Senile Plaques Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
External Link https://www.disgenet.org/browser/0/1/0/C0333463
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Genes

240 genes associated with the disease Senile Plaques in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
A2M alpha-2-macroglobulin
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ACE angiotensin I converting enzyme
ACHE acetylcholinesterase (Yt blood group)
ACOT7 acyl-CoA thioesterase 7
ACTB actin, beta
ACTBL2 actin, beta-like 2
ACTG1 actin gamma 1
ACTG2 actin, gamma 2, smooth muscle, enteric
ADAM10 ADAM metallopeptidase domain 10
ADAP1 ArfGAP with dual PH domains 1
AEBP1 AE binding protein 1
AGER advanced glycosylation end product-specific receptor
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR1 angiotensin II receptor, type 1
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
AIF1 allograft inflammatory factor 1
AIM2 absent in melanoma 2
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
AKR1C4 aldo-keto reductase family 1, member C4
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALB albumin
ALOX5 arachidonate 5-lipoxygenase
APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
APMAP adipocyte plasma membrane associated protein
APOE apolipoprotein E
APP amyloid beta (A4) precursor protein
AQP4 aquaporin 4
ATM ATM serine/threonine kinase
BACE1 beta-site APP-cleaving enzyme 1
BACE2 beta-site APP-cleaving enzyme 2
BCHE butyrylcholinesterase
BDNF brain-derived neurotrophic factor
BGN biglycan
C1D C1D nuclear receptor corepressor
C1R complement component 1, r subcomponent
C2ORF40 chromosome 2 open reading frame 40
C9ORF72 chromosome 9 open reading frame 72
CASP3 caspase 3, apoptosis-related cysteine peptidase
CAST calpastatin
CCL2 chemokine (C-C motif) ligand 2
CCND1 cyclin D1
CD70 CD70 molecule
CDK1 cyclin-dependent kinase 1
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CETN1 centrin, EF-hand protein, 1
CETP cholesteryl ester transfer protein, plasma
CGA glycoprotein hormones, alpha polypeptide
CHAT choline O-acetyltransferase
CHGA chromogranin A
CHMP2B charged multivesicular body protein 2B
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal)
CLU clusterin
COL25A1 collagen, type XXV, alpha 1
CREBBP CREB binding protein
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CRP C-reactive protein, pentraxin-related
CST3 cystatin C
CTF1 cardiotrophin 1
CTSD cathepsin D
CTSK cathepsin K
CTSZ cathepsin Z
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1
CYP46A1 cytochrome P450, family 46, subfamily A, polypeptide 1
DAD1 defender against cell death 1
DCN decorin
DSCAM Down syndrome cell adhesion molecule
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
EIF4E eukaryotic translation initiation factor 4E
ENO2 enolase 2 (gamma, neuronal)
FGF1 fibroblast growth factor 1 (acidic)
FHL5 four and a half LIM domains 5
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FPR2 formyl peptide receptor 2
FSIP1 fibrous sheath interacting protein 1
GAP43 growth associated protein 43
GFAP glial fibrillary acidic protein
GLP1R glucagon-like peptide 1 receptor
GLUL glutamate-ammonia ligase
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GPC1 glypican 1
GPI glucose-6-phosphate isomerase
GRAP2 GRB2-related adaptor protein 2
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1
GRN granulin
GSAP gamma-secretase activating protein
HDAC9 histone deacetylase 9
HMOX1 heme oxygenase 1
HOOK1 hook microtubule-tethering protein 1
HOOK2 hook microtubule-tethering protein 2
HOOK3 hook microtubule-tethering protein 3
HPGDS hematopoietic prostaglandin D synthase
HPSE heparanase
HPSE2 heparanase 2 (inactive)
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10
HSPB1 heat shock 27kDa protein 1
HSPB2 heat shock 27kDa protein 2
HSPB3 heat shock 27kDa protein 3
HSPB6 heat shock protein, alpha-crystallin-related, B6
HSPB8 heat shock 22kDa protein 8
HTT huntingtin
ICAM1 intercellular adhesion molecule 1
IDE insulin-degrading enzyme
IGF2 insulin-like growth factor 2
IGFALS insulin-like growth factor binding protein, acid labile subunit
IL10 interleukin 10
IL13 interleukin 13
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL2 interleukin 2
IL4 interleukin 4
IL6 interleukin 6
ITM2B integral membrane protein 2B
KNG1 kininogen 1
LIF leukemia inhibitory factor
LOX lysyl oxidase
LPL lipoprotein lipase
LRP1 low density lipoprotein receptor-related protein 1
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
MAOB monoamine oxidase B
MAP2 microtubule-associated protein 2
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK8 mitogen-activated protein kinase 8
MAPK9 mitogen-activated protein kinase 9
MAPT microtubule-associated protein tau
MELTF melanotransferrin
METAP2 methionyl aminopeptidase 2
MME membrane metallo-endopeptidase
MMRN1 multimerin 1
MPO myeloperoxidase
MT3 metallothionein 3
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MX1 MX dynamin-like GTPase 1
NDFIP1 Nedd4 family interacting protein 1
NDRG2 NDRG family member 2
NEU1 sialidase 1 (lysosomal sialidase)
NLRP1 NLR family, pyrin domain containing 1
NLRP3 NLR family, pyrin domain containing 3
NOLC1 nucleolar and coiled-body phosphoprotein 1
NRDC nardilysin convertase
NRGN neurogranin (protein kinase C substrate, RC3)
NTN1 netrin 1
OGA O-GlcNAcase
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
OPN1LW opsin 1 (cone pigments), long-wave-sensitive
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
PABPC4 poly(A) binding protein, cytoplasmic 4 (inducible form)
PAEP progestagen-associated endometrial protein
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1
PCBP4 poly(rC) binding protein 4
PDC phosducin
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
POLD1 polymerase (DNA directed), delta 1, catalytic subunit
POLDIP2 polymerase (DNA-directed), delta interacting protein 2
POTEM POTE ankyrin domain family, member M
PPARA peroxisome proliferator-activated receptor alpha
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A
PRNP prion protein
PSEN1 presenilin 1
PSEN2 presenilin 2
PTEN phosphatase and tensin homolog
PTGDR prostaglandin D2 receptor (DP)
PTGDS prostaglandin D2 synthase 21kDa (brain)
PZP pregnancy-zone protein
RAB3A RAB3A, member RAS oncogene family
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic)
RBL2 retinoblastoma-like 2
REEP5 receptor accessory protein 5
RMDN1 regulator of microtubule dynamics 1
RMDN2 regulator of microtubule dynamics 2
RMDN3 regulator of microtubule dynamics 3
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RTN1 reticulon 1
RTN3 reticulon 3
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
S100A1 S100 calcium binding protein A1
S100A6 S100 calcium binding protein A6
S100A9 S100 calcium binding protein A9
S100B S100 calcium binding protein B
SCARB1 scavenger receptor class B, member 1
SDF4 stromal cell derived factor 4
SEPT2 septin 2
SEPTIN1 septin 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SFRP1 secreted frizzled-related protein 1
SH2B1 SH2B adaptor protein 1
SIRT1 sirtuin 1
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
SLC30A3 solute carrier family 30 (zinc transporter), member 3
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SNCB synuclein, beta
SNCG synuclein, gamma (breast cancer-specific protein 1)
SOD1 superoxide dismutase 1, soluble
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SORT1 sortilin 1
SRPX sushi-repeat containing protein, X-linked
STK16 serine/threonine kinase 16
SUCLA2 succinate-CoA ligase, ADP-forming, beta subunit
SYBU syntabulin (syntaxin-interacting)
SYN1 synapsin I
SYP synaptophysin
SYPL2 synaptophysin-like 2
TAOK2 TAO kinase 2
TARDBP TAR DNA binding protein
TCL1B T-cell leukemia/lymphoma 1B
TDO2 tryptophan 2,3-dioxygenase
TFDP1 transcription factor Dp-1
TGFB1 transforming growth factor, beta 1
TGFB2 transforming growth factor, beta 2
TLR3 toll-like receptor 3
TLR4 toll-like receptor 4
TMEM106B transmembrane protein 106B
TMEM176B transmembrane protein 176B
TMEM230 transmembrane protein 230
TNF tumor necrosis factor
TPH2 tryptophan hydroxylase 2
TREM1 triggering receptor expressed on myeloid cells 1
TREM2 triggering receptor expressed on myeloid cells 2
TRPC1 transient receptor potential cation channel, subfamily C, member 1
TSHZ1 teashirt zinc finger homeobox 1
TTR transthyretin
UBB ubiquitin B
USF1 upstream transcription factor 1
VCP valosin containing protein
WNK1 WNK lysine deficient protein kinase 1
XK X-linked Kx blood group
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble