Selinexor _RKO Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Selinexor perturbation in RKO cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Selinexor _RKO drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.0850332
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0826801
HDAC9 histone deacetylase 9 0.0666985
PBX3 pre-B-cell leukemia homeobox 3 0.0630571
FLNB filamin B, beta 0.0619169
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0614129
FHIT fragile histidine triad 0.0584986
ANK2 ankyrin 2, neuronal 0.0583631
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0581471
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0581176
LPP LIM domain containing preferred translocation partner in lipoma 0.0578058
CALD1 caldesmon 1 0.0576755
LAMB3 laminin, beta 3 0.0565475
NAV2 neuron navigator 2 0.0558231
G0S2 G0/G1 switch 2 0.049297
MT1X metallothionein 1X 0.0492184
SMYD3 SET and MYND domain containing 3 0.0490346
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0447302
EXT1 exostosin glycosyltransferase 1 0.0444698
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0430217
MCTP1 multiple C2 domains, transmembrane 1 0.0422608
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0420136
SAMD4A sterile alpha motif domain containing 4A 0.0419963
RAD51B RAD51 paralog B 0.041425
IFI16 interferon, gamma-inducible protein 16 0.0386687
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.038234
ERBIN erbb2 interacting protein 0.0358964
DENND1A DENN/MADD domain containing 1A 0.0339245
EXOC4 exocyst complex component 4 0.0338505
PRRC2C proline-rich coiled-coil 2C 0.0328598
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 0.0324333
DGKI diacylglycerol kinase, iota 0.0324045
UPP1 uridine phosphorylase 1 0.032155
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0321452
SAMD12 sterile alpha motif domain containing 12 0.0319986
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.0311089
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0308156
FRMD6 FERM domain containing 6 0.0307147
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0303609
ELL2 elongation factor, RNA polymerase II, 2 0.0299857
LRMDA leucine rich melanocyte differentiation associated 0.0294375
GOLGA4 golgin A4 0.027862
UST uronyl-2-sulfotransferase 0.0273407
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 0.0270221
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0265702
BCAS3 breast carcinoma amplified sequence 3 0.026142
JMJD1C jumonji domain containing 1C 0.0256556
CAPRIN2 caprin family member 2 0.0252906
FER fer (fps/fes related) tyrosine kinase 0.0252562
MAPKAP1 mitogen-activated protein kinase associated protein 1 0.0250628
SLC38A2 solute carrier family 38, member 2 0.0250365
BNC2 basonuclin 2 0.0249319
OGA O-GlcNAcase 0.0246772
EFL1 elongation factor like GTPase 1 0.0236925
COL27A1 collagen, type XXVII, alpha 1 0.023556
MACF1 microtubule-actin crosslinking factor 1 0.0235164
SP100 SP100 nuclear antigen 0.0234128
PRKCE protein kinase C, epsilon 0.0227596
CCDC91 coiled-coil domain containing 91 0.0227286
SHANK1 SH3 and multiple ankyrin repeat domains 1 0.022715
ANO6 anoctamin 6 0.0224647
DST dystonin 0.0224239
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0222714
BLTP1 bridge-like lipid transfer protein family member 1 0.0222243
MTAP methylthioadenosine phosphorylase 0.0219498
FNIP1 folliculin interacting protein 1 0.0216985
PLSCR1 phospholipid scramblase 1 0.0214474
FNDC3B fibronectin type III domain containing 3B 0.0211527
PTPRG protein tyrosine phosphatase, receptor type, G 0.0208916
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0206852
HDAC8 histone deacetylase 8 0.0204936
BCAR3 breast cancer anti-estrogen resistance 3 0.0204914
ARHGAP22 Rho GTPase activating protein 22 0.0203884
TTC17 tetratricopeptide repeat domain 17 0.0202093
DOCK6 dedicator of cytokinesis 6 0.0199708
GIGYF2 GRB10 interacting GYF protein 2 0.0197833
RB1CC1 RB1-inducible coiled-coil 1 0.0197126
PUM3 pumilio RNA binding family member 3 0.0196158
OSBPL8 oxysterol binding protein-like 8 0.0196152
AKAP9 A kinase (PRKA) anchor protein 9 0.019586
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0191778
HMGA2 high mobility group AT-hook 2 0.0189407
MAPK8 mitogen-activated protein kinase 8 0.0188273
ECPAS Ecm29 proteasome adaptor and scaffold 0.0188271
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.0187466
SOS1 son of sevenless homolog 1 (Drosophila) 0.0183086
BTBD9 BTB (POZ) domain containing 9 0.0182993
SBF2 SET binding factor 2 0.0182885
RASA2 RAS p21 protein activator 2 0.0181338
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 0.0180809
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0176077
ASPH aspartate beta-hydroxylase 0.0175776
CPQ carboxypeptidase Q 0.0175383
ZBTB20 zinc finger and BTB domain containing 20 0.0173216
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0171657
RIGI RNA sensor RIG-I 0.0171081
CAMKMT calmodulin-lysine N-methyltransferase 0.017081
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0167013
ARB2A ARB2 cotranscriptional regulator A 0.0165291
ADTRP androgen-dependent TFPI-regulating protein 0.0163727

decreased expression

Symbol Name Standardized Value
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.142391
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.129844
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0977569
FTL ferritin, light polypeptide -0.0961111
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0911838
RPLP1 ribosomal protein, large, P1 -0.0743072
PTMA prothymosin, alpha -0.0739951
RPL35A ribosomal protein L35a -0.0733983
RPS8 ribosomal protein S8 -0.0650943
RPL7A ribosomal protein L7a -0.0646374
RPL8 ribosomal protein L8 -0.060197
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0596948
RPS19 ribosomal protein S19 -0.0538055
MKI67 marker of proliferation Ki-67 -0.0532321
RPS6 ribosomal protein S6 -0.0530565
RAD21 RAD21 homolog (S. pombe) -0.0512247
RPS20 ribosomal protein S20 -0.0506626
DIAPH3 diaphanous-related formin 3 -0.0500509
TMSB10 thymosin beta 10 -0.0495811
TPT1 tumor protein, translationally-controlled 1 -0.0491038
RPLP2 ribosomal protein, large, P2 -0.0468605
RPL7 ribosomal protein L7 -0.0465381
PKM pyruvate kinase, muscle -0.0447705
GNAS GNAS complex locus -0.0445125
RPL31 ribosomal protein L31 -0.0435862
RPS13 ribosomal protein S13 -0.0432791
RPL19 ribosomal protein L19 -0.0430783
POTEF POTE ankyrin domain family, member F -0.0427222
RPLP0 ribosomal protein, large, P0 -0.0423775
RPL11 ribosomal protein L11 -0.0410801
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0405042
RPS29 ribosomal protein S29 -0.0390419
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0381167
LOC112694756 uncharaterized LOC112694756 -0.0379142
RPL12 ribosomal protein L12 -0.0375967
RPL35 ribosomal protein L35 -0.0373785
RPL37A ribosomal protein L37a -0.0370529
RPS23 ribosomal protein S23 -0.0370129
KIF5B kinesin family member 5B -0.0362686
RPS25 ribosomal protein S25 -0.036136
S100A2 S100 calcium binding protein A2 -0.0358121
RPL4 ribosomal protein L4 -0.0357603
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0354104
RPS27 ribosomal protein S27 -0.0349561
HMGA1 high mobility group AT-hook 1 -0.0348617
EEF2 eukaryotic translation elongation factor 2 -0.0342944
RPL30 ribosomal protein L30 -0.0338053
YBX1 Y box binding protein 1 -0.0337265
EEF1G eukaryotic translation elongation factor 1 gamma -0.033593
RPS16 ribosomal protein S16 -0.033511
RPL5 ribosomal protein L5 -0.0331408
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0328538
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.032818
S100A9 S100 calcium binding protein A9 -0.03227
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0322559
DLC1 DLC1 Rho GTPase activating protein -0.0321896
KPNB1 karyopherin (importin) beta 1 -0.0321847
PA2G4 proliferation-associated 2G4, 38kDa -0.0320697
AHNAK AHNAK nucleoprotein -0.0319817
PFN1 profilin 1 -0.0317482
CENPF centromere protein F, 350/400kDa -0.0317087
RTN4 reticulon 4 -0.0312399
TTR transthyretin -0.0307929
EIF1 eukaryotic translation initiation factor 1 -0.0304082
RPL23 ribosomal protein L23 -0.0303685
RPS21 ribosomal protein S21 -0.0300103
EGR1 early growth response 1 -0.0297907
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0287695
ATP5F1B ATP synthase F1 subunit beta -0.0285951
BHLHE40 basic helix-loop-helix family, member e40 -0.0280856
ATAD2 ATPase family, AAA domain containing 2 -0.0280652
VDAC1 voltage-dependent anion channel 1 -0.0279026
RPS24 ribosomal protein S24 -0.0278336
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0275388
RPL36A ribosomal protein L36a -0.0272478
TUBB4B tubulin, beta 4B class IVb -0.027166
RPS5 ribosomal protein S5 -0.0265804
UBB ubiquitin B -0.0264982
ENO1 enolase 1, (alpha) -0.0264789
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0256382
RPS11 ribosomal protein S11 -0.0255118
RPL37 ribosomal protein L37 -0.0254043
RPL32 ribosomal protein L32 -0.0252776
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0252085
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0251473
CLTC clathrin, heavy chain (Hc) -0.025123
RPL36 ribosomal protein L36 -0.0250621
PGK1 phosphoglycerate kinase 1 -0.0250573
RPL13A ribosomal protein L13a -0.0249794
DEK DEK proto-oncogene -0.0246072
SMC4 structural maintenance of chromosomes 4 -0.0245274
TPX2 TPX2, microtubule-associated -0.0244991
RPL34 ribosomal protein L34 -0.02428
PHIP pleckstrin homology domain interacting protein -0.0239689
ENO2 enolase 2 (gamma, neuronal) -0.0236928
S100A6 S100 calcium binding protein A6 -0.023582
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0234765
MTPN myotrophin -0.0234666
CANX calnexin -0.023261
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0232197