Selinexor _Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Selinexor perturbation in Hs 766T cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Selinexor _Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0393082
EXOC4 exocyst complex component 4 0.0365778
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0336277
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0313883
FOXP1 forkhead box P1 0.0307139
DOCK5 dedicator of cytokinesis 5 0.027103
MBNL2 muscleblind-like splicing regulator 2 0.0262577
CEMIP cell migration inducing protein, hyaluronan binding 0.0260756
AOPEP aminopeptidase O (putative) 0.0246591
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0246387
HSPG2 heparan sulfate proteoglycan 2 0.0245909
DST dystonin 0.0240135
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0223781
ZCCHC7 zinc finger, CCHC domain containing 7 0.0219406
MSN moesin 0.0208035
DOCK4 dedicator of cytokinesis 4 0.0207309
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0206794
RNF217 ring finger protein 217 0.0206287
PTK2 protein tyrosine kinase 2 0.0201828
RABGAP1L RAB GTPase activating protein 1-like 0.0200966
SULF1 sulfatase 1 0.0198735
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0195386
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0190099
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.018903
AKAP13 A kinase (PRKA) anchor protein 13 0.018669
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0186282
BCAR3 breast cancer anti-estrogen resistance 3 0.0185724
APP amyloid beta (A4) precursor protein 0.0184265
FNIP1 folliculin interacting protein 1 0.0180282
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0176455
BBS9 Bardet-Biedl syndrome 9 0.0173306
CALB1 calbindin 1, 28kDa 0.0169638
UBAP2 ubiquitin associated protein 2 0.0167315
PCLO piccolo presynaptic cytomatrix protein 0.0165795
DHFR dihydrofolate reductase 0.0164307
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0163902
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0162128
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0160599
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0157671
SLTM SAFB-like, transcription modulator 0.0157427
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) 0.0154565
FAM107B family with sequence similarity 107, member B 0.0153381
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0151823
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6 0.0151565
SDC4 syndecan 4 0.0149243
XPO1 exportin 1 0.0149005
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.014611
TBC1D5 TBC1 domain family, member 5 0.0145292
DUSP4 dual specificity phosphatase 4 0.0142428
VEGFC vascular endothelial growth factor C 0.0139638
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0139385
MRPS6 mitochondrial ribosomal protein S6 0.0137884
PDLIM5 PDZ and LIM domain 5 0.0137882
GRAMD1B GRAM domain containing 1B 0.0134861
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0133379
GPR39 G protein-coupled receptor 39 0.0131618
GRB10 growth factor receptor-bound protein 10 0.0130469
HDAC9 histone deacetylase 9 0.0130423
MYOF myoferlin 0.0125963
GPRC5B G protein-coupled receptor, class C, group 5, member B 0.0124479
RND3 Rho family GTPase 3 0.0124169
SMG7 SMG7 nonsense mediated mRNA decay factor 0.0122644
MECOM MDS1 and EVI1 complex locus 0.0122359
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0121955
PCF11 PCF11 cleavage and polyadenylation factor subunit 0.0121616
ZZZ3 zinc finger, ZZ-type containing 3 0.012018
METTL15 methyltransferase like 15 0.0119504
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0119406
PCDH9 protocadherin 9 0.0118962
TBC1D22A TBC1 domain family, member 22A 0.0117667
MYO10 myosin X 0.0114934
RRAS2 related RAS viral (r-ras) oncogene homolog 2 0.0114106
OSER1 oxidative stress responsive serine-rich 1 0.011238
FRAS1 Fraser extracellular matrix complex subunit 1 0.011155
PLK2 polo-like kinase 2 0.0109623
CNIH3 cornichon family AMPA receptor auxiliary protein 3 0.0108516
EXT1 exostosin glycosyltransferase 1 0.0107951
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0107152
AFG2A AFG2 AAA ATPase homolog A 0.0105554
KYNU kynureninase 0.0105142
PCMTD1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 0.0104851
DNAJC13 DnaJ (Hsp40) homolog, subfamily C, member 13 0.0103572
LNPEP leucyl/cystinyl aminopeptidase 0.0101408
UBAP2L ubiquitin associated protein 2-like 0.0101259
PMM2 phosphomannomutase 2 0.010072
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0100431
SDCBP syndecan binding protein (syntenin) 0.00982977
PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 0.00980041
NME7 NME/NM23 family member 7 0.00973343
LPP LIM domain containing preferred translocation partner in lipoma 0.00969904
SPIRE1 spire-type actin nucleation factor 1 0.00961136
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.00959573
GPR176 G protein-coupled receptor 176 0.00946519
RABGGTB Rab geranylgeranyltransferase, beta subunit 0.00943659
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 0.00942235
WDFY3 WD repeat and FYVE domain containing 3 0.00937243
NUBPL nucleotide binding protein-like 0.00936053
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.00935287
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.00935259
TTC28 tetratricopeptide repeat domain 28 0.00934975

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.20822
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.200471
MT2A metallothionein 2A -0.143141
TPT1 tumor protein, translationally-controlled 1 -0.121963
NDRG1 N-myc downstream regulated 1 -0.118645
B2M beta-2-microglobulin -0.103534
RPS6 ribosomal protein S6 -0.0997182
CLU clusterin -0.0962657
TMSB10 thymosin beta 10 -0.0961551
RPS21 ribosomal protein S21 -0.0958698
RPS8 ribosomal protein S8 -0.0919028
MTSS1 metastasis suppressor 1 -0.091601
S100A10 S100 calcium binding protein A10 -0.0895291
PTMA prothymosin, alpha -0.0840465
IFITM3 interferon induced transmembrane protein 3 -0.0821804
IFITM1 interferon induced transmembrane protein 1 -0.0734319
RPLP1 ribosomal protein, large, P1 -0.0723009
TIMP3 TIMP metallopeptidase inhibitor 3 -0.071993
HLA-B major histocompatibility complex, class I, B -0.0701597
RPLP2 ribosomal protein, large, P2 -0.0694513
ENO1 enolase 1, (alpha) -0.0693411
RPL11 ribosomal protein L11 -0.0692529
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0673067
TMSB4X thymosin beta 4, X-linked -0.0662532
STC1 stanniocalcin 1 -0.0659518
RPS19 ribosomal protein S19 -0.0634305
RPS13 ribosomal protein S13 -0.0625309
PGK1 phosphoglycerate kinase 1 -0.0622309
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0593532
RPL35A ribosomal protein L35a -0.0592203
KTN1 kinectin 1 (kinesin receptor) -0.0579714
MEF2A myocyte enhancer factor 2A -0.057844
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0572994
LOC112694756 uncharaterized LOC112694756 -0.0567681
LDHA lactate dehydrogenase A -0.0556708
RPS12 ribosomal protein S12 -0.0555609
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0554813
RIGI RNA sensor RIG-I -0.0554068
GNAS GNAS complex locus -0.0553874
RPL23 ribosomal protein L23 -0.0537539
RPS3 ribosomal protein S3 -0.0527938
RPS24 ribosomal protein S24 -0.0527741
RPS25 ribosomal protein S25 -0.052667
H1-0 H1.0 linker histone -0.0512065
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0511803
RPL34 ribosomal protein L34 -0.050511
POTEF POTE ankyrin domain family, member F -0.0501365
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0495192
RPL37 ribosomal protein L37 -0.0491581
IFI6 interferon, alpha-inducible protein 6 -0.0486458
FTL ferritin, light polypeptide -0.0485985
RPL12 ribosomal protein L12 -0.0485331
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0483879
S100A9 S100 calcium binding protein A9 -0.0473164
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0472749
CAV1 caveolin 1, caveolae protein, 22kDa -0.0471258
ASPH aspartate beta-hydroxylase -0.046667
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0445801
SP100 SP100 nuclear antigen -0.0440827
RPL19 ribosomal protein L19 -0.0439122
RPLP0 ribosomal protein, large, P0 -0.0437361
RPL8 ribosomal protein L8 -0.0433389
RPL37A ribosomal protein L37a -0.0430631
VCL vinculin -0.0430291
ZNFX1 zinc finger, NFX1-type containing 1 -0.0428236
S100A6 S100 calcium binding protein A6 -0.0423085
RPL31 ribosomal protein L31 -0.0417793
SAMD9 sterile alpha motif domain containing 9 -0.0414558
IFI27 interferon, alpha-inducible protein 27 -0.0404729
RPS23 ribosomal protein S23 -0.0401148
PSD3 pleckstrin and Sec7 domain containing 3 -0.039684
RPL36 ribosomal protein L36 -0.0388259
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0384972
FLNB filamin B, beta -0.0383842
RPS27 ribosomal protein S27 -0.0379569
RACK1 receptor for activated C kinase 1 -0.037893
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0378662
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0377503
LMNA lamin A/C -0.0371485
KIAA1217 KIAA1217 -0.0370302
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0370058
GOLGA4 golgin A4 -0.0369218
HM13 histocompatibility (minor) 13 -0.0368206
RPL35 ribosomal protein L35 -0.0365586
NAP1L1 nucleosome assembly protein 1-like 1 -0.0365506
KRT17 keratin 17, type I -0.0365495
RPL9 ribosomal protein L9 -0.0362961
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0361967
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0359421
RPS14 ribosomal protein S14 -0.035548
RPS29 ribosomal protein S29 -0.0353866
NAMPT nicotinamide phosphoribosyltransferase -0.0353584
RPL5 ribosomal protein L5 -0.0351526
ANGPTL4 angiopoietin-like 4 -0.0349038
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0347834
S100A2 S100 calcium binding protein A2 -0.0344461
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0343459
ANXA2 annexin A2 -0.0340101
RPL26 ribosomal protein L26 -0.0339089
PRRC2C proline-rich coiled-coil 2C -0.0336759