Selinexor _AN3 CA Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Selinexor perturbation in AN3 CA cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Selinexor _AN3 CA drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MEST mesoderm specific transcript 0.30156
VEGFA vascular endothelial growth factor A 0.054455
PDE4D phosphodiesterase 4D, cAMP-specific 0.039653
OGA O-GlcNAcase 0.0394841
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0334808
RNF150 ring finger protein 150 0.0308359
PDE10A phosphodiesterase 10A 0.029642
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.027931
FRMD6 FERM domain containing 6 0.0232644
SAMD4A sterile alpha motif domain containing 4A 0.0217753
ARRDC3 arrestin domain containing 3 0.0215049
FGFR2 fibroblast growth factor receptor 2 0.0208431
CCNL1 cyclin L1 0.0204922
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 0.0203944
GNG2 guanine nucleotide binding protein (G protein), gamma 2 0.0202672
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0200271
MMP16 matrix metallopeptidase 16 (membrane-inserted) 0.0200103
BCAS3 breast carcinoma amplified sequence 3 0.0196649
FOXJ3 forkhead box J3 0.0194923
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 0.0190928
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0186315
PTEN phosphatase and tensin homolog 0.018444
ANKRD33B ankyrin repeat domain 33B 0.0179048
UST uronyl-2-sulfotransferase 0.0174132
PRKN parkin RBR E3 ubiquitin protein ligase 0.0172829
XPO1 exportin 1 0.0172093
ADGRA3 adhesion G protein-coupled receptor A3 0.0168751
ATP11B ATPase, class VI, type 11B 0.0167534
PCLO piccolo presynaptic cytomatrix protein 0.0164451
ZBTB10 zinc finger and BTB domain containing 10 0.0163574
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0161483
ADAM17 ADAM metallopeptidase domain 17 0.0156663
RBM39 RNA binding motif protein 39 0.0155088
RIMOC1 RAB7A interacting MON1-CCZ1 complex subunit 1 0.0153775
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0153621
RICTOR RPTOR independent companion of MTOR, complex 2 0.01535
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0153391
SPPL3 signal peptide peptidase like 3 0.0152469
NGFR nerve growth factor receptor 0.0152011
GSN gelsolin 0.0151864
MED14 mediator complex subunit 14 0.0151807
DST dystonin 0.0150495
OTUD7B OTU deubiquitinase 7B 0.0149428
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0148131
TRAPPC11 trafficking protein particle complex 11 0.014758
CLIC4 chloride intracellular channel 4 0.0146988
ZNF91 zinc finger protein 91 0.0145832
TEX14 testis expressed 14 0.0145054
GLS2 glutaminase 2 (liver, mitochondrial) 0.0144778
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 0.0143418
DCAF6 DDB1 and CUL4 associated factor 6 0.0142765
DMXL2 Dmx-like 2 0.0142263
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0142253
RTN4 reticulon 4 0.0141706
PPP4R2 protein phosphatase 4, regulatory subunit 2 0.014157
GPHN gephyrin 0.0141434
YTHDC1 YTH domain containing 1 0.0141053
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0140175
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0139653
AOPEP aminopeptidase O (putative) 0.0139375
ALCAM activated leukocyte cell adhesion molecule 0.01393
ARHGAP10 Rho GTPase activating protein 10 0.0139142
IRF1 interferon regulatory factor 1 0.0138975
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa 0.0138306
COL4A5 collagen, type IV, alpha 5 0.0137479
FAM91A1 family with sequence similarity 91, member A1 0.0136747
CSNK1G3 casein kinase 1, gamma 3 0.0136527
HOXC6 homeobox C6 0.0131381
ZNF516 zinc finger protein 516 0.0130505
ITGB8 integrin, beta 8 0.0130483
SOD2 superoxide dismutase 2, mitochondrial 0.0130222
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 0.01301
HSPA4L heat shock 70kDa protein 4-like 0.0129884
HOXA9 homeobox A9 0.0129263
SLTM SAFB-like, transcription modulator 0.0128641
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0128596
CCNG2 cyclin G2 0.0127778
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.012751
MANBA mannosidase, beta A, lysosomal 0.0126895
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2 0.0126046
DPH6 diphthamine biosynthesis 6 0.0125554
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0125255
IVNS1ABP influenza virus NS1A binding protein 0.0124683
PALS2 protein associated with LIN7 2, MAGUK p55 family member 0.0124301
KIF1B kinesin family member 1B 0.0123974
MYO9A myosin IXA 0.0123838
TTC1 tetratricopeptide repeat domain 1 0.0123135
SS18 synovial sarcoma translocation, chromosome 18 0.0123016
DLG5 discs, large homolog 5 (Drosophila) 0.0122038
LAPTM4B lysosomal protein transmembrane 4 beta 0.0121684
CDK8 cyclin-dependent kinase 8 0.0121563
PRTG protogenin 0.0120118
SCGB1D1 secretoglobin, family 1D, member 1 0.0119447
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1 0.0118845
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 0.0118571
PDK4 pyruvate dehydrogenase kinase, isozyme 4 0.0117526
RNF24 ring finger protein 24 0.0117509
ATF7IP activating transcription factor 7 interacting protein 0.0117452
GAB2 GRB2-associated binding protein 2 0.0117154
DCUN1D3 DCN1, defective in cullin neddylation 1, domain containing 3 0.0116808

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.235704
PEG10 paternally expressed 10 -0.131989
MGP matrix Gla protein -0.13075
CADM2 cell adhesion molecule 2 -0.107289
PRKG1 protein kinase, cGMP-dependent, type I -0.103775
RPS6 ribosomal protein S6 -0.0978889
PTMA prothymosin, alpha -0.0903982
RPS8 ribosomal protein S8 -0.0847484
RPLP1 ribosomal protein, large, P1 -0.0694872
HMGA2 high mobility group AT-hook 2 -0.0692263
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0673332
CENPF centromere protein F, 350/400kDa -0.0606665
ACTG1 actin gamma 1 -0.0598596
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0595893
TPT1 tumor protein, translationally-controlled 1 -0.0594737
RPS24 ribosomal protein S24 -0.0577879
RPL37A ribosomal protein L37a -0.0573328
FGFR1 fibroblast growth factor receptor 1 -0.0569075
RPS23 ribosomal protein S23 -0.0540308
JMJD1C jumonji domain containing 1C -0.0540009
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0532589
RPL34 ribosomal protein L34 -0.0528648
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0495709
RPL35A ribosomal protein L35a -0.0495448
SOX4 SRY (sex determining region Y)-box 4 -0.0492627
TMSB10 thymosin beta 10 -0.0474321
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0461
SLC38A2 solute carrier family 38, member 2 -0.0447353
RPL23 ribosomal protein L23 -0.044201
KPNB1 karyopherin (importin) beta 1 -0.0435411
RPLP2 ribosomal protein, large, P2 -0.04319
TPK1 thiamin pyrophosphokinase 1 -0.0430211
TRIO trio Rho guanine nucleotide exchange factor -0.0427126
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0421895
RANBP17 RAN binding protein 17 -0.0415971
DEK DEK proto-oncogene -0.0415532
SSBP2 single-stranded DNA binding protein 2 -0.0405865
NIPBL Nipped-B homolog (Drosophila) -0.0403858
RPS11 ribosomal protein S11 -0.0403069
SBF2 SET binding factor 2 -0.0394179
RPLP0 ribosomal protein, large, P0 -0.039131
RPS19 ribosomal protein S19 -0.0390801
RPL31 ribosomal protein L31 -0.0388455
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0385704
FAF1 Fas (TNFRSF6) associated factor 1 -0.0375778
RPL26 ribosomal protein L26 -0.0373521
FTL ferritin, light polypeptide -0.0369889
RPL12 ribosomal protein L12 -0.0362721
RPS27A ribosomal protein S27a -0.0362524
RACK1 receptor for activated C kinase 1 -0.0360902
MT2A metallothionein 2A -0.0357063
RPS25 ribosomal protein S25 -0.0356914
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0354501
MYOF myoferlin -0.0330684
PUM2 pumilio RNA-binding family member 2 -0.0324975
RPS13 ribosomal protein S13 -0.0323871
RPL37 ribosomal protein L37 -0.0323758
RPS20 ribosomal protein S20 -0.0321592
RPS14 ribosomal protein S14 -0.0321001
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.031833
RAB7A RAB7A, member RAS oncogene family -0.0313198
ZBTB20 zinc finger and BTB domain containing 20 -0.0310716
SEPTIN11 septin 11 -0.0309088
RPL30 ribosomal protein L30 -0.030454
SMC3 structural maintenance of chromosomes 3 -0.0304523
PARD3 par-3 family cell polarity regulator -0.0303929
ENO1 enolase 1, (alpha) -0.0301713
HMGA1 high mobility group AT-hook 1 -0.0299112
PGK1 phosphoglycerate kinase 1 -0.0298445
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0297166
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.029585
TMSB4X thymosin beta 4, X-linked -0.0291138
RPL11 ribosomal protein L11 -0.0289847
CBFB core-binding factor, beta subunit -0.0288707
RPS10 ribosomal protein S10 -0.0288561
LOC112694756 uncharaterized LOC112694756 -0.0285493
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.028189
RPS12 ribosomal protein S12 -0.0281339
SERBP1 SERPINE1 mRNA binding protein 1 -0.0279308
RPL5 ribosomal protein L5 -0.0279024
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0277637
RPL19 ribosomal protein L19 -0.0276378
COL1A2 collagen, type I, alpha 2 -0.0276376
RPL32 ribosomal protein L32 -0.0275681
TULP4 tubby like protein 4 -0.0275516
RSL1D1 ribosomal L1 domain containing 1 -0.027332
RPL36 ribosomal protein L36 -0.0272315
RPL8 ribosomal protein L8 -0.0271949
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0271729
KIF5B kinesin family member 5B -0.0271162
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0270956
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0268765
RPS3 ribosomal protein S3 -0.0267744
RPS21 ribosomal protein S21 -0.0266218
STRN3 striatin, calmodulin binding protein 3 -0.0266072
MARCHF6 membrane associated ring-CH-type finger 6 -0.0262288
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0261766
RPS29 ribosomal protein S29 -0.0261155
IPO7 importin 7 -0.0260529
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0260505