Selinexor _NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Selinexor perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Selinexor _NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.234965
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.131822
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0956209
NDRG1 N-myc downstream regulated 1 0.080692
SDC4 syndecan 4 0.0667652
ARRDC3 arrestin domain containing 3 0.0511623
TSC22D2 TSC22 domain family, member 2 0.0442942
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.042991
G0S2 G0/G1 switch 2 0.0394545
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0384196
BHLHE40 basic helix-loop-helix family, member e40 0.0365915
FAM13A family with sequence similarity 13, member A 0.0359486
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0359443
PCLO piccolo presynaptic cytomatrix protein 0.0345803
HMGB2 high mobility group box 2 0.033813
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0326161
HSPA8 heat shock 70kDa protein 8 0.0318927
RYBP RING1 and YY1 binding protein 0.0311009
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0307568
HILPDA hypoxia inducible lipid droplet-associated 0.0307386
LDHA lactate dehydrogenase A 0.0301339
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0299795
ZFP36L1 ZFP36 ring finger protein-like 1 0.0294403
NAMPT nicotinamide phosphoribosyltransferase 0.0291501
UPP1 uridine phosphorylase 1 0.0286332
ENO1 enolase 1, (alpha) 0.0284335
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0279875
CANX calnexin 0.0279329
XPO1 exportin 1 0.0277777
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.027247
FAM162A family with sequence similarity 162, member A 0.0270859
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0268863
DSPP dentin sialophosphoprotein 0.0264939
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0264842
PDIA4 protein disulfide isomerase family A, member 4 0.0264499
MSN moesin 0.0254615
TXNIP thioredoxin interacting protein 0.0254155
CALR calreticulin 0.0247524
TMSB4X thymosin beta 4, X-linked 0.0244154
OGA O-GlcNAcase 0.0242275
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.022708
SQSTM1 sequestosome 1 0.0223266
EZR ezrin 0.0218245
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain 0.0216611
FXR1 fragile X mental retardation, autosomal homolog 1 0.0212526
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0209751
IGFBP3 insulin-like growth factor binding protein 3 0.0209578
S100A6 S100 calcium binding protein A6 0.020932
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0201079
CCNG2 cyclin G2 0.0198457
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0197434
BZW1 basic leucine zipper and W2 domains 1 0.0193052
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 0.0190977
CTSB cathepsin B 0.0183152
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.0179602
MXD1 MAX dimerization protein 1 0.0174458
EMP1 epithelial membrane protein 1 0.0173373
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0167298
STEAP4 STEAP family member 4 0.0164147
EEF2 eukaryotic translation elongation factor 2 0.0163997
SSBP2 single-stranded DNA binding protein 2 0.0161024
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.0160285
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0156669
FHIT fragile histidine triad 0.0153954
AHNAK AHNAK nucleoprotein 0.0153765
DUSP6 dual specificity phosphatase 6 0.0145895
PDIA6 protein disulfide isomerase family A, member 6 0.0144189
HSPA4L heat shock 70kDa protein 4-like 0.0142346
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0140906
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.013964
DSG2 desmoglein 2 0.0138231
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0136087
APLP2 amyloid beta (A4) precursor-like protein 2 0.0134577
FOSL1 FOS-like antigen 1 0.0132396
ADAM9 ADAM metallopeptidase domain 9 0.0131346
MT2A metallothionein 2A 0.0131187
PPME1 protein phosphatase methylesterase 1 0.0130661
TFPI2 tissue factor pathway inhibitor 2 0.0129634
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0129576
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0129005
H1-0 H1.0 linker histone 0.0126869
ADM adrenomedullin 0.0125874
TMED2 transmembrane emp24 domain trafficking protein 2 0.0125654
ICAM1 intercellular adhesion molecule 1 0.0125638
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0125337
AHNAK2 AHNAK nucleoprotein 2 0.0123722
IFI16 interferon, gamma-inducible protein 16 0.0121963
YBX1 Y box binding protein 1 0.0121074
RNF150 ring finger protein 150 0.0120247
TFRC transferrin receptor 0.0119934
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 0.0118786
NUP58 nucleoporin 58 0.0117239
PGK1 phosphoglycerate kinase 1 0.0117136
RLF rearranged L-myc fusion 0.0116192
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0114818
EGLN1 egl-9 family hypoxia-inducible factor 1 0.01147
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0113602
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.011256
SCNN1A sodium channel, non voltage gated 1 alpha subunit 0.0112322
KLF10 Kruppel-like factor 10 0.0111883

decreased expression

Symbol Name Standardized Value
POTEF POTE ankyrin domain family, member F -0.130762
RPL35A ribosomal protein L35a -0.0961579
FTL ferritin, light polypeptide -0.0819024
TMSB10 thymosin beta 10 -0.0765001
FN1 fibronectin 1 -0.0619955
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0585213
ACTG1 actin gamma 1 -0.0572993
ERBIN erbb2 interacting protein -0.0557785
EXT1 exostosin glycosyltransferase 1 -0.0551337
RPS23 ribosomal protein S23 -0.053072
RPS13 ribosomal protein S13 -0.052916
LPP LIM domain containing preferred translocation partner in lipoma -0.0519587
DTNA dystrobrevin, alpha -0.0517355
GOLGA4 golgin A4 -0.0488802
PTMA prothymosin, alpha -0.04867
RPS29 ribosomal protein S29 -0.0475148
RPL23 ribosomal protein L23 -0.0458737
TPT1 tumor protein, translationally-controlled 1 -0.0457988
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0456927
EFNA5 ephrin-A5 -0.045069
RPS8 ribosomal protein S8 -0.0438734
RPL9 ribosomal protein L9 -0.0430578
KMT2C lysine (K)-specific methyltransferase 2C -0.0414337
STRN3 striatin, calmodulin binding protein 3 -0.0398393
RPL31 ribosomal protein L31 -0.0398067
RPS25 ribosomal protein S25 -0.0380634
LIMCH1 LIM and calponin homology domains 1 -0.0380531
RCOR1 REST corepressor 1 -0.0374508
ANKRD17 ankyrin repeat domain 17 -0.0373069
MAP4 microtubule-associated protein 4 -0.0366624
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0365911
AKAP13 A kinase (PRKA) anchor protein 13 -0.0365514
SEC31A SEC31 homolog A (S. cerevisiae) -0.0359422
CCND1 cyclin D1 -0.0358866
SH3KBP1 SH3-domain kinase binding protein 1 -0.0358722
VCL vinculin -0.0358092
IFI27 interferon, alpha-inducible protein 27 -0.0349036
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0347815
FBXO34 F-box protein 34 -0.0345424
NIPBL Nipped-B homolog (Drosophila) -0.0340853
RPLP2 ribosomal protein, large, P2 -0.0340741
ZFAND3 zinc finger, AN1-type domain 3 -0.0340575
RPL34 ribosomal protein L34 -0.0338783
ZBTB20 zinc finger and BTB domain containing 20 -0.0335348
HLA-B major histocompatibility complex, class I, B -0.0334664
RPL37A ribosomal protein L37a -0.0332722
PRRC2C proline-rich coiled-coil 2C -0.0331069
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha -0.0329001
FBXO32 F-box protein 32 -0.0323961
SETD5 SET domain containing 5 -0.032292
PTK2 protein tyrosine kinase 2 -0.0321137
KDM2A lysine (K)-specific demethylase 2A -0.0320856
TMEM165 transmembrane protein 165 -0.0314551
NUMB numb homolog (Drosophila) -0.0314523
MBNL1 muscleblind-like splicing regulator 1 -0.0314449
FNDC3B fibronectin type III domain containing 3B -0.0313989
RPS17 ribosomal protein S17 -0.0311179
RPLP1 ribosomal protein, large, P1 -0.0309177
TJP1 tight junction protein 1 -0.0306295
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0303666
RPS6 ribosomal protein S6 -0.0302048
RPS12 ribosomal protein S12 -0.0300429
MYO6 myosin VI -0.0300411
FNIP1 folliculin interacting protein 1 -0.0293924
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 -0.0291932
MYO1E myosin IE -0.0288678
KRT7 keratin 7, type II -0.0287904
RBM25 RNA binding motif protein 25 -0.0287529
RPL11 ribosomal protein L11 -0.0284924
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0281347
ENO2 enolase 2 (gamma, neuronal) -0.0280886
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0279195
ANKRD12 ankyrin repeat domain 12 -0.0278912
PDLIM5 PDZ and LIM domain 5 -0.0275249
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0274302
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0270081
RAB7A RAB7A, member RAS oncogene family -0.0269451
CSNK1A1 casein kinase 1, alpha 1 -0.0269089
UBE2H ubiquitin-conjugating enzyme E2H -0.0268968
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0264035
ATP11A ATPase, class VI, type 11A -0.026122
LMO7 LIM domain 7 -0.0260375
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0259217
RASAL2 RAS protein activator like 2 -0.0259045
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0258727
MCU mitochondrial calcium uniporter -0.0258009
SIK3 SIK family kinase 3 -0.0257059
ZFAND6 zinc finger, AN1-type domain 6 -0.0255021
TTC3 tetratricopeptide repeat domain 3 -0.0252685
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0251983
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -0.025142
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0250917
EIF1 eukaryotic translation initiation factor 1 -0.025078
GSK3B glycogen synthase kinase 3 beta -0.0249884
MAP1B microtubule-associated protein 1B -0.0247455
UBAP1 ubiquitin associated protein 1 -0.0246513
GPBP1 GC-rich promoter binding protein 1 -0.0246124
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0246085
USP15 ubiquitin specific peptidase 15 -0.0244565
DLG1 discs, large homolog 1 (Drosophila) -0.0243872