Selinexor _HEC-1-A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Selinexor perturbation in HEC-1-A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Selinexor _HEC-1-A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PCLO piccolo presynaptic cytomatrix protein 0.17001
MT2A metallothionein 2A 0.0818158
HMGA1 high mobility group AT-hook 1 0.0485913
MYH9 myosin, heavy chain 9, non-muscle 0.0428746
XPO1 exportin 1 0.0416608
POTEF POTE ankyrin domain family, member F 0.0391668
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0359694
RNF150 ring finger protein 150 0.0350166
FOSL1 FOS-like antigen 1 0.0335305
NDRG1 N-myc downstream regulated 1 0.0313774
UPP1 uridine phosphorylase 1 0.0303535
MYADM myeloid-associated differentiation marker 0.0270446
PCBP2 poly(rC) binding protein 2 0.0270288
EGR1 early growth response 1 0.0260433
CCNL1 cyclin L1 0.0245385
MACC1 metastasis associated in colon cancer 1 0.0243081
SNX9 sorting nexin 9 0.0237621
SEPTIN9 septin 9 0.0235746
MYEOV myeloma overexpressed 0.0228982
ITGB8 integrin, beta 8 0.0224428
AXL AXL receptor tyrosine kinase 0.0218741
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0214181
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0212929
ADAM9 ADAM metallopeptidase domain 9 0.0199755
IRS2 insulin receptor substrate 2 0.0196757
LAMA4 laminin, alpha 4 0.0196218
PPP1R13L protein phosphatase 1, regulatory subunit 13 like 0.0188298
ANXA11 annexin A11 0.0186254
ZFP36L1 ZFP36 ring finger protein-like 1 0.0185817
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0167407
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.0165532
TBC1D5 TBC1 domain family, member 5 0.0165023
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0159052
PDGFC platelet derived growth factor C 0.0156151
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0155809
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0155541
DOCK6 dedicator of cytokinesis 6 0.0154121
MT1X metallothionein 1X 0.0153096
WASF2 WAS protein family, member 2 0.0152499
SKAP2 src kinase associated phosphoprotein 2 0.0151191
AGRN agrin 0.0148171
RPL3 ribosomal protein L3 0.0146215
KIF5C kinesin family member 5C 0.0145658
CLDN4 claudin 4 0.0143079
ANKRD36 ankyrin repeat domain 36 0.0141939
VEGFA vascular endothelial growth factor A 0.0137227
MIDEAS mitotic deacetylase associated SANT domain protein 0.0134951
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0132295
CYB5R3 cytochrome b5 reductase 3 0.0132066
PAX8 paired box 8 0.0131344
ZMIZ2 zinc finger, MIZ-type containing 2 0.0130012
EZR ezrin 0.012961
NOTCH2 notch 2 0.0129219
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0127148
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0125813
LINGO2 leucine rich repeat and Ig domain containing 2 0.0125209
CCNG2 cyclin G2 0.012428
SFPQ splicing factor proline/glutamine-rich 0.012397
ZNF638 zinc finger protein 638 0.0123233
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0123104
ENO2 enolase 2 (gamma, neuronal) 0.0121246
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.012041
TINAGL1 tubulointerstitial nephritis antigen-like 1 0.0119402
FSD1L fibronectin type III and SPRY domain containing 1-like 0.0118586
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0118438
TNFAIP2 tumor necrosis factor, alpha-induced protein 2 0.011809
SHB Src homology 2 domain containing adaptor protein B 0.0118058
MSANTD3 Myb/SANT-like DNA-binding domain containing 3 0.0117371
OGA O-GlcNAcase 0.0116766
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0116441
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0114441
SGMS2 sphingomyelin synthase 2 0.0114283
ATN1 atrophin 1 0.0112353
SMIM44 small integral membrane protein 44 0.0110163
CENPF centromere protein F, 350/400kDa 0.0109448
SMAD3 SMAD family member 3 0.0109293
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.0108009
MSN moesin 0.0107304
DMXL1 Dmx-like 1 0.0105809
TNIP1 TNFAIP3 interacting protein 1 0.0105657
PFN1 profilin 1 0.0105427
RNF213 ring finger protein 213 0.0105106
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.010501
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0104974
WEE1 WEE1 G2 checkpoint kinase 0.0104486
ESYT2 extended synaptotagmin-like protein 2 0.0101457
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0101003
CLDN7 claudin 7 0.0100578
CD47 CD47 molecule 0.00997889
GRAMD2B GRAM domain containing 2B 0.0099281
ICAM1 intercellular adhesion molecule 1 0.00989811
PTPN3 protein tyrosine phosphatase, non-receptor type 3 0.00982762
KIF18B kinesin family member 18B 0.00979984
ZNF292 zinc finger protein 292 0.00970898
EPHA2 EPH receptor A2 0.0096984
KIF23 kinesin family member 23 0.00969236
UGCG UDP-glucose ceramide glucosyltransferase 0.0096056
ITGB4 integrin, beta 4 0.00946406
UBA6 ubiquitin-like modifier activating enzyme 6 0.00946084
RNF145 ring finger protein 145 0.00943788

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.151266
AHNAK AHNAK nucleoprotein -0.10624
ASPH aspartate beta-hydroxylase -0.100149
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0927887
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0815114
TPT1 tumor protein, translationally-controlled 1 -0.0709989
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.068848
ACTG1 actin gamma 1 -0.0650439
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.065
TMSB4X thymosin beta 4, X-linked -0.0622117
APP amyloid beta (A4) precursor protein -0.0563474
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0541719
CANX calnexin -0.0521529
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0492222
TMSB10 thymosin beta 10 -0.0460293
LAMB3 laminin, beta 3 -0.0459282
MKI67 marker of proliferation Ki-67 -0.0453665
ALCAM activated leukocyte cell adhesion molecule -0.0420049
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0411077
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0402072
PTMA prothymosin, alpha -0.0393662
HMGA2 high mobility group AT-hook 2 -0.0392627
RPL23 ribosomal protein L23 -0.0376117
SQSTM1 sequestosome 1 -0.0370888
CSNK1A1 casein kinase 1, alpha 1 -0.0362701
EIF1 eukaryotic translation initiation factor 1 -0.0360019
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0354329
RTN3 reticulon 3 -0.0346715
IARS1 isoleucyl-tRNA synthetase 1 -0.0340614
TAS2R14 taste receptor, type 2, member 14 -0.0335876
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3 -0.0331857
ZBTB20 zinc finger and BTB domain containing 20 -0.0331109
GPATCH8 G patch domain containing 8 -0.0329182
H1-0 H1.0 linker histone -0.0326118
DLC1 DLC1 Rho GTPase activating protein -0.0325254
PRELID2 PRELI domain containing 2 -0.0323237
RPS24 ribosomal protein S24 -0.0322434
DSG2 desmoglein 2 -0.0321774
LDHA lactate dehydrogenase A -0.0316819
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0314945
IGFBP3 insulin-like growth factor binding protein 3 -0.0314364
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -0.0313903
MAP4 microtubule-associated protein 4 -0.0310307
LOC112694756 uncharaterized LOC112694756 -0.0309078
NF1 neurofibromin 1 -0.0307622
NIPBL Nipped-B homolog (Drosophila) -0.0305312
GNAS GNAS complex locus -0.030337
RPL19 ribosomal protein L19 -0.0299673
RPL4 ribosomal protein L4 -0.0294542
RPL26 ribosomal protein L26 -0.0289858
TAOK1 TAO kinase 1 -0.0288899
RPS6 ribosomal protein S6 -0.0287686
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0287153
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0286342
TJP1 tight junction protein 1 -0.028333
CDK13 cyclin-dependent kinase 13 -0.0281992
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0281269
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0281141
RPL34 ribosomal protein L34 -0.0280849
LPP LIM domain containing preferred translocation partner in lipoma -0.0279479
ZFAND3 zinc finger, AN1-type domain 3 -0.0278831
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0268197
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0266738
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0265676
SENP5 SUMO1/sentrin specific peptidase 5 -0.0265353
BIRC6 baculoviral IAP repeat containing 6 -0.0263909
ANKRD17 ankyrin repeat domain 17 -0.0263116
RSL1D1 ribosomal L1 domain containing 1 -0.0262229
RPLP0 ribosomal protein, large, P0 -0.0257501
ANKRD10 ankyrin repeat domain 10 -0.0256369
WWOX WW domain containing oxidoreductase -0.0251203
PSD3 pleckstrin and Sec7 domain containing 3 -0.0250457
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.024916
PDIA5 protein disulfide isomerase family A, member 5 -0.024825
RPS27A ribosomal protein S27a -0.0247898
MBNL1 muscleblind-like splicing regulator 1 -0.0247587
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0247042
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0246094
INTS6 integrator complex subunit 6 -0.0245166
GOLGA4 golgin A4 -0.0241866
PTPRK protein tyrosine phosphatase, receptor type, K -0.0240038
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0239901
BICD1 bicaudal D homolog 1 (Drosophila) -0.0238454
EGFR epidermal growth factor receptor -0.0236121
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0235858
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0234347
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0234193
CCDC138 coiled-coil domain containing 138 -0.0232158
NSD2 nuclear receptor binding SET domain protein 2 -0.0229769
OSBPL10 oxysterol binding protein-like 10 -0.0229149
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0228994
RPL38 ribosomal protein L38 -0.0228413
CLTC clathrin, heavy chain (Hc) -0.0228393
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0227169
ANKRD11 ankyrin repeat domain 11 -0.0224866
RPL31 ribosomal protein L31 -0.022456
EXT1 exostosin glycosyltransferase 1 -0.0224431
CAMTA1 calmodulin binding transcription activator 1 -0.022374
RPL12 ribosomal protein L12 -0.0220204
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) -0.0219319