Selinexor _CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Selinexor perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Selinexor _CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VCL vinculin 0.112241
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.109386
PCLO piccolo presynaptic cytomatrix protein 0.105561
CEMIP cell migration inducing protein, hyaluronan binding 0.104316
FNDC3B fibronectin type III domain containing 3B 0.0883587
RNF213 ring finger protein 213 0.0744021
VMP1 vacuole membrane protein 1 0.0717301
ARID5B AT rich interactive domain 5B (MRF1-like) 0.0633258
RNF150 ring finger protein 150 0.0618951
AKAP12 A kinase (PRKA) anchor protein 12 0.0562689
ZSWIM6 zinc finger, SWIM-type containing 6 0.054954
ANTXR1 anthrax toxin receptor 1 0.0520655
GLCCI1 glucocorticoid induced 1 0.0513377
PLAT plasminogen activator, tissue 0.0473532
CCNG2 cyclin G2 0.0469727
BCAS3 breast carcinoma amplified sequence 3 0.0467457
RIGI RNA sensor RIG-I 0.0447106
NPAS2 neuronal PAS domain protein 2 0.0438418
THBS1 thrombospondin 1 0.0419017
RAD51B RAD51 paralog B 0.0402677
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0391548
FHIT fragile histidine triad 0.0385193
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0374004
SOD2 superoxide dismutase 2, mitochondrial 0.0361198
FRMD4A FERM domain containing 4A 0.0341641
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0338334
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.0333527
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0315424
MCL1 myeloid cell leukemia 1 0.0311384
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0309491
TLE4 transducin-like enhancer of split 4 0.0309078
PDE10A phosphodiesterase 10A 0.0299806
TPM1 tropomyosin 1 (alpha) 0.0297031
ZBTB20 zinc finger and BTB domain containing 20 0.0295875
RAP1B RAP1B, member of RAS oncogene family 0.0294694
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0294417
PMP22 peripheral myelin protein 22 0.0293376
SP100 SP100 nuclear antigen 0.0292063
THSD4 thrombospondin, type I, domain containing 4 0.0285631
MX2 MX dynamin-like GTPase 2 0.0281519
PLSCR1 phospholipid scramblase 1 0.0280248
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0279534
SLC38A2 solute carrier family 38, member 2 0.027553
STK38L serine/threonine kinase 38 like 0.0270966
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 0.0268917
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0266518
TIMP3 TIMP metallopeptidase inhibitor 3 0.0248829
LPP LIM domain containing preferred translocation partner in lipoma 0.0245798
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0245296
ELL2 elongation factor, RNA polymerase II, 2 0.024426
PHF3 PHD finger protein 3 0.0244216
IFI44L interferon-induced protein 44-like 0.0244193
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.024142
GSE1 Gse1 coiled-coil protein 0.0238183
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0236315
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.0230689
BDKRB2 bradykinin receptor B2 0.0230047
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.0228145
CCDC57 coiled-coil domain containing 57 0.0226906
PDE4D phosphodiesterase 4D, cAMP-specific 0.0224683
NRG1 neuregulin 1 0.0221898
TANK TRAF family member-associated NFKB activator 0.0219478
TET1 tet methylcytosine dioxygenase 1 0.0219112
CDK12 cyclin-dependent kinase 12 0.0218756
TBC1D22A TBC1 domain family, member 22A 0.0218378
PCBP3 poly(rC) binding protein 3 0.0217394
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 0.0216964
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0216802
RABGAP1L RAB GTPase activating protein 1-like 0.0214973
CEMIP2 cell migration inducing hyaluronidase 2 0.0213225
SPTBN1 spectrin, beta, non-erythrocytic 1 0.021251
INTS6 integrator complex subunit 6 0.0210753
SMYD3 SET and MYND domain containing 3 0.0210736
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0209991
UBAP2 ubiquitin associated protein 2 0.0204383
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0204062
BPTF bromodomain PHD finger transcription factor 0.0203817
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.0201157
ZBTB1 zinc finger and BTB domain containing 1 0.0200871
DUSP16 dual specificity phosphatase 16 0.0200484
FHL2 four and a half LIM domains 2 0.0196222
BABAM2 BRISC and BRCA1 A complex member 2 0.0194792
MYO1E myosin IE 0.0194589
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A 0.0192068
FNDC3A fibronectin type III domain containing 3A 0.0190535
PPP1R10 protein phosphatase 1, regulatory subunit 10 0.0188238
KCTD16 potassium channel tetramerization domain containing 16 0.0187719
KDM4C lysine (K)-specific demethylase 4C 0.0185358
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0184282
GMDS GDP-mannose 4,6-dehydratase 0.0183347
ADARB1 adenosine deaminase, RNA-specific, B1 0.0183169
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0182703
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0181489
RPTOR regulatory associated protein of MTOR, complex 1 0.0181387
TUFT1 tuftelin 1 0.0180203
HOMER1 homer scaffolding protein 1 0.0178917
OSMR oncostatin M receptor 0.0178052
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 0.0177902
ASPH aspartate beta-hydroxylase 0.0177323
FER fer (fps/fes related) tyrosine kinase 0.0176824

decreased expression

Symbol Name Standardized Value
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.313667
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.18995
PTMA prothymosin, alpha -0.136347
VIM vimentin -0.117704
MAP1B microtubule-associated protein 1B -0.107433
COL1A1 collagen, type I, alpha 1 -0.0864691
SYT1 synaptotagmin I -0.0827934
IGF2 insulin-like growth factor 2 -0.0775823
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0721054
RPL19 ribosomal protein L19 -0.0713338
RPS6 ribosomal protein S6 -0.0704599
RPLP1 ribosomal protein, large, P1 -0.0670908
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0642853
RPL23 ribosomal protein L23 -0.0604393
RPL35A ribosomal protein L35a -0.0602228
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0590595
COL3A1 collagen, type III, alpha 1 -0.056956
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.055483
EIF1 eukaryotic translation initiation factor 1 -0.0513761
HELZ helicase with zinc finger -0.0513653
WDR45B WD repeat domain 45B -0.0505648
S100A6 S100 calcium binding protein A6 -0.0492696
TMSB10 thymosin beta 10 -0.0483836
PKM pyruvate kinase, muscle -0.046962
ANXA2 annexin A2 -0.0460823
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0458936
LPIN1 lipin 1 -0.0457684
FTL ferritin, light polypeptide -0.0456763
GLG1 golgi glycoprotein 1 -0.0444683
FAM13A family with sequence similarity 13, member A -0.0430861
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0416727
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0406732
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.0405862
MARCHF6 membrane associated ring-CH-type finger 6 -0.0376372
AHNAK AHNAK nucleoprotein -0.0365203
RACK1 receptor for activated C kinase 1 -0.0363314
DCAF7 DDB1 and CUL4 associated factor 7 -0.0358427
SCG2 secretogranin II -0.0354162
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0351932
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0351281
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0346477
NPEPPS aminopeptidase puromycin sensitive -0.0345616
RPL34 ribosomal protein L34 -0.034414
RPS19 ribosomal protein S19 -0.0342628
APP amyloid beta (A4) precursor protein -0.0337582
LMNA lamin A/C -0.0336587
PRKCA protein kinase C, alpha -0.0336321
HMBOX1 homeobox containing 1 -0.0329212
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0324825
TPT1 tumor protein, translationally-controlled 1 -0.0322189
TENT5A terminal nucleotidyltransferase 5A -0.0318277
RPL12 ribosomal protein L12 -0.0312233
ACTG1 actin gamma 1 -0.030569
SPAG9 sperm associated antigen 9 -0.0305552
RPL31 ribosomal protein L31 -0.0304673
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) -0.0299715
RPS24 ribosomal protein S24 -0.029953
GNAS GNAS complex locus -0.0297993
KDM3A lysine (K)-specific demethylase 3A -0.0297686
PTPRK protein tyrosine phosphatase, receptor type, K -0.0297283
RPL38 ribosomal protein L38 -0.0293725
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0290426
MAP4 microtubule-associated protein 4 -0.0288015
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0286659
EEF2 eukaryotic translation elongation factor 2 -0.0286647
MSI2 musashi RNA-binding protein 2 -0.0285842
PRRC2B proline-rich coiled-coil 2B -0.0285828
C1ORF21 chromosome 1 open reading frame 21 -0.0283618
SETD5 SET domain containing 5 -0.0283481
RPLP0 ribosomal protein, large, P0 -0.0278167
CSDE1 cold shock domain containing E1, RNA-binding -0.0275712
CUL3 cullin 3 -0.0275186
CCND1 cyclin D1 -0.0272077
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0270439
VDAC1 voltage-dependent anion channel 1 -0.0270379
TMEM123 transmembrane protein 123 -0.0269546
RPS12 ribosomal protein S12 -0.0268788
RPS16 ribosomal protein S16 -0.026832
RPL36 ribosomal protein L36 -0.0267871
POTEF POTE ankyrin domain family, member F -0.0266545
LCORL ligand dependent nuclear receptor corepressor-like -0.0265255
WAC WW domain containing adaptor with coiled-coil -0.0264453
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0263902
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D -0.0263184
GOLGA4 golgin A4 -0.0262434
RPS27 ribosomal protein S27 -0.0258287
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0256502
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0256022
DKK2 dickkopf WNT signaling pathway inhibitor 2 -0.0255252
NF1 neurofibromin 1 -0.0253813
SMAD3 SMAD family member 3 -0.0253527
TPR translocated promoter region, nuclear basket protein -0.0252915
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0252816
RPL32 ribosomal protein L32 -0.0252007
TLK2 tousled-like kinase 2 -0.025145
AOPEP aminopeptidase O (putative) -0.0250795
ATRNL1 attractin-like 1 -0.0249706
HAND2 heart and neural crest derivatives expressed 2 -0.0249529
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.024898
CDC27 cell division cycle 27 -0.0248008