Selinexor _NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Selinexor perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

180 genes differentially expressed following the Selinexor _NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide 0.13661
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.127707
FAT1 FAT atypical cadherin 1 0.115684
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.10709
LPP LIM domain containing preferred translocation partner in lipoma 0.106494
PCLO piccolo presynaptic cytomatrix protein 0.0903253
PTPRK protein tyrosine phosphatase, receptor type, K 0.0893232
EGFR epidermal growth factor receptor 0.0866853
AKAP12 A kinase (PRKA) anchor protein 12 0.0818611
XPO1 exportin 1 0.0815069
RPS8 ribosomal protein S8 0.0794768
TPM4 tropomyosin 4 0.074858
LGALS12 lectin, galactoside-binding, soluble, 12 0.07203
BIRC6 baculoviral IAP repeat containing 6 0.0682718
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0680756
SAMD4A sterile alpha motif domain containing 4A 0.0668595
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.0662519
TCF12 transcription factor 12 0.0658353
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0648482
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 0.0634254
ALCAM activated leukocyte cell adhesion molecule 0.0604033
MACF1 microtubule-actin crosslinking factor 1 0.0591256
APP amyloid beta (A4) precursor protein 0.0590314
BBX bobby sox homolog (Drosophila) 0.0585761
PARD3B par-3 family cell polarity regulator beta 0.0565264
CPEB4 cytoplasmic polyadenylation element binding protein 4 0.0543459
ERBB4 erb-b2 receptor tyrosine kinase 4 0.0538019
FER fer (fps/fes related) tyrosine kinase 0.0533274
PTK2 protein tyrosine kinase 2 0.0527541
ZC3H3 zinc finger CCCH-type containing 3 0.0518258
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0502215
SRPK2 SRSF protein kinase 2 0.0489683
CERS6 ceramide synthase 6 0.0447262
JMJD1C jumonji domain containing 1C 0.0445428
UBE2H ubiquitin-conjugating enzyme E2H 0.0441305
N4BP2L2 NEDD4 binding protein 2-like 2 0.0430914
SMYD3 SET and MYND domain containing 3 0.0428127
OGA O-GlcNAcase 0.0421059
KDM2A lysine (K)-specific demethylase 2A 0.0411577
KMT2C lysine (K)-specific methyltransferase 2C 0.040501
RERE arginine-glutamic acid dipeptide (RE) repeats 0.040485
RPS6 ribosomal protein S6 0.0402854
PATJ PATJ crumbs cell polarity complex component 0.0393239
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.038699
INHBA inhibin, beta A 0.0383483
TXNRD1 thioredoxin reductase 1 0.038194
TAS2R14 taste receptor, type 2, member 14 0.0364269
ENO1 enolase 1, (alpha) 0.0364069
EREG epiregulin 0.0362498
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.034949
AOPEP aminopeptidase O (putative) 0.034845
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0334083
UTRN utrophin 0.0333348
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.0314524
SMAD3 SMAD family member 3 0.0295067
CADM2 cell adhesion molecule 2 0.0294209
THSD4 thrombospondin, type I, domain containing 4 0.0287051
GMDS GDP-mannose 4,6-dehydratase 0.0278194
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0277876
VMP1 vacuole membrane protein 1 0.0268293
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0262346
EXT1 exostosin glycosyltransferase 1 0.0241444
COL8A1 collagen, type VIII, alpha 1 0.0237757
RPS12 ribosomal protein S12 0.0233739
SLTM SAFB-like, transcription modulator 0.0232657
CMIP c-Maf inducing protein 0.0224495
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0223419
PRKD3 protein kinase D3 0.0211108
EPS8 epidermal growth factor receptor pathway substrate 8 0.0209607
RPLP1 ribosomal protein, large, P1 0.0202905
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0198272
FNDC3B fibronectin type III domain containing 3B 0.0189738
ELL2 elongation factor, RNA polymerase II, 2 0.01894
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0184583
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0178972
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) 0.0176416
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0157575
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0145907
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0137607
MARCHF7 membrane associated ring-CH-type finger 7 0.0136547
PARD3 par-3 family cell polarity regulator 0.0136337
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.0123355
FTH1 ferritin, heavy polypeptide 1 0.0115271
SQSTM1 sequestosome 1 0.0110585
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) 0.0106017
GRB10 growth factor receptor-bound protein 10 0.0105979
NHSL1 NHS-like 1 0.00988526
TRIO trio Rho guanine nucleotide exchange factor 0.00973295
RIGI RNA sensor RIG-I 0.00828313
PCBP3 poly(rC) binding protein 3 0.00603386
FNIP1 folliculin interacting protein 1 0.00341884
NAP1L1 nucleosome assembly protein 1-like 1 0.00341547
SND1 staphylococcal nuclease and tudor domain containing 1 0.00248499
DOCK4 dedicator of cytokinesis 4 0.00241795
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.00164543
DSCAM Down syndrome cell adhesion molecule 0.00157346
RAD51B RAD51 paralog B 0.00144775
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.00132422
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.00110739

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.232586
PDE4D phosphodiesterase 4D, cAMP-specific -0.208754
NKD1 naked cuticle homolog 1 (Drosophila) -0.19928
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.149384
EFNA5 ephrin-A5 -0.144637
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.123236
VIM vimentin -0.114201
PSD3 pleckstrin and Sec7 domain containing 3 -0.101725
PDE10A phosphodiesterase 10A -0.0996081
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0990153
PTMA prothymosin, alpha -0.0961452
RORA RAR-related orphan receptor A -0.0924089
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0849557
GOLGA4 golgin A4 -0.0808548
ATXN1 ataxin 1 -0.075116
TPT1 tumor protein, translationally-controlled 1 -0.0746955
LAMA4 laminin, alpha 4 -0.0746307
PGK1 phosphoglycerate kinase 1 -0.0738853
NALF1 NALCN channel auxiliary factor 1 -0.0704642
B2M beta-2-microglobulin -0.069603
NBEAL1 neurobeachin-like 1 -0.0680869
PRRC2C proline-rich coiled-coil 2C -0.0674912
RPL35A ribosomal protein L35a -0.0633579
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0593899
SETD5 SET domain containing 5 -0.0592378
LOC102724023 ES1 protein homolog, mitochondrial -0.0583783
RPL26 ribosomal protein L26 -0.0557455
NAV2 neuron navigator 2 -0.0552272
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.053864
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0534414
SEC31A SEC31 homolog A (S. cerevisiae) -0.0525288
SPAG9 sperm associated antigen 9 -0.0517446
HDLBP high density lipoprotein binding protein -0.0501556
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0456599
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0441826
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0439434
GPC6 glypican 6 -0.0434591
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0418881
CDH13 cadherin 13 -0.0406896
PRKCA protein kinase C, alpha -0.0403807
VCL vinculin -0.0395375
NDRG1 N-myc downstream regulated 1 -0.0391818
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0390982
RPL23 ribosomal protein L23 -0.0384227
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0378523
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0361069
ZNF292 zinc finger protein 292 -0.0358621
ELOVL5 ELOVL fatty acid elongase 5 -0.0344669
MT2A metallothionein 2A -0.0304209
FNDC3A fibronectin type III domain containing 3A -0.0302225
BPTF bromodomain PHD finger transcription factor -0.0302178
ESYT2 extended synaptotagmin-like protein 2 -0.0301755
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0299246
PTPRM protein tyrosine phosphatase, receptor type, M -0.0294647
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 -0.0290603
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0285798
PDLIM5 PDZ and LIM domain 5 -0.0277125
SBF2 SET binding factor 2 -0.0248477
MAML2 mastermind-like 2 (Drosophila) -0.0247729
ASPH aspartate beta-hydroxylase -0.0246496
AKAP13 A kinase (PRKA) anchor protein 13 -0.0242104
FOS FBJ murine osteosarcoma viral oncogene homolog -0.023689
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.023005
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0227192
LDHA lactate dehydrogenase A -0.0227055
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0219849
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0218076
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0214508
DST dystonin -0.0193125
RBM25 RNA binding motif protein 25 -0.0186017
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0185295
TBC1D22A TBC1 domain family, member 22A -0.0156884
CALR calreticulin -0.0143373
EIF1 eukaryotic translation initiation factor 1 -0.0142904
RPS19 ribosomal protein S19 -0.0138271
TMSB10 thymosin beta 10 -0.0120717
PRELID2 PRELI domain containing 2 -0.012001
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0119908
MYO1E myosin IE -0.0104142
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.00459207
HLA-B major histocompatibility complex, class I, B -0.00177544