Selinexor _NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Selinexor perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Selinexor _NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PCLO piccolo presynaptic cytomatrix protein 0.134478
PDE4D phosphodiesterase 4D, cAMP-specific 0.0752602
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0590615
UPP1 uridine phosphorylase 1 0.0396129
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0385975
CEMIP cell migration inducing protein, hyaluronan binding 0.0372375
GRAMD1B GRAM domain containing 1B 0.0324917
SLTM SAFB-like, transcription modulator 0.030337
TBC1D22A TBC1 domain family, member 22A 0.0282213
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0279007
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0277773
XPO1 exportin 1 0.0255364
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 0.0252786
PM20D1 peptidase M20 domain containing 1 0.0244532
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0241899
RNF150 ring finger protein 150 0.0240576
LGALS12 lectin, galactoside-binding, soluble, 12 0.0239245
RAD51B RAD51 paralog B 0.0227216
AJAP1 adherens junctions associated protein 1 0.0222927
EPAS1 endothelial PAS domain protein 1 0.022242
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0221087
NTSR1 neurotensin receptor 1 (high affinity) 0.0209468
THSD4 thrombospondin, type I, domain containing 4 0.0202861
RAB27B RAB27B, member RAS oncogene family 0.0185149
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0176166
CD163L1 CD163 molecule-like 1 0.0173555
MCTP1 multiple C2 domains, transmembrane 1 0.0173317
CXCL3 chemokine (C-X-C motif) ligand 3 0.0172182
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0169021
BABAM2 BRISC and BRCA1 A complex member 2 0.0164602
ZC3H12B zinc finger CCCH-type containing 12B 0.0162858
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0160407
MAML3 mastermind-like 3 (Drosophila) 0.0156846
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0147771
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) 0.0146677
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0145274
CCNG2 cyclin G2 0.0141033
DNAH14 dynein, axonemal, heavy chain 14 0.0140901
CHMP1B charged multivesicular body protein 1B 0.0135166
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0134126
CCDC91 coiled-coil domain containing 91 0.0133929
MREG melanoregulin 0.0123525
MAP7 microtubule-associated protein 7 0.0122112
SMAD3 SMAD family member 3 0.0121081
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0120547
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0115113
SIPA1L2 signal-induced proliferation-associated 1 like 2 0.0114039
MYH9 myosin, heavy chain 9, non-muscle 0.0111563
BASP1 brain abundant, membrane attached signal protein 1 0.0108754
ATG10 autophagy related 10 0.0107079
RPSA2 ribosomal protein SA 2 0.0105725
MYOM1 myomesin 1 0.0104586
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.010435
FGF14 fibroblast growth factor 14 0.0102708
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) 0.0102317
YAP1 Yes-associated protein 1 0.010058
BMP6 bone morphogenetic protein 6 0.0100276
TPST1 tyrosylprotein sulfotransferase 1 0.00980909
SHB Src homology 2 domain containing adaptor protein B 0.00968291
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0096258
ERN1 endoplasmic reticulum to nucleus signaling 1 0.00959227
FAM169A family with sequence similarity 169, member A 0.00958761
SPAG16 sperm associated antigen 16 0.0095704
CUL4A cullin 4A 0.00954891
EXOC6B exocyst complex component 6B 0.0093762
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.00935163
PRKG1 protein kinase, cGMP-dependent, type I 0.00929198
DPH6 diphthamine biosynthesis 6 0.00927856
MT1X metallothionein 1X 0.00924573
SAMD12 sterile alpha motif domain containing 12 0.0091419
NGFR nerve growth factor receptor 0.00890396
FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial 0.00887768
HSPA4L heat shock 70kDa protein 4-like 0.00887624
SH3RF2 SH3 domain containing ring finger 2 0.00883457
CDYL chromodomain protein, Y-like 0.00854095
BBS9 Bardet-Biedl syndrome 9 0.00853458
LRRC8D leucine rich repeat containing 8 family, member D 0.00848657
FOXJ3 forkhead box J3 0.00845326
TBCEL tubulin folding cofactor E-like 0.00837762
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.00833842
B3GNT5 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 0.00832815
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.00832263
SDC1 syndecan 1 0.00820164
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21 0.00811798
WDR70 WD repeat domain 70 0.00805355
FHIT fragile histidine triad 0.00799351
BARX2 BARX homeobox 2 0.00794378
BCAS3 breast carcinoma amplified sequence 3 0.00784174
NCKAP1 NCK-associated protein 1 0.00777365
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.00770483
SLC25A26 solute carrier family 25 (S-adenosylmethionine carrier), member 26 0.00765431
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.00761252
TTC28 tetratricopeptide repeat domain 28 0.00751452
XPO6 exportin 6 0.00749639
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 0.00746896
KIFC3 kinesin family member C3 0.0074131
ATF7IP2 activating transcription factor 7 interacting protein 2 0.00734577
ANO10 anoctamin 10 0.00732589
CXCL8 chemokine (C-X-C motif) ligand 8 0.00732186
WWOX WW domain containing oxidoreductase 0.00718091

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.342544
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.288142
TMSB10 thymosin beta 10 -0.166439
NDRG1 N-myc downstream regulated 1 -0.134823
LMO7 LIM domain 7 -0.107899
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.106634
TPT1 tumor protein, translationally-controlled 1 -0.090883
PTMA prothymosin, alpha -0.0904854
ANXA2 annexin A2 -0.0819951
S100A10 S100 calcium binding protein A10 -0.0796721
ASPH aspartate beta-hydroxylase -0.0781955
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0669123
FTL ferritin, light polypeptide -0.0666704
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0626907
TXNRD1 thioredoxin reductase 1 -0.0607267
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0602083
PKM pyruvate kinase, muscle -0.0591921
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.058607
RPL35A ribosomal protein L35a -0.0585917
EGR1 early growth response 1 -0.05524
SEC31A SEC31 homolog A (S. cerevisiae) -0.0528004
RPS25 ribosomal protein S25 -0.0520221
RPLP1 ribosomal protein, large, P1 -0.0500623
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0493374
ACTG1 actin gamma 1 -0.0486755
EIF1 eukaryotic translation initiation factor 1 -0.0484865
TES testin LIM domain protein -0.0477528
RPS8 ribosomal protein S8 -0.0471788
LOC112694756 uncharaterized LOC112694756 -0.046366
EFNA5 ephrin-A5 -0.0457606
CAV1 caveolin 1, caveolae protein, 22kDa -0.0456019
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0451723
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0449447
CST3 cystatin C -0.0448334
HDLBP high density lipoprotein binding protein -0.0442653
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0441746
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0430475
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0424379
ENO1 enolase 1, (alpha) -0.0423545
LAMB3 laminin, beta 3 -0.0420395
RPS3 ribosomal protein S3 -0.0419701
MT2A metallothionein 2A -0.0418579
RAB1A RAB1A, member RAS oncogene family -0.0413922
SEC61G Sec61 gamma subunit -0.0413665
RPL37A ribosomal protein L37a -0.0413302
RPS24 ribosomal protein S24 -0.0409513
ZMYND8 zinc finger, MYND-type containing 8 -0.0408288
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0406982
WASF2 WAS protein family, member 2 -0.0404471
RNF213 ring finger protein 213 -0.039981
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.039395
CANX calnexin -0.0393068
RPL31 ribosomal protein L31 -0.0392054
PGK1 phosphoglycerate kinase 1 -0.0390081
AHNAK AHNAK nucleoprotein -0.0384837
RPL34 ribosomal protein L34 -0.03846
TMEM165 transmembrane protein 165 -0.0384039
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0363631
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0363
ANKRD12 ankyrin repeat domain 12 -0.0355662
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.0352803
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.03521
LAMC2 laminin, gamma 2 -0.0348343
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0344763
LDHA lactate dehydrogenase A -0.0344014
RPS6 ribosomal protein S6 -0.0343364
MYOF myoferlin -0.0340712
SCEL sciellin -0.0338982
BIRC3 baculoviral IAP repeat containing 3 -0.0336871
PDIA3 protein disulfide isomerase family A, member 3 -0.0332613
KRT18 keratin 18, type I -0.032598
SPAG9 sperm associated antigen 9 -0.0323359
TJP1 tight junction protein 1 -0.0322705
AKR1C1 aldo-keto reductase family 1, member C1 -0.0321469
RPL11 ribosomal protein L11 -0.0319068
B2M beta-2-microglobulin -0.0317824
SEPTIN2 septin 2 -0.0313305
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0312036
IGFBP3 insulin-like growth factor binding protein 3 -0.0311545
S100A6 S100 calcium binding protein A6 -0.0305175
RPS23 ribosomal protein S23 -0.0304917
AGR2 anterior gradient 2 -0.0304605
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0303436
S100P S100 calcium binding protein P -0.0294847
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0293793
RPL37 ribosomal protein L37 -0.0291782
MYO1D myosin ID -0.0290665
EZR ezrin -0.0289512
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 -0.028631
CAMTA1 calmodulin binding transcription activator 1 -0.028524
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0284127
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0282482
FNDC3B fibronectin type III domain containing 3B -0.0282388
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0282119
DSPP dentin sialophosphoprotein -0.0281366
TRIM56 tripartite motif containing 56 -0.0278876
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.0277889
KDM2A lysine (K)-specific demethylase 2A -0.0274969
HLA-B major histocompatibility complex, class I, B -0.0273636
BIRC6 baculoviral IAP repeat containing 6 -0.0273507