509 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | 0.00706371 |
| POLH | polymerase (DNA directed), eta | 0.00703491 |
| PM20D1 | peptidase M20 domain containing 1 | 0.00702241 |
| RRM2B | ribonucleotide reductase M2 B (TP53 inducible) | 0.00697552 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.00697425 |
| TMEM245 | transmembrane protein 245 | 0.00695375 |
| AEBP2 | AE binding protein 2 | 0.00694361 |
| RAB3B | RAB3B, member RAS oncogene family | 0.00693386 |
| RABGAP1 | RAB GTPase activating protein 1 | 0.00691214 |
| UBE3D | ubiquitin protein ligase E3D | 0.00689401 |
| FGD4 | FYVE, RhoGEF and PH domain containing 4 | 0.00689228 |
| OGA | O-GlcNAcase | 0.0068368 |
| RPL3 | ribosomal protein L3 | 0.00681356 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.00681312 |
| SLC25A21 | solute carrier family 25 (mitochondrial oxoadipate carrier), member 21 | 0.00681113 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.00673557 |
| TSR1 | TSR1, 20S rRNA accumulation, homolog (S. cerevisiae) | 0.0067039 |
| RPL19 | ribosomal protein L19 | 0.00669646 |
| MORC4 | MORC family CW-type zinc finger 4 | 0.00652306 |
| SLC44A2 | solute carrier family 44 (choline transporter), member 2 | 0.00648145 |
| C6ORF141 | chromosome 6 open reading frame 141 | 0.00646685 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.00643329 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | 0.00643071 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.00640773 |
| UBAP2 | ubiquitin associated protein 2 | 0.00636992 |
| SIPA1L2 | signal-induced proliferation-associated 1 like 2 | 0.00635786 |
| CYBRD1 | cytochrome b reductase 1 | 0.00632219 |
| GRIN2C | glutamate receptor, ionotropic, N-methyl D-aspartate 2C | 0.00628544 |
| PTCD3 | pentatricopeptide repeat domain 3 | 0.00624976 |
| RETSAT | retinol saturase (all-trans-retinol 13,14-reductase) | 0.00619071 |
| CD24 | CD24 molecule | 0.00618681 |
| GADD45A | growth arrest and DNA-damage-inducible, alpha | 0.00614957 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.00613689 |
| FKBP4 | FK506 binding protein 4, 59kDa | 0.0061289 |
| SLU7 | SLU7 splicing factor homolog (S. cerevisiae) | 0.00608142 |
| BCAS3 | breast carcinoma amplified sequence 3 | 0.00607196 |
| CAMKMT | calmodulin-lysine N-methyltransferase | 0.00604585 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | 0.00604228 |
| SYNE1 | spectrin repeat containing, nuclear envelope 1 | 0.00603418 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.00598418 |
| Symbol | Name | Standardized Value |
|---|---|---|
| EFNA5 | ephrin-A5 | -0.181075 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.129497 |
| NDRG1 | N-myc downstream regulated 1 | -0.111016 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.10236 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.101609 |
| ANXA2 | annexin A2 | -0.0988314 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.097985 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0971946 |
| VCL | vinculin | -0.0952231 |
| ASPH | aspartate beta-hydroxylase | -0.0948342 |
| RNF213 | ring finger protein 213 | -0.0916103 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0900044 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0852733 |
| SMAD3 | SMAD family member 3 | -0.0841004 |
| FLNB | filamin B, beta | -0.0835614 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0781538 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0747758 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0737729 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0718126 |
| TMSB10 | thymosin beta 10 | -0.0667877 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0663183 |
| OSMR | oncostatin M receptor | -0.0654483 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | -0.0654423 |
| RIGI | RNA sensor RIG-I | -0.063661 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0618454 |
| EHBP1 | EH domain binding protein 1 | -0.0614407 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0603618 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0575789 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0571572 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0567672 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -0.0558159 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0552937 |
| EGFR | epidermal growth factor receptor | -0.0544665 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0539603 |
| AUTS2 | autism susceptibility candidate 2 | -0.05283 |
| RRBP1 | ribosome binding protein 1 | -0.0526126 |
| CA12 | carbonic anhydrase XII | -0.0522019 |
| PDE10A | phosphodiesterase 10A | -0.0518833 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.0518804 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0516229 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.051497 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0514295 |
| SBF2 | SET binding factor 2 | -0.0513607 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0513532 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0511634 |
| SPAG9 | sperm associated antigen 9 | -0.0494994 |
| RAI14 | retinoic acid induced 14 | -0.0484272 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0484148 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | -0.048083 |
| KYNU | kynureninase | -0.0469805 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0462875 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0452922 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0452013 |
| RIN2 | Ras and Rab interactor 2 | -0.0448742 |
| PDE8A | phosphodiesterase 8A | -0.0447441 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0444446 |
| TJP1 | tight junction protein 1 | -0.0444355 |
| GPC6 | glypican 6 | -0.0440482 |
| ACTN4 | actinin, alpha 4 | -0.0439042 |
| HMGA2 | high mobility group AT-hook 2 | -0.0437974 |
| RASA2 | RAS p21 protein activator 2 | -0.0436456 |
| SP100 | SP100 nuclear antigen | -0.0436395 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0434038 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0433352 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0431283 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0428229 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0419973 |
| ABTB3 | ankyrin repeat and BTB domain containing 3 | -0.0415841 |
| KDM7A | lysine (K)-specific demethylase 7A | -0.0411237 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0409517 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | -0.0404568 |
| DGKD | diacylglycerol kinase, delta 130kDa | -0.0403659 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0403375 |
| PNPT1 | polyribonucleotide nucleotidyltransferase 1 | -0.0402417 |
| PLSCR1 | phospholipid scramblase 1 | -0.0401534 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0396952 |
| ACTG1 | actin gamma 1 | -0.0390766 |
| DENND4A | DENN/MADD domain containing 4A | -0.0388737 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0386284 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0384552 |
| USP34 | ubiquitin specific peptidase 34 | -0.0382762 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.037963 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.037854 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0378185 |
| STC1 | stanniocalcin 1 | -0.037498 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.036827 |
| TNS3 | tensin 3 | -0.0367215 |
| PGK1 | phosphoglycerate kinase 1 | -0.0366812 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.036557 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0364737 |
| FBXO11 | F-box protein 11 | -0.0364721 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0363492 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0358196 |
| DAPK1 | death-associated protein kinase 1 | -0.0355098 |
| TPM1 | tropomyosin 1 (alpha) | -0.0354543 |
| CMIP | c-Maf inducing protein | -0.0354395 |
| LOXL2 | lysyl oxidase-like 2 | -0.0353349 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.035195 |
| NAV2 | neuron navigator 2 | -0.0348135 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0343649 |
