Selinexor _COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Selinexor perturbation in COLO 205 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Selinexor _COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LMO7 LIM domain 7 0.164355
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.114507
INTS6 integrator complex subunit 6 0.0675519
DSCAML1 Down syndrome cell adhesion molecule like 1 0.0642806
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0484729
TOX3 TOX high mobility group box family member 3 0.0444781
ERN1 endoplasmic reticulum to nucleus signaling 1 0.0435009
MYO1E myosin IE 0.0406373
RNF213 ring finger protein 213 0.0330914
SIPA1L2 signal-induced proliferation-associated 1 like 2 0.032998
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0312072
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0306569
NCEH1 neutral cholesterol ester hydrolase 1 0.0281605
DPP4 dipeptidyl-peptidase 4 0.0271088
AKAP13 A kinase (PRKA) anchor protein 13 0.026736
TUFT1 tuftelin 1 0.0263196
PLAUR plasminogen activator, urokinase receptor 0.0262304
DUSP10 dual specificity phosphatase 10 0.0259944
VCL vinculin 0.0244181
PLSCR2 phospholipid scramblase 2 0.0240768
LURAP1L leucine rich adaptor protein 1-like 0.02293
SHB Src homology 2 domain containing adaptor protein B 0.0227872
SMAD3 SMAD family member 3 0.0223296
ANXA2 annexin A2 0.0215866
ELOF1 elongation factor 1 homolog (S. cerevisiae) 0.0210393
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0206998
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0200782
SOD2 superoxide dismutase 2, mitochondrial 0.0199861
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0197894
DST dystonin 0.0192858
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 0.0186653
EPS8 epidermal growth factor receptor pathway substrate 8 0.0180201
VMP1 vacuole membrane protein 1 0.017199
ST14 suppression of tumorigenicity 14 (colon carcinoma) 0.0167374
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0166797
EFNB2 ephrin-B2 0.0166271
EREG epiregulin 0.0163519
MCL1 myeloid cell leukemia 1 0.0163181
KYNU kynureninase 0.0162007
EZR ezrin 0.0160598
KRT23 keratin 23, type I 0.0160405
MCU mitochondrial calcium uniporter 0.0158865
NABP1 nucleic acid binding protein 1 0.0155273
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0148078
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.0147308
ZSWIM6 zinc finger, SWIM-type containing 6 0.0146953
OCLN occludin 0.0145648
RSAD2 radical S-adenosyl methionine domain containing 2 0.0142486
SDC4 syndecan 4 0.0136489
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.013574
EXT1 exostosin glycosyltransferase 1 0.0132928
RND3 Rho family GTPase 3 0.0131443
XDH xanthine dehydrogenase 0.0130322
FHIT fragile histidine triad 0.0130248
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0128753
UBAP2 ubiquitin associated protein 2 0.0128345
SCNN1A sodium channel, non voltage gated 1 alpha subunit 0.0127276
STS steroid sulfatase (microsomal), isozyme S 0.0120931
CDHR2 cadherin-related family member 2 0.0118393
CATSPERB catsper channel auxiliary subunit beta 0.0116715
TRIM22 tripartite motif containing 22 0.0116465
TMC5 transmembrane channel-like 5 0.0116142
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0115696
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0111663
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0110835
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.011073
MGAT4A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A 0.0109818
CCNG2 cyclin G2 0.0109445
RBM47 RNA binding motif protein 47 0.0108392
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0107873
BCL6 B-cell CLL/lymphoma 6 0.0106684
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 0.0105944
CACHD1 cache domain containing 1 0.010577
POF1B premature ovarian failure, 1B 0.0104703
EPB41L5 erythrocyte membrane protein band 4.1 like 5 0.0103197
YAP1 Yes-associated protein 1 0.0102722
WEE1 WEE1 G2 checkpoint kinase 0.0102099
SULT1C4 sulfotransferase family, cytosolic, 1C, member 4 0.0101929
FNIP2 folliculin interacting protein 2 0.00987365
DUSP16 dual specificity phosphatase 16 0.00985082
TRIB1 tribbles pseudokinase 1 0.00955062
LARP4B La ribonucleoprotein domain family, member 4B 0.00935494
ZHX2 zinc fingers and homeoboxes 2 0.00935253
FAM120A family with sequence similarity 120A 0.00917458
MUC13 mucin 13, cell surface associated 0.0091557
RFX2 regulatory factor X, 2 (influences HLA class II expression) 0.00913669
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.00911615
UBAP2L ubiquitin associated protein 2-like 0.00905472
PCCA propionyl CoA carboxylase, alpha polypeptide 0.00905288
F2RL1 coagulation factor II (thrombin) receptor-like 1 0.00891883
ARRDC3 arrestin domain containing 3 0.00891816
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 0.00889381
CFLAR CASP8 and FADD-like apoptosis regulator 0.00886678
PDLIM5 PDZ and LIM domain 5 0.00882073
ATF7IP2 activating transcription factor 7 interacting protein 2 0.00875048
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 0.0087275
LNX1 ligand of numb-protein X 1, E3 ubiquitin protein ligase 0.00865405
C3ORF52 chromosome 3 open reading frame 52 0.00861567
CEMIP2 cell migration inducing hyaluronidase 2 0.00861199
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 0.00858634

decreased expression

Symbol Name Standardized Value
B2M beta-2-microglobulin -0.180805
TPT1 tumor protein, translationally-controlled 1 -0.159991
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.128139
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.121408
PTMA prothymosin, alpha -0.107746
HLA-B major histocompatibility complex, class I, B -0.10218
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0922464
ZMYND8 zinc finger, MYND-type containing 8 -0.0786318
RPS6 ribosomal protein S6 -0.071488
LYZ lysozyme -0.0670122
LCN2 lipocalin 2 -0.0668366
BTBD9 BTB (POZ) domain containing 9 -0.0633601
FTL ferritin, light polypeptide -0.062668
GMDS GDP-mannose 4,6-dehydratase -0.062662
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0605339
TXNIP thioredoxin interacting protein -0.0596654
EIF1 eukaryotic translation initiation factor 1 -0.0572207
RPL35A ribosomal protein L35a -0.056841
PDIA3 protein disulfide isomerase family A, member 3 -0.0556691
AHI1 Abelson helper integration site 1 -0.0550929
RHOBTB3 Rho-related BTB domain containing 3 -0.0548349
LOC102724023 ES1 protein homolog, mitochondrial -0.053992
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0519588
TMSB10 thymosin beta 10 -0.0514791
NDRG1 N-myc downstream regulated 1 -0.0506333
RPL23 ribosomal protein L23 -0.050582
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.048796
IFI6 interferon, alpha-inducible protein 6 -0.0481406
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.0475452
UBR2 ubiquitin protein ligase E3 component n-recognin 2 -0.0464112
LOC112694756 uncharaterized LOC112694756 -0.0459777
PRRC2C proline-rich coiled-coil 2C -0.0457706
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.045137
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0447504
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0444428
PKM pyruvate kinase, muscle -0.0440706
ENO1 enolase 1, (alpha) -0.0438188
RPL34 ribosomal protein L34 -0.0437875
IFI27 interferon, alpha-inducible protein 27 -0.0437029
RRBP1 ribosome binding protein 1 -0.0436701
RPLP1 ribosomal protein, large, P1 -0.0436661
EPCAM epithelial cell adhesion molecule -0.0428054
H1-0 H1.0 linker histone -0.0424995
RUNX1 runt-related transcription factor 1 -0.0423643
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0421114
ZMYM2 zinc finger, MYM-type 2 -0.041618
CANX calnexin -0.0415594
RPS8 ribosomal protein S8 -0.0410572
GOLGB1 golgin B1 -0.0406755
UBC ubiquitin C -0.0405593
PTBP3 polypyrimidine tract binding protein 3 -0.0403316
RPL19 ribosomal protein L19 -0.0398798
PRKCA protein kinase C, alpha -0.0396838
NCOR1 nuclear receptor corepressor 1 -0.0392193
GOLGA4 golgin A4 -0.03888
RPL7L1 ribosomal protein L7-like 1 -0.0388381
PGK1 phosphoglycerate kinase 1 -0.0387126
FTH1 ferritin, heavy polypeptide 1 -0.0378525
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.0377826
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0369715
HLA-A major histocompatibility complex, class I, A -0.0368689
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0365472
GCC2 GRIP and coiled-coil domain containing 2 -0.0361898
ABHD2 abhydrolase domain containing 2 -0.0353902
C6ORF132 chromosome 6 open reading frame 132 -0.0351797
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.035039
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0346758
S100A6 S100 calcium binding protein A6 -0.0346321
SLC38A1 solute carrier family 38, member 1 -0.0345238
PATJ PATJ crumbs cell polarity complex component -0.0343988
SPATA13 spermatogenesis associated 13 -0.0341997
ACBD3 acyl-CoA binding domain containing 3 -0.0341206
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0339319
HLA-C major histocompatibility complex, class I, C -0.0337369
RPS19 ribosomal protein S19 -0.0337267
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0332157
RPL12 ribosomal protein L12 -0.0332001
MORF4L2 mortality factor 4 like 2 -0.033116
RNF149 ring finger protein 149 -0.0330985
DLG1 discs, large homolog 1 (Drosophila) -0.0329956
DSTN destrin (actin depolymerizing factor) -0.0329065
CALR calreticulin -0.0328425
RBM39 RNA binding motif protein 39 -0.0327747
RPL11 ribosomal protein L11 -0.0326257
NIPBL Nipped-B homolog (Drosophila) -0.0325605
GNAS GNAS complex locus -0.0324573
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0319207
RNF43 ring finger protein 43 -0.0317029
RPS24 ribosomal protein S24 -0.0316489
PERP PERP, TP53 apoptosis effector -0.0316211
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0315414
NF1 neurofibromin 1 -0.0313904
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0313326
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0310638
ITGA6 integrin, alpha 6 -0.0308641
MSI2 musashi RNA-binding protein 2 -0.0307714
TM9SF2 transmembrane 9 superfamily member 2 -0.0305908
TTC3 tetratricopeptide repeat domain 3 -0.0304087
MAP7 microtubule-associated protein 7 -0.0303547
EGLN3 egl-9 family hypoxia-inducible factor 3 -0.0303528