| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Selinexor perturbation in HCT15 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Selinexor _HCT15 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| XPO1 | exportin 1 | 0.139101 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0853407 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0803854 |
| PTMA | prothymosin, alpha | 0.0690153 |
| OGA | O-GlcNAcase | 0.0613799 |
| TXNRD1 | thioredoxin reductase 1 | 0.0595792 |
| CCNG2 | cyclin G2 | 0.0533843 |
| SCNN1A | sodium channel, non voltage gated 1 alpha subunit | 0.0481988 |
| POTEF | POTE ankyrin domain family, member F | 0.0404149 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0387904 |
| RPL3 | ribosomal protein L3 | 0.0365245 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0359805 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0358765 |
| TUBA1B | tubulin, alpha 1b | 0.0336418 |
| EZR | ezrin | 0.0335944 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.032893 |
| ARRDC3 | arrestin domain containing 3 | 0.0321147 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0317585 |
| TPM3 | tropomyosin 3 | 0.0312157 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0307387 |
| LDHA | lactate dehydrogenase A | 0.0306206 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | 0.0293786 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0284499 |
| MKI67 | marker of proliferation Ki-67 | 0.0283353 |
| NUP50 | nucleoporin 50kDa | 0.0282458 |
| ATF3 | activating transcription factor 3 | 0.0282254 |
| HMGA1 | high mobility group AT-hook 1 | 0.0276384 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0273464 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0260738 |
| HMGN2 | high mobility group nucleosomal binding domain 2 | 0.0249244 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.0249156 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0235718 |
| TMF1 | TATA element modulatory factor 1 | 0.0230187 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0222893 |
| MED15 | mediator complex subunit 15 | 0.022287 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0222799 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.0221444 |
| ENO1 | enolase 1, (alpha) | 0.0214581 |
| LRRC8D | leucine rich repeat containing 8 family, member D | 0.0211711 |
| FN1 | fibronectin 1 | 0.0209265 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0208549 |
| TCP1 | t-complex 1 | 0.0205867 |
| FAM120A | family with sequence similarity 120A | 0.0205762 |
| MYADM | myeloid-associated differentiation marker | 0.020202 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0200932 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | 0.0193988 |
| PTPN3 | protein tyrosine phosphatase, non-receptor type 3 | 0.0193863 |
| TMOD3 | tropomodulin 3 (ubiquitous) | 0.0193494 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | 0.0193351 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0191743 |
| PRPF8 | pre-mRNA processing factor 8 | 0.0189513 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0188787 |
| MAPK1IP1L | mitogen-activated protein kinase 1 interacting protein 1-like | 0.0187115 |
| PPME1 | protein phosphatase methylesterase 1 | 0.0186255 |
| SBNO1 | strawberry notch homolog 1 (Drosophila) | 0.0184348 |
| ANXA2 | annexin A2 | 0.0181711 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0181664 |
| TRAM1 | translocation associated membrane protein 1 | 0.0179994 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | 0.0179941 |
| BAZ2A | bromodomain adjacent to zinc finger domain, 2A | 0.0179556 |
| SET | SET nuclear proto-oncogene | 0.0178883 |
| STK32A | serine/threonine kinase 32A | 0.0178261 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0178166 |
| RNF24 | ring finger protein 24 | 0.0178087 |
| ANO10 | anoctamin 10 | 0.0176532 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | 0.0175562 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0174306 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.017354 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0172743 |
| DOCK6 | dedicator of cytokinesis 6 | 0.0167341 |
| HSPA4L | heat shock 70kDa protein 4-like | 0.0166717 |
| KDM1A | lysine (K)-specific demethylase 1A | 0.0166662 |
| FLNA | filamin A, alpha | 0.0166635 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0166608 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0165512 |
| GSPT1 | G1 to S phase transition 1 | 0.0163254 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0161836 |
| DSPP | dentin sialophosphoprotein | 0.016014 |
| IKBIP | IKBKB interacting protein | 0.0159892 |
| RNPS1 | RNA binding protein S1, serine-rich domain | 0.0159761 |
| TXNIP | thioredoxin interacting protein | 0.0158578 |
| BRD2 | bromodomain containing 2 | 0.0158161 |
| PRRC2A | proline-rich coiled-coil 2A | 0.015813 |
| YBX1 | Y box binding protein 1 | 0.0158124 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.015649 |
| FGD4 | FYVE, RhoGEF and PH domain containing 4 | 0.0154754 |
| EIF2AK1 | eukaryotic translation initiation factor 2-alpha kinase 1 | 0.0154304 |
| ANXA11 | annexin A11 | 0.0154117 |
| AGPAT5 | 1-acylglycerol-3-phosphate O-acyltransferase 5 | 0.0152117 |
| EIF5 | eukaryotic translation initiation factor 5 | 0.015189 |
| SUPT6H | suppressor of Ty 6 homolog (S. cerevisiae) | 0.0151069 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0150781 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0150066 |
| HYOU1 | hypoxia up-regulated 1 | 0.0149622 |
| PTEN | phosphatase and tensin homolog | 0.0149248 |
| SAMD8 | sterile alpha motif domain containing 8 | 0.014913 |
| PRDX2 | peroxiredoxin 2 | 0.0147462 |
| BPNT2 | 3'(2'), 5'-bisphosphate nucleotidase 2 | 0.014688 |
| DIAPH3 | diaphanous-related formin 3 | 0.014651 |
| FNTA | farnesyltransferase, CAAX box, alpha | 0.0146073 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TPT1 | tumor protein, translationally-controlled 1 | -0.173239 |
| AHNAK | AHNAK nucleoprotein | -0.160584 |
| PATJ | PATJ crumbs cell polarity complex component | -0.112987 |
| INTS6 | integrator complex subunit 6 | -0.0901556 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0824588 |
| VCL | vinculin | -0.076922 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0742599 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0703856 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0691228 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0623884 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.061835 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.058591 |
| SERINC5 | serine incorporator 5 | -0.0545746 |
| MCL1 | myeloid cell leukemia 1 | -0.0544238 |
| TMSB10 | thymosin beta 10 | -0.0539542 |
| EGR1 | early growth response 1 | -0.0538601 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0531069 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0516078 |
| USP34 | ubiquitin specific peptidase 34 | -0.0512086 |
| PRELID2 | PRELI domain containing 2 | -0.0511122 |
| PARD3 | par-3 family cell polarity regulator | -0.049062 |
| SLCO1B3-SLCO1B7 | SLCO1B3-SLCO1B7 readthrough | -0.0478902 |
| ADD1 | adducin 1 (alpha) | -0.0478392 |
| NF1 | neurofibromin 1 | -0.0465462 |
| CUX1 | cut-like homeobox 1 | -0.0462635 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0457323 |
| RPS6 | ribosomal protein S6 | -0.0448788 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0447474 |
| RPL34 | ribosomal protein L34 | -0.0433167 |
| RAD51B | RAD51 paralog B | -0.0433158 |
| KDM4C | lysine (K)-specific demethylase 4C | -0.0423934 |
| RPL35A | ribosomal protein L35a | -0.0417813 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0416899 |
| RPS24 | ribosomal protein S24 | -0.0407453 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0402135 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0400844 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | -0.0400217 |
| S100A10 | S100 calcium binding protein A10 | -0.03997 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.039798 |
| SNX14 | sorting nexin 14 | -0.0395845 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0394375 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.0393736 |
| KLF6 | Kruppel-like factor 6 | -0.0392339 |
| DENND1A | DENN/MADD domain containing 1A | -0.0385885 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0373461 |
| LRRC23 | leucine rich repeat containing 23 | -0.036494 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | -0.0364916 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.036373 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0360919 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0356627 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0354459 |
| RSF1 | remodeling and spacing factor 1 | -0.0350903 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0350518 |
| KDM4B | lysine (K)-specific demethylase 4B | -0.0349449 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0349401 |
| SBF2 | SET binding factor 2 | -0.0347949 |
| CADPS | Ca++-dependent secretion activator | -0.0347204 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0346576 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0343642 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | -0.0343006 |
| CTBP2 | C-terminal binding protein 2 | -0.034228 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.0338055 |
| CACNB4 | calcium channel, voltage-dependent, beta 4 subunit | -0.0335036 |
| GNAS | GNAS complex locus | -0.0332117 |
| SCARB1 | scavenger receptor class B, member 1 | -0.0331405 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0328772 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.032702 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0323083 |
| RPLP0 | ribosomal protein, large, P0 | -0.031946 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0317688 |
| RPL26 | ribosomal protein L26 | -0.031654 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0314484 |
| SMYD3 | SET and MYND domain containing 3 | -0.031299 |
| PALD1 | phosphatase domain containing, paladin 1 | -0.0312082 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0308386 |
| ARF1 | ADP-ribosylation factor 1 | -0.0306697 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0306096 |
| GOLGB1 | golgin B1 | -0.0305673 |
| RPL37A | ribosomal protein L37a | -0.0304658 |
| FDPS | farnesyl diphosphate synthase | -0.0300953 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0297352 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0296426 |
| BBX | bobby sox homolog (Drosophila) | -0.0296358 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0293785 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0291958 |
| FNIP1 | folliculin interacting protein 1 | -0.0288102 |
| CDK13 | cyclin-dependent kinase 13 | -0.0286128 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0284122 |
| UBAP2 | ubiquitin associated protein 2 | -0.0283965 |
| ATXN1 | ataxin 1 | -0.0283103 |
| WAC | WW domain containing adaptor with coiled-coil | -0.028263 |
| CEP95 | centrosomal protein 95kDa | -0.0281764 |
| EPCAM | epithelial cell adhesion molecule | -0.0280921 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.028057 |
| FUT11 | fucosyltransferase 11 (alpha (1,3) fucosyltransferase) | -0.0278782 |
| FRMD5 | FERM domain containing 5 | -0.0278534 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0272379 |
| FAT1 | FAT atypical cadherin 1 | -0.0271238 |
| RPLP2 | ribosomal protein, large, P2 | -0.0271167 |
| AEBP2 | AE binding protein 2 | -0.0268627 |
