Selinexor _NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Selinexor perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Selinexor _NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PCLO piccolo presynaptic cytomatrix protein 0.0801306
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0528523
NTM neurotrimin 0.0498268
XPO1 exportin 1 0.0422394
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0322337
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0271338
EEF2 eukaryotic translation elongation factor 2 0.0256821
CFL2 cofilin 2 (muscle) 0.0248639
TSC22D2 TSC22 domain family, member 2 0.0247532
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0245009
NGFR nerve growth factor receptor 0.023745
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.023
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0228078
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0216577
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0213633
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0208394
HIP1 huntingtin interacting protein 1 0.0207949
ADAM9 ADAM metallopeptidase domain 9 0.0206115
GOLM2 golgi membrane protein 2 0.0204843
ANXA5 annexin A5 0.0202011
TMF1 TATA element modulatory factor 1 0.0201287
ERRFI1 ERBB receptor feedback inhibitor 1 0.0200929
TRIO trio Rho guanine nucleotide exchange factor 0.0200378
FXR1 fragile X mental retardation, autosomal homolog 1 0.0199245
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0196657
TENM3 teneurin transmembrane protein 3 0.0195493
FER fer (fps/fes related) tyrosine kinase 0.0185099
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0181143
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0177435
CASC3 cancer susceptibility candidate 3 0.0177325
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0176971
GSE1 Gse1 coiled-coil protein 0.0176962
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0176917
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0175091
OGA O-GlcNAcase 0.0174825
NUP58 nucleoporin 58 0.0174173
ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 0.0173906
CCN2 cellular communication network factor 2 0.0173813
PDGFC platelet derived growth factor C 0.0172421
RSRC2 arginine/serine-rich coiled-coil 2 0.017172
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit 0.0170559
SPAG9 sperm associated antigen 9 0.0167805
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0166899
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.0166631
OTUD7B OTU deubiquitinase 7B 0.0163952
FAR1 fatty acyl CoA reductase 1 0.0163395
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0162602
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0162464
PPA2 pyrophosphatase (inorganic) 2 0.0162337
DOT1L DOT1-like histone H3K79 methyltransferase 0.0158909
KMT2E lysine (K)-specific methyltransferase 2E 0.0158062
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 0.0156095
CELF2 CUGBP, Elav-like family member 2 0.0156091
PUM2 pumilio RNA-binding family member 2 0.0155686
RAD18 RAD18 E3 ubiquitin protein ligase 0.0154327
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide 0.0154067
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0152989
PCNX1 pecanex 1 0.0152868
EIF4B eukaryotic translation initiation factor 4B 0.0152579
TMTC3 transmembrane and tetratricopeptide repeat containing 3 0.015086
ZNF326 zinc finger protein 326 0.0150613
SCAF4 SR-related CTD-associated factor 4 0.0150449
CDC27 cell division cycle 27 0.0150247
NFE2L1 nuclear factor, erythroid 2-like 1 0.0150011
ZMYM4 zinc finger, MYM-type 4 0.0149641
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 0.0149411
PPME1 protein phosphatase methylesterase 1 0.0148016
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0147852
DDB2 damage-specific DNA binding protein 2, 48kDa 0.0147793
MAST2 microtubule associated serine/threonine kinase 2 0.0147703
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0147548
PPP2R2C protein phosphatase 2, regulatory subunit B, gamma 0.014712
SRRM1 serine/arginine repetitive matrix 1 0.0147048
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 0.0146878
PPP4R1 protein phosphatase 4, regulatory subunit 1 0.0146286
SUMO1 small ubiquitin-like modifier 1 0.0146061
CCPG1 cell cycle progression 1 0.0145619
TXNRD1 thioredoxin reductase 1 0.0145389
MIER1 mesoderm induction early response 1, transcriptional regulator 0.0144352
DIXDC1 DIX domain containing 1 0.0144023
CKAP5 cytoskeleton associated protein 5 0.014288
STK38 serine/threonine kinase 38 0.0142548
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.0142173
ZNF638 zinc finger protein 638 0.0141794
MTREX Mtr4 exosome RNA helicase 0.0141623
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0141328
PER1 period circadian clock 1 0.0141055
SS18L1 synovial sarcoma translocation gene on chromosome 18-like 1 0.0140209
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0140167
SEL1L sel-1 suppressor of lin-12-like (C. elegans) 0.0139786
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 0.0139329
ADGRB3 adhesion G protein-coupled receptor B3 0.0139098
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0138725
BAG6 BCL2-associated athanogene 6 0.013838
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0137701
EHBP1 EH domain binding protein 1 0.0137145
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0136821
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0136428
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa 0.0135522
NBR1 neighbor of BRCA1 gene 1 0.0135471

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.170002
TMSB10 thymosin beta 10 -0.148135
GPC3 glypican 3 -0.130426
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.1284
RPS16 ribosomal protein S16 -0.125801
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.10707
PTMA prothymosin, alpha -0.107063
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.104849
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.101626
RPS8 ribosomal protein S8 -0.0972781
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) -0.0943409
RPL23 ribosomal protein L23 -0.0825238
RPL35A ribosomal protein L35a -0.0810887
ACTG1 actin gamma 1 -0.0810727
TPT1 tumor protein, translationally-controlled 1 -0.0804366
RPS12 ribosomal protein S12 -0.0781335
RPS6 ribosomal protein S6 -0.0756322
PHIP pleckstrin homology domain interacting protein -0.0719579
MDK midkine (neurite growth-promoting factor 2) -0.0705635
GNAS GNAS complex locus -0.0672903
COL1A2 collagen, type I, alpha 2 -0.0652729
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 -0.0637078
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0626268
CALR calreticulin -0.0615271
RPL37 ribosomal protein L37 -0.0574532
ISG15 ISG15 ubiquitin-like modifier -0.0558687
RPL37A ribosomal protein L37a -0.0554738
COL11A1 collagen, type XI, alpha 1 -0.054805
ANKRD12 ankyrin repeat domain 12 -0.0529453
RPS19 ribosomal protein S19 -0.0522705
PCDH9 protocadherin 9 -0.0521963
B2M beta-2-microglobulin -0.051778
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.0516413
RPL11 ribosomal protein L11 -0.0514167
RPL5 ribosomal protein L5 -0.0508304
CADM2 cell adhesion molecule 2 -0.0507306
PGK1 phosphoglycerate kinase 1 -0.0506313
RPS27A ribosomal protein S27a -0.0506302
RPL12 ribosomal protein L12 -0.0495249
RPL31 ribosomal protein L31 -0.0486663
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -0.0483975
ENO1 enolase 1, (alpha) -0.0482363
RPLP1 ribosomal protein, large, P1 -0.0474122
NR2F1 nuclear receptor subfamily 2, group F, member 1 -0.0469903
FNDC3A fibronectin type III domain containing 3A -0.0457071
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0447818
CTNNA3 catenin (cadherin-associated protein), alpha 3 -0.0440523
LRRC4C leucine rich repeat containing 4C -0.0440106
FTL ferritin, light polypeptide -0.0435806
JMJD1C jumonji domain containing 1C -0.0426967
RPS3 ribosomal protein S3 -0.0425963
SLIT2 slit homolog 2 (Drosophila) -0.0422847
PDE4D phosphodiesterase 4D, cAMP-specific -0.0417461
TMSB4X thymosin beta 4, X-linked -0.0414276
RPLP0 ribosomal protein, large, P0 -0.041322
RPS13 ribosomal protein S13 -0.041086
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0403698
PLEKHG1 pleckstrin homology domain containing, family G (with RhoGef domain) member 1 -0.0398266
RPL36A ribosomal protein L36a -0.0398197
PRKD1 protein kinase D1 -0.0396392
APOE apolipoprotein E -0.039446
FAM171B family with sequence similarity 171, member B -0.0391469
ADGRL2 adhesion G protein-coupled receptor L2 -0.0388868
PEG10 paternally expressed 10 -0.0387679
MORF4L2 mortality factor 4 like 2 -0.0382228
CAVIN1 caveolae associated protein 1 -0.038219
STRN3 striatin, calmodulin binding protein 3 -0.0381559
HMGB1 high mobility group box 1 -0.0380625
MAML2 mastermind-like 2 (Drosophila) -0.0376073
MT2A metallothionein 2A -0.036964
CDH10 cadherin 10, type 2 (T2-cadherin) -0.0365568
PPP1R12A protein phosphatase 1, regulatory subunit 12A -0.0363469
HS3ST5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 -0.0363414
RPL9 ribosomal protein L9 -0.0359491
SLC38A1 solute carrier family 38, member 1 -0.0359241
RACK1 receptor for activated C kinase 1 -0.0358016
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0352902
RPL34 ribosomal protein L34 -0.0350301
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.035028
EIF1 eukaryotic translation initiation factor 1 -0.0350053
PCDH7 protocadherin 7 -0.0350045
INTS6 integrator complex subunit 6 -0.0345835
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0344777
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0343551
RPS29 ribosomal protein S29 -0.0342483
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0342104
S100A10 S100 calcium binding protein A10 -0.0341877
RPLP2 ribosomal protein, large, P2 -0.0341142
BRWD1 bromodomain and WD repeat domain containing 1 -0.0338718
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) -0.0336831
RPL32 ribosomal protein L32 -0.0336269
RPL38 ribosomal protein L38 -0.0334424
NRG1 neuregulin 1 -0.0332181
NPAS3 neuronal PAS domain protein 3 -0.0330704
NALF1 NALCN channel auxiliary factor 1 -0.0330091
RAB1A RAB1A, member RAS oncogene family -0.0330051
ZC3H12B zinc finger CCCH-type containing 12B -0.0329777
ZNF292 zinc finger protein 292 -0.0329426
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0325373
CDH19 cadherin 19, type 2 -0.0318995