Selinexor _Panc 03.27 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Selinexor perturbation in Panc 03.27 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Selinexor _Panc 03.27 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PCLO piccolo presynaptic cytomatrix protein 0.106924
AHNAK AHNAK nucleoprotein 0.073528
LMO7 LIM domain 7 0.0632031
PLSCR1 phospholipid scramblase 1 0.0399776
SMAD3 SMAD family member 3 0.03697
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0367341
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0346141
SEPTIN9 septin 9 0.0338644
HDAC9 histone deacetylase 9 0.0315723
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0302163
EXT1 exostosin glycosyltransferase 1 0.0299664
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 0.0298241
LPP LIM domain containing preferred translocation partner in lipoma 0.0290359
LAMB3 laminin, beta 3 0.0289972
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0272767
SAMD4A sterile alpha motif domain containing 4A 0.0272038
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.027018
CLDN1 claudin 1 0.0269162
AFDN afadin, adherens junction formation factor 0.0263243
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0261359
RIMKLB ribosomal modification protein rimK-like family member B 0.0257344
BMAL2 basic helix-loop-helix ARNT like 2 0.0242036
LAMC2 laminin, gamma 2 0.0241016
PATJ PATJ crumbs cell polarity complex component 0.0233307
INHBA inhibin, beta A 0.02328
SENP5 SUMO1/sentrin specific peptidase 5 0.0232288
APP amyloid beta (A4) precursor protein 0.0231009
BACE2 beta-site APP-cleaving enzyme 2 0.0228266
MUC4 mucin 4, cell surface associated 0.0226607
ATF3 activating transcription factor 3 0.0225851
AHNAK2 AHNAK nucleoprotein 2 0.0220283
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0215677
BTBD9 BTB (POZ) domain containing 9 0.0215104
DSPP dentin sialophosphoprotein 0.021275
HSPA8 heat shock 70kDa protein 8 0.0210395
MYO5B myosin VB 0.0209481
DOCK1 dedicator of cytokinesis 1 0.0207996
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0207073
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0198687
BCAS3 breast carcinoma amplified sequence 3 0.0198556
TNIP1 TNFAIP3 interacting protein 1 0.0197914
OGA O-GlcNAcase 0.0196018
KDM3A lysine (K)-specific demethylase 3A 0.0193411
RABGAP1L RAB GTPase activating protein 1-like 0.0190308
RPL41 ribosomal protein L41 0.0190168
CFLAR CASP8 and FADD-like apoptosis regulator 0.0189699
MYO1E myosin IE 0.018758
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0187001
ZHX2 zinc fingers and homeoboxes 2 0.0185413
JARID2 jumonji, AT rich interactive domain 2 0.0181086
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0179095
RNF213 ring finger protein 213 0.0179014
DUSP10 dual specificity phosphatase 10 0.017665
ZC3H12C zinc finger CCCH-type containing 12C 0.0175308
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.0172838
KYNU kynureninase 0.0172329
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.016982
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0166599
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.016441
THSD4 thrombospondin, type I, domain containing 4 0.0163719
TRAPPC9 trafficking protein particle complex 9 0.0162701
SYT14 synaptotagmin XIV 0.0160293
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0159118
NPC1 Niemann-Pick disease, type C1 0.0157045
CXCL8 chemokine (C-X-C motif) ligand 8 0.0155282
PLAUR plasminogen activator, urokinase receptor 0.0154281
JAK1 Janus kinase 1 0.0148625
SLC35F3 solute carrier family 35, member F3 0.0148206
GMDS GDP-mannose 4,6-dehydratase 0.0147976
BCAR3 breast cancer anti-estrogen resistance 3 0.0146385
FMNL2 formin-like 2 0.0146289
KLF5 Kruppel-like factor 5 (intestinal) 0.0146186
ANKRD10 ankyrin repeat domain 10 0.014566
ITGB8 integrin, beta 8 0.0145529
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit 0.0145115
SMYD3 SET and MYND domain containing 3 0.0143767
H1-0 H1.0 linker histone 0.0143435
AEBP2 AE binding protein 2 0.014314
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0140272
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0140119
RND3 Rho family GTPase 3 0.0139568
EMP1 epithelial membrane protein 1 0.0139131
VPS8 vacuolar protein sorting 8 homolog (S. cerevisiae) 0.0139103
NCOA3 nuclear receptor coactivator 3 0.013853
FNIP1 folliculin interacting protein 1 0.0137625
FHIT fragile histidine triad 0.0136602
SAMD12 sterile alpha motif domain containing 12 0.0134605
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 0.0133095
MTAP methylthioadenosine phosphorylase 0.0132208
DNAJC13 DnaJ (Hsp40) homolog, subfamily C, member 13 0.0131784
RALY RALY heterogeneous nuclear ribonucleoprotein 0.0131524
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.01313
SOD2 superoxide dismutase 2, mitochondrial 0.013084
RPTOR regulatory associated protein of MTOR, complex 1 0.0128402
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.0127888
SENP2 SUMO1/sentrin/SMT3 specific peptidase 2 0.0124716
ERBIN erbb2 interacting protein 0.012431
ALCAM activated leukocyte cell adhesion molecule 0.0123672
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.0123043
KLF12 Kruppel-like factor 12 0.012296

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.404024
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.176461
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.119075
HMGA1 high mobility group AT-hook 1 -0.117296
RPS6 ribosomal protein S6 -0.102535
TMSB10 thymosin beta 10 -0.10176
POTEF POTE ankyrin domain family, member F -0.0907301
NDRG1 N-myc downstream regulated 1 -0.0888202
RPL23 ribosomal protein L23 -0.0837009
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0807651
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0737607
FOSL1 FOS-like antigen 1 -0.0733901
RPL35A ribosomal protein L35a -0.0716558
LDHA lactate dehydrogenase A -0.0687938
IFI27 interferon, alpha-inducible protein 27 -0.0673066
B2M beta-2-microglobulin -0.0667261
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0643037
PCBP2 poly(rC) binding protein 2 -0.06405
RACK1 receptor for activated C kinase 1 -0.0631361
SMC4 structural maintenance of chromosomes 4 -0.0629726
RPS19 ribosomal protein S19 -0.0626235
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0594941
KTN1 kinectin 1 (kinesin receptor) -0.0590885
EGR1 early growth response 1 -0.0576681
TSC22D2 TSC22 domain family, member 2 -0.0560129
HLA-A major histocompatibility complex, class I, A -0.0552781
RPS13 ribosomal protein S13 -0.0548
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0529792
RPS8 ribosomal protein S8 -0.0528067
TPI1 triosephosphate isomerase 1 -0.0523552
KRT19 keratin 19, type I -0.0520355
MT2A metallothionein 2A -0.0517574
DLG1 discs, large homolog 1 (Drosophila) -0.0513392
FTL ferritin, light polypeptide -0.0506582
FAM3C family with sequence similarity 3, member C -0.0500591
CCNL1 cyclin L1 -0.0498247
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0497853
RPLP1 ribosomal protein, large, P1 -0.0495176
RPS12 ribosomal protein S12 -0.0491352
LOC112694756 uncharaterized LOC112694756 -0.047403
GOLGA4 golgin A4 -0.0456699
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0452835
S100A6 S100 calcium binding protein A6 -0.0448377
RPL12 ribosomal protein L12 -0.0445927
TXNIP thioredoxin interacting protein -0.0436703
CENPF centromere protein F, 350/400kDa -0.0435715
TPM4 tropomyosin 4 -0.0433268
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0428992
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0424886
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0414734
PKM pyruvate kinase, muscle -0.0410303
PLAU plasminogen activator, urokinase -0.040486
UGCG UDP-glucose ceramide glucosyltransferase -0.0403812
PTMA prothymosin, alpha -0.0392509
ANKRD12 ankyrin repeat domain 12 -0.0389318
PRRC2C proline-rich coiled-coil 2C -0.0388891
LY6E lymphocyte antigen 6 complex, locus E -0.0388522
TMEM123 transmembrane protein 123 -0.0387021
PDIA3 protein disulfide isomerase family A, member 3 -0.0383133
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0382488
HLA-B major histocompatibility complex, class I, B -0.0375459
RPL36 ribosomal protein L36 -0.0369721
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0367124
KMT2E lysine (K)-specific methyltransferase 2E -0.0367068
PTBP3 polypyrimidine tract binding protein 3 -0.0365149
FTH1 ferritin, heavy polypeptide 1 -0.0364774
TAPBP TAP binding protein (tapasin) -0.036473
RIOK3 RIO kinase 3 -0.0362606
EIF1 eukaryotic translation initiation factor 1 -0.0359237
RPS14 ribosomal protein S14 -0.0353574
BIRC3 baculoviral IAP repeat containing 3 -0.0351616
RPS23 ribosomal protein S23 -0.0351429
DDIT4 DNA-damage-inducible transcript 4 -0.0350415
RPL11 ribosomal protein L11 -0.0343853
RPS15 ribosomal protein S15 -0.0340728
MKI67 marker of proliferation Ki-67 -0.0335738
S100A10 S100 calcium binding protein A10 -0.0332725
RPL8 ribosomal protein L8 -0.0328043
DIAPH3 diaphanous-related formin 3 -0.0327009
H3-3B H3.3 histone B -0.032682
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0323962
PGK1 phosphoglycerate kinase 1 -0.0322971
WDR45B WD repeat domain 45B -0.0322779
IFITM3 interferon induced transmembrane protein 3 -0.0322308
RPL28 ribosomal protein L28 -0.0322006
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0319808
RPL32 ribosomal protein L32 -0.0319613
RBM25 RNA binding motif protein 25 -0.0316316
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.031271
PDE8A phosphodiesterase 8A -0.0312436
YBX1 Y box binding protein 1 -0.0307679
EZR ezrin -0.0306119
RTN4 reticulon 4 -0.0303938
CDCP1 CUB domain containing protein 1 -0.030099
KDM2A lysine (K)-specific demethylase 2A -0.0300313
VIM vimentin -0.0299418
CAV1 caveolin 1, caveolae protein, 22kDa -0.02989
KPNB1 karyopherin (importin) beta 1 -0.0298661
ARHGAP29 Rho GTPase activating protein 29 -0.0297813
F3 coagulation factor III (thromboplastin, tissue factor) -0.0296056