Selinexor _SHP-77 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Selinexor perturbation in SHP-77 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Selinexor _SHP-77 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ST18 suppression of tumorigenicity 18, zinc finger 0.0332568
PCLO piccolo presynaptic cytomatrix protein 0.0321128
COL22A1 collagen, type XXII, alpha 1 0.0149079
PDZRN3 PDZ domain containing ring finger 3 0.0147979
ARRDC3 arrestin domain containing 3 0.0144031
TUFT1 tuftelin 1 0.0138524
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6 0.0132446
XPO1 exportin 1 0.0127583
TMEM255B transmembrane protein 255B 0.0118824
NDST4 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 0.0112204
RIMBP2 RIMS binding protein 2 0.0106062
EPHA4 EPH receptor A4 0.010059
FMN1 formin 1 0.0099093
RNF150 ring finger protein 150 0.00971392
MSN moesin 0.00963115
WNK3 WNK lysine deficient protein kinase 3 0.00949041
LRRC8D leucine rich repeat containing 8 family, member D 0.00941914
STK32A serine/threonine kinase 32A 0.00882444
VEGFA vascular endothelial growth factor A 0.00875149
IVNS1ABP influenza virus NS1A binding protein 0.00862189
PTPN3 protein tyrosine phosphatase, non-receptor type 3 0.00851035
BPNT2 3'(2'), 5'-bisphosphate nucleotidase 2 0.00839433
CDK13 cyclin-dependent kinase 13 0.00821555
CACNB2 calcium channel, voltage-dependent, beta 2 subunit 0.00821269
CNTNAP5 contactin associated protein-like 5 0.00819617
CCNH cyclin H 0.00812806
TSPYL2 TSPY-like 2 0.0079682
SLC43A2 solute carrier family 43 (amino acid system L transporter), member 2 0.00770532
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.00766065
MACROD2 MACRO domain containing 2 0.00751649
INTS6 integrator complex subunit 6 0.0075129
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.00740717
ITPRID2 ITPR interacting domain containing 2 0.00732512
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.00730385
CHGB chromogranin B 0.00727089
ACVR1 activin A receptor, type I 0.00721929
ANKUB1 ankyrin repeat and ubiquitin domain containing 1 0.00719997
PRPF40B PRP40 pre-mRNA processing factor 40 homolog B (S. cerevisiae) 0.00719049
MAGED2 melanoma antigen family D2 0.00713294
ATP6V1H ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H 0.00706961
CD24 CD24 molecule 0.00695561
FLNA filamin A, alpha 0.00694462
IGFBP5 insulin-like growth factor binding protein 5 0.00687129
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) 0.00685811
ZBTB1 zinc finger and BTB domain containing 1 0.0068017
ZNF532 zinc finger protein 532 0.00679062
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 0.00674021
CHIC2 cysteine-rich hydrophobic domain 2 0.00664449
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 0.00660321
AP1G2 adaptor-related protein complex 1, gamma 2 subunit 0.00655971
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta 0.00644506
MBTD1 mbt domain containing 1 0.0064067
MYT1L myelin transcription factor 1-like 0.00636505
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.00634678
LRATD1 LRAT domain containing 1 0.00628508
SNTG1 syntrophin, gamma 1 0.00620939
SLIT2 slit homolog 2 (Drosophila) 0.00619764
KCNMB3 potassium channel subfamily M regulatory beta subunit 3 0.00618565
ZNF337 zinc finger protein 337 0.0060946
SZT2 seizure threshold 2 homolog (mouse) 0.00608803
CREB1 cAMP responsive element binding protein 1 0.00606898
TOX3 TOX high mobility group box family member 3 0.00603048
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.00601963
SRRM4 serine/arginine repetitive matrix 4 0.00592629
SPIN3 spindlin family, member 3 0.00586669
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 0.00586308
CDK14 cyclin-dependent kinase 14 0.0058473
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21 0.00581261
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.0058113
CCNG2 cyclin G2 0.00577604
SLC44A2 solute carrier family 44 (choline transporter), member 2 0.00576345
IPCEF1 interaction protein for cytohesin exchange factors 1 0.00575142
GALK2 galactokinase 2 0.00574667
FNDC3B fibronectin type III domain containing 3B 0.00573668
EPC2 enhancer of polycomb homolog 2 (Drosophila) 0.00566963
TTC27 tetratricopeptide repeat domain 27 0.00564807
WDR1 WD repeat domain 1 0.00554315
MAP3K7 mitogen-activated protein kinase kinase kinase 7 0.00554173
TNS1 tensin 1 0.00553513
AEBP2 AE binding protein 2 0.00552978
FOSL2 FOS-like antigen 2 0.00546695
GOLGA3 golgin A3 0.00546621
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.00546128
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 0.00546082
ANO6 anoctamin 6 0.00541485
FAM120B family with sequence similarity 120B 0.00537291
SIPA1L2 signal-induced proliferation-associated 1 like 2 0.00536966
PLXNA2 plexin A2 0.00535456
EFL1 elongation factor like GTPase 1 0.00531155
ZFYVE16 zinc finger, FYVE domain containing 16 0.00526641
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 0.00524762
TMEM165 transmembrane protein 165 0.00518854
EEFSEC eukaryotic elongation factor, selenocysteine-tRNA-specific 0.00517234
RBM12B RNA binding motif protein 12B 0.00515282
SLC45A4 solute carrier family 45, member 4 0.00514628
BCR breakpoint cluster region 0.00514584
SHB Src homology 2 domain containing adaptor protein B 0.00513835
SLC38A6 solute carrier family 38, member 6 0.00513508
SLC8A3 solute carrier family 8 (sodium/calcium exchanger), member 3 0.00513386
CAPRIN2 caprin family member 2 0.00512952

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.197333
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.140994
TENM1 teneurin transmembrane protein 1 -0.117344
CALCA calcitonin-related polypeptide alpha -0.106279
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.101467
ENO1 enolase 1, (alpha) -0.0997628
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0969831
NALF1 NALCN channel auxiliary factor 1 -0.0908603
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0855122
FTL ferritin, light polypeptide -0.0789732
PEG10 paternally expressed 10 -0.0727577
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0675677
CENPF centromere protein F, 350/400kDa -0.0623136
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0594559
NRG1 neuregulin 1 -0.0588829
GPC6 glypican 6 -0.058224
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0576825
RPS21 ribosomal protein S21 -0.0573745
RPS3 ribosomal protein S3 -0.0571536
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0564857
MT2A metallothionein 2A -0.0544511
STC1 stanniocalcin 1 -0.0537304
RPL26 ribosomal protein L26 -0.0527216
RPS6 ribosomal protein S6 -0.0523223
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0503852
PDE10A phosphodiesterase 10A -0.0497482
RPS8 ribosomal protein S8 -0.0486823
RPS27A ribosomal protein S27a -0.0470502
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0470187
LOC112694756 uncharaterized LOC112694756 -0.0466931
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0466291
INHBA inhibin, beta A -0.0465007
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0462336
VGF VGF nerve growth factor inducible -0.0460023
PGK1 phosphoglycerate kinase 1 -0.0459306
MATR3 matrin 3 -0.0444652
RAD21 RAD21 homolog (S. pombe) -0.0441993
MAP1B microtubule-associated protein 1B -0.0436797
RPL8 ribosomal protein L8 -0.042992
RPL11 ribosomal protein L11 -0.0425209
RPL37A ribosomal protein L37a -0.042376
RPLP1 ribosomal protein, large, P1 -0.0414063
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.041172
NIPBL Nipped-B homolog (Drosophila) -0.0410677
NCOR1 nuclear receptor corepressor 1 -0.0409454
RTN4 reticulon 4 -0.0399657
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0397532
ZNF292 zinc finger protein 292 -0.0391541
ARB2A ARB2 cotranscriptional regulator A -0.0389348
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.038104
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0378546
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0377607
RPL23 ribosomal protein L23 -0.0375634
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0375038
KTN1 kinectin 1 (kinesin receptor) -0.0375036
SYT1 synaptotagmin I -0.0372261
SINHCAF SIN3-HDAC complex associated factor -0.0372026
ACTG1 actin gamma 1 -0.0371336
NAP1L1 nucleosome assembly protein 1-like 1 -0.036692
MKI67 marker of proliferation Ki-67 -0.0366809
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0366756
DTNA dystrobrevin, alpha -0.0365986
NCKAP5 NCK-associated protein 5 -0.0364401
KPNB1 karyopherin (importin) beta 1 -0.0359326
RIMS2 regulating synaptic membrane exocytosis 2 -0.0357457
IFI6 interferon, alpha-inducible protein 6 -0.035156
TMSB4X thymosin beta 4, X-linked -0.035133
CCDC88A coiled-coil domain containing 88A -0.0346337
TMSB10 thymosin beta 10 -0.0343935
S100A9 S100 calcium binding protein A9 -0.0343015
RPL37 ribosomal protein L37 -0.0341029
NFIA nuclear factor I/A -0.0336724
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0334822
EIF5B eukaryotic translation initiation factor 5B -0.033462
RPL5 ribosomal protein L5 -0.0333808
RPL7 ribosomal protein L7 -0.0331571
RPS12 ribosomal protein S12 -0.0331236
TXNRD1 thioredoxin reductase 1 -0.0327616
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0322021
SET SET nuclear proto-oncogene -0.0319533
PDE4B phosphodiesterase 4B, cAMP-specific -0.0316501
PCM1 pericentriolar material 1 -0.0314113
ATP5F1E ATP synthase F1 subunit epsilon -0.031207
PRRC2C proline-rich coiled-coil 2C -0.0311553
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0309052
PKM pyruvate kinase, muscle -0.0308855
SMC1A structural maintenance of chromosomes 1A -0.0306651
EEF2 eukaryotic translation elongation factor 2 -0.0306639
PDIA6 protein disulfide isomerase family A, member 6 -0.0305586
RPL32 ribosomal protein L32 -0.0301822
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0301575
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.0301055
RBM25 RNA binding motif protein 25 -0.030096
RPS16 ribosomal protein S16 -0.0300457
RPS19 ribosomal protein S19 -0.0295962
SERBP1 SERPINE1 mRNA binding protein 1 -0.0293696
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0292628
RPS25 ribosomal protein S25 -0.0292059
SEPTIN7 septin 7 -0.0291348
CADM1 cell adhesion molecule 1 -0.0291175