Selinexor _C-33 A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Selinexor perturbation in C-33 A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Selinexor _C-33 A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RNF150 ring finger protein 150 0.0898334
CTNNA3 catenin (cadherin-associated protein), alpha 3 0.0722946
SS18L1 synovial sarcoma translocation gene on chromosome 18-like 1 0.047066
XPO1 exportin 1 0.0461806
PCLO piccolo presynaptic cytomatrix protein 0.0457569
FNDC3B fibronectin type III domain containing 3B 0.0455173
NEBL nebulette 0.0358267
DMXL1 Dmx-like 1 0.0353418
DIXDC1 DIX domain containing 1 0.0318185
PRTG protogenin 0.0315555
DOCK9 dedicator of cytokinesis 9 0.0298428
RAD54L2 RAD54-like 2 (S. cerevisiae) 0.0294041
SPECC1 sperm antigen with calponin homology and coiled-coil domains 1 0.0265489
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 0.0252174
OSBPL10 oxysterol binding protein-like 10 0.0250699
NGFR nerve growth factor receptor 0.024734
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0243087
LARS1 leucyl-tRNA synthetase 1 0.023787
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0234577
HSPA4L heat shock 70kDa protein 4-like 0.0225515
DOCK6 dedicator of cytokinesis 6 0.0223461
ZNF146 zinc finger protein 146 0.0221593
GPHN gephyrin 0.021412
OTUD7B OTU deubiquitinase 7B 0.0211415
ARHGAP32 Rho GTPase activating protein 32 0.0208731
FMNL2 formin-like 2 0.0206521
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0204527
EFR3B EFR3 homolog B (S. cerevisiae) 0.0197054
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0186677
RAI14 retinoic acid induced 14 0.0186525
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0185727
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0185136
FEZ2 fasciculation and elongation protein zeta 2 (zygin II) 0.0181389
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0176862
PTPN3 protein tyrosine phosphatase, non-receptor type 3 0.0175686
PDE3B phosphodiesterase 3B, cGMP-inhibited 0.0174746
ZCCHC7 zinc finger, CCHC domain containing 7 0.017438
SIPA1L2 signal-induced proliferation-associated 1 like 2 0.0174295
DHX36 DEAH (Asp-Glu-Ala-His) box polypeptide 36 0.0173003
ERBB4 erb-b2 receptor tyrosine kinase 4 0.0172315
NAF1 nuclear assembly factor 1 ribonucleoprotein 0.0167269
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 0.0164841
TRPM4 transient receptor potential cation channel, subfamily M, member 4 0.0164778
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0164705
FGD4 FYVE, RhoGEF and PH domain containing 4 0.0162153
VRK2 vaccinia related kinase 2 0.0161121
ANKRD33B ankyrin repeat domain 33B 0.0160131
ANO10 anoctamin 10 0.0158581
CCDC57 coiled-coil domain containing 57 0.0154671
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0154366
HSPA8 heat shock 70kDa protein 8 0.0154095
BRF1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit 0.0153602
ZNF609 zinc finger protein 609 0.0153341
TBC1D5 TBC1 domain family, member 5 0.0148127
ARFIP1 ADP-ribosylation factor interacting protein 1 0.0143445
MACROD1 MACRO domain containing 1 0.0141688
KANK1 KN motif and ankyrin repeat domains 1 0.0140785
TLK2 tousled-like kinase 2 0.0140441
KCNH1 potassium channel, voltage gated eag related subfamily H, member 1 0.0139894
GNL3 guanine nucleotide binding protein-like 3 (nucleolar) 0.0139538
CDK12 cyclin-dependent kinase 12 0.0138475
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0138111
CLCN3 chloride channel, voltage-sensitive 3 0.0137208
TMEM178B transmembrane protein 178B 0.0136377
CUX1 cut-like homeobox 1 0.0133943
ARRDC3 arrestin domain containing 3 0.0133592
R3HDM2 R3H domain containing 2 0.0133441
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0132773
RNF220 ring finger protein 220 0.0132412
CENPF centromere protein F, 350/400kDa 0.0130786
HMGA1 high mobility group AT-hook 1 0.013032
SH3PXD2A SH3 and PX domains 2A 0.0129561
PPP2R2C protein phosphatase 2, regulatory subunit B, gamma 0.0129336
CCSER1 coiled-coil serine-rich protein 1 0.0129268
SLTM SAFB-like, transcription modulator 0.0128684
TBCD tubulin folding cofactor D 0.0127877
MDN1 MDN1, midasin homolog (yeast) 0.012755
ANKRD13A ankyrin repeat domain 13A 0.0126817
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase 0.0126563
DOCK7 dedicator of cytokinesis 7 0.0126523
XPO6 exportin 6 0.0125577
KIAA1671 KIAA1671 0.0125542
DENND4C DENN/MADD domain containing 4C 0.0124456
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0123601
SLC43A2 solute carrier family 43 (amino acid system L transporter), member 2 0.012213
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like 0.0122025
HSPG2 heparan sulfate proteoglycan 2 0.0119027
HCFC1 host cell factor C1 0.0118799
CAPN5 calpain 5 0.0118671
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 0.0118247
IARS1 isoleucyl-tRNA synthetase 1 0.0116641
CLCN2 chloride channel, voltage-sensitive 2 0.0113566
TNRC18 trinucleotide repeat containing 18 0.0112619
MEF2A myocyte enhancer factor 2A 0.0112232
FMNL3 formin-like 3 0.0112155
RABGAP1L RAB GTPase activating protein 1-like 0.011024
NR5A2 nuclear receptor subfamily 5, group A, member 2 0.0110061
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0109717
ZRANB3 zinc finger, RAN-binding domain containing 3 0.010955
TTC17 tetratricopeptide repeat domain 17 0.0108661

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.148418
UBC ubiquitin C -0.128637
ADGRG6 adhesion G protein-coupled receptor G6 -0.111114
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D -0.101722
RPL23 ribosomal protein L23 -0.0883882
TMSB10 thymosin beta 10 -0.0776332
NALF1 NALCN channel auxiliary factor 1 -0.0685653
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.0682394
JMJD1C jumonji domain containing 1C -0.0681352
RPS8 ribosomal protein S8 -0.0673658
GNAS GNAS complex locus -0.0640901
SMYD3 SET and MYND domain containing 3 -0.0629698
PTMA prothymosin, alpha -0.06242
B2M beta-2-microglobulin -0.0620831
SOX4 SRY (sex determining region Y)-box 4 -0.062025
NR2F1 nuclear receptor subfamily 2, group F, member 1 -0.0601597
RPS6 ribosomal protein S6 -0.0591135
RPS27A ribosomal protein S27a -0.0580495
ZFAND3 zinc finger, AN1-type domain 3 -0.0577519
NFIA nuclear factor I/A -0.0575953
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0563347
RAP1B RAP1B, member of RAS oncogene family -0.056181
SEPTIN7 septin 7 -0.0551034
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.054919
IFI6 interferon, alpha-inducible protein 6 -0.0523548
KMT2C lysine (K)-specific methyltransferase 2C -0.0523099
ENO1 enolase 1, (alpha) -0.052238
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0515572
RPS19 ribosomal protein S19 -0.0496801
RPLP1 ribosomal protein, large, P1 -0.0494799
ANKRD12 ankyrin repeat domain 12 -0.0470991
RPS4X ribosomal protein S4, X-linked -0.0469665
RTN4 reticulon 4 -0.0467939
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0466683
RPL36 ribosomal protein L36 -0.0462987
RPL28 ribosomal protein L28 -0.0460651
RPL31 ribosomal protein L31 -0.0455139
NIPBL Nipped-B homolog (Drosophila) -0.0454928
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.045487
EGR1 early growth response 1 -0.0453569
WDR45B WD repeat domain 45B -0.0453512
LOC112694756 uncharaterized LOC112694756 -0.0453384
KDM3A lysine (K)-specific demethylase 3A -0.0447093
MED13L mediator complex subunit 13-like -0.0446194
RPL26 ribosomal protein L26 -0.0443545
RPS5 ribosomal protein S5 -0.0442109
RPS21 ribosomal protein S21 -0.044058
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.043926
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0438828
NAP1L1 nucleosome assembly protein 1-like 1 -0.0432219
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0432138
RPL11 ribosomal protein L11 -0.0425753
ZNF292 zinc finger protein 292 -0.0421483
RPL5 ribosomal protein L5 -0.0421351
EGLN1 egl-9 family hypoxia-inducible factor 1 -0.0418913
USP34 ubiquitin specific peptidase 34 -0.0418894
PNISR PNN-interacting serine/arginine-rich protein -0.0418862
RPLP2 ribosomal protein, large, P2 -0.0417022
DST dystonin -0.0414567
RPL32 ribosomal protein L32 -0.0413938
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0410561
PGK1 phosphoglycerate kinase 1 -0.0409414
KIAA1958 KIAA1958 -0.0405403
ZC3H12B zinc finger CCCH-type containing 12B -0.0405399
TPT1 tumor protein, translationally-controlled 1 -0.0404893
RPS11 ribosomal protein S11 -0.039849
USP9X ubiquitin specific peptidase 9, X-linked -0.0397742
COL5A2 collagen, type V, alpha 2 -0.0394411
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0393946
RPL37A ribosomal protein L37a -0.0389999
RPS24 ribosomal protein S24 -0.0382586
ENAH enabled homolog (Drosophila) -0.0381131
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0378328
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.037736
RPL34 ribosomal protein L34 -0.0376813
TOX thymocyte selection-associated high mobility group box -0.0372668
FBXO11 F-box protein 11 -0.0369239
NFIB nuclear factor I/B -0.0369126
SLF1 SMC5-SMC6 complex localization factor 1 -0.0369061
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0366828
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0364962
RPS3 ribosomal protein S3 -0.0364818
JUN jun proto-oncogene -0.0363934
EFNA5 ephrin-A5 -0.036054
RBM25 RNA binding motif protein 25 -0.0358436
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0356264
RPL12 ribosomal protein L12 -0.0355967
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0354781
RPS29 ribosomal protein S29 -0.0354246
FAM162A family with sequence similarity 162, member A -0.0353124
BBX bobby sox homolog (Drosophila) -0.0345916
RPL19 ribosomal protein L19 -0.0345667
MYL12B myosin, light chain 12B, regulatory -0.0340562
PEG10 paternally expressed 10 -0.0340064
PHF21A PHD finger protein 21A -0.0337967
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 -0.0336757
PABPN1 poly(A) binding protein, nuclear 1 -0.0335903
LCORL ligand dependent nuclear receptor corepressor-like -0.0333692
FOXO3 forkhead box O3 -0.0331384
MAP3K14 mitogen-activated protein kinase kinase kinase 14 -0.0328662