Selinexor _HT-29 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Selinexor perturbation in HT-29 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Selinexor _HT-29 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PCLO piccolo presynaptic cytomatrix protein 0.116196
ITPKC inositol-trisphosphate 3-kinase C 0.0725267
PLAUR plasminogen activator, urokinase receptor 0.0609265
AHNAK AHNAK nucleoprotein 0.053046
KRT20 keratin 20, type I 0.0459775
XPO1 exportin 1 0.0457094
PDE4D phosphodiesterase 4D, cAMP-specific 0.0420232
RPS19 ribosomal protein S19 0.0375578
EMP1 epithelial membrane protein 1 0.0361677
ST14 suppression of tumorigenicity 14 (colon carcinoma) 0.0356879
SCNN1A sodium channel, non voltage gated 1 alpha subunit 0.032279
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0308955
RPLP1 ribosomal protein, large, P1 0.0293019
RPS3 ribosomal protein S3 0.0274579
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0267601
B2M beta-2-microglobulin 0.0265761
PELI1 pellino E3 ubiquitin protein ligase 1 0.025564
RPLP2 ribosomal protein, large, P2 0.025423
NCEH1 neutral cholesterol ester hydrolase 1 0.0248482
EZR ezrin 0.0236758
MUC13 mucin 13, cell surface associated 0.0230708
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0224491
LRRC8D leucine rich repeat containing 8 family, member D 0.0223053
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0218603
RND3 Rho family GTPase 3 0.0217347
ETV6 ets variant 6 0.0201209
RPS8 ribosomal protein S8 0.0200053
TUFT1 tuftelin 1 0.019214
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 0.0190454
DPP4 dipeptidyl-peptidase 4 0.0187094
RPL31 ribosomal protein L31 0.0185662
RPL21 ribosomal protein L21 0.0180103
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0179672
CCNG2 cyclin G2 0.0174835
SAMD12 sterile alpha motif domain containing 12 0.0173718
INTS6 integrator complex subunit 6 0.0172249
MCL1 myeloid cell leukemia 1 0.0169279
NAMPT nicotinamide phosphoribosyltransferase 0.016922
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0169044
RPS29 ribosomal protein S29 0.0165207
RPS11 ribosomal protein S11 0.0159945
RPL37A ribosomal protein L37a 0.0158333
ADD3 adducin 3 (gamma) 0.0156615
HSPA4L heat shock 70kDa protein 4-like 0.0156435
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 0.0155302
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0155076
RPS17 ribosomal protein S17 0.0153372
TM4SF4 transmembrane 4 L six family member 4 0.0153071
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0152743
ARRDC3 arrestin domain containing 3 0.0152624
KLF6 Kruppel-like factor 6 0.0152018
RAD51B RAD51 paralog B 0.0149088
GPHN gephyrin 0.0149014
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0148941
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0146654
ITGA1 integrin, alpha 1 0.0146163
RPL13A ribosomal protein L13a 0.0145414
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 0.0144705
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0143904
MMP7 matrix metallopeptidase 7 0.0142951
TXNIP thioredoxin interacting protein 0.0141097
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.013973
VEGFA vascular endothelial growth factor A 0.013963
RPL36 ribosomal protein L36 0.0137242
RPS27A ribosomal protein S27a 0.0136755
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.0136539
PDZRN3 PDZ domain containing ring finger 3 0.0135836
HOXB3 homeobox B3 0.0134475
BCAS1 breast carcinoma amplified sequence 1 0.0133322
RPS23 ribosomal protein S23 0.0132434
RPS13 ribosomal protein S13 0.0132244
RPS10 ribosomal protein S10 0.0131406
RPL19 ribosomal protein L19 0.0128633
PKM pyruvate kinase, muscle 0.0126878
RPL9 ribosomal protein L9 0.0126814
LSR lipolysis stimulated lipoprotein receptor 0.012666
APOL1 apolipoprotein L, 1 0.0125264
MACROD2 MACRO domain containing 2 0.0123079
MYADM myeloid-associated differentiation marker 0.0121558
FNDC3B fibronectin type III domain containing 3B 0.0121401
OCLN occludin 0.0120677
SIPA1L2 signal-induced proliferation-associated 1 like 2 0.0120115
TLE4 transducin-like enhancer of split 4 0.011939
RPS21 ribosomal protein S21 0.0119151
VIM vimentin 0.0118069
FRAS1 Fraser extracellular matrix complex subunit 1 0.0117147
ACTG1 actin gamma 1 0.0114694
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0112707
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A 0.0112459
MT2A metallothionein 2A 0.0111864
ADM adrenomedullin 0.0110154
TNIP1 TNFAIP3 interacting protein 1 0.0108413
RPL38 ribosomal protein L38 0.0107936
RPS15 ribosomal protein S15 0.0107108
FOXP1 forkhead box P1 0.0106926
TMEM51 transmembrane protein 51 0.0106392
AKAP12 A kinase (PRKA) anchor protein 12 0.0106032
GALK2 galactokinase 2 0.0105627
PHACTR2 phosphatase and actin regulator 2 0.0105593
AEBP2 AE binding protein 2 0.0105432

decreased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 -0.100362
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 -0.091827
SMAD3 SMAD family member 3 -0.0749871
RAD21 RAD21 homolog (S. pombe) -0.0743898
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0743661
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0717328
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0704341
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0592093
PDIA3 protein disulfide isomerase family A, member 3 -0.057996
EIF3H eukaryotic translation initiation factor 3, subunit H -0.057511
GCLC glutamate-cysteine ligase, catalytic subunit -0.0557233
WWC1 WW and C2 domain containing 1 -0.0550432
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0540887
GMDS GDP-mannose 4,6-dehydratase -0.052598
NF1 neurofibromin 1 -0.0515886
PATJ PATJ crumbs cell polarity complex component -0.0515336
KMT2C lysine (K)-specific methyltransferase 2C -0.0512127
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0504803
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0484716
EXT1 exostosin glycosyltransferase 1 -0.047265
TJP1 tight junction protein 1 -0.0464086
ARHGAP32 Rho GTPase activating protein 32 -0.045314
IARS1 isoleucyl-tRNA synthetase 1 -0.0445982
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0439265
SLC45A4 solute carrier family 45, member 4 -0.0437562
COG5 component of oligomeric golgi complex 5 -0.0436001
VCL vinculin -0.0426461
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0425807
HM13 histocompatibility (minor) 13 -0.0423424
GARS1 glycyl-tRNA synthetase 1 -0.0421917
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0420013
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0413059
KIAA0232 KIAA0232 -0.0410254
ATXN1 ataxin 1 -0.0409102
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.0408791
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0406304
FLNB filamin B, beta -0.0403478
SEC31A SEC31 homolog A (S. cerevisiae) -0.0397434
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0395775
ANXA2 annexin A2 -0.0394155
BIRC6 baculoviral IAP repeat containing 6 -0.0393022
LAMA4 laminin, alpha 4 -0.0391584
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.038903
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0386087
SETX senataxin -0.0380203
TES testin LIM domain protein -0.037778
RTN3 reticulon 3 -0.0377759
STK24 serine/threonine kinase 24 -0.0372346
AKAP13 A kinase (PRKA) anchor protein 13 -0.0370847
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0369325
SQSTM1 sequestosome 1 -0.0362233
RAB10 RAB10, member RAS oncogene family -0.0359031
CTBP2 C-terminal binding protein 2 -0.034999
TMEM65 transmembrane protein 65 -0.0347816
PSME4 proteasome (prosome, macropain) activator subunit 4 -0.0345821
CD2AP CD2-associated protein -0.0342303
CANX calnexin -0.034007
FTH1 ferritin, heavy polypeptide 1 -0.033812
AGO2 argonaute RISC catalytic component 2 -0.0337394
BTBD9 BTB (POZ) domain containing 9 -0.0337372
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0336591
RAB7A RAB7A, member RAS oncogene family -0.0335625
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0334812
GOLGA4 golgin A4 -0.0332482
KDM6A lysine (K)-specific demethylase 6A -0.0330333
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.0328684
PICALM phosphatidylinositol binding clathrin assembly protein -0.0327407
SBF2 SET binding factor 2 -0.0326716
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0320759
ANKRD12 ankyrin repeat domain 12 -0.0319156
PRRC2C proline-rich coiled-coil 2C -0.031901
AKAP9 A kinase (PRKA) anchor protein 9 -0.0318583
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0318421
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.030654
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) -0.030575
SEPTIN9 septin 9 -0.0303282
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 -0.0301784
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0301553
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0301217
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0300838
HDLBP high density lipoprotein binding protein -0.0300187
ARHGAP29 Rho GTPase activating protein 29 -0.0296595
NT5C2 5'-nucleotidase, cytosolic II -0.0296045
TOP1 topoisomerase (DNA) I -0.0295284
IPO7 importin 7 -0.0295008
LOC112694756 uncharaterized LOC112694756 -0.0294676
RBM39 RNA binding motif protein 39 -0.0293871
CLTC clathrin, heavy chain (Hc) -0.0293726
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0290868
MYO1E myosin IE -0.0290741
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0290305
TM9SF3 transmembrane 9 superfamily member 3 -0.0290096
BCL2L1 BCL2-like 1 -0.0288709
ZNF207 zinc finger protein 207 -0.0288433
PHF20L1 PHD finger protein 20-like 1 -0.0287944
RAB1A RAB1A, member RAS oncogene family -0.0287096
NTN4 netrin 4 -0.0286914
CALU calumenin -0.0282978
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0280719
TMEM41B transmembrane protein 41B -0.0280667